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There is a staggering amount of artwork on display here. It is said that if you stood at each piece for just one minute, it would take you four years to see everything. Created by Pope Julius II in the early 16th century, the museums have expanded over the past 500 years to their current size of more than 12 acres! Highlights include the Borgia Apartments, the Raphael Rooms, the Gallery of Maps, and of course, the sublime Sistine Chapel.

Nestled at the base of the Valley of the Ten Peaks, Moraine Lake boasts turquoise waters that change color throughout the day as sunlight refracts off the minuscule particles of glacier-ground rock suspended within. Though it has a B-list rating compared to Lake Louise’s A-list status, this spot is arguably the more spectacular of the two. It’s located a little less than nine miles from the hamlet of Lake Louise. When you arrive, you can hike up to the Rockpile (clearly visible at the front of the lake) for the best vantage point, or spend a day exploring one of the neighboring valleys.

Be forewarned: The parking lot often fills up by 10 a.m., so go early.

“Dude” is a word that’s used a lot around Rancho Pescadero, a small hotel in the surfing town of Todos Santos, located in the Mexican state of Baja California. The rooms here, however, don’t reflect the dude aesthetic, which is to say they are clean and classy. Spacious suites offer comfortable spots to relax, with most having retractable glass doors that eliminate barriers between indoors and outdoors and open up onto terraces that have hammocks or lounge beds. Terra-cotta tile floors, rattan and wood furniture, and locally made accents—such as hand-embroidered throw pillows—are some of the decor elements found in rooms. Surfers won’t feel totally out of their element, though; world-famous breaks are less than 10 minutes away and staff can give pointers on the best spots to hang ten. Apart from surfing, the hotel encourages guests to spend a lot of time relaxing and immersing themselves in the laid-back Baja lifestyle.

It may seem unbelievable now, given the pace of Siem Reap’s evolution, but reliably great coffee and other deli and bakery staples were tough to find before Blue Pumpkin set up shop near the turn of the millennium. Success may have changed the venture—it now has a number of outlets in Siem Reap, and several more in Phnom Penh—but the philosophy of serving simple but high-quality Asian and Western dishes remains intact. Menu highlights include generously proportioned breakfasts and sandwiches, decadent cakes, famous yogurt shakes, and a wide selection of homemade ice creams and sorbets.

Swift streams and waterfalls continue to carve these vertiginous and rugged valleys as they pour into the sea. One of the most stunning wilderness areas on earth, it also contains ancient Hawaiian ruins of graves, temples, house platforms, and terraced fields. The fear factor increases past the initial two-mile path to Hanakāpīʻai Beach (best visited in summertime, as winter swells tend to wash it away). Only experienced hikers in good condition and with proper gear should venture further along the famous 11-mile Kalalau Trail. Check for path and park closures before making plans and don’t forget the $20/night permit to crash at a campsite. However long you trek, stay on the main path and pack out what you brought in.

Often described as the Grand Canyon of the Pacific, this 10-mile-long Kauai valley is a kaleidoscopic array of scarlet earth, verdant valleys, and raw volcanic crags. Bands of color streak the corrugated landscape, each representing a different eruption and layer of lava. Waimea Canyon Drive has a series of lookouts; among the most popular is Waimea Canyon (past the Mile 10 marker on Highway 550), where a number of rivers once cascaded down the gently sloping shield volcano. When part of its flank collapsed, the rivers combined with dramatic results. Continue into the mountains to explore Koke’e State Park beyond. Its small, free museum contains a 3-D map, which sheds light on the canyon’s wild beauty, while the gift shop specializes in local art, crafts, and Niihau shell jewelry.

Overlooking a postcard-perfect Venetian street (a former canal, now paved over) in the artistic Dorsoduro district, this 500-year-old merchant’s townhouse has been revamped as the boutique hotel Ca’Pisani. Behind the traditional exterior lies a modern den with clean lines and sharp, geometric forms that’s enhanced by original work from one of Italy’s most notable Futurist artists, Fortunato Depero. Architects Roberto Luigi Canovaro and Pierluigi Pescolderung balanced original design elements—exposed beam ceilings, brickwork—with 1930s touches, including one-of-a-kind inlay door designs and custom masonry and marble work.

Gaze out at the city’s rooftops from the hotel’s roof terrace, or mingle with locals over wine or an espresso at the street-level café. With the Peggy Guggenheim collection and the Gallerie dell’Accademia gallery just a stroll away, you’ll be able to journey from 16^th-century Venice to the 20^th century all in a few famous paintings.

This little village fuels many a Chilean’s vision of the south—Germanic towns nestled among sapphire-hued lakes—and is often synonymous with summer vacation. Frutillar, just north of Puerto Varas, seems to be straight from Bavaria with its majestic “casonas,” built in the German tradition—a nod to the strong ancestry and settlement in the region. Frutillar’s lakefront has black-sand beaches, the shimmering lake dotted with white swans, magnificent views of the Osorno volcano, manicured lawns, and darling boutiques and cafes along the town’s streets. During the last week of January and first week of February, music lovers flock to Frutillar for the classical music festival where maestros from all over the world play in the Teatro del Lago, with some of the best acoustics in Chile. Besides strolling the relaxed lakefront, Frutillar is perfect to stop for a coffee and “kuchen,” a delectable German cake found throughout the lake district made with seasonal fruit.

Located across the Tiber River from the Centro Storico, Trastevere is a kaleidoscope of ivy-covered buildings, complicated Italian history, and bombastic nightlife. The heart of the neighborhood is Piazza Santa Maria, a large square where street performers show off their stuff, and Porta Portese’s massive Sunday flea market. Film buffs can take a walk through the maze-like side streets for a glimpse of director Pier Paolo Pasolini’s early life before heading off to one of the neighborhood’s many bars for a craft beer or aperitivo.

One of my highest recommendations for drinks is the Grand Hyatt Shanghai. The Grand Hyatt occupies the top 36 floors of the 88-story Jin Mao Tower in the Jetsons-looking Pudong district, so at sunset (or anytime) you have a stunning view (with no cover charge!) of all of Shanghai. There are lots of choices for eating and drinking in the Grand Hyatt. When I was there at sunset, nobody else was in the Cloud 9 sky lounge (which is like a night club with a 360-degree view from the 87th floor), so I went down to the 53rd-floor Lobby Lounge, which still seemed plenty high, and enjoyed the view and the cocktails there.

Yes, Hauz Khas Village is perhaps most known for its artsy vibe, boutique shops, and trendy restaurants. But before it became a lively commercial district, Hauz Kaus was (and remains) a 13th-century historical complex with a mosque, tombs, and an Islamic seminary. Take a break from the bustle of shopping and dining to explore the sites from Muslim royalty, then spend some time at the charming lake with its swans, ducks, and other wildlife.

It’s hard to say what’s most appealing about the ultraluxurious Four Seasons Gresham Palace, a stately Art Nouveau hotel on the banks of the Danube. Perhaps it’s the central location, on the Pest side of the iconic Chain Bridge, or the swank accommodations, which range from lovely river-racing rooms with marble bathrooms and deep soaking tubs to sumptuous suites, the largest of which measures 1,464 square feet and features a dining room with crystal stemware and private butler service. With its top-floor infinity pool and picture windows overlooking the city, the spa alone makes a stay worthwhile—a coup in a city known for its thermal bath complexes—but for many travelers, it’s the hearty dishes served at Kollázs Brasserie & Bar (rotisserie lamb shoulder with eggplant and olives; octopus and scallops with potato paprikash) that seal the deal.

The Feldherrenhallewas was modelled after the “Loggia dei Lanzi " in Florence. It was commissioned by King Ludwig I of Bavaria and constructed between 1841 to 1844. It was built as a monument to celebrate the Bavarian army and its victorious generals. Unfortunately it’s also the place of a tragic incident. On November 9, 1923, a confrontation between the Bavarian State Police and an illegally organized march by the followers of Adolf Hitler took place here. When the police issued the stop of the march, the protestors continued. The State Police tried to regain control of the crowd and opened fire. Four policemen and sixteen marchers were killed and many more were injured as a result. Consequently, Hitler was arrested and sentenced to prison.

If one is going to throw around the word “iconic,” let’s make sure it’s used appropriately. As with Zuni. The awkwardly shaped restaurant—it’s in a narrow storefront with wider spaces on the mezzanine—was opened in 1979 by Billy West. West’s best move was hiring chef Judy Rodgers in 1987. She put in a brick oven—and thus the Zuni roast chicken was born. This dish, more than any other (except perhaps the Caesar salad), defines Zuni. The chicken is roasted in the brick oven and served over a bread salad: greens with chewy bread croutons. Simple, perfectly cooked, and seasonal. Rodgers died in 2013, but the restaurant soldiers on without her. The menu changes with the season and with what the local farms are growing, and will doubtless explain the provenance of your meat. Rodgers, along with her peer across the bay, Alice Waters, pioneered California cooking, and the cooks who have passed through here have gone on to define today’s vibrant restaurant scene.

When you think of a chocolate factory, a hip and airy space in the heart of one of the city’s hottest neighborhoods may not spring to mind. But therein lies the surprise that is Dandelion Chocolate: part factory, part café, part boutique, and located in the heart of the Mission. Like beans for coffee and grapes for wine, Dandelion brings the idea of single-origin sourcing to each bar it creates. Rather than add strange ingredients to alter the flavor of the chocolate, Dandelion uses just two ingredients—cocoa beans and sugar—which allows each bean’s unique flavor and terroir to shine. Drop in for hot chocolate (with handmade marshmallows) or a chocolate dessert created by Dandelion’s pastry chef, shop for gifts, and take a twirl through the factory, where beans are roasted, cracked, sorted, winnowed, ground, and tempered before being molded. Each bar is wrapped by hand in gorgeous paper and ribbon and affixed with a label that tells a story about the cocoa bean’s origin. For a deeper dive into chocolate, Dandelion has a schedule of classes for adults and kids, and even leads trips to cocoa farms.