Not only is the Lower East Side one of Manhattan's most "hipster" and quirky neighborhoods, but it's also home to the Tenement Museum. Although this museum doesn't get as much praise as the MET or the MoMA, it's definitely worth a visit, even if you're only in town for three days.
Telling the stories of 97 Orchard Street, a visit includes a walk inside the actual building where nearly 7000 working class immigrants lived during the 19th and 20th centuries. Moving to New York is never an easy task, and this was especially true for immigrants at this time. Learning what life was like for these families not only gives great perspective on the American Dream but also enhances the neighborhood and its unique history and transformation.