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Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

You haven’t truly experienced Texas until you’ve visited the hallowed grounds of the Alamo. Established in 1718 as the Mission San Antonio de Valero, the building is best known as the site of the 1836 Battle of the Alamo, a 13-day siege under Mexican president General Antonio López de Santa Anna that ultimately killed nearly all of the Texan defenders. To stroll past the limestone facade and envision the battle that played out here is truly a once-in-a-lifetime experience. For a real treat, book an after-hours tour and get the Texas landmark all to yourself as you walk in the footsteps of the fallen soldiers.

Sydney’s 158-acre botanic garden, which hugs the harbor between Mrs Macquarie’s Chair and the Sydney Opera House, is home to nearly 9,000 plant species. Depending on the season of your visit, you might seek out spring peaches and wisteria or tropical orchids and summer lotus flowers. On any occasion, don’t miss descendants of the 200-million-year-old Wollemi pine, a dinosaur of a conifer only discovered in 1994. The gardens are also studded with sculptures from historical statues to modern works by Bronwyn Oliver, Paul Selwood, and Keld Moseholm. The quartz-and-sandstone Wurrungwuri depicts an Aboriginal shield once used by the traditional owners of this land. Tours are offered throughout the year, including a 1.5-hour Aboriginal history tour on the food and medicinal properties of native Australian plants.

Facing the Arabian Sea and the Gateway of India monument, the Taj Mahal Palace Hotel blends Moorish, Florentine, and Indian architecture. The historic palace wing reopened in 2010 with 243 new rooms and 42 suites, including one that houses the sitar on which legendary Indian musician Ravi Shankar composed his Concerto No. 1. George Harrison checked into the Taj in 1966 to take lessons from the maestro.

Near the wharf along upper Bay Street, a distinctive, street-level arcade connects several historic stone buildings, which once functioned as arrowroot warehouses. For centuries, these rows of Georgian stone arches and second-floor overhangs have sheltered Kingstown’s workers, walkers, and vendors from the hot sun and occasional shower—hence Kingstown’s nickname, the “City of Arches.”

Elwood Bar and Grill now lies in the shadow of Comerica Park on Adams but it was built in 1936 by Charles Noble at the corner of Elizabeth Street and Woodward Avenue. Moved in 1997 to make way for the new Tigers stadium (Comerica Park) it was and still is downtown Detroit’s most recognizable art deco diner. Now restored following its move, it is the premier place for sports fans, history buffs, couples, singles, and anyone looking for a good time to hang out on game day or any other day of the year. Its proximity to Comerica Park and Ford Field (the latter is where the Lions play), also makes it ideal both for pre- and post-game enjoyment. A recently expanded menu also makes it a great place not just to drink, but also to eat.

Why we love it: A hotel-cum-art-museum with a historical pedigree

The Highlights:
- 6,200 square feet of on-site exhibition space
- Historical details like the art nouveau dome in the lobby
- A hip restaurant with great cocktails

The Review:
This downtown hotel is the eighth property in the 21c collection, a concept founded by art collectors and preservationists Laura Lee Brown and Steve Wilson that blurs the lines between a boutique hotel and a contemporary art museum. Housed in what was once the Savoy Hotel and Grill—a luxurious destination for train travelers in the early 1900s—the 21c Kansas City pairs historical details (stunning stained-glass windows, original hotel sinks in each room) with modern art (including curated exhibitions, site-specific installations, and cultural programming). Designed by architecture firm Deborah Berke Partners and the Kansas City–based Hufft Projects, the 120 spacious rooms and suites carry the juxtaposition even further, complementing high ceilings and large windows with punchy purple sofas and original artwork.

Located between Kansas City’s Power & Light District and River Market, the hotel is ideally situated for exploring the city’s best dining and shopping, as well as the 100-plus market stalls selling produce, baked goods, and flowers. When you don’t feel like leaving the property, however, there’s The Savory at 21c restaurant, housed in what was once the oldest restaurant west of the Mississippi and a favorite of prominent figures like President Truman (his preferred booth still sits in the bar and lounge area). Here, Kansas City native Joe West now serves a creative take on classic Americana, with a traditional cocktail list to match. In case you feel yourself slipping into nostalgia, just head out to the lobby, where a massive glowing chandelier by Ken+Julia Yonetani will remind you that you’re at one of Kansas City’s most modern stays.

The Ottoman Bank Museum is in the basement of SALT Galata, an arts center located in the former Ottoman Bank. It’s a destination that will appeal mostly to those interested in the history of the Ottoman Empire in its decline at the end of the 19th century. But doesn’t everyone find the late Ottoman period fascinating? The struggles that characterized the era, with a country torn between its Ottoman past and a desire to both modernize and Westernize, played out at the bank. The institution that would become the state bank of the Ottoman Empire was founded in 1856 as a joint venture of British and French banks and the Ottoman government and was managed by a committee of British and French financiers until it was effectively dissolved during World War I. The museum includes many surprisingly engaging displays and documents tracing the bank’s history—its commercial ventures, demographic information on investors and employees, charts detailing the economic turmoil of the period. Architectural plans of the headquarters illustrate its unusual design that featured a neo-classical entrance facing the European quarter and an Ottoman-inspired rear elevation, facing Istanbul’s Old City across the Golden Horn. Deposit slips, photos of employees, and old bank notes in the original vault are on display in almost exhausting, encyclopedic comprehensiveness. If your interest wanes, you don’t need to feel any pressure to linger—entrance is free.

225 meters below the surface of the earth, visitors make their way through dim passageways that miners in the late 1800s had navigated in search of gold. The tour guide ‘jokingly’ points out that if for some reason we get stuck down there, the only way out is a via a steep emergency exit tunnel. In the photo for this post, there is a miner located beyond the struts (which are used to support the ceiling), who’s job it is to demonstrate what it was like in the past when miners excavated the gold bearing ore with nothing but a candle for light! During the tour, you’ll learn about the gold rush that caused the formation of Johannesburg and you’ll also be shown some interesting historical items, like dynamite which was manufactured by Alfred Nobel

Even a Brussels native would be forgiven for thinking, at first glance, that the Dominican is a historic building. After all, the façade incorporates many of the features that existed when renowned 19^th-century French painter Jacques-Louis David lived at this address. And, inside, the site’s former incarnation as a 15^th-century Dominican monastery appears in such details as the courtyard colonnade and original stone floors in the serene Monastery Corridor. The soaring ceilings, oversized windows, and ornate ironwork of the Grand Lounge and its adjacent bar call to mind the grand cafés of early 20^th-century Europe, while rooms are adorned with vibrant paintings of classical subjects, like those by David and his contemporaries.

As historic as it all is, though, there’s no doubt that the Dominican is a modern hotel. The contemporary decor harmoniously complements its surroundings, and each of the 150 luxurious rooms has been individually designed. Many afford views of the impressive La Monnaie, the city’s opera house, located next door. The lounge is one of Brussels’ hottest spots for everything from power lunches to date nights, and the gym even has a private boxing room.

Located in Wood Dale, Yesterday’s Farm Museum is trip to a different era. The barn pictured above is part of the Wood Dale Historical Society, and it was constructed back in the 1850s. This massive structure is referred to as a ‘T’ barn due to the unique design for its time period. It features a hayloft, a feeding area for the horses, and a place for the cows to get their grub on as well (pictured above). But the coolest part is that during October, as Halloween approaches, the folks here provide hayrides for family and friends, and also feature spooky ghost stories at night in the barn. They don’t currently have a website, so please call 630-595-8777 for information and upcoming events.

The historic Crazy Mountain Inn is a great place to stop while cruising through Montana, especially if you arrive with a growling stomach. The Inn’s legendary chicken-fried steak will set you right (and put you in the mood for a 10-mile trek, or a fireside nap, depending on your constitution). The Sour Cream Lemon Pie is qually famed, though lighter breakfasts, lunches, and dinners do come out of the kitchen from time to time.

Ningbo’s Old Bund was the place where historic British and Dutch traders lived and you can still see remaining architecture. The swooped lines of Chinese-style buildings are replaced by old stone buildings with familiar details. Also known as Laowaitan, the area is now a lively street full of bars and restaurants. In the evenings, find bamboo sticks of vegetables, seafood, and meat grilled over big chunks of charcoal and smothered in spices—the perfect snack after a few drinks at the Old Bund.

In the historic Candelaria district, the 42-room Hotel de la Ópera occupies two colonial townhouses and parts of a 1940s art deco mansion. Head up to the rooftop restaurant, El Mirador, to enjoy ajiaco (potato soup with corn, chicken, and aji chili) along with views of the city’s main cathedral. From $162. 57/(0) 1-336-2066. This appeared in the August/September 2013 issue. Image courtesy of Hotel de la Ópera

On the non-descript, busy corner of Bucareli and Morelos streets in Mexico City is a café with a famous history: Fidel Castro and Che Guevarra met here at Café La Habana several times, chain smoking and drinking strong coffee, to plan the Cuban Revolution. Nowadays, you can still get excellent coffee—and pretty good food—while you plan something a little less dramatic (but more enjoyable), like your vacation itinerary. Old journalists and businessmen congregate here for hours on end while salt-of-the-earth, slightly surly waitresses take your order and bring you your food and drink. Come for breakfast and order their chilaquiles, motuleños, or molletes, and wash it down with an espresso or café americano.