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Long before the West was even wild, between the years 600 and 1450, an ancient group of peoples known as the Hohokam brought life to the Arizona desert with an intricate canal system. Parts of it are still in use today and, in addition to providing water for crops and sustenance, they serve as recreational spots. In downtown Scottsdale, the Arizona Canal runs through two of the area’s most popular districts—Scottsdale Waterfront and SouthBridge. Shop for fashion finds at Amy Inc. or sweet and sassy children’s threads from the Garage. Brunch at the Herb Box is a local favorite (red velvet pancakes!) and, around the corner, Culinary Dropout draws a trendy crowd with its gastro-pub fare and cocktail list. Art lovers should roam the Arizona Canal to take in the city’s free public installations, especially the Soleri Bridge and Plaza. A first from Italian architect Paolo Soleri, the structure marks annual solar events and evokes his fascination for planetary movement.

It’s a single street after Amsterdam‘s Negen Straats (Nine Streets), but Hazenstraat, the Tiende Straatje (Tenth Street), rates a ten in serious shoppers’ books. Lined with boutiques, cafés and galleries, this cobbled strip in the Bohemian-chic Jordaan begins starts at Lauriergracht, where French urban artist Invader installed one of 26 mini-mosaics inspired by Space Invaders characters. Highlights include: The English Bookshop, as much a literary gathering spot as a place to buy books and DVDs made from them; Petsalon, a hat shop that’s been a Jordaan fixture for 25+ years; Brown Clothes, featuring Kings Road-inspired couture; Joep Buijs’ art studio, with paintings of colorful women, children and dogs; Olivaria, Holland’s oldest olive specialty shop; Coffeeshop Biba, a back-to-the-60s-style smoke shop that’s grown up with the flower children; Chocolátl, a chocoholic’s Nirvana; Cats ‘n Things, for all things feline; Saarein. a bar for all “queer minded people"; La Festa Pizzeria/Bed & Breakfast; ‘t Stuivertje, serving continental cuisine; and Flamework, Daniela Malaica’s glass jewelry shop proffering vibrant necklaces and other contemporary accessories inspired by her African-Italian roots.

What sets Pizzeria Biga apart from other Italian restaurants and pizza parlors is the care that goes into their menu and the daily creation of the dishes and pizzas that exit their kitchen. Yet that same care starts long before the wood fired ovens are even lit. Head chef Luciano Del Signore developed a type of yeast with which to make his dough that allows for the absence of sugar, the inclusion of a probiotic, and results a perfectly charred Napoletana pizza pie. Many who struggle with gluten and wheat sensitivities will likely find that his pizza doesn’t bother them. Small plates and an excellent craft beer menu are also tempting but the pizza is the real star of the simple yet extensive menu. I also enjoyed their arugula salad, meatballs, and risotto balls. The large selection of toppings really pleased me as well. However, it’s the basil ice cream and the house-made pistachio gelato that I am still craving days later.

No matter how many postcards you’ve seen of Rome’s iconic Colosseum, you just don’t get it until you pass beneath its crumbling arches. Built by Emperor Vespasian in 72 C.E., the huge amphitheater held 50,000 spectators and marked its opening with 100 days of brutal spectacles like gladiator combat and animal fights. The Colosseum was in use for four centuries, and now you can tour the ruins. Walk through the Hypogeum, an intricate series of tunnels and elevators originally used to transport animals, slaves, and gladiators, to the performance above, or take a moonlit tour to have one of the world’s most storied structures all to yourself.

Chances are you’ve seen Maria Pinto’s works at some point in recent years—she’s known for dressing the likes of First Lady Michelle Obama, Oprah Winfrey, and Brooke Shields. That fan base is only growing with the opening of her West Loop Style Studio, where women can shop M2057 by Maria Pinto, a ready-to-wear collection inspired by urban architecture and design. Created for the time-pressed but fashion-forward woman, Pinto’s pieces marry runway ideas with a low-maintenance aesthetic (the upscale fabrics might be imported from Italy, but they’re also machine-washable and wrinkle-resistant—perfect for travel). In addition to plenty of day-to-night options like dresses, skirts, tops, and pants, the boutique also carries belts and jewelry by outside artists, curated by Pinto.

This glamorous villa is situated on Capri’s main road—and just a five-minute walk to the port—but JK Place feels like a refuge from the tourist throngs. Interiors have a chic, polished aesthetic that’s the embodiment of la dolce vita: The crisp white-and-navy spaces are filled with beautiful art and antiques, dramatic fireplaces, and colorful bouquets of blooms, while large windows and panoramic terraces capture views of rugged green hills that fall into the sea. (Yes, that’s Mount Vesuvius looming in the distance.) Posh touches continue in the guest rooms—think monogrammed pillows, canopy beds, wingback chairs, and marble- and mosaic-tiled bathrooms. Lemon trees scent the air throughout the property, from the elegant pool deck and on-site spa to the terrace bar, where sunset aperitivos are accompanied by tasty bites such as sea bream sliders and quail-egg canapés.

The history of the palaces and streets and artwork of Florence comes alive during this multimedia theater performance, acted out (in English) in a small baroque church. The show tells the story of two feuding Medici siblings—the last grand duke of the dynasty, Gian Gastone, and his sister, Anna Maria Luisa—and the patto di famiglia, or family pact, that bequeathed the family treasures to the city-state their forebears had ruled for hundreds of years. Long before there was reality television, there was family drama, Florentine style.

The Hotel Flora is an ivy-clad 17^th-century palazzo tucked down a narrow alleyway in San Marco. It’s hidden from the crowds, but still an easy stroll to the buzz of San Marco Palazzo and the Grand Canal. Like all grand Venetian homes, it’s had its share of interesting inhabitants over the years, including a School of Painting, a salon for well-known local artists. Continuing the artistic legacy, the Romanelli family—photographers, writers, and antique collectors among them—has owned the hotel for the last 50 years.

In the classic manner of a pension, the hotel is intimate and the staff welcoming and friendly. Rooms are cozy and decorated with traditional antique furnishings, heavy drapes, and bold brocade wallpaper in some. Pop down to the Victorian-styled bar for an aperitif, or linger over an espresso with a good read in the hushed garden.

Hilton Molino Stucky on Giudecca Island is a zippy five-minute boat ride (free for guests) away from bustling Piazza San Marco, and ideally located for those craving a tad more tranquility without missing out on any of those sweeping Venetian vistas. Once a working flourmill, this brick, industrial-era fortress has been reimagined as a luxury hotel with all of the modern bells and whistles. Take a break from museum hopping with a day spent surveying the city below from the city’s only rooftop pool (followed by quality time spent in the spa). Of course, with several dining options just steps from your room, you could happily spend most of your time right here.

If mixing business with pleasure, this hotel—with Executive Suites, a ballroom for events, several conference rooms, and a business center—makes for a superbly scenic day at the office.

Situated between two lakes at the bottom of the Jungfrau mountain in the Bernese Highlands of Switzerland, this venerable five-star hotel and spa, which dates back to 1865, offers scenery and comfort in equal measure. Subtly balancing tradition and modernity, the rooms are bright, spacious, and brimming with refined furnishings and fabrics. Plus, all come with picturesque views across the town of Interlaken or the Harder Kulm mountain. There are several higher-end suites to choose from; modernists might like the clean lines of the stylish Bel-Air suite, while hedonists will love the lavish Tower Suite, with its two terraces, kitchenette, bar, and dining room.

The hotel’s two restaurants serve Mediterranean-inspired dishes from the south of France and Italy, and there are two handsome bars and a gloriously expansive spa for further diversion.

Set in an 18th-century palazzo, once a former bank, the Park Hyatt Milan boasts interiors designed by American-born, Paris-based architect Edward Tuttle. It aims to wow from the outset. Guests are greeted by a lobby decorated with sophisticated materials such as warm travertine stone and alabaster, and topped with a 30-foot glass-domed cupola. There’s a discernibly modern aesthetic throughout the rest of the hotel, though, from the vibrant modern art scattered throughout the public areas to the contemporary color palettes (creams, beiges, and gentle grays). Rooms are correspondingly elegant, with high ceilings, expensive dark woods, rich wool carpets, and hand-selected furnishings (Murano light fixtures, Bang & Olufsen TVs). The bathrooms are especially impressive, not only because of their generous size and marbled interiors, but also thanks to the mirrored walls, double sinks, octagonal stone and glass showers, and Lauro Tonatto bath products.

A. Caraceni is often described as the very best in Milan when it comes to tailors. At this shop, you’ll only find high-quality suits, impeccable cuts, and polished styles. The Caraceni tailoring legacy goes back more than a century, when the needle-working family was still in Rome. What followed was a line of talented tailors who have traversed continents to create beautiful suits. Everything at the store is hand-sewn, from formal smoking jackets to more casual hunting wear. Pick up a double-breasted jacket, the shop’s signature piece.

Gabriele Bonci’s famous pizza-by-the-slice joint serves some of the best pizza in town. The slow-leavened dough is made from organic stoneground flour, and toppings change throughout the day. Pizzarium also sells excellent bread and supplì (fried rice balls with various fillings). If you dare, get one of every slice. Doing so will certainly push Pizzarium out of the moderate budget range, but it is a worthwhile splurge. Pair your pizza with a craft beer from the fridge. Beware: the tiny place gets crowded at lunch, there are only a couple of benches outside to sit on, and there is no table service.

The beautiful “suburb” of Genoa, Nervi boasts a lovely series of green parks (something Genoa lacks overall) and a well-tended passeggiata path that runs directly along the rocky shore. Especially popular with families on the weekend, the path is easily accessible from the Nervi train station (a 10-minute ride from Brignole Station in central Genoa). Spend the day escaping the bustle of central Genoa by walking along the shore, enjoying the museums tucked into centuries-old palaces in the parks, and having dinner at a small fish restaurant along the coast.

Built on the foundations of a 16th century fortification, the Museo delle Culture del Mondo is housed in the 19th century Castello D’Albertis - the private home of the global traveler and collector of antiquities. Veer off the standard art/church museum trail, and up the massive staircase to the Castello, to see a beautifully preserved piece of Genovese history (and some super fascinating collections of global interest). While the walk is quite the hike, the view from the top floor library of the museum is stunning.