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Founded in the 9th century, Santa Maria della Scala was one of Europe’s first hospitals. It was also one of the first hospitals anywhere to disinfect its equipment and only stopped taking in patients in the 1980s. (The writer Italo Calvino died here in 1961.) The early history of the hospital is illustrated in the 15th-century frescoes decorating the walls of the Pilgrim’s Hall, and there is a fascinating archaeological museum housed in the labyrinthine basement rooms.

Ask anyone you know who grew up in the Bay Area about the Exploratorium, and they’ll likely be able to share stories of class trips and seeing their hair stand on end at an installation about electricity or fun-house mirrors that taught about optics and visual perception. This is not, however, a museum simply for kids—though curious kids will definitely be entertained while learning. Instead, its exhibits aim to raise the scientific literacy of visitors of all ages, by providing engaging, amusing, and hands-on experiences. Long housed at the Palace of Fine Arts, the Exploratorium opened in its current, and much larger, space on Piers 15 and 17 in 2013. One advantage of the new waterfront location is the North Gallery and its outdoor spaces, focused on environmental phenomena like the wind, rain, and tides. The completely dark Tactile Dome and the disorienting Monochromatic Room may prove not just the highlights of your visit to the Exploratorium but the most memorable, or at least strangest, moments of your time in San Francisco.

The Newseum is an interactive, ever-evolving tribute to our First Amendment freedoms of religion, speech, press, assembly, and petition. Powerful exhibits such as eight sections of the Berlin Wall (the largest display outside Germany) provide historical context for the importance of free press, while timely exhibits about the civil rights movement provoke reflection on the progress of achieving equality. The daily-updated “Front Pages” gallery of local, national, and international publications is a comparative study on current events, while the archive of headlines highlighting momentous events from the 1400s through today is an engaging history lesson. Peruse Pulitzer Prize–winning photography, enjoy panoramic views down Pennsylvania Avenue, and test your journalistic skills with a recorded mock-broadcast—reading a teleprompter is not as easy as you may think!

Visitors flock to southern Arizona for sun and saguaros... ...but for a hole in the ground? Other than the ones on golf courses? From the 1960’s to the 1980’s, Tucson was ringed by eighteen steel-and-concrete-reinforced holes in the ground--highly secure shafts in the desert that housed intercontinental ballistic missiles tipped with multi-megaton nuclear bombs. “Peace through Deterrance” was the idea, as the propaganda-phrase goes... Of the 54 Titan Missile complexes that were scattered around the country, only this one, about 45 minutes south of Tucson, has been preserved and opened to the public. It’s a startling reminder of how thin the line was that separated the “Cold War” from “M.A.D."--"mutual assured destruction.” It would only have taken 30 minutes from its desert launch for this missile to deliver unimaginable destruction--via a 9 megaton nuclear warhead--up to 6300 miles (10,000km) away... On a lighter note, some of the filming of one of the Star Trek films took place here. You can visit the subterranean control bunker and staff living quarters, access corridors, and the missile silo itself. Tours are offered on the hour year-round, with additional tours offered every thirty minutes from January through April. Closed Christmas and Thanksgiving. Whether you’re coming from the left or from the right, politically, the sobering reality of this fusion of human nature and technology is worth going underground for if you’re driving down I-19.

Much of Mexico City’s fervid contemporary art movement—galleries and collectors abound; the scene is now a launching pad for Mexican artists looking to conquer the world—can be traced to art patron Eugenio López Alonso, heir to the Jumex packaged-juice fortune, who over decades has amassed Latin America’s most extensive contemporary art collection and brought dozens of artists to the international spotlight. The collection’s flagship museum, itself a work of art by the British architect David Chipperfield, is a surprisingly intimate exhibition space that supports a rotating calendar of shows; the basement bookstore will delight bibliophiles and design freaks alike. Right nearby lies the Museo Soumaya, whose dramatic architectural form (which earned it the nickname “the Blender”) makes up for a collection some consider erratic.

After 80 some odd years as one of Houston’s most lauded and refined hotels, the historic Warwick Hotel went from Bach to rock, when new owners gave it a slick makeover and renamed it Hotel ZaZa in 2007. A bold beacon in the Museum District, the dimly lit hotel is a virtual playground for adults, with daring decor, baroque details, and an outdoor pool with private piazza-themed cabanas. While it maintains much of its original 1920s architectural elegance and details, including Baccarat chandeliers, the interior walls are splashed with modern art and iconic editorial-photo shots of beloved celebs.

Many rooms and event spaces are themed, including the space-inspired “Houston, We Have a Problem” Suite and the Conspiracy Room, which nods to Prohibition. A recent refresh includes newly renovated 11^th-floor meeting rooms, new mattresses, new carpet, spa and fitness center upgrades (including treatment room tweaks and the addition of innovative infrared saunas), and new in-room flat-screen TVs. Bottom line: even an overnight stay feels like a true escape.

Controlled by the François Pinault Foundation, the same trust in charge of Christie’s auction house, this is a museum-worthy gallery in the heart of Venice. Set inside a 17th-century customs house, it showcases Pinault’s impressive private collection, comprised of some 2,500 pieces of modern art. The location, at the point of land where the Grand Canal meets the Giudecca Canal, is equally spectacular. After you’ve finished browsing the art collection, grab a pastry or a small bite at the in-house Dogana Cafe.

Berggasse 19 is the address of a modest house on a modest street, but it was there that much of the modern world and culture were changed forever. For nearly 50 years, the Freud house—now, officially, the Sigmund Freud Museum—was the home and office of the legendary psychoanalyst, until 1938 when he finally departed for London as Nazi forces were descending on Vienna. The rooms are filled with old books, antiques, personal artifacts, and correspondence, though not the famous couch (which is now at the Freud museum in London). In 2019, the house will undergo a yearlong €4 million renovation to its facade and exhibition spaces. If you walk the Ringstrasse over to the Burgtheater area, you can see the University of Vienna that was once the General Hospital where Herr Professor worked for many years.

The 10th century temple of Banteay Srei, known as the ‘Citadel of Women’, is one of the prettiest temples with intricately detailed carvings and decorative features painstakingly carved into the pink sandstone. It’s also one of the most compact and can easily be explored in an hour or two. You can make a day trip of the journey out there (25km from Siem Reap) by combining it with visits to the nearby Landmine Museum and Banteay Srei Butterfly Centre.

Tucked deep in the heart of the ancient city, this is an easy Palazzo to miss—but don’t miss it. My favorite of the Genovese museums, five floors of this massive palace are dedicated to the history and splendor of Genoa—the first three being the restored palace of the Spinola family, and the top two serving as the National Gallery. Explore beautiful frescoes, ceramics from the 1700s, actual clothing from the 15th century, and a massive original Rubens, among the many other varied treasures.

“She’s an original yet timeless Québec fashion designer—a rare combination. Marie Saint Pierre is known for using unusual fabrics with soft colors as well as black and white. Her designs feel really classic. I stop in when I need something chic and comfortable,” says Nathalie Bondil, head curator at the Montreal Museum of Fine Arts.

This brand-new hotel next to the massive, newly opened Music City Center convention space is one of Nashville’s hottest places to stay. Opened in fall of 2013, it’s also in the heart of the action and within easy walking distance of Schermerhorn Symphony Center, the honky-tonks of Lower Broadway, and the Country Music Hall of Fame and Museum. But even if you never left the building, you’d find 800 rooms, five restaurants and live music spaces, a spa and rooftop pool deck.

There’s no shortage of architecturally-interesting museums and performance spaces in Spain but few come by their intrigue as honestly as Matadero Madrid (which was once the city’s abattoir). Built in a neo-Moorish style, the sprawling center hosts all kinds of creative endeavors today, from a Bicycle Film Festival to concerts to design exhibitions.

It takes some German engineering to surf in land-locked Bavaria. But endless rides are possible on the Eisbach wave, a man-made, standing curl in the middle of a narrow artificial stream that runs through the English Garden. It has drawn both international river surfers—even in winter—and gawking crowds since soon after the wave was created in 2000. The Eisbach wave is located at the southern edge of the English Garden park, near the Haus der Kunst art museum. This appeared in the November/December 2011 issue.

A 1,200-acre green space filled with museums, theaters, and gardens, Balboa Park is the center of art and culture in San Diego. It’s also one of the city’s most historic sites, built for the Panama–California exhibition in 1915. While the museums are definitely worth seeing, there are also a number of free attractions, including the photogenic Botanical Building, which houses more than 2,100 plants (including Venus flytraps); the Desert Garden, filled with succulents from around the world; and a sculpture court with works by Miró and Rodin. For one of the area’s best views, purchase a timed ticket to climb the California Tower in the Museum of Man. The ornate structure reopened to the public in 2015 after being closed for nearly 80 years and features a spiral staircase to the eighth floor, where you can catch a glimpse of the Cuyamaca Mountains, the Cabrillo Bridge, and even Mexico’s Coronado Islands.