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Wedged between former cotton mills in the neighborhood of Cabbagetown, Agave is an Atlanta favorite for its eclectic Southwestern cuisine. The posole soup and spicy tequila anejo shrimp with grits put a Southern spin on Southwestern classics. Most of the dishes come in gluten-free varieties. Try the classic margaritas or go funky with mango or passionfruit varieties.

Watching the river flow by with a margarita in hand is one of the best ways to while away an afternoon in San Antonio, and at Casa Rio, you can do just that. The restaurant’s colorful umbrellas have lined the River Walk since 1946, providing a postcard-perfect backdrop for sampling enchiladas, flautas, fajitas, and, of course, icy-cold margaritas. The oldest restaurant on the riverfront, Casa Rio is beloved for its authentic Tex-Mex cuisine, but its real charm lies in its ambience. Request an outdoor table and let your worries float away with the river. Just be sure to decide between frozen and on the rocks first.

The outdoor cantina upstairs at the famed Coyote Cafe makes a perfect spot to perch and enjoy a bird’s-eye view of the bustle of the Santa Fe streets. Try the Lava Lamp cocktail, a more-delicious-than-it-sounds blend of draft beer and a frozen margarita. Other concoctions like the prickly pear margarita make excellent companions to the warm, thickly cut tortilla chips and fire-roasted salsa.

Just 12 miles north of Santa Fe, this picturesque spot is perfect for table-side, made-to-order guacamole and a cold margarita (or two) on a spacious, relaxed scenic patio full of flowers and stunning high-desert mountain views. You might not want to leave.

A local favorite, Bar La Ranita (Little Frog) is attached to the Hotel Rana Cansada (Tired Frog) and has been around since 1984. The ambiance is laid back, but the prices are affordable and the margaritas pack a powerful punch.

Cocktails are not a huge part of the Italian culture, especially not those involving tequila. But at Bar Les Rouges, the three brothers who own the bar mix up one amazing margarita (They even come to your table asking you to sample which salt you want on the rim. Go for the smoked one, it’s perfection!). Housed in a dimly lit and slightly crumbling 16th-century palace, this is one of the most romantic spots in town—a perfect date night out.

Head up to the fifth floor of the bustling, popular La Fonda Hotel for stellar sunset views of city and distant mountains. Arrive early to beat the crowds and settle in. Relax with the signature margarita called the Bell Ringer, makes the experience all the more authentic.

I first visited Wahoo’s Fish Taco in Denver and have been going back ever since. It seems much more appropriate that Wahoo’s, with its surfboarding theme, has a location in Hawaii. The location I frequented is in Ala Moana. Time permitting, I would get my food to go and sit at the Ala Moana Beach park for a picnic dinner. Wahoo’s has a good selection of burritos, salads, and tacos. A pitcher of margaritas or local beers are usually popular with a group as well! If you collect stickers, just ask at the counter and if they have any on hand, they will gift one to you.

Set at the end of Duval Street, near Sunset Pier and Mallory Square, Pier House takes advantage of its waterfront address with three tiers of balconies and a pocket-sized stretch of private beach. Its location means guests are within walking distance of all of Old Town’s highlights, from the Clinton Square Market to the Harry S. Truman Little White House. Many come to follow in the footsteps of the mayor of Margaritaville himself, Jimmy Buffet, who played his first gig in town in the hotel’s now infamous Chart Room Bar. Order a rum runner, then head to the heated outdoor pool; though it’s on the small side, it has sweet views to Key West Bight. After an adventure-packed day, the rooms and suites offer low-key comfort, decorated with traditional furniture and local art and overlooking the ocean or tropical gardens and koi ponds. Equally serene is the full-service spa, one of the few on Key West.

El Burrito is a casual little Mexican cantina that serves excellent fajitas, tacos, and burritos, and legendary coconut margaritas that might make it difficult for you to find your way back to your hotel. But hey, you’re on vacation, and deserve to let loose every now and then. El Burrito sits at the heart of the Puntacana Village complex, a short ride from the beach, Playa Blanca, the Westin, the ecological reserve, and more.

Years ago when Mexico City’s southern neighborhoods were in fact small, independent cities, the quarter known as San Ángel Inn was a sylvan getaway for well-heeled urbanites. No longer an inn, the area’s namesake—a former Carmelite convent from the eighteenth century—persists as an iconic, country-club-style restaurant and lounge. Its venerable walls, gardens, and fountains call up colonial gentility and ward away the urban chaos just outside the door; strolling mariachis are the sole “disruption.” Sip what many believe is the city’s best margarita amid an impeccable, songbird-serenaded garden.

This used to be a hacienda, but it was turned into a restaurant almost 50 years ago. The food is phenomenal and the margaritas are famous—in fact, they’re my favorite thing on the menu. There is always a band or a pianist playing.

For the best views in Gardiner, pop down onto the big patio at the Iron Horse Bar & Grill and gaze out over the river, mountains, and unspoilt terrain of Montana and Yellowstone National Park. Order up a heaping pile of elk nachos, a few craft beers, a hulking bison meatloaf, and perhaps a mulberry margarita or two, and chill on Gardiner’s only real cowboy pation. Keep an eye out for bears on the banks of the river.

A bit of a dive a mile and a half from Santa Fe’s tourist center, Maria’s has been a local favorite since 1952. The food is straightforward and delicious, but the place is at least as beloved for its margaritas—an eight-page menu lists more than 200 choices, all made with 100 percent agave tequila and lemon juice—which routinely win “best of” awards from local publications. Read more about green chilis. This appeared in the January/February 2014 issue.

The flavor and Spanish Colonial charm of San Miguel de Allende come to life at Los Sombreros, where the atmosphere is as enchanting as the satiny mole Poblano sauce. If you travel with a friend, try the 10-course tasting menu. For $75, it serves two and includes dishes like pozole soup, fig and panela cheese salad, and chile relleno. Los Sombreros also has more than a dozen margaritas to choose from as well as specialty drinks like the Tijuana Donkey with tequila, ginger beer and fresh lime.

Cocktails in Hawaii are likely to evoke tiny umbrellas, wedges of pineapple, and unnatural-colored liquid. Honolulu bar Pint + Jigger takes a different tack, mixing up cocktails like the Smoking Gun margarita, with smoked macadamia nut simple syrup and aged tequila. They also have an extensive whiskey list, nearly two dozen beers on tap, and another 40 in bottle, representing both local microbrews and globally known favorites. The gastropub menu is also a standout, serving many bar food classics like burgers and fish-and-chips made in-house, with suggested cocktail and beer pairings.