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Lake Maggiore, the second largest Italian lake after Lake Garda, holds the three jewel-like Borromean Islands, Isola Bella, Isola Madre, and the quaint and picturesque, Isola dei Pescatori.

If you are coming to Genoa to find a luxurious seaside escape, get out of the urban city and make sure you stay at least one night at the Grand Hotel Miramare in Santa Margherita Ligure (roughly 45 minutes from Genoa by train). With a full service spa, massive saltwater pool, and breathtaking ocean views, this hotel makes a perfect base to explore the entirety of the Italian Riviera (including neighboring Portofino, the tiny villages of Cinque Terre, and the hidden beaches that dot the coastline). With these sea views, it is definitely worth splurging on an oceanfront room. (Unfortunately, this hotel is closed January through March, so you may need to plan accordingly.)

Switzerland draws influence from neighboring countries France, Germany, and Italy to produce some of the most refined dining in Europe. From traditional mountainside restaurants serving up fondue, raclette, and rösti to exquisite inner-city dining in Zurich and Geneva, the Swiss simply excel at gastronomy. Explore Switzerland’s best alpine restaurants, seafood eateries, and melt-in-the-mouth Swiss cheese hotspots—including a few Michelin-starred treats along the way.

If Southern California had ever been annexed by La Serenissima Repubblica di Venezia, the Fairmont Grand Del Mar would be the governor’s palace—all marble columns, gold-leafed staircases, and hand-stenciled ceilings. Even the 400-acre grounds, with their classical fountains, garden rotundas, and neatly arranged cypresses, are true to the retro Italianate vibe. The luxuries, however, are modern—namely, the 18-hole Tom Fazio–designed golf course and the critically acclaimed restaurant Addison. There, Relais & Châteaux grand chef William Bradley lures locals and travelers with his contemporary French cuisine, a seasonal tasting menu, and a wine list of more than 3,500 selections. (There are a few other drinking and dining options, too, including a casual all-day option, a clubby grill room, and a nightclub for live music and weekend DJs.)

The hotel’s 249 guest rooms and suites feature European-style soaking tubs, and views over the gardens, golf club, or Los Peñasquitos Canyon Preserve. Two opulent villas—ranging in size from 4,500 to 5,000 square feet—are tailor-made for families and larger groups. The spa here is also one of San Diego’s best: Book a signature Renaissance spa therapy, and follow the scent of eucalyptus-infused mist all the way down a grand staircase to your Moor mud wrap.

Gothic and grand, this 18th-century former nobleman’s home stands proudly on the banks of the Grand Canal in the San Marco district. Venetian-born owner and interior designer (among her many talents) Francesca Possati has restored this historic home to its regal glory. She has worked with local artists to breathe new life into original woodwork, ornate trompe l’oeil ceilings, and silk wall hangings, resulting in a once-again polished and posh palazzo. The distinctly Venetian rooms—many with canal views—are styled with rich fabrics, bold wall coverings, and pristine period antiques and illuminated by Murano glass chandeliers. Of course, they’ve been updated with the latest modern perks (like Italian marble and whirlpool tubs in the bathroom).

Stroll the art-filled hallways, splurge for a tasting menu at the elegant restaurant, and watch the gondolas float by from the red-awninged terrace. La dolce vita, indeed.

Boston deserves far more attention for its food scene than the city usually gets. From reinvented lobster rolls and other fresh seafood to small plates put out by James Beard-award winning chefs, there’s a near-dizzying selection of good eats to choose from. You’ll want to add extra days to your trip as you start to wend your way through menu options featuring coastal Italian food, clam chowder and raw bars, dry-aged steaks, wood-grilled pizzas, upscale tinned fish (yes, really), and so much more.

Thrifters, costume lovers, and antique collectors can all find something to love at Junkee Clothing Exchange, one of Reno’s most charming vintage stores. You can bring your clothes to sell for store credit, or simply wander among the racks of sequined dresses, costume accessories, vintage boots, and fur coats. Don’t forget to admire the creepy-cool goth-circus artwork hanging on the walls, and the elaborate chandeliers. The other half of the store is a large antique mall with individual stalls run by separate sellers. You’ll find everything from vintage rhinestone jewelry to garden-party hats and World’s Fair souvenirs. Prices are reasonable and they carry clothing for men and women in a wide range of sizes.

Cesare al Casaletto is far off the well-beaten tourist track, but it is easy to get to: just take the 8 tram from Piazza Venezia or Largo Argentina and get off at the very last stop. Fifty yards from the tram tracks sits Rome‘s best trattoria, where spectacular fried appetizers (get them all, or at least the gnocchi fritti and polpette di bollito) give way to classic pasta dishes like carbonara and gricia. The second courses are excellent and fall-off-the-tailbone braised oxtail is a favorite. Pair it all with fairly priced natural wines from all over Italy and be sure to leave room for dessert, preferably the panna cotta.

If you have a gorgeously sunny afternoon, walk the Corso Italia to the small fishing village of Boccadasse, still considered to be part of Genoa. About an hour’s walk from central town, this seaside stroll will take you past black stone beaches, children’s parks, and countless bars and restaurants enjoying the beautiful sea views. When you arrive, make sure to roll up your pants and step in the water, as the sea spray alone is said to have healing properties.

Set in a 12th-century palace that looks like the setting for a Wes Anderson film, Palazzo Avino is skirted in flower-filled gardens terraced across a cliffside in Ravello. Interiors are as opulent as the storybook architecture, filled with antiques and marble and featuring charming details such as stained-glass windows, Hermès textiles, and antique carpets. Picturesque is an understatement for the panoramas that extend from the sunbathing lawns that surround the pool area. Even the fitness facilities take advantage of the vistas: Cardio machines are set in cabanas in the gardens, making for arguably the world’s most scenic spinning sessions. Since you’re right in the center of town, guests can walk to several restaurants and bars or stay put at the hotel’s Michelin-starred Rossellinis, an alfresco lunch spot known for its lobster and champagne pairings; if you’re looking for something more spirited, opt for one of the 100 different martinis on the menu at the Lobster & Martini Bar.

JK Place Firenze is a far cry from Florence’s obsession with all things Renaissance. Set amid the buzz of Piazza di Santa Maria Novella, this onetime private mansion is decked out in black, white, peach, gray, and chrome, with inflections of 1950s movie stars, 1970s pop art, and ornate 19th-century architecture. The reception feels like a library, and the breakfast room is a glassed-over former courtyard with a hefty antique wooden communal table. Free drinks, fresh fruit, and homemade treats (and bubbles at cocktail hour) can be found at all hours in the guests-only lounge area. Impress your well-heeled friends by inviting them to dine on the piazza terrace, presided over by the appropriately black-and-white Basilica di Santa Maria Novella, before moving downstairs to the clubby J.K. Pink Room. Slip upstairs to your individually designed room for a divine night’s sleep, then awake ready to take on one of the world’s most historic cities.

A journey into Morocco’s Berber territory, where tradition and modern life meet.

Completed in 1916, this Italian-inspired villa on Biscayne Bay was the home of the early 20th-century industrialist James Deering and is now a National Historic Landmark. The house was modeled after historic villas and country estates in the Veneto region of northern Italy. The heart and main living area of the house is the Courtyard, which was originally open to the sky. Diego Suarez, who had worked in Florence, designed the gorgous formal gardens with classic Italianate flair, but modified for the heat and humidity of southern Florida. Thousands of varieties of orchids flourish in the greenhouse, while subtropical trees, palms, and low hedges highlight the lines of the gardens’ layout.

Castle Ho’s motto, the owner of lovely boutique 1861, is quite simple. “Women who love being women and dressing the part.” Such is the premise of her work, and it definitely transposes into her boutique. The store is decorated in what seems to be a vintage fashionista’s dream: airy space, high ceilings,Vvictorian inspiration, and soft eggshell, champagne and pastel pink hues everywhere. No boys allowed! The multi-brand store focuses on feminine, timeless pieces first and foremost, and incorporates up-and-coming designers into the mix, like UK-based Emily and Finn and Torontonians Pink Martini, along with Montrealers lines Coccolily and Arti Gogna. Don’t be fooled by the perfect, fairy-tale decor; the prices are more than fair and very few things are over $100 in the store. Guilt-free, stylish shopping? I like.

Bauman Rare Books is well known among antiquarian booksellers, and marks a striking contrast to most of the shops and boutiques you’ll find in Las Vegas. Having worked in the rare book business in the past, I can’t resist a beautifully tooled leather binding and the crinkle of pages brought to life by engravings.