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AFAR chose a destination at random—by literally spinning a globe—and sent writer Ryan Knighton to Egypt’s sprawling capital with just 24 hours’ notice.

Hotel Bo is a so-called design concept hotel, and its particular concept is the unification of contemporary and traditional Chiapaneco architecture and design. (Chiapaneco means indigenous to the state of Chiapas, where San Cristobal de las Casas is located.) The four elements—wind, water, fire, and earth—are central to the hotel’s aesthetic, with different design details, such as fireplaces and candles, alluding to these elements. Rooms are decorated with some local crafts, and beds are dressed with colorful spreads. The hotel really is in the heart of San Cristobal, within easy walking distance of markets, restaurants, and the city’s main sights, many of which are architectural gems dating back to the colonial era.

Pearl was founded in 1881 as a traditional brewery. These days, however, the bustling complex is less about beer than its 15 restaurants, dozen-plus retailers, and numerous family-friendly events, including a twice-weekly farmers’ market. Start with lunch at La Gloria, chef Johnny Hernandez’s nod to interior Mexico, followed by dessert at Bakery Lorraine, where you’ll find an enticing rainbow of Parisian-style macarons. If you’re in the mood to shop, pick up a tailored guayabera from Dos Carolinas, or a piece of handcrafted jewelry from Ten Thousand Villages. Pearl Brewery is even home to Hotel Emma, a true gem in San Antonio’s boutique-lodging scene, in case you don’t want to leave.

An exploration of Tlaxcala can begin and end in the Plaza de la Constitución, the zocalo in the old town center. Within walking distance are the Plaza Xicohtencatl, often full of crafts and food stalls, the Ex-Convento Franciscano de la Asuncion (built in the 1530s and one of Mexico‘s earliest monasteries and cathedrals, boasting a visually spectacular interior within its stone walls), several intriguing museums, and the municipal market. Around the zocalo itself you’ll find a colonial-style arcade of restaurants, cafes, and shops, the government building with an interior courtyard painted with historic murals, the Hotel Posada San Francisco an appealingly intimate bar, and plenty of places to park yourself and kick back in the shade. Ninety-five percent of the tourists you’ll encounter will be Mexican.

In early April, I spent a week on a yoga retreat at Amansala in Tulum, Mexico. We had four hours of yoga and Pilates practice a day, and I spent the rest of my time on the beach, swimming in the ocean, reading books (I finished Gabrielle Hamilton’s excellent memoir, Blood, Bones, and Butter), drinking coconut juice, and snacking on delicious homemade tortillas, salad, salsas, and guacamole. At night we ventured out to explore, and discovered a wonderful new open-air restaurant called Hartwood, where I wish I could eat every night.

Chile en nogada is a poblano chile pepper, stuffed with peccadillo (shredded meat, aromatic diced dried fruit and spices), topped with a walnut-cream sauce and pomegranate seeds. This dish from Puebla is not often found on menus of Mexican restaurants in the U.S. It’s not even that common south of the border, except during the August-September season surrounding Mexican Independence Day. If you’re in downtown Tucson, however, you can try it at Penca. In a repurposed space with exposed brick and hip cocktails, this restaurant is also a worthy destination for brunch or late afternoon tacos. Choose from carnitas, fish, lengua, cabeza, nopales, carne asada, and more. The corn-tortillas are handmade right after you place your order. (The tortillas alone are almost worth the trip.) Mexico City is the inspiration. The food is fresh, and the scene is full of optimism: downtown Tucson is reinventing itself with a new streetcar for a live-work-play vibe. Taste and see how this desert city continues to evolve. (Penca has recently been named one of the best bars in the country. Start your meal here with a creative cocktail!)

When the neon lights come up in Sin City, everyone comes out to play. A 24-hour destination, there is no shortage of after dark adventures to be had in Las Vegas. Here we present some of our favorite bars, lounges, clubs, and shows in one of the world’s favorite party cities.

Walk along ancient city walls or seafront promenades, go behind the scenes for a Game of Thrones tour or take off your shoes and gaze at the glistening Adriatic on a pebble beach—and just try to resist becoming completely enchanted by the Dalmatian Coast.

Montréal has been described as the cultural capital of Canada, and while Toronto may disagree, a strong argument can be made on behalf of Québec’s largest city. Its mix of anglophone and francophone cultures—as well as the influence of First Nations and other communities—makes its unique, and fascinating. From landmarks that date from the days of New France to the city’s contemporary art scene, here’s a guide to some of Montréal’s highlights.

You can find the best of the best in Milan. Whether you’re in the market for iconic and hand-tailored Italian suits, fashionable bicycles, or a ballet flats, there are artisans and boutiques in this city that will present you with treasures. And design? From haute couture to interior, industrial, and architectural design, some of the world’s most amazing designers, homegrown and international, have set up shop in Milan to showcase ingenious products and style. Come to the market and prepare to be knocked out.

Look for the word “lokantası"—these canteen-style restaurants offer some of the tastiest home-cooked meals in the city.

Mitla is located in the Oaxaca Valley, just a short distance from Oaxaca City. However you get there, it’s worth the visit. It’s not a large site; an hour and a half will be more than enough time to walk around. There are so many things that set Mitla apart from other ruins in Mexico. First off, it’s neither Maya nor Aztec. Its influence comes from the Zapotec and Mixtec cultures. It sits right on the desert floor, so cactus, desert scrub, and aloe plants punctuate the surrounding landscape rather than jungle. There are no pyramids to climb; the highest structure on the site probably has no more than 10 or so steps to get to the top. There are no stone sculptures or carved walls to be seen anywhere. Instead, the decoration on the buildings are beautiful geometric patterns created by inlaid and interlocked pieces of stone (grecas). Amazingly enough, no two walls have the same grecas, and on some of the walls, you can still see the original red-painted stone. Some of the walls and the cupolas of the San Pedro Church (built by the invading Spaniards) have been restored to their red-colored glory. The desert backdrop, the grecas, the pops of red color – it all adds up to a very special place!

For traditional Mexican handicrafts, Mercado Coral Negro is the easiest place to find all your wares. Here you can purchase jewelry, mayan relics, and unique creations from all over the region. The most beautiful items are the embroidered garments created from local cotton and dyed using traditional methods.

Georgia O’Keeffe called the grouping of weathered rock outcroppings near Abiquiu “The White Place” and immortalized it in paintings. The land is so arid, and so little changes in New Mexico, that the location and signature V shape have survived. A great hike, close to Abiquiu. Cowboys and Aliens was also shot nearby!

Baja Beans Roasting Company purchases beans from a family farm in Puebla and roasts them in a vintage coffee roaster in Todos Santos. Order a latte to sip in the café’s garden patio, or buy a bag of beans to bring home. Baja Beans Roasting Company, 52/(01) 612-167-3139. This appeared in the March/April 2012 issue.