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Painted by Michelangelo between 1508 and 1512, the frescoes on the Sistine Chapel ceiling are considered some of the finest art ever produced. These religious paintings include nine scenes from the Book of Genesis, of which The Creation of Adam is undoubtedly the most iconic.

Multnomah Falls is a gorgeous sight located about 45 minutes by car outside of Portland, Oregon, on the Columbia River Gorge. Several hikes of differing degrees of difficulty offer vantage points to view the falls. The sound of the rushing water is a soothing composition from Mother Nature.

Set within the Banco de la República’s museum complex, the Botero Museum offers a sampling of paintings and sculptures by famed Colombian artist Fernando Botero, best known for his still lifes and his exaggeratedly rotund human figures. Botero donated 123 of his own pieces to the institution, as well as 85 from his personal collection—including treasures by Chagall, Picasso, Monet, and Miró. The gracious colonial-era mansion includes an area that displays contemporary Latin American and European artworks. Audio guides are available in English, French, and Spanish.

After Toronto, Montréal is the Canadian city with the largest population of residents of Italian descent. For more than a century, the community has been centered in one of the city’s most charming neighborhoods, Little Italy. The way to the heart of this neighborhood is arguably through its stomach or, rather, the Jean-Talon Market, where residents have come to buy produce and stock their pantries since 1933. Even if you aren’t shopping for fresh vegetables or fruits, it’s a good place to come to sample Québecois products and buy gifts like local jams, jellies, and maple products to take back home.

Built into rocky cliffs that tumble down to the sea, Hotel Santa Caterina is the embodiment of Amalfi Coast dreams. Bougainvillea blooms adorn corners of the 19th-century mansion, while lush terraced gardens teem with citrus trees and vine-covered pergolas. Public spaces are decorated in an elegant Mediterranean style, peppered with antique pieces and sweet details such as hand-painted majolica tiles, while light-filled guest rooms and suites feature Bulgari toiletries and balconies with sea views. Elevators are on hand to whisk guests down to the beach and a saltwater pool, where chic loungers and parasols line a stone sundeck and uninterrupted vistas lurk around every corner. You’ll find classic Italian fare and fresh seafood on the menu at the beachside bar as well as two restaurants, both of which spill out onto terraces. Even the spa offers a dose of local flavor with a signature Amalfi gold lemon massage. The Gambardella family has owned the property for generations, which may account for the consistently charming service and the loyalty of guests, who return year after year.

Calling all lovers of food: Shilin Night Market is the largest of many night markets in Taipei. It is easily accessible by MRT and has endless stalls of restaurants/stands as well as shops. Bring a friend so you can share and experience more of the many dishes that this great market has to offer. If you do take the MRT, make sure you get to the platform before 12am because the trains stop running after that. If you stay past 12am, you will need to catch a cab to get back to your hotel.

Much more than just a restaurant or smoothie stop, Choice Health Bar is a culinary fusion of food, lifestyle, and positivity. This small restaurant in the Lahaina industrial park serves fresh kale salads and heaping acai bowls. The place is a favorite hangout for island locals from surfers and paddlers to vegans. Just because it’s healthy, don’t think the food will taste like cardboard. Creative concoctions pepper a menu that is constantly being reinvented, and you’d never expect that a quinoa quiche could possibly taste so good. Locals also love Choice for the laid-back atmosphere and powerful, positive vibes. A sign on the door informs all patrons that this is officially a “bummer free zone,” and instead of simply “super-sizing” your meal, you can “make it epic” with ‘superfoods’ like kale and cacao. Consistently voted as the island’s top pick for healthy, vegan cuisine, Choice is the absolute best spot on the West Side for infusing your body with nutrients.

Tempt fate at the Monkey Paw’s Book-O-Matic machine, where for the price of a toonie you’ll be delivered an archaic tome in the vein of Elementary Arabic, Vol. 3. I’ll let you know how my studying gets on. The Monkey’s Paw is an eclectic vintage bookstore on Dundas with a collection of unique books, vintage maps, and bugs preserved in Lucite.

“Mixed-use space” doesn’t come close to describing this hip destination on the banks of the Garonne River. Covering nearly five acres, the Darwin Ecosystème is first and foremost an incubator for sustainable development. Here, in renovated warehouses on the former Niel military barracks, several businesses have set up shop to help propel the green economy. Also on-site is everything from a bike-polo field, skate park, music venue, and free-expression space for graffiti artists to an urban farm, gourmet grocer, and Bordeaux’s largest organic restaurant. When you visit, be sure to stop by Les Chantiers de la Garonne, a “beach bar” on the riverbank where you can relax on a lounge chair with some oysters and Darwin beer (brewed on the premises), then dance the night away to electro beats.

The rooftop restaurant of the Westin Excelsior hotel wins top prize for being the most panoramic spot for a meal in Florence; floor-to-ceiling, wraparound windows permit 360-degree views over the entire city and the hills beyond. Chef Matteo Lorenzini’s superb food lives up to the magnificent setting—so against the romantic backdrop of Brunelleschi’s Duomo and the thousand twinkling lights of the city, you can feast on seared scallops with chestnuts and lime, spaghetti with clams and crab cream, and Barbary duck.

If you’re a sucker for chalkboards, simple design, local products, and good food and coffee, Revival Market is your place. Everything served at this café is homemade, from the flaky chocolate croissants and kolachs (fruit-filled pastries) to the breakfast tacos and sandwiches. While you’re there, you can also drool over the artisanal charcuterie and other local products.

The W Taipei showcases the city’s geography and cutting-edge technology. The lobby’s light installation reacts to human motion, and guest rooms feature dramatic skyline views. The W is also home to some of Taipei’s hottest nightspots, including the Bar at Yen on the top floor. From $314. 886/(0) 2-7703-8888. This appeared in the November/December 2012 issue.

Prague is absolutely one of the most beautiful cities in the world. Its abundant beauty is not only related to the variety of architecture styles (Gothic; Art- Nouveau and Baroque) but also to natural elements such as wild swans that gracefully float along the Vltava River at sunset. Wherever you step in; a restaurant, a bar, a pizzeria... no matter, you will feel embraced. Czech citizens speak Czech, German and English (especially the young crowd). Even though Prague‘s touristic appeal brings thousands of tourists every year, it is a very affordable city and doesn’t give off any feelings of greediness at its core. Food and fun are affordable here. One of the simplest and most exuberant things to do in Prague is walking along the Vltava River. Cross Charles Bridge, enjoy old town, check out the Astronomical clock and do not skip the “Dancing Building”! It’s a masterpiece and a must see. If you love architecture, design, art, photography or even if you are just a visual person, you will have a great time when you see this building because it’s just so cool! It’s also easy to spot as it’s located in Old Town and it’s also a hotel. The building was designed by Croatian-Czech architect Vlado Milunić in cooperation with Canadian-American architect Frank Gehry (the same architect that designed Disney Opera Hall in Downtown Los Angeles). The Dancing House was designed in 1992 and completed in 1996. The building design was controversial at the time because the house stands out among the Baroque, Gothic and Art Nouveau buildings for which Prague is famous. However, then-Czech president Václav Havel (who also lives nearby) gave all of his support hoping that the building would become a center of cultural activity. It turned out to be a great decision to support the project since designers, architects, artists, and enthusiasts from all around the world are drawn in flocks to see “Fred and Ginger”, a nickname given by Gehry as the building resembles a pair of dancers. The nickname is not commonly used but refers to famous dancers Fred Astaire and Ginger Rogers.

Hungry hikers (known as hill walkers in Scotland) will find refuge at Monachyle Mhor, a 2,000-acre farm located deep in the middle of Trossachs National Park, just past the grave site of folk hero Rob Roy. The main draw of the 14-room pink farmhouse is the food: Chef-owner Tom Lewis, a rising star on the U.K. culinary scene, prepares meals sourced from the farm. The hotel also offers classes on baking bread and churning butter, and coordinates hunting trips and mushroom-foraging excursions. After a day exploring the land, retire to one of the comfortable rooms, equipped with fireplaces, steam rooms, and views of a loch.

Featuring Polynesian-Asian-French-fusion cuisine, this contemporary-chic beachfront eatery in Maharepa, owned by French-born restaurateur Bruno Jamais, is a sunny spot where you can indulge in some upscale Papeete-meets-Paris dining—maybe paired with a glass of bubbly. Devotees adore dishes such as marinated tuna tartare with wasabi, avocado and fried shallots. A three-course lunch runs about $60 per person (without beverages).