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Once the center of commerce in Charleston, the City Market is now the heart of tourism. Although its location near the cruise terminal can make it feel like a kitschy open-air market in the Caribbean, the tackiness is part of its charm. Yes, you’ll find Christmas ornaments painted with Rainbow Row and enough cutely packaged pralines to give you a stomachache, but you’ll also see Gullah artisans weaving the finest examples of sweetgrass baskets available. Peak season brings 140 different merchants, and weekends include live music and food vendors. The market’s a requisite stop for any visitor and a one-stop gift shop for loved ones back home.

One of the best views of Florence can be savored from the Piazzale Michelangelo, a short walk across the Arno River from downtown Florence. For a fun afternoon head to the square and enjoy an enchanting panorama of the city, followed by a relaxing alfresco lunch at one of the nearby restaurants. The Piazzale Michelangelo is also worth a visit at night to get a very different glimpse of Florence. The lights of the Duomo and the buildings surrounding it make for a magical nighttime scene.

A French-era hill station, this national park stretches from the coast to the Annamite mountain range at the Lao border. More than 1400 species of plants, including rare ferns and orchids, have been discovered in Bach Ma, representing a fifth of the flora of Vietnam. It is also a great place for bird spotting.

In reality, the 1,620-hectare (4,000-acre) Barro Colorado Island is a hilltop. Or, at least it was until the creation of Gatún Lake turned it into the largest island in the Canal Zone, one where the Smithsonian Institute operates a research center and gives morning tours. Ships sail tightly past the island, offering the chance to glimpse toucans, iguanas and bats that live among the 1,300 plant species and 381 bird species of this vital tropical woodland.

As obvious as it may sound, what sets Sanctuary apart from any other Scottsdale resort is location. Sitting on the north side of Camelback Mountain yet minutes from downtown Scottsdale, it has a balance of desert mountain isolation and easy access that no other Scottsdale resort can match. Since Sanctuary opened in 2002, the combination has especially appealed to publicity-shy celebs (Beyoncé and Jay-Z even stayed here while on their honeymoon). The views from the floor-to-ceiling windows in the adobe casitas look out at the mountain and across Paradise Valley. The casitas have wood-block floors, glass-tiled showers, and, in many of them, oversize tubs with romantic votive candles.

On a hopping night, Noorderlicht (Northern Lights) blazes with colorful lights visible clear across the IJ River—hence its name. For those drinking and jamming to live music on a waterfront terrace warmed by a roaring bonfire, the setting is more intimate. We’ve reached Noorderlicht, a “cultural café” in Noord-Amsterdam, via free ferry from Central Station. Destination: NDSM yard, a revitalized shipyard that belies its maritime/industrial heritage with warehouses and shipping containers transformed into nightclubs, hotels and student housing. Dotted with fishing villages, condos and restaurants, the eclectic neighborhood calls itself “Art City.” With its airplane hangar shape and greenhouse-like architecture, Noorderlicht enhances the funky landscape. The popular café draws creative types who come for waterfront dining, drinking and dancing. Inside, warm-hued wall hangings, wooden flooring, tables ornamented with polished driftwood and a disco ball contribute to an inviting ambiance. Seasonal lunch and dinner menus feature organic and regional dishes, plus casual fare like frites and burgers. Noorderlicht’s grassy terrace offers a spectacular view of Amsterdam city center from the other side of the Ij River. Dine on wicker chairs, cushioned couches and picnic tables as musicians perform overlooking the waterfront. A roster of events ranges from campfires and poetry readings to DJ nights that usually inspire some pumping and grinding in a young, energetic crowd.

Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

A true desert outpost, the Peruvian town of Mancora enjoys the most sunshine hours of anywhere in the country. Unlike the rest of Peru the water is warm enough to surf without a wetsuit, a welcome complement to an area already featuring some of the best waves in South America. Hemingway knew what he was doing when he set up shop in nearby Cabo Blanco, an authentic fishing village where the ceviche is some of the freshest on the planet and the days pass with a simple peacefulness unique to many coastal escapes. While outdoor activities abound around Mancora, from kitesurfing to fishing to morning yoga sessions, on this particular morning the to-do list consists of nothing more than a good book, a cold drink, and watching whales splash on the endless horizon.

The feudal lord Arnust of Begur built his castle on a coastal hilltop in the 11th century, and to this day it remains the centerpiece of the medieval town that rose up around it. The castle was sold to the city in 1604; it has played a key role in a number of conflicts since then, including the Spanish War of Independence at the beginning of the 19th century. Visitors can only explore the outside of the fortress, which does, however, offer spectacular views of the coast.

The cornerstone of the Kensington Street Precinct, at the heart of the funky Chippendale neighborhood, the Old Clare is the storied pub she used to be and so much more. Tonkin Zulaikha Greer Architects built a glass-and-steel walkway between the former Clare Hotel and the neighboring Carlton United Brewery building, both dating to the early 20th century, to create a 62-room boutique hotel that simultaneously feels historic and edgy. Original wood panels and brick walls blend seamlessly into spotted gum floors and nude-colored walls, exemplifying the creative reuse that pervades the Chippendale suburb, an inner-city district of galleries and cafés situated at the crossroads of Glebe, Redfern, Surry Hills, Chinatown, and the Central Business District. The design echoes other landmark Sydney restorations by Tonkin Zulaikha Greer such as the Paddington Reservoir Gardens and Carriageworks, an arts complex located just down the road. The Old Clare also brings two more standout restaurants to Chippendale, including the first Australian venture by Michelin-starred British chef Jason Atherton. Whether guests soak in the egg-shaped tub in their loft room, take a sunrise yoga class on the rooftop pool deck, or sip a “Ginny Hendricks,” a watermelon-dill concoction with bitters and Hendrick’s gin, at the midcentury-modern bar, they’ll have a story to tell. The Old Clare is a tale that keeps getting better.

As the first boutique hotel in Koreatown, the Line might have been able to get away with cutting a few corners while still attracting a cool clientele. It probably didn’t need to get the hottest young Korean-American chef in L.A. on board (to run one of the most comprehensive and exciting restaurant and bar networks yet seen, by the way), nor did the Sydell Group—the arbiters of cool behind the Nomad Hotel in New York—have to put their stamp on it. The hotel would have been nice enough had the concrete midcentury building not been entirely reimagined by designer Sean Knibb, known for designing half the cool spots in L.A. and more than a few celebrities’ homes. There didn’t need to be a desert greenhouse–inspired pool deck that’s become a hangout for beautiful people at all hours, nor did the famously trendy Houston Brothers (of no Vacancy and Harvard & Stone) have to throw in a midcentury-inspired cocktail bar. Nor did the typical hotel gift shop have to be reimagined as a design and lifestyle store curated by Poketo. The rooms and suites would have been just fine had they not been turned into artsy, industrial-style lofts, outfitted with original commissioned artwork, a minibar of Korean and Western snacks, and Baxter of California toiletries. Of course, all of this did happen, and now Koreatown is home to one of the hottest hotels in L.A.

Arguably the most luxurious yoga resort in Bali, Como Shambhala has 30 rooms, suites, and villas set on 23 acres of jungle-covered riverbank near Ubud, each with its own butler and infinity pool. Yoga programs led by visiting masters such as Rodney Yee are held throughout the year and typically include five hours of daily practice over five days. The spa offers Balinese and Ayurvedic treatments, and off-site activities range from jungle treks to visits to Ubud’s famous temples.

With Indonesian names that translate to earthy concepts like “wind song” or “forest in the mist,” the terracotta and thatched-roof residences at the 22-acre Como Shambhala Estate encourage quiet reflection. They jut from the hillsides and line the Ayung riverbed, offering refuge from the frenetic scene nearby in Ubud.

Most people come here as part of a yoga or health retreat, and everything—from the dining experiences to the custom health programs—is designed to guide guests toward reaching their wellness goals with help from a cadre of resident experts, including a dietician, Ayurvedic doctor, reflexologist, and an Oriental medicine specialist, as well as fitness, yoga, Pilates, and qigong instructors. But it’s not all work. After a day of rugged outdoor adventure—the resort can arrange for hiking, biking, and paddleboarding down the Ayung—retire to your private spring-water infinity pool and meditate on the events yet to come.

The island of Ireland has a history of emigration—a million people emigrated during famine times, and today on the U.S. census, 40 million people claim Irish roots; worldwide, the figure is around 70 million. EPIC is the world’s first digital museum where, through a series of interactive exhibits, you learn the stories of the Irish around the world, and learn about their input and influence on everything from art, culture and music to sports, science, and even politics (22 U.S. presidents have claimed Irish roots). The museum is self-guided so you can spend as much time as you like in each section. A separate genealogy service at the end helps those tracing their Irish roots. The museum’s setting in the vaults of Dublin’s old dockside warehouse at CHQ adds to the experience.

In this modern age of Spotify, iTunes, and Pandora, record stores often seem sad and bitter places. Not so Waterloo, where music lovers—both staff and customers—celebrate the art. Bands playing Austin come in for in-store performances and signings, and you may recognize a few famous faces browsing the new and vintage vinyl and CD sections. As expected at a record store, the staff have big opinions but are friendly, and can help you navigate the 6,400-square-foot space. A highly recommended, if dangerous (prices are very reasonable but the desired objects are many), shopping stop.

There are a lot of reasons to travel to Scottsdale, but let’s not lose sight of one of the best – the wild, Wild West. A working cattle ranch, Arizona Cowboy College is everything you’d want from a western adventure. Their one- and three-day sessions teach you all about horsemanship and ranching. You’ll eat meals in the main house and sleep in the bunkhouse, and can even sign up for a week-long course where you’ll hit the trails for a real cattle drive and sleep under the stars.