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Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

Located beneath the San Diego–Coronado Bridge, this public space might not be green and tranquil, but it tells a story of perseverance. In 1970, residents of the predominantly Latino Barrio Logan neighborhood staged a nonviolent takeover when the state attempted to build a California Highway Patrol station on land the city had promised would be a community park. Their protests were ultimately successful; the area was designated a park shortly thereafter. In 1973, brightly hued murals touching on Chicano identity and struggles began appearing on the concrete pillars surrounding the space. Today, visitors can see more than 50, which are considered so culturally significant that they earned the park National Historic Landmark status in 2016.

Eating raw herring is a right of passage for many who visit Amsterdam. Order yours from the friendly Dutch matrons in blue and white-striped aprons at Stubbe’s Haaring, a herring stand with a view on the bridge over Singel Canal, just off Haarlemerstraat. For decades, this local institution has satisfied the fish cravings of Dutchies and visitors with lightly brined herring, smoked eel and other delicacies from the North Sea. Unless you want bragging rights, there’s no need to eat your buttery snack Dutch style, grabbing it by the tail, throwing your head back and lowering the fish whole into your gaping mouth. Most locals eat it in a less flashy way: cut up into small pieces, covered with onions and sweet pickles, topped with a Dutch flag. It’s served on a waxed paper plate, sans bread or cutlery. Use the flag-festooned toothpick to stab the soft, mild-flavored morsels and bring them to your mouth. For a more filling meal, order a broodje haring (herring sandwich) on a soft, white bun, filled with fish, pickles and onions. Eet smakelijk!

Austin’s very own grand dame, this landmark hotel opened in 1886 as the city’s first iconic hotel, both a testament to and display of the success of cattle baron Jesse Driskill, who wanted to build his beloved frontier town a palace to rival those in New York, Chicago, and San Francisco. The city fared better than Mr. Driskill did; financial troubles forced him to sell the hotel just two years after opening, and he died of a stroke just another two years later. After some initial ups and downs, his hotel ultimately flourished, housing a rotating cast of Texas elite and hosting important political events in Austin—in particular, gubernatorial inaugural balls—in the 20th century. President Lyndon Johnson had an especially close relationship with the hotel, from his first date with his wife to awaiting presidential re-election results in one of the suites.

Multimillion-dollar renovations in 2008 restored the hotel to its original grandeur, maintaining its historic charm alongside all the amenities of a modern luxury hotel. Brave guests might request a room on the reportedly haunted fifth floor. And, no stay at the Driskill is complete without a cocktail in the elegant Driskill Bar, where cattle, oil, or railroad barons would still fit in.

Graffiti, stencil, sticker, and poster art, and temporary sculptures are all part of San Salvador’s street art scene, with themes of pieces touching on topics as diverse as anti-capitalist sentiment, social justice, political history, women’s and indigenous people’s rights, and pop culture. Use the Facebook page of Street Art El Salvador as an informal guide to the capital’s biggest, most interesting pieces and to learn more about the artists who made them.

If walls could talk, you’d be stuck in conversation with the Fillmore for hours. The building was a dance hall when it opened in 1912 and a roller rink during the 1940s, and led its first concerts in 1952 with artists like James Brown and Ike & Tina Turner. But in the mid-1960s, the venue really had its moment. Concert promoter Bill Graham made the ballroom a hub for psychedelic music and brought would-be legends like the Grateful Dead, Big Brother and the Holding Company, Jefferson Airplane, and Santana to the stage. Needless to say, there’s history here. Learn it best by attending a show. The standing-room-only ballroom still brings in big-name artists—think Lorde and the 1975—at budget-friendly prices, along with a constant stream of smaller acts. There’s a full-service restaurant and a bar, and the vibrant collections of old photos, artwork, newspaper clippings, posters, and billings will school you on the club’s colorful past.

Trey Foshee, executive chef of George’s at the Cove in La Jolla, is one of the most talented and respected chefs in San Diego. At his casual Mexican restaurant near La Jolla Shores, he cooks with equal skill, using only the best ingredients to create pure, intense flavors. Head to Galaxy Taco for heirloom Masienda corn tortillas, made-to-order guacamole, and epic margaritas with top-shelf liquor and charred fruit. A balance of sweet, sour, and smoke, the Oaxacan Guava (Los Javis mezcal, guava, lime, orange-vanilla shrub, and grapefruit) is a must.

From Top Chef: All-Stars winner Richard Blais comes this Little Italy favorite, a fast-casual spot specializing in humanely raised chicken and eggs. Here, the fried chicken is crispy and not too greasy, and sandwiches like the Malibu Barbie Q (chicken thigh, cornmeal onion ring, pineapple mustard) are addictive. An almost entirely outdoor spot, the Crack Shack features a walk-up window, bocce ball court, and cocktail bar. For something more traditional, head next door to Blais’s second concept, Juniper & Ivy, where you can enjoy an ever-changing menu of seasonal shared plates. From time to time, the restaurant hosts a Farm Dinner centered on a special ingredient like lamb from a local purveyor, making for one of the best splurge meals in the city.

Walk down this narrow alley connecting Valencia and Mission Streets and you’ll be surrounded by dozens of colorful murals by local artists depicting environmental and social justice, artistic freedom, and community collaboration. Funded by the nonprofit Intersection for the Arts, more than 700 murals have been painted in this vibrant display of public art since CAMP began in 1992. In a city known for its rising rents and gentrification—and especially in the Mission neighborhood at its epicenter—Clarion Alley is a sight worth visiting.

In the daylight, tacones (high heels) can be dangerous on cobblestoned streets, but during a night on the town, they’re great for dancing. San Miguel offers something for everyone’s taste. Salsa lessons can be enjoyed at places like Hacienda Guadalupe. Live music, at clubs like VC & Friends and on rooftops like Quince or Bond’s 007 Gin Bar, brings out everyone’s best Travolta moves. The younger set opts for the dance floors at El Grito and Mint, where the velvet rope amps up the Manhattan factor. That said, what happens on the dance floor at Cent’anni (pictured here)—even after a comforting Italian dinner—tends to be much more impromptu, lively, and festive.

Day-trippers in search of awesome views, cool drinks, and light bites score at this oasis in the middle of Arikok National Park. The menu is simple and heavy on island favorites, from fried whole fish to seafood served with plantains, salad, and pan bait (a pancake-like bread). There are also hamburgers and cold sandwiches, along with frozen cocktails and local beer. Still, it’s the views that really stun. From its perch between Boca Prins Bay and the Fontein Cave, the restaurant has sweeping vistas of desert, hills, and sea.

Head up to the fifth floor of the bustling, popular La Fonda Hotel for stellar sunset views of city and distant mountains. Arrive early to beat the crowds and settle in. Relax with the signature margarita called the Bell Ringer, makes the experience all the more authentic.

Bonafide is a classic Argentine café whose roots reach back to 1917 in Buenos Aires. The name stands for “good faith” to reflect his family’s history in the coffee business and a symbol of trust for his clients. They also sell “Bocaditos” (sweet bites) and “Nugaton” (wafers filled with nougat cream), which have become classic Argentine chocolate snacks. Peatonal Sarmiento 102 - Mendoza. Tel: +54 261 423-7915

Family style restaurant where you can sample virtually everything on the menu. Salad sampler, pasta sampler, meat sampler. GET IT ALL

Baja Beans Roasting Company purchases beans from a family farm in Puebla and roasts them in a vintage coffee roaster in Todos Santos. Order a latte to sip in the café’s garden patio, or buy a bag of beans to bring home. Baja Beans Roasting Company, 52/(01) 612-167-3139. This appeared in the March/April 2012 issue.