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The California Academy of Sciences is an unfortunately stuffy name for an institution that is anything but staid. The country’s largest natural-history museum includes an aquarium, a planetarium, an enormous rain-forest exhibit under a 27-meter-tall (90-foot-tall) dome, and a living roof that looks like a science-fiction fantasy. A visit here can feel like a trip to an amusement park, with a series of attractions to check out, but all of them are educational. The building itself is part of the appeal of the Academy. (Like the nearby de Young, the old home of the California Academy of Sciences was damaged in the 1989 Loma Prieta earthquake, and starchitect Renzo Piano designed its very environmentally friendly replacement.) It would be easy to spend an entire day or more seeing all of the Academy’s exhibits, so be prepared to pick and choose among them.

Tower Cafe, which sits next to the landmark Tower Theater and original Tower Records, is a favorite among locals. The outdoor garden seating makes you want to stay for a long, relaxing meal; the bubbling fountains (with birds stopping for quick baths), canopies of Japanese maples, baskets of hanging flowers, and benches welcoming you along the surrounding path form an oasis that can be enjoyed much of the year. Tower serves globally-inspired food with a menu that changes frequently to highlight seasonal ingredients and the chef’s new creations. The restaurant is best known for its breakfast, and its most famous dish is the seasonal French toast (a baguette stuffed with custard, baked and served with cinnamon butter and a compote of seasonal fruits such as raspberries, blackberries, and blueberries). Their beautiful desserts are worth at least a look--go inside the eclectically decorated interior and peek in the dessert case. The Yin/Yang cheesecake (dark and white chocolate) is one of my favorite choices. Tower also has a great selection of California beers and wines. Tower Cafe is open every day from 8:00 a.m. to 11:00 p.m. or later on weekends. Breakfast is served until 11:00 a.m. on weekdays and until 3:00 p.m. on weekends; however, be warned because weekends here are packed!

Hampden is known for beehive hairdos, cat-eye glasses, kitchsy decor like the pink flamingo, and ladies who call everyone “hon.” Now, though, Hampden is Baltimore’s hipster neighborhood with an array of thrift stores, antique shops, boutiques, and restaurants. It’s worth taking at least a half day to browse the many shops, grab a great meal, and maybe buy some Baltimore souvenirs. On First Fridays (of the month) many shops serve wine, stay open a little later, and offer special deals. John Waters’ Baltimore, from the musical Hairspray, manifests itself in Hampden, specifically on 36th Street, which is simply called “The Avenue.” The proprietress of Cafe Hon (featured on Kitchen Nightmares) has worked to maintain the John Waters-inspired vibe as a tourist attraction, which can really be seen during Honfest where beehives and kitsch take over in early June. Some favorites in the area include: Trohv for Baltimore souvenirs; Ma Petit Shoe for shoes and chocolate (can’t go wrong there); Wine Source for an impressive array of beers and wines; Daniela Pasta and Pastry (for pastries); Spro for coffee; and the Golden West, Grano (Grano Emporio and Grano Pasta Bar), Corner BYOB, or the Food Market for dinner.

The sprawling contemporary museum, MASS MoCA, is responsible for bringing North Adams to life, and offers some of the most cutting edge art around. Xu Bing’s Tobacco Project {above} is made from over half a million cigarettes arranged to mimic a tiger skin rug. It makes a thought provoking statement on the global tobacco trade, luxury and colonialism, and is typical of the installations you will see there. The complex also hosts a variety of musical events including dance and films. Luckily Split, the in house restaurant has coffee, treats and tasty lunches.

If it’s not wintertime or you can’t get tickets to see the Maple Leafs play, then the next best way to experience Canada‘s game is by visiting the Hockey Hall of Fame. Situated in downtown Toronto, the museum is located on the lower floor of the Brookfield Place shopping center. It’s a short walk from the CN Tower and other attractions. (If you’re driving, you’ll need to find either metered parking or a parking garage, as there is no designated parking lot for the museum itself.) The Hall of Fame itself contains displays about historic moments in the game’s history, iconic jerseys and memorabilia from players, interactive games for children, and a room where the entire family can get up close with the Stanley Cup trophy.

Originally a private summer home, Casa Bonita is now a beautiful 12-room resort run by the third generation of the Schiffino family. Located on the Dominican Republic’s southwestern coast near the town of Barahona, the property was constructed from felled trees and thatch, giving it a luxuriously rustic vibe. Inspired by nature, rooms feature white linens, palm wood accents, and wicker furnishings; some have private balconies overlooking the jungle, others have infinity pools with ocean views, and the two-bedroom Villa Bonita includes a terrace with a grill.

The resort’s farm-to-table restaurant uses produce from the local community and on-site Pat’s Organic Garden, while the spa incorporates traditional Dominican ingredients like coffee, chocolate, and coconut into each of its indulgent treatments. Also available to guests are activities like water sports, tennis, yoga, horseback riding, mountain biking, and a zip-line canopy tour through the jungle. Should you want to venture off property, the UNESCO-designated Jaragua-Bahoruco-Enriquillo Biosphere Reserve is just next door. There are also coffee plantations, lakes, and caves with ancient tribal art nearby.

The scenic drive to Poás National Park alone makes a stay at El Silencio Lodge worth it, but you don’t need to leave the grounds to see the country’s largest active volcano. The 16 Zen cottages enjoy serene views of the steaming mass from private decks and also have gas fireplaces, outdoor whirlpool tubs, king beds, and an earth-hued color scheme that evokes the tropical setting in streamlined luxury. Fruits and vegetables from a 5,000-square-foot organic greenhouse on site are used to make continental fare (osso buco risotto, parmesan-crusted chicken) and Costa Rican favorites (cassava croquettes, tamarind pork), which are served in two elegant glass-walled restaurants. An open-air yoga studio invites you to reflect on the beauty of your surroundings, while locally sourced treatments at the spa incorporate healing ingredients like Costa Rican clay and chocolate. Those who prefer more active leisure can join the designated eco-concierge for guided hikes along the property’s private cloud forest trails, spotting waterfalls, hummingbirds, and seasonal quetzals along the way.

Bar Raval looks ordinary from the outside, but inside, the sinuous lines of the floor-to-ceiling mahogany woodwork—bar, walls, window frames—instantly bring Gaudí to mind. Created to mimic the spirit of Barcelona’s pintxos bars (in addition to the Catalonian influence of the decor, platters of food are laid out on the bar, as is the Basque pintxos tradition), the space is often packed. In the mornings, patrons sip lattes and enjoy doughnuts finished with a lick of chocolate and spiced hazelnut.

Two blocks from Union Square, Hotel Adagio is a stylish retreat from the frenetic energy of downtown San Francisco. Built in 1927, the Spanish colonial revival building has a stunning cream facade with intricately carved arches that surround the entrance and windows. The interior also retains many of its original features, including rope crown molding and the top floor’s hand-painted ceilings. Conference-goers and event attendees will be impressed with the hotel venues’ city views, elaborate woodwork, and high ceilings.

Hotel Adagio is part of the Marriott’s Autograph Collection, and the recently renovated rooms are appropriately named Audition, Act One, Encore, Applause, and Actor’s Studio. The decor uses a contemporary palette that mixes warm burgundy and chocolate hues with lime green and white. Get ready for a night out as you jam to your own music, thanks to each room’s iHome docking station. Then, head down to the hotel bar, the Mortimer, to start the evening with a craft cocktail.

Opened in time for the 2000 Sydney Olympics, the Establishment is a pioneering 31-room boutique hotel housed in an 1890s steel plant near the modern-day stock exchange building downtown. Managed by the hospitality group Merivale—which started as a fashion house specializing in fascinator hats and mini skirts—the hotel is popular among brand executives who book the 328-square-foot Loft Penthouse for product launches and photo shoots. Rooms feature wood furnishings, swinging metal doors, animal hides, and suedelike daybeds as well as such amenities as Apple TV, Bose surround sound, and Lululemon yoga mats. Bathrooms are particularly luxurious here, with marble floors, freestanding tubs, Bulgari products, and tall windows that open up to Sydney’s bustling business district. The best part about the Establishment, though, is the internal access it offers to some of the city’s hottest bars and restaurants, which are housed within the same complex as the hotel. And after enjoying live music and a few stiff cocktails at the speakeasy Palmer & Co, guests are welcomed to bed with Sleep Tight tea and a homemade chocolate chip cookie.

One of Budapest‘s most history-laden spots, the enormous Heroes’ Square is framed by art museums near the City Park. But the main focal point here is Millennium Memorial, a tall column and colonnade structure completed in 1905 that commemorates the Hungarian conquering of the area a thousand years before (hence the name) and the founding of Hungary in 1896. The statues decorating the memorial depict the seven chieftains of the Magyars, and the figure atop the column is the archangel Gabriel. Fun fact: The first underground subway in continental Europe, built in 1896, terminated here. Be sure to visit at night because the square is even more majestic when lit up.

A benchmark name in Bordeaux wines, Mouton Rothschild is also one of France’s greatest wine producers. At the estate—the first of two Rothschild estates in Pauillac (the second is the renowned Château Lafitte)—you’ll want to explore everything from the winemaking facilities to the two excellent museums (one covers the history of the château, while the other houses the original works by artists like Chagall and Warhol that have appeared on Mouton Rothschild’s labels since 1945). Tastings are also available here, so leave plenty of time to enjoy this sophisticated estate to the fullest.

New York has Ellis Island; Buenos Aires has the Hotel de Inmigrantes. The huge waterfront building, located near the old port docks in what’s today known as Puerto Madero, served as the temporary home for waves of European immigrants arriving to Argentina between 1911-53. Today, the Hotel de Inmigrantes is an intriguing (and free) museum that few tourists see: come to see photos and memorabilia representing the many immigrant groups who came through the port of Buenos Aires, plus colorful advertisements for trans-Atlantic passages and model boats.

Parco Sempione is Milan‘s biggest park and it has everything- cute caffès, picturesque setting, a medieval castle, a modern museum, a pond and charming foot bridges. If the sun is shining, this is the perfect place for a morning or afternoon walk, a lazy picnic or just a day off. The surrounding area includes beautiful residences, historic monuments, like Leonardo’s Last Supper and the Castel Sforzesco, restaurants and shops. Expect some interesting developments as the city gears up for World Expo 2015, including a super-contemporary visitor’s center in front of Castel Sforzesco.

The beautiful “suburb” of Genoa, Nervi boasts a lovely series of green parks (something Genoa lacks overall) and a well-tended passeggiata path that runs directly along the rocky shore. Especially popular with families on the weekend, the path is easily accessible from the Nervi train station (a 10-minute ride from Brignole Station in central Genoa). Spend the day escaping the bustle of central Genoa by walking along the shore, enjoying the museums tucked into centuries-old palaces in the parks, and having dinner at a small fish restaurant along the coast.