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Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

Just 25 minutes from Cancún’s international airport is Belmond Maroma Resort & Spa, surrounded by 200 acres of preserved jungle. Guests here still enjoy direct access to the Caribbean Sea and its powdery, white-sand beach, as well as to a wide variety of physical fitness and wellness activities and services. Rooms are generous in size and are filled with sunlight, let in through large windows. Tile floors and design accents—throw pillows and furniture, for instance—have an earthy color palette. Many rooms feature indigenous artwork and handmade furniture. Though it might be tempting to stay within the confines of the resort, the area is home to a number of worthwhile attractions, including the Maya site of Tulum and a biosphere reserve; the concierge can provide information about both, as well as tips for guided excursions and reputable outfitters.

The façade may be classic, the doormen crisp, and the location tony, but once inside Le Royal Monceau, you’ll feel an independent, unexpectedly edgy spirit running through this luxury hotel. Opened in 1928, the historic spot, now part of the Raffles collection, underwent a complete renovation in the mid-2000s, overseen by interiors master Phillipe Starck, who—true to form—filled the spaces with contemporary style, dramatic flair (like oversized lobby sculptures and a stairwell adorned with dozens of chandeliers), and over 350 pieces of art, many culled from the hotel’s private collection. Art is a big focus here overall: along with a well-stocked art-library-cum-bookstore (which draws a lot of gift-seeking locals) and an on-site showroom curated by local gallerists (recent shows have spotlighted street artists, from Basquiat to Banksy), there’s a resident Art Concierge—the first in Paris—who can create bespoke itineraries for guests and arrange for special access, studio tours, and VIP experiences (including, with enough notice, an after-hours visit to the Louvre).

The torrent of Anglo eateries that have popped up across Paris in recent years can largely be attributed to the searing success of Rose Bakery. I had my doubts years ago when I first heard about the internationally-staffed organic canteen - how good could English food be, really? Expensive though it may be, it’s one of my favorite places to go for warm cheese scones, fresh vegetable and a variety of cakes suitable for breakfast or afternoon tea. Rose began in London, hopped over to Paris on rue des Martyrs, expanded to the Marais, settled into a 3rd location within La Maison Rouge foundation in the 12th and most recently took over a 2nd floor corner of the chic department store Le Bon Marché. And that’s saying nothing of their international locations. Its appeal was virtually immediate and RB quickly established itself as the spot among hipsters, artists, celebrities (the likes of Natalie Portman and Julie Delpy, who I spotted last year) and tourists for organic, English fare. They open early, excel at pancakes and healthy veggie options and sell a number of British products to-go. Other establishments may have come onto the scene but Rose is a breakfast mainstay.

Spoken of in almost reverential terms by people that have traveled there, Sa Pa is often seen as a holy grail of destinations in Vietnam. Part of that is because of the environment—a cool mountain town that has lured visitors with its salubrious air and alpine scenery since the early 20th century, when the French constructed facilities for sick officers to recover—as well as its remoteness, located close to the Chinese border in the country’s extreme north. Most visitors come to Sa Pa for the hiking in the nearby valley peppered with minority-ethnic-group villages, or to climb Mount Fansipan, the country’s tallest peak, which is located just southwest of the town. Conquering the summit once required a two-to-three-day hike, but now can more easily be reached with the help of a cable car (opened in 2016) that gets you most of the way.

Hôtel Fenua Mata’i’oa is a low-key boutique hotel with five individually decorated suites, each with a funky mix of handicrafts and loudly patterned artwork and upholstery. As one of the smaller options on the island, the property feels more like a guesthouse than a proper hotel, but it still features comforts such as a full bar and restaurant, private island dining experiences, and lomilomi massages. The hotel also offers a number of Tahitian cultural experiences, including traditional crafts and private Polynesian dance lessons. The proceeds of both activities go to help support a local NGO. Traditional Tahitian dance and music performances can also be arranged. And for guests who really want an immersive experience, Fenua Mata’i’oa offers traditional Polynesian wedding ceremonies, staged right on the hotel’s verdant grounds.

This colonial artifact overlooks the turquoise Indian Ocean and the Coast Line train that runs along it. Sights from the ocean-view rooms stretch to the city of Colombo, 20 minutes away. Trainspotters should request a room at the hotel’s north end to score a balcony with views of the ocean and the tracks. From $105, 94/(0) 11-271-1711, mountlaviniahotel.lk

An archipelago within an archipelago is already an astonishing fact to grasp, but Îles des Saintes, made up of nine islets, only two of them inhabited, is full of yet more surprises. Hop on a daily ferry ride south from Trois-Rivieres in Basse-Terre to these gorgeous offshore islands around a stunning aquamarine bay dotted with sailboats and hugged by coral reefs. Also known as Les Saintes, these islands combine a traditional Caribbean setting of secluded beaches, forts, and towering palm trees with a chic French village lifestyle. The streets here are free of cars, the winding roads to be explored by electric scooter or on foot. Hike to Fort Napoleon for a breathtaking panoramic view over Les Saintes Bay, explore the surrounding waters by catamaran, go diving off the bluffs, sample some of Guadeloupe’s best French and Creole fusion restaurants, and shop the boutiques for French fashions and local jewelry.

On a tree-studded peninsula between Monaco and Nice, this whitewashed luxury boutique hotel features 28 rooms and suites with a serenely chic vibe (think crisp white linens and richly patterned textiles, contemporary art and modern streamlined furnishings). A third of the units reside in the hotel’s main building, a mansion that dates back to 1889 but was fully restored and updated in 2003, and three additional rooms designed to resemble ship cabins are built into a wall with direct views onto the sea; the rest of the accommodations are housed in a quiet Italianate structure and a separate edifice at the edge of the property. Cap Estel’s Michelin-starred restaurant highlights seasonal ingredients, many of which are sourced from the on-site gardens. Guests who come to disconnect from the jet-set scene can relax in the hammam or waterside sauna, or with a massage and dip in the saltwater pool, though many guests would just as soon head straight into the azure waves of the Mediterranean, accessed through the hotel’s private beach.

Caesarea, the city and harbor that Herod built, is now preserved as a national park. A walk along its pathways allows visitors to experience the city’s role as part of ancient Rome and its days during the Crusades in the Byzantine era. Check out a concert at the partially restored amphitheater, or dive in Caesarea’s sunken harbor and underwater archaelogical park. Ancient ruins, including the remains of Herod’s palace, sit along the coastline. A state-of-the-art visitor center offers a historical perspective, complete with famous figures presented as hologram tour guides: King Herod, Rabbi Akiva, the Apostle Paul, and Hannah Senesh. Right outside the park’s boundaries, find a modern city with restaurants, cafés, and some eclectic galleries selling wine, cheese, olive oil, and jewelry—plus a lovely stretch of Mediterranean beach.

We’d heard that Blé Sucré makes the best croissants in Paris; so, of course, we had to check it out. They were absolute magic heaven: a bit crackly on the outside, with moist, delicate wisps of buttery pastry on the inside. The chocolate croissant was equally amazing. We ate it outside with an espresso. Go on a weekday at lunchtime when there’s virtually no line. Be prepared to wait during the weekends.

Another hot spot in Pigalle located in yet another former brothel. Dirty Dick, despite the name, isn’t a place of perdition but the city’s second tiki bar, where Polynesian folklore and the American fifties come to life in the details: lounge music that teeters between surf-rock and exotica, barmen in Hawaiian tops, bamboo stools, Maori sculptures, and a jungle-inspired smoking room. The cocktails, of course, are tropical and range from classic (mai tai) to homemade drinks like the Amazombie served for four people in a smoking crater. Should the bar be jammed, which is likely in the late hours of the night, head directly across the street to Glass, the other leading cocktail bar on the street.

The renowned Meadowood Resort mixes the grandeur of a chalet with the amenities of a five-star resort—located in a private canyon within minutes of downtown St. Helena. The shaded, secluded property revolves around 99 rooms, most of which have high and exposed ceilings, private patios or balconies, wainscoted walls, and beds so comfortable you may never want to get up. Other amenities make Meadowood distinctive, too: Many rooms have heated bathroom floors; some also have deep soaking tubs. Elsewhere on the 250-acre property, all guests have access to the on-site spa, which was renovated in 2017; an on-site fitness center; hiking trails; tennis courts; and a daily wine reception. There’s even a croquet lawn—feel free to grab a mallet and hit some balls or sign up to take lessons with the Napa Valley’s only croquet pro. Of course the on-site restaurant, The Restaurant at Meadowood, is another big draw. More casual meals can be ordered from The Grill. Guests are entitled to a complimentary house car for transport into St. Helena or Yountville.

Serving up creative French and Polynesian fare, as well as some wood oven pizza choices, Blue Banana is a trendy restaurant right on the lagoon in Punaauia. Portions are small but well presented and there is an impressive wine list, including French vintages, stored in the air-conditioned cellar. The ambiance is buzzy and it is best to arrive pre-sunset and ask for a table out on the pontoon to watch the sunset over Moorea in the background.

In the 17th century, the British and French were fierce rivals for control of St. Kitts. The only thing that eventually brought them together was the existential threat of an attack by the island’s native Carib inhabitants—a fear so real that, in 1626, a joint force of British and French soldiers cornered and massacred more than 2,000 Caribs at what came to be known as Bloody Point. Today, guests can visit the historic site by hiking along the river—which was said to have run red for three days after the slaughter—from the village of Challengers through Stone Fort Canyon, where they can also find 100 petroglyphs carved into the rocks.