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This Cuzco corner presents a notable juxtaposition between ancient Incan and Spanish colonial architecture. Since the Incas worshipped their sun god, Inti, above all others, this temple in their imperial capital was the most important of the entire realm. It was here that they brought the idols of all peoples they assimilated, to offer them representation as they demanded allegiance in Cuzco. When the Spanish arrived, they tore down much of the temple and built a monastery on top of it. However, the walls that do remain provide stunning examples of pre-Hispanic engineering, particularly the rounded outer wall that can be seen from Avenida del Sol.

This former royal palace is one of the largest museums in the world, and its art collection is considered one of the most comprehensive. It contains around 400,000 works, although—mercifully, perhaps—not all are on display at any one time. There are some pieces that never get taken off the walls. The Mona Lisa and her smile attract millions of visitors each year. Other must-see masterpieces include the sculptures Winged Victory of Samothrace and Michelangelo’s Rebellious Slave, and the Eugène Delacroix painting The Death of Sardanapalus. There’s no real trick to avoiding crowds at the always-packed museum. The best you can do is try to go in the off-season, early or late in the day, and on a weekday. Your chances of being alone with the Mona Lisa will still be slim to none, but you might be able to actually see that enigmatic smile behind the Plexiglas.

At this luxury collection of six historic homes—some from the 16th century—guests can book a bedroom or an entire house, all within blocks of Santo Domingo’s most important attractions. You won’t find out which room or home you’ll be staying in until your arrival, but you’re sure to be pleased. Located in the heart of the Zona Colonial, the casas are exquisite. Two were part of former convents, one was a monastery, and another was once the private home of a famous Dominican fashion designer. Each one features unique decor and its own courtyard, and five of the six have private swimming pools. Upon check-in, you’ll receive a loaner iPhone to communicate with your house butler and the round-the-clock concierge team, who can help arrange excursions like culinary tours in the Old City and visits to one of the Caribbean’s largest organic cocoa producers.

This beloved boutique hotel in the center of Tel Aviv is named after Norman Lourie, the South African-born renaissance man who became not only a “one-man film industry” in Israel, according to a 1948 issue of Variety, but also the nation’s first luxury hotelier. It comes courtesy of Lourie’s son, who bought two adjacent buildings off King Albert Square—both designed in the 1920s Eclectic style—and had them painstakingly transformed into a modern urban retreat. Guests of the hotel can look forward to a rooftop infinity pool, a Japanese tapas restaurant with gorgeous views, a lengthy menu of unique excursions, and, of course, the Norman Series—a monthly event at the Library Bar, during which you can catch various leaders (think diplomats, economists, artists, and scientists) in conversation. Rooms here are equally singular; no two are alike, though all feature Frette linens, beautiful bouquets, and homemade treats at turndown.

The former residence of Würzburg’s prince-bishops, this UNESCO World Heritage site is one of the most important Baroque palaces in Europe. It was—remarkably, given its scale and level of detail both inside and out—built almost entirely within a single generation. Court architect Balthasar Neumann oversaw the construction, while leading architects from Germany and France created the fabulous ornamentation. Woodcarvers, sculptors, and artists from Italy—including Giovanni Battista Tiepolo, regarded as one of the greatest fresco painters of the 18th century—also contributed to the design.

Rebuilt after World War II, the palace now features a bevy of architectural styles, from German and Viennese Baroque to French château. Inside, the White, Imperial, and Garden halls are can’t-miss attractions, as are the grand staircase and ceiling fresco by Tiepolo and the Mirror Cabinet. Before leaving, be sure to take a walk in the court gardens, which feature fountains, charming yew trees, and a group of cherub statues by Johann Peter Wagner.

The historic and modern center of the city, the Piazza del Duomo (the square surrounding the cathedral’s base) remains a popular meeting place, hangout and hub of Milanese life. Local vendors setup shop (selling fresh coconut in the summer, toys and tourist wares), kids run and play (free from traffic) and shoppers trickle in from the walking street surrounding the huge plaza. The statue of Victor Emmanuel II, the first king of Italy, is the best place to meet, sit, recharge and watch the city go by.

Rembrandt purchased this sizable former merchant’s house in 1639, when he was at the peak of his fame as a portraitist of the city’s elite. He lived, painted, and taught in the multistory building for nearly 20 years, and on the topmost floor—the site of his studio and workshop—crafted what is considered his masterpiece, the Night Watch. The home’s interior is not original but rather a faithful re-creation, based upon a room-by-room inventory conducted after the artist declared bankruptcy in 1656 and was eventually forced to leave. Be sure to catch the free daily paint-preparation and etching demonstrations; the former is particularly interesting to understand how difficult—and expensive—it was to acquire and process paint in that era. Though there are no Rembrandt paintings at this museum, you will find a large number of his superb etchings on view in the ground-floor exhibition space.

There is a staggering amount of artwork on display here. It is said that if you stood at each piece for just one minute, it would take you four years to see everything. Created by Pope Julius II in the early 16th century, the museums have expanded over the past 500 years to their current size of more than 12 acres! Highlights include the Borgia Apartments, the Raphael Rooms, the Gallery of Maps, and of course, the sublime Sistine Chapel.

What began in 1854 as a high school—then grew into a college and, later, a law school—has served as one of San Antonio’s top hotels since 1968. Located near the River Walk, not far from the city’s historic district, the leafy former campus is centered around a seven-story, Spanish colonial-style main building with 338 guest rooms. Each one mixes original touches like wood-beamed ceilings, exposed brick walls, and French doors with modern amenities like HDTVs, marble baths, and Wi-Fi (complimentary for loyalty club members). Some even look out on the River Walk, while others offer views of a verdant garden. Healthy extras like in-room fitness kits, a 24-hour gym, and a year-round heated pool help offset the indulgences served at the on-site restaurants and bars, which include the fine-dining Las Canarias (don’t miss the popular Sunday brunch.) Younger guests can look forward to game-filled backpacks and scavenger hunts, while adults will enjoy the award-winning spa and restaurant at La Mansion’s sister property, Mokara, located across the river.

Who doesn’t need a pain killer once in a while? Take it in the form of a glass of wine from a pharmacy that is more than 100 years old, where the drugs were replaced by wine bottles in the glass-door cabinets. To accompany the wine, you can taste different Portuguese products or you can choose a plate with several types of sausage and cheese. The tables are made of old wine barrels and you can sit on some wooden benches.

Situated on the northern end of Delaware Park, the Buffalo Zoo offers family-friendly fun for warm summer days. Built in 1975, it’s the third-oldest zoo in the country, but the facilities have been updated over the years to provide spacious habitats for the resident animals. The underground sea lion exhibit and Rainforest Falls are favorites, as they allow visitors to get close—but not too close—to the animals. Also be sure to catch a glimpse of the giraffes enjoying the sunshine from their street-side enclosure. To avoid crowds, arrive early in the day—the place can get packed, especially on nice days.

When people think of Florence, they usually think of Renaissance art and crowded museums filled with altarpieces and “Madonna and Child” images. While the Renaissance is the biggest draw of this historic city, there is a lot more to its art-museum scene. The Palazzo Strozzi is a fine example of a museum that doesn’t just showcase great art but also plays an important role in the community. Inside this Renaissance palace—a work of art in itself—visitors will find temporary exhibitions that cover a variety of time periods and cultures.

On Thursday evenings, the courtyard is transformed into a social hub with hip Florentines having drinks and coffee at the café and on outdoor couches. The museum also offers free entrance to the downstairs exhibition space on select evenings and, in summer, hosts movie and music nights. Palazzo Strozzi has also gotten on board with making art an interactive experience, especially for children. Parents can purchase a family ticket which includes kid-friendly activities including workshops, sketching in the galleries, storytelling, and “stroller tours.”

Founded in 2004, this exquisite Chinatown boutique sells unique jewelry pieces designed by Cindy Yokoyama. “I started as a painter and fell in love with abstraction,” she says. “Many of my pieces still reflect elements of this, including asymmetry.” She also plays with order and chaos, and mixes urban elements with natural organic ones beautifully. Expect seeds and shells mixed among metallics... and the azure hues of Hawai‘i’s sea and lush greens of its slopes. Of special note: earring sets where two teardrops complement each other, rather than matching—showcasing stones like lapis lazuli, fossilized coral, and bumble bee jasper.

If you love antiquing or if you’re just searching for a Mexico City souvenir with a bit of history behind it, it’s hard to imagine a more pleasant way to spend a Saturday morning in the capital than visiting Plaza del Angel, a giant antique market with dozens of galleries, located in the Zona Rosa. You can visit during the week, too, but on Saturdays, temporary vendors join those who have permanent spaces here to sell all sorts of wares, from postcards and pictures to religious relics, furniture, books, magazines, and handcrafts.

The story behind the founding of the Museo del Juguete Antiguo México (Museum of the Antique Mexican Toy) is almost as charming and intriguing as the collection of toys itself. Roberto Shimizu, Sr., who founded the museum with his son, Roberto Shimizu, Jr., began collecting toys when he was a child and in the decades since, has amassed a collection of literally millions of toys. He decided it was important for the collection to be accessible and visible to the public, partly to document the history of toy-making in Mexico and the world. The space occupied by the museum covers several floors, but it’s barely large enough to showcase all of Shimizu’s treasures, which he has catalogued carefully in numerous notebooks and binders. That may be hard to believe, given the fact that the museum is crammed wall-to-wall and floor-to-ceiling with toys of every type: from plastic soldiers to board games and Barbies to model trains. The museum is a cabinet of curiosities for the kid in all of us.