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The Palacio Duhau Park Hyatt is a true palace. Built by an English Argentine railway executive, this Tudor Revival mansion dates to the late 1800s. The Duhau family, which bought the property in the 1920s, added an additional neoclassical building modeled after Le Château du Marais outside Paris. The property sat empty for a few decades at the end of the 20th century until a local developer partnered with Hyatt to turn it into a hotel. After a $74 million renovation, they helped preserve much of the original artwork and red marble flooring, invigorating the once faded Belle Epoque elegance. A larger, sleek tower with modern guest facilities was also added.

The property today is a testament to the grandeur of the most European city in the Americas. There are crystal chandeliers, intricate ironwork, and travertine marble bathrooms. There’s a bar where one can indulge in cigars and brandy, after, of course, dining at one of several high-profile restaurants with wine cellars designed to impress even the most hard-core oenophile.

O. Fournier is a modern architectural marvel located 80 miles (90 minutes) from downtown Mendoza in the district of San Carlos. It is one of Valle de Uco’s farthest wineries to visit, but it’s worth the drive to enjoy O. Fournier scenic views, distinctive design, and award-winning restaurant. José Manuel Ortega, a Spanish banker, bought the land in 2000 and contracted local architects to begin building O. Fournier in 2002. No expense was spared and no detail was overlooked to achieve Ortega’s vision. His talented wife, Nadia Harón, who delved into her passion for cooking when the pair moved to Mendoza, has become one of the country’s most notable chefs. Her restaurant, Urban at O. Fournier, blends Argentine and Mediterranean-Spanish flavors and traditions using fresh ingredients grown on the property’s 650-acre farm. If you find yourself falling in love with O. Fournier’s wine and landscape, you may just be tempted to purchase a small plot of land from Ortega to harvest your own wine and create your own signature blends. Reservations to visit the winery and restaurant must be made in advance.

Downtown Mendoza’s finest luxury hotel, the Park Hyatt Mendoza Hotel, Casino & Spa enjoys a privileged location on Plaza Independencia with choice rooms overlooking the Andes mountains. A stunning 19^th-century Spanish colonial whitewashed façade gleams beautifully with majestic columns and ornate cornices. Behind the historic entrance lies a modern, six-story hotel with a contemporary art collection featuring the works of 23 renowned local artists.

Park Hyatt Mendoza’s signature service extends to 186 luxurious guestrooms and suites, plus a spa, health club, casino, and outdoor swimming pool. The hotel’s Grill Q is known for its steaks, while its fine-dining restaurant Bistro M features an impressive two-story wine library with a Wine Spectator stamp of approval for having one of the most outstanding wine lists in the world. The Vines Wine Bar & Vinoteca is a contemporary bar offering local wines.

The name makes it sound like the driest place in Christendom, but the SAT, as it’s known by locals, is at the forefront of coolth. This giant building on Boulevard Saint-Laurent near Rue Sainte-Catherine is dedicated to electronic culture and entertainment, which means it hosts some of the best art events, dance parties and music performances in town. The top level of its four storeys includes the famous Satosphere, a dome structure that allows for mind-blowing, immersive 360-degree visual projections. Events include presentations and master classes in addition to dance nights by the likes of Borgore, Brodinski and MYD. Don’t forget to stop by the in-house restaurant, the FoodLab, which is constantly pushing the gastronomical envelope. Photo: Sébastien Roy

Take home the essence of Argentina with a fragrance inspired by pampas grasses, the northern desert, or Patagonian lupine blossoms. Fueguia 1833, a perfume lab on ultra-chic Avenida Alvear in Recoleta, creates scents from all-natural ingredients. Only the best-quality plants and spices available at production time make the cut, meaning aromas vary from batch to batch. Each bottle bears an engraved lot number, and large flagons come in handsome handmade boxes. Even better: A Fueguia scent does more than make you irresistible—a portion of all proceeds goes to the NGO Help Argentina, a fund-raising organization that supports environmental, human-rights, and public education charities.

The second location of the Sydell Group’s New York flagship, NoMad Los Angeles embraces its past as the Bank of Italy—imposing columns and all. In the lobby of the landmarked building, much of the original Neoclassical style, such as the Doric columns, coffered ceiling, and marble floors, was preserved, complemented by the addition of floral textiles in rich jewel tones. Even the original vault, which once housed 12,000 safety deposit boxes, and its 50-ton door were kept intact. The color palette across the 241 lavish rooms draws from the exquisitely maintained gold-and-blue Italianate lobby ceiling, with custom furniture, original artwork from design studio be-poles, and freestanding bathtubs in most rooms adding to the luxurious feel. Details like nightly turndown service, marble bathrooms, and custom linens by Bellino mean a five-star stay is all but guaranteed.

A two-hour drive south of Buenos Aires is the huge and pristine laguna of Chascomús. Fed by several streams, it’s a popular destination for fishermen, boaters and windsurfers. Rent a bicycle in the town to pedal around the lake, or hire a rowboat for an hour or two - you might catch a fish without even trying.

Seven miles from La Romana, this enchanting national park comprises a 2,600-foot-long cave system with stalactites and stalagmites, plus almost 500 pictographs and petroglyphs created by the Tainos who inhabited the island at the time the Spaniards first arrived. Good lighting, ramps, footpaths, and an elevator make these caves easily accessible.

Located around the block from the neighborhood’s main hub, Sunset Junction, Silver Lake Pool & Inn is a quiet oasis in the walkable (yes, walkable . . . in L.A.), creative enclave of Silver Lake. Its bright, airy guest rooms with stylish design elements, such as terrazzo countertops and leather lounge chairs, are a peaceful retreat from the hustle and bustle of the city. Complete with comfortable king or queen beds, cotton Turkish robes, luxurious walk-in rain showers, and an impressive mini-bar selection (think: Madre mezcal, Salt Point canned cocktails), it has everything you’d need to keep the vacation vibes flowing. And if for whatever reason you don’t, the friendly staff is happy to help.

Cesare al Casaletto is far off the well-beaten tourist track, but it is easy to get to: just take the 8 tram from Piazza Venezia or Largo Argentina and get off at the very last stop. Fifty yards from the tram tracks sits Rome‘s best trattoria, where spectacular fried appetizers (get them all, or at least the gnocchi fritti and polpette di bollito) give way to classic pasta dishes like carbonara and gricia. The second courses are excellent and fall-off-the-tailbone braised oxtail is a favorite. Pair it all with fairly priced natural wines from all over Italy and be sure to leave room for dessert, preferably the panna cotta.

The Hong Kong-based Swire Hotels launches in the U.S. with their 352-room EAST, Miami, located in city’s bustling financial district. L.A.-based Studio Collective and New York’s Clodagh Design paired up to design the interiors, which mix intricate woodwork with sleek furnishings. Original artwork from notable names such as China-born Zha Songgang and Miami-based Alexander Mijares hangs throughout the hotel, along with photographs that highlight Miami’s colorful scenery and Modernist architecture. Quinto La Huella, an outpost of a famous seafood restaurant in José Ignacio, Uruguay, promises to draw locals and visitors alike, while the hotel’s rooftop space serves Asian-inspired tapas with views of the skyline. From $259

La Casa de La Abuela is a Oaxaca mainstay, on the corner between the Zocalo and the Alameda, Oaxaca’s two central squares. Find the entrance on Hidalgo street, and climb the steps up to the second floor. As soon as you enter you’ll see a big clay comal and a woman making fresh tortillas, the sign that this is the real deal: authentic Oaxacan food. They serve local specialties including four kinds of mole (almendrado, coloradito, amarillo and mole negro). Choose a spot by the window to enjoy your meal while you watch the action in the square below.

With a smart and simple chalkboard menu of cheese plates, salads, sandwiches made with homemade bread, good coffee, and Argentinian wines by the glass, Pain et Vin is a lovely venue for lunch or an afternoon glass of Malbec rosado. The Palermo Soho eatery doubles as a tasting space and shop: look for Friday evening events open to the public, or stop by to choose from the excellent selection of boutique wines to take on a picnic to the park.

As the saying goes, “When in Rome...,” and in Mendoza, this means slipping into an immodestly cut bikini bottom to blend in with the locals. Get rid of those American tan lines with some of the most adorable bikinis in the southern hemisphere. Two young Mendocenean sisters design and stamp the bathing suits themselves, making each one slightly unique. You can mix and match tops and bottoms for size and cut. The only question is, do you have enough courage to wear it back at home? With your flattering new tan lines, you just might.

Avenue Arístides Villanueva, simply known as Aristides by the locals, is Mendoza‘s main nightlife drag. Lined with bars, Irish pubs, restaurants, dance clubs and hostels, Aristides is where all the action happens. In warm weather months, crowds flock to the outdoor tables lining the sidewalk. It’s a great option for bar hopping and getting a dose of the late-night Mendocenan culture.