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Most people know the Lou Ruvo Brain Health Center by its appearance—the nonlinear building was designed by Frank Gehry and bears the architect’s signature curves and twists. Inside, however, medical professionals perform incredible feats daily. The facility treats patients with degenerative brain diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. Because the center is an active medical facility, access to the public is limited, but architecture fans are welcome to swing by, marvel at the undulating walls, and wonder how Gehry does what he does with metal.

No swimming in this wash—it’s the treated urban waste on its way to Lake Mead. But a brand-new $15 million visitor center offers an interesting education on how the system has greatly improved in recent years in order to allow the Wetlands and its vegetation and wildlife to thrive. The volunteers there can also help interested guests navigate the miles of concrete and gravel walking trails.

The Alvear Palace is a Buenos Aires landmark. Dreamed up by businessman and socialite Dr. Rafael de Miero, who wanted to bring back 1920s Paris grandeur to his hometown, the hotel was erected in 1932 on the corner of Avenida Alvear and Ayacucho after a decade of on-and-off construction. Then after much fanfare, it expanded in 1940, taking over an old mansion next door. For several decades, Alvear Palace was owned by the Duke of Hornes, a cousin of King Juan Carlos I, though Argentina’s economic situation saw the hotel’s reputation steadily decline. Since Anglo-Argentine developer David Sutton Dabbah (also co-owner of Patagonia’s Llao Llao Hotel & Resort) purchased the property in 1984, the Palace has been renovated and renovated again, top-to-bottom in 2011, which lowered the room count and revived the lavish Louis XV furnishings, and most recently in 2016, with the debut of sleek rooftop suites, an indoor pool, solarium, and a rooftop bar. Bathroom amenities are custom-made by Hermès. The lobby bar exudes Belle Epoque elegance, and many of the rooms, while still as picture-perfect as ever, could be mistaken for another century. There are touches of modern luxury in the spa, but over-the-top opulence is still the dominant theme running through the signature French restaurant and afternoon tea, as high society lingers.

The Palacio Duhau Park Hyatt is a true palace. Built by an English Argentine railway executive, this Tudor Revival mansion dates to the late 1800s. The Duhau family, which bought the property in the 1920s, added an additional neoclassical building modeled after Le Château du Marais outside Paris. The property sat empty for a few decades at the end of the 20th century until a local developer partnered with Hyatt to turn it into a hotel. After a $74 million renovation, they helped preserve much of the original artwork and red marble flooring, invigorating the once faded Belle Epoque elegance. A larger, sleek tower with modern guest facilities was also added.

The property today is a testament to the grandeur of the most European city in the Americas. There are crystal chandeliers, intricate ironwork, and travertine marble bathrooms. There’s a bar where one can indulge in cigars and brandy, after, of course, dining at one of several high-profile restaurants with wine cellars designed to impress even the most hard-core oenophile.

Cesare al Casaletto is far off the well-beaten tourist track, but it is easy to get to: just take the 8 tram from Piazza Venezia or Largo Argentina and get off at the very last stop. Fifty yards from the tram tracks sits Rome‘s best trattoria, where spectacular fried appetizers (get them all, or at least the gnocchi fritti and polpette di bollito) give way to classic pasta dishes like carbonara and gricia. The second courses are excellent and fall-off-the-tailbone braised oxtail is a favorite. Pair it all with fairly priced natural wines from all over Italy and be sure to leave room for dessert, preferably the panna cotta.

A refined yet rustic restaurant and guesthouse nestled into the rural landscape of Mendoza’s Uco Valley, Finca Blousson is a hidden treasure for wine lovers seeking life’s simplest pleasures. Pair the Bistro’s blend of Argentine and French Provencal fare with wines sourced from the region’s top local boutique wineries, and you’ll be treating yourself to an unforgettable experience. The intimate country guesthouse has three cozy rooms overlooking the vineyard or a spectacular view of the mountains. Owners Victoria Jones and her French partner, Patrick Blousson, will look after you like a member of their own family. Route 94, km 14, on the road to The Manzano Histórico, Tunuyan, Valle de Uco, Mendoza; +54 9 261 15 655 3382

For serious wine enthusiasts, this is the closed-door dining experience of choice. On Wednesday through Saturday at at Casa Coupage, a pair of sommeliers serve a seasonal tasting menu with wine pairings to nine tables inside their elegant Palermo apartment. In this intimate environment, dinner doubles as an informal wine course - the sommelier talks you through everything you taste, discussing the grape, terroir and winemaker, answering your questions, even helping you choose a few bottles to take home with you.

Certain things in life are simply impossible to adequately capture in a mere photograph. Iguazú Falls is definitely one of them, and above is my best effort to convey the epic expanse of ‘The Devil’s Throat.’ Situated on the border of Brazil and Argentina, the falls are the watery dividing line between the two countries at this exact point. I accessed the falls from the Argentinian side, via Iguazú National Park and took a mini train (the Rainforest Ecological Train, to be exact), some trails, and more than a few catwalks to reach this particular vantage point. Unlike some falls in the US and Canada, in the southern hemisphere you can get dangerously close to the roaring waters of these grand spectacles. The sound is deafening, the spray is enticing, and the visuals are simply amazing. As I stood there, trying to take it all in, all I could do was feel my heart pounding as I stared into the mouth of the devil. Most depictions of Lucifer entail horns, a tail and copious amounts of fire meant to terrify all who are witness to his power. I can assure you, though made of mere cliffs and water, THIS devil could douse any other devil and never look back.

This super-exclusive private club opened recently in the chic Palermo Soho district. Members or friends of members can go to the garden bar for poolside drinks. It’s all the buzz in Buenos Aires. 54/(11) 4832-5276.

I love the wines of Mendoza, Argentina, but I wanted to marry the wines of Catena Zapata when I had the chance to drink them whilst overlooking the green vineyards backdropped by the soaring, snowcapped Andes peaks. The wines of Catena are mostly big reds made from malbec or cabernet, and they make some chardonnay and sauvignon blanc as well. The winery is fashioned after a stepped Maya pyramid and is furnished with state of the art equipment. Wine tours last about an hour and a half and finish at the tasting room, where you can purchase bottles of wine. Catena Zapata and the rest of the Mendoza region wineries are only open by appointment, so be sure to have a day’s worth of wine tours booked in advance for your itinerary. Be sure not to skip over the city of Mendoza, as there are many wine tasting rooms featuring wines from the region and selling limited releases and other rarities not readily available at the wineries.

I can think of worse places to be stuck than Bozeman, Montana. And when my flight was recently cancelled, stranding me there for two days, I decided to venture downtown and check out Plonk Wine Bar. Plonk is a term that refers to a poor quality wine. But the 600-plus bottle wine list here was full of surprising selections, like the Celler Cal Pla Black Slate—a blend of Garnacha, Cabernet Sauvignon, and a bit of Merlot and Syrah from Spain‘s Priorat region. Equally impressive are Plonk’s cocktail and craft beer selections. I snagged a seat at the bar, took in the cowboy-meets-wine country ambiance, and ordered a glass of Torrontes from Argentina. The bartender suggested I pair it with a decadent dish of seared scallops with foie gras and braised short ribs. It was exactly what I needed to make my travel frustrations disappear.

The hot-right-now Fierro Hotel bills itself as the ‘Hotel for the Gourmand,’ and it’s no wonder - the boutique hotel is famous on the foodie scene for hosting special events like ‘One Table,’ the biweekly TFIF Happy Hour brings in the talent of celebrity bartender Fede Cuco, and - drum roll, please - resident chef Hernán Gipponi and his restaurant were recently recognized at the Latin America’s 50 Best Restaurants Awards 2013. To see what Gipponi - who honed his craft at Michelin-starred restaurants in Spain - can do, come for the nine-course modern Argentinian tasting menu, or splurge on his classy weekend brunch.

Standing in Plaza Congreso, you might find yourself staring up at the Moulin Rouge-like windmill adorning an Art Nouveau building on the corner. Approaching the door, you’ll see it’s covered in cobwebs - this architectural landmark, once a glamorous cafe where politicians had coffee and tea between meetings, has been abandoned for years. Confiteria El Molino (‘el molino’ means ‘windmill’) has been closed since 1996, though local activists keep pushing to fund its restoration. So far, it hasn’t happened, and the fairy tale-like building on the corner adds an eerie ghostly feel to the busy urban intersection.

Tucked away on the second floor of a courtyard building in the residential Recoleta neighborhood, the shoe store Comme Il Faut is a magnet for tango dancers. Customers provide their shoe sizes to cheerful saleswomen, and stacks of shoeboxes—in every color and heel height—emerge from the back.

Posada Borravino is tucked away along one of Mendoza’s oldest poplar-lined streets in the city’s Chacras de Coria neighborhood. The country inn has eight distinct guestrooms that offer a peaceful respite in a quiet Mendocenean neighborhood. The hotel’s design is simple but elegant. Rooms feel clean and refreshing with rustic yet stylish furniture, patina walls, and high, white-washed wooden ceilings.

A boutique hotel experience in every sense, here guests frequently mingle in the sun-drenched living room and cultivate friendships over bottles of malbec and long evening asados (barbecues). The back garden provides an inviting place to enjoy a good book, dip in the small swimming pool, or simply soak up the tranquil atmosphere. The staff is friendly and knowledgeable about what to do and see in Mendoza—from winery tours to adventure activities. In the evenings, Posada Borravino is lit up by dozens of scented candles, creating a magical ambience that casts a rosy glow on your entire stay.