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Founded in the 9th century, Santa Maria della Scala was one of Europe’s first hospitals. It was also one of the first hospitals anywhere to disinfect its equipment and only stopped taking in patients in the 1980s. (The writer Italo Calvino died here in 1961.) The early history of the hospital is illustrated in the 15th-century frescoes decorating the walls of the Pilgrim’s Hall, and there is a fascinating archaeological museum housed in the labyrinthine basement rooms.

Tower Cafe, which sits next to the landmark Tower Theater and original Tower Records, is a favorite among locals. The outdoor garden seating makes you want to stay for a long, relaxing meal; the bubbling fountains (with birds stopping for quick baths), canopies of Japanese maples, baskets of hanging flowers, and benches welcoming you along the surrounding path form an oasis that can be enjoyed much of the year. Tower serves globally-inspired food with a menu that changes frequently to highlight seasonal ingredients and the chef’s new creations. The restaurant is best known for its breakfast, and its most famous dish is the seasonal French toast (a baguette stuffed with custard, baked and served with cinnamon butter and a compote of seasonal fruits such as raspberries, blackberries, and blueberries). Their beautiful desserts are worth at least a look--go inside the eclectically decorated interior and peek in the dessert case. The Yin/Yang cheesecake (dark and white chocolate) is one of my favorite choices. Tower also has a great selection of California beers and wines. Tower Cafe is open every day from 8:00 a.m. to 11:00 p.m. or later on weekends. Breakfast is served until 11:00 a.m. on weekdays and until 3:00 p.m. on weekends; however, be warned because weekends here are packed!

Hampden is known for beehive hairdos, cat-eye glasses, kitchsy decor like the pink flamingo, and ladies who call everyone “hon.” Now, though, Hampden is Baltimore’s hipster neighborhood with an array of thrift stores, antique shops, boutiques, and restaurants. It’s worth taking at least a half day to browse the many shops, grab a great meal, and maybe buy some Baltimore souvenirs. On First Fridays (of the month) many shops serve wine, stay open a little later, and offer special deals. John Waters’ Baltimore, from the musical Hairspray, manifests itself in Hampden, specifically on 36th Street, which is simply called “The Avenue.” The proprietress of Cafe Hon (featured on Kitchen Nightmares) has worked to maintain the John Waters-inspired vibe as a tourist attraction, which can really be seen during Honfest where beehives and kitsch take over in early June. Some favorites in the area include: Trohv for Baltimore souvenirs; Ma Petit Shoe for shoes and chocolate (can’t go wrong there); Wine Source for an impressive array of beers and wines; Daniela Pasta and Pastry (for pastries); Spro for coffee; and the Golden West, Grano (Grano Emporio and Grano Pasta Bar), Corner BYOB, or the Food Market for dinner.

Originally a private summer home, Casa Bonita is now a beautiful 12-room resort run by the third generation of the Schiffino family. Located on the Dominican Republic’s southwestern coast near the town of Barahona, the property was constructed from felled trees and thatch, giving it a luxuriously rustic vibe. Inspired by nature, rooms feature white linens, palm wood accents, and wicker furnishings; some have private balconies overlooking the jungle, others have infinity pools with ocean views, and the two-bedroom Villa Bonita includes a terrace with a grill.

The resort’s farm-to-table restaurant uses produce from the local community and on-site Pat’s Organic Garden, while the spa incorporates traditional Dominican ingredients like coffee, chocolate, and coconut into each of its indulgent treatments. Also available to guests are activities like water sports, tennis, yoga, horseback riding, mountain biking, and a zip-line canopy tour through the jungle. Should you want to venture off property, the UNESCO-designated Jaragua-Bahoruco-Enriquillo Biosphere Reserve is just next door. There are also coffee plantations, lakes, and caves with ancient tribal art nearby.

The scenic drive to Poás National Park alone makes a stay at El Silencio Lodge worth it, but you don’t need to leave the grounds to see the country’s largest active volcano. The 16 Zen cottages enjoy serene views of the steaming mass from private decks and also have gas fireplaces, outdoor whirlpool tubs, king beds, and an earth-hued color scheme that evokes the tropical setting in streamlined luxury. Fruits and vegetables from a 5,000-square-foot organic greenhouse on site are used to make continental fare (osso buco risotto, parmesan-crusted chicken) and Costa Rican favorites (cassava croquettes, tamarind pork), which are served in two elegant glass-walled restaurants. An open-air yoga studio invites you to reflect on the beauty of your surroundings, while locally sourced treatments at the spa incorporate healing ingredients like Costa Rican clay and chocolate. Those who prefer more active leisure can join the designated eco-concierge for guided hikes along the property’s private cloud forest trails, spotting waterfalls, hummingbirds, and seasonal quetzals along the way.

Bar Raval looks ordinary from the outside, but inside, the sinuous lines of the floor-to-ceiling mahogany woodwork—bar, walls, window frames—instantly bring Gaudí to mind. Created to mimic the spirit of Barcelona’s pintxos bars (in addition to the Catalonian influence of the decor, platters of food are laid out on the bar, as is the Basque pintxos tradition), the space is often packed. In the mornings, patrons sip lattes and enjoy doughnuts finished with a lick of chocolate and spiced hazelnut.

Two blocks from Union Square, Hotel Adagio is a stylish retreat from the frenetic energy of downtown San Francisco. Built in 1927, the Spanish colonial revival building has a stunning cream facade with intricately carved arches that surround the entrance and windows. The interior also retains many of its original features, including rope crown molding and the top floor’s hand-painted ceilings. Conference-goers and event attendees will be impressed with the hotel venues’ city views, elaborate woodwork, and high ceilings.

Hotel Adagio is part of the Marriott’s Autograph Collection, and the recently renovated rooms are appropriately named Audition, Act One, Encore, Applause, and Actor’s Studio. The decor uses a contemporary palette that mixes warm burgundy and chocolate hues with lime green and white. Get ready for a night out as you jam to your own music, thanks to each room’s iHome docking station. Then, head down to the hotel bar, the Mortimer, to start the evening with a craft cocktail.

Opened in time for the 2000 Sydney Olympics, the Establishment is a pioneering 31-room boutique hotel housed in an 1890s steel plant near the modern-day stock exchange building downtown. Managed by the hospitality group Merivale—which started as a fashion house specializing in fascinator hats and mini skirts—the hotel is popular among brand executives who book the 328-square-foot Loft Penthouse for product launches and photo shoots. Rooms feature wood furnishings, swinging metal doors, animal hides, and suedelike daybeds as well as such amenities as Apple TV, Bose surround sound, and Lululemon yoga mats. Bathrooms are particularly luxurious here, with marble floors, freestanding tubs, Bulgari products, and tall windows that open up to Sydney’s bustling business district. The best part about the Establishment, though, is the internal access it offers to some of the city’s hottest bars and restaurants, which are housed within the same complex as the hotel. And after enjoying live music and a few stiff cocktails at the speakeasy Palmer & Co, guests are welcomed to bed with Sleep Tight tea and a homemade chocolate chip cookie.

Ask anyone you know who grew up in the Bay Area about the Exploratorium, and they’ll likely be able to share stories of class trips and seeing their hair stand on end at an installation about electricity or fun-house mirrors that taught about optics and visual perception. This is not, however, a museum simply for kids—though curious kids will definitely be entertained while learning. Instead, its exhibits aim to raise the scientific literacy of visitors of all ages, by providing engaging, amusing, and hands-on experiences. Long housed at the Palace of Fine Arts, the Exploratorium opened in its current, and much larger, space on Piers 15 and 17 in 2013. One advantage of the new waterfront location is the North Gallery and its outdoor spaces, focused on environmental phenomena like the wind, rain, and tides. The completely dark Tactile Dome and the disorienting Monochromatic Room may prove not just the highlights of your visit to the Exploratorium but the most memorable, or at least strangest, moments of your time in San Francisco.

The Newseum is an interactive, ever-evolving tribute to our First Amendment freedoms of religion, speech, press, assembly, and petition. Powerful exhibits such as eight sections of the Berlin Wall (the largest display outside Germany) provide historical context for the importance of free press, while timely exhibits about the civil rights movement provoke reflection on the progress of achieving equality. The daily-updated “Front Pages” gallery of local, national, and international publications is a comparative study on current events, while the archive of headlines highlighting momentous events from the 1400s through today is an engaging history lesson. Peruse Pulitzer Prize–winning photography, enjoy panoramic views down Pennsylvania Avenue, and test your journalistic skills with a recorded mock-broadcast—reading a teleprompter is not as easy as you may think!

Visitors flock to southern Arizona for sun and saguaros... ...but for a hole in the ground? Other than the ones on golf courses? From the 1960’s to the 1980’s, Tucson was ringed by eighteen steel-and-concrete-reinforced holes in the ground--highly secure shafts in the desert that housed intercontinental ballistic missiles tipped with multi-megaton nuclear bombs. “Peace through Deterrance” was the idea, as the propaganda-phrase goes... Of the 54 Titan Missile complexes that were scattered around the country, only this one, about 45 minutes south of Tucson, has been preserved and opened to the public. It’s a startling reminder of how thin the line was that separated the “Cold War” from “M.A.D."--"mutual assured destruction.” It would only have taken 30 minutes from its desert launch for this missile to deliver unimaginable destruction--via a 9 megaton nuclear warhead--up to 6300 miles (10,000km) away... On a lighter note, some of the filming of one of the Star Trek films took place here. You can visit the subterranean control bunker and staff living quarters, access corridors, and the missile silo itself. Tours are offered on the hour year-round, with additional tours offered every thirty minutes from January through April. Closed Christmas and Thanksgiving. Whether you’re coming from the left or from the right, politically, the sobering reality of this fusion of human nature and technology is worth going underground for if you’re driving down I-19.

Much of Mexico City’s fervid contemporary art movement—galleries and collectors abound; the scene is now a launching pad for Mexican artists looking to conquer the world—can be traced to art patron Eugenio López Alonso, heir to the Jumex packaged-juice fortune, who over decades has amassed Latin America’s most extensive contemporary art collection and brought dozens of artists to the international spotlight. The collection’s flagship museum, itself a work of art by the British architect David Chipperfield, is a surprisingly intimate exhibition space that supports a rotating calendar of shows; the basement bookstore will delight bibliophiles and design freaks alike. Right nearby lies the Museo Soumaya, whose dramatic architectural form (which earned it the nickname “the Blender”) makes up for a collection some consider erratic.

After 80 some odd years as one of Houston’s most lauded and refined hotels, the historic Warwick Hotel went from Bach to rock, when new owners gave it a slick makeover and renamed it Hotel ZaZa in 2007. A bold beacon in the Museum District, the dimly lit hotel is a virtual playground for adults, with daring decor, baroque details, and an outdoor pool with private piazza-themed cabanas. While it maintains much of its original 1920s architectural elegance and details, including Baccarat chandeliers, the interior walls are splashed with modern art and iconic editorial-photo shots of beloved celebs.

Many rooms and event spaces are themed, including the space-inspired “Houston, We Have a Problem” Suite and the Conspiracy Room, which nods to Prohibition. A recent refresh includes newly renovated 11^th-floor meeting rooms, new mattresses, new carpet, spa and fitness center upgrades (including treatment room tweaks and the addition of innovative infrared saunas), and new in-room flat-screen TVs. Bottom line: even an overnight stay feels like a true escape.

Controlled by the François Pinault Foundation, the same trust in charge of Christie’s auction house, this is a museum-worthy gallery in the heart of Venice. Set inside a 17th-century customs house, it showcases Pinault’s impressive private collection, comprised of some 2,500 pieces of modern art. The location, at the point of land where the Grand Canal meets the Giudecca Canal, is equally spectacular. After you’ve finished browsing the art collection, grab a pastry or a small bite at the in-house Dogana Cafe.

The 10th century temple of Banteay Srei, known as the ‘Citadel of Women’, is one of the prettiest temples with intricately detailed carvings and decorative features painstakingly carved into the pink sandstone. It’s also one of the most compact and can easily be explored in an hour or two. You can make a day trip of the journey out there (25km from Siem Reap) by combining it with visits to the nearby Landmine Museum and Banteay Srei Butterfly Centre.