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Housed in a historic turn-of-the-20th-century building renovated to include nearly 10,500 square feet of exhibition space, 21c Museum Hotel is equal parts art gallery and modern lodging. Guests and the public will find a range of programs, from solo and group shows to rotating installations, curated by Alice Gray Stites. You’ll also find a touch of whimsy in the form of the brand’s signature penguin sculptures, a playful gesture that extends to the guest rooms. Featuring light hardwood floors, white walls, and colorful modern furnishings, they serve as a coordinating backdrop for original works by local artists; flat-screen televisions, Nespresso coffee makers, and Malin + Goetz bath amenities keep things comfortable. Downstairs, the chef at Gray & Dudley transforms ingredients from neighborhood markets and farms into dishes like pan-roasted duck breast with apple purée and black-eyed pea falafel. Another must-try indulgence? The small spa requires 24-hour advance reservations, but the calm respite after a day of sightseeing makes it worth the wait.

The indoor dining room and lounge and outdoor patios surrounded by greenery at this chic waterfront restaurant in Brickell are elegant, and pretty much every table has an paralleled view of downtown Miami and the bay. The menu is Italian-influenced and consistently good, and the service is always on point. Lighter dishes made with quinoa and vegetables are on offer, along with favorites such as fried chicken and beef short ribs.

Work your way from Excelsior’s top floors (slinky Chloé dresses, Balmain leather jackets) to the main floor (watches, speakers, a sea of colorful iPad cases), then down to the subterranean floors for the impressive wine shop and restaurants.

My friend Andy says you can’t go to Milan without having an evening in Brera, the tiny artsy area adjacent to Milan’s fashion center. Bar Brera is the hangout of choice for expensive liquor and people watching.

Artist Dan Flavin’s last installation is the Church of Santa Maria Annuciata in Chiesa Rossa, fondly known as simply Chiesa Rossa. Flavin’s light installation is a technicolor dream of electric hues across the main nave and central apse.

The modern minimalism of Le Méridien Chambers boutique hotel is accented by all things art. Graffiti-covered stairwells and hallways lead to rooms, each with their own original piece of art by the likes of Brits Damien Hirst and Gary Hume. Located in the vibrant Theatre District, entertainment from live music to stand-up comedy is just outside the door. As a guest, you’ll be granted free admission to the popular Walker Art Museum one mile away. Aside from the art, there are thoughtful amenities like the rain shower and heated floors, and fresh Italian cuisine at the hotel’s Marin Restaurant & Bar.

Walking through the narrow streets of Boston‘s North End might have you thinking about a delicious Italian meal. Take the time, however to explore the area on Hanover Street where the surrounding brick buildings suddenly give way to a park where Paul Revere stands guard. Commemorating his ride to warn the colonists of the impending British Invasion, the statue stands in front of a small park leading to the famous Old North Church. The setting is a perfect spot to relive the beginning of the American Revolution, and after exploring, leaves you in a location filled to the brim with restaurants and cafes to recharge before moving on.

At this Michelin-starred restaurant, food is a performance art and the results deserve a standing ovation. That said, this is Prague, so although the food and presentation are comparable to other first-class dining experiences in Europe, the vibe and the service isn’t stuffy at all. At La Degustation Boheme Bourgeoise, the ingredients sourced from local producers, are based on the recipes penned by the famous 19th-century cookbook writer, Marie B. Svobodová, author of Cookery School. The eight-course menu is punctuated by interstitial amuse bouches and paired with Central European, French, and Italian wines, as well as cucumber, sour cherry, and red currant juice; recent menu courses include beetroot with licorice goat kefir, kohlrabi with whey and nutmeg, and duck with pear and cinnamon.

“Buongiorno, Signor Farley,” said Umberto, the head waiter at Hotel Missoni’s Cucina restaurant. By the beginning of the third day of my stay, the staff knew my name. And what I drank with breakfast. An espresso doppio was delivered to my table a minute later. “Prego,” the server said.

You’d think I was in Italy. In fact, I was 2,500 miles southeast of the country’s heel, in the capital of diminutive, oil-rich Kuwait. Opened in spring 2011, Hotel Missoni, owned by the eponymous fashion and home furnishings house, is one of many designer-conceived hotels that have popped up around the globe.

I have to confess: I have a complicated relationship with fashion. Maybe it’s related to my childhood. (Isn’t everything?) In the seventh grade, I wore a T-shirt to school that read, “My Son Is in the Navy.” My trend-conscious peers, who clearly had no sense of irony, laughed at me until the final bell rang. When I wore bowling shoes to high school, I was similarly mocked. How would I do in a hotel designed by a couturier?

I was picked up at the airport in Kuwait City in a Maserati (a complimentary perk for all Missoni guests). Not a bad start.

The property (like its sister hotel in Edinburgh, which opened in June 2009) is the brainchild of the Missoni family matriarch, Rosita. The hotel’s 169 rooms were designed to feel like her home. Compact Hans Wegner wishbone chairs and tuliplike Eero Saarinen–designed tables rest on hardwood floors, and everything—espresso cups, towels, even the swimming pool—displays the colorful striped patterns Missoni is known for. Generous helpings of turquoise, gold, and beige are splashed throughout the hotel to evoke the bayfront landscape outside, and every room looks out on the ever-expanding Kuwait City skyline. Like many things Italian, the hotel is simple and comfortable.

The Missoni team, which is fine-tuning its approach before opening hotels in larger markets, learns fast. There are no design hotel clichés here: no faucets with the function designed out of them, no overly formal staff. “Are those Camper shoes?” a waiter asked me one day at breakfast. I nodded. “Like bowling shoes,” he said. “Very cool.” Here, it seemed, fashion and I got along great.

965/2577-0000, from $414. This appeared in the September, 2012 issue.

Originally a private summer home, Casa Bonita is now a beautiful 12-room resort run by the third generation of the Schiffino family. Located on the Dominican Republic’s southwestern coast near the town of Barahona, the property was constructed from felled trees and thatch, giving it a luxuriously rustic vibe. Inspired by nature, rooms feature white linens, palm wood accents, and wicker furnishings; some have private balconies overlooking the jungle, others have infinity pools with ocean views, and the two-bedroom Villa Bonita includes a terrace with a grill.

The resort’s farm-to-table restaurant uses produce from the local community and on-site Pat’s Organic Garden, while the spa incorporates traditional Dominican ingredients like coffee, chocolate, and coconut into each of its indulgent treatments. Also available to guests are activities like water sports, tennis, yoga, horseback riding, mountain biking, and a zip-line canopy tour through the jungle. Should you want to venture off property, the UNESCO-designated Jaragua-Bahoruco-Enriquillo Biosphere Reserve is just next door. There are also coffee plantations, lakes, and caves with ancient tribal art nearby.

Renowned Costa Rican architect Ronald Zürcher looked to his country’s colonial past when designing this hacienda-style property—witness its central courtyard, arched doorways, and terra-cotta roofs. Set amid a 30-acre coffee plantation just outside the capital city of San Jose, the hotel’s 308 traditional accommodations follow suit with dark wood furnishings, but a modern aesthetic pervades renovated guest rooms with streamlined furniture, intricately patterned bathroom tiles, and expansive views that extend from green lawns to forested mountains and urban skyline; some include small balconies that overlook the hotel’s two pools. On-site dining options include gourmet takes on Costa Rican fare at Hacienda Kitchen, Peruvian specialties at La Isabela, and fresh-made sushi at La Castilla, as well as a sports bar and café. The open-air great room invites reading and quiet conversations, but if you’re up for something a little more energetic, there are tennis courts, a driving range, a fitness center, and invigorating coffee scrubs at the spa.

An offshoot of the highly acclaimed restaurant Talulah’s Garden, this neighboring cafe and market offers a casual spot for eating in and gourmet foods and treats for taking out. Located directly on Washington Square park, the cafe serves wine and beer and premium La Colombe coffee. Talulah’s Daily is a comfortable place to enjoy healthy prepared foods and creative sandwiches, with many options for vegetarians. The gourmet shop offers a variety of unique non-perishable food treats that will survive your trip home.

Open daily, even on Sundays, the Condamine market is a combination covered and outdoor market where residents come to stock up their larders with regional specialties, local produce, and fish directly from the sea below. Grab a coffee at one of the old-fashioned cafés, or savour the regional “socca” chick pea pancake as you watch the Monegasque go about their daily business—visiting the newsstand, gossiping with neighbors, letting their kids loose in the play area. Photo : Sylvia Sabes

At Elias, a quaint little eatery located next to the National Gallery (another afar.com highlight), you’ll find exciting food at competitive prices. The people at Elias focus on fuss-free food: organic drinks, hand-brewed coffee, Norwegian beers, and solid homemade food – not a latté, Coca Cola or Pepsi in sight! The walls display different works of art throughout the year, and music sessions are often held here. A centrally located foodie destination that you certainly won’t find anywhere else.

Both Hilo and Kona have quaint downtown areas with small shops and cafes. Kona has been updated more recently to accommodate travelers who predominantly stay on the Kona side of the Big Island. With coffee shops, restaurants like the Kona Canoe Club and Mahina Pizza, and shops including the Pacific Fine Art Gallery and ABC Stores, you can spend an entire day browsing for Aloha shirts, art, and souvenirs before enjoying the sunset from one of Kailua-Kona’s many beachside restaurants.