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Painted by Michelangelo between 1508 and 1512, the frescoes on the Sistine Chapel ceiling are considered some of the finest art ever produced. These religious paintings include nine scenes from the Book of Genesis, of which The Creation of Adam is undoubtedly the most iconic.

Why we love it: A 900-year-old fortress-cum-prison reimagined as a luxurious getaway

The Highlights:
- Historical details like artifacts, original ironwork, and a stone arch bearing the seal of Abdul Hamid II
- A fourth-floor infinity pool with uninterrupted views of the Mediterranean Sea
- A full-service spa with a Turkish hammam

The Review:
Located right on the main square in the old city of Jaffa, The Setai Tel Aviv is steeped in history. Built by the Crusaders as a fortress in the 12th century, the property later served as a kishle (jailhouse) under the Ottoman Empire, then a British command post during Israel’s War of Independence. When it became a hotel, the original building, with its stone corridors and inner courtyards, underwent a meticulous restoration that included archaeological digs to uncover several artifacts, which guests can now see in the lobby. Those eager to learn more about the hotel’s history can also walk through the large entry arch, crowned by the seal of Abdul Hamid II, or check out the stone-and-iron prison cells behind the grotto-like lobby bar.

Spread over three newly created floors, the 120 rooms and suites feature an Ottoman-inspired design, complete with richly colored Turkish rugs, laser-cut pendant lamps, dark wood furniture, and sleek, textured headboards. Spacious bathrooms further the luxurious vibe with granite sinks, large bathtubs, and separate rain showers. Elsewhere on property is Jaya, where guests can indulge in an ample breakfast buffet and new-Mediterranean kosher food for lunch and dinner; former prison yards that serve as the hotel’s stunning front and rear courtyards, with comfy seating among verdant lemon trees; and a basement spa, which boasts a traditional Turkish hammam. Still, the hotel’s principal amenity has to be the fabulous infinity pool with panoramic views of the Mediterranean and downtown Tel Aviv—sunsets here are nothing short of spectacular.

Everyone who visits Santa Fe walks along the famed Canyon Road. Originating as an old footpath that once accessed water, it now primarily showcases an expansive range of shops and galleries with Native American art and landscape paintings. A stroll is not complete without a stop at one of the award-winning restaurants, a la Geronimo and the Compound.

Bogotá’s museum of all things gold is one of Colombia’s greatest treasures. Yet despite the name, you’ll find more here than just the precious metal. In addition to stunning displays drawing on a collection of more than 30,000 gold treasures, you’ll find highlights from the institution’s more than 20,000 artifacts of clay, textiles, and other materials that reveal the history of Colombia’s diverse pre-Hispanic cultures. Audio guides enhance the experience with information on the objects’ purpose and provenance that connects various periods and movements. The museum shop offers dazzling (if somewhat expensive) souvenirs fashioned by members of Colombia’s many indigenous nations.

Celebrated on Broadway and in film as the title character in The Unsinkable Molly Brown (with unsinkable being a reference to her survival as a passenger of the Titanic), Margaret Brown was born in Missouri and moved to Leadville, Colorado, with two of her siblings when she was 18. She later met and married J.J. Brown, and the couple became rich after J.J. devised a method of reaching gold in one of the mines. They moved to Denver and bought this house in 1894. It went through several owners after the Browns, but it was eventually acquired in 1970 by Historic Denver, a foundation that restored it to the state it was in when the Browns lived there. The house is open for tours that offer a deeper dive into Margaret’s interesting life as a socialite and philanthropist.

Fortuny fabrics, with their iridescent, waterlike shimmer, were born here in Venice at the Giudecca factory. You can’t visit the factory (trade secrets, you know) but the Fortuny showroom is open to the public. Along with fabrics for sale, you can also view some of Mario Fortuny’s art as well as mementos of the iconic process that created such tactile velvets and silks.

A few years ago, Bósforo was a nondescript bar in the capital’s Centro Histórico (Historic Center) neighborhood. Its decor was nothing to write home about; in fact, it was so dark it was hard to make out whether there was any decor to speak of. Fast forward to today, and the dark, dull interior hasn’t changed. Nor has the bar’s focus: mezcal. The smokier cousin of tequila is an agave-based spirit that has grown exponentially in popularity over the past several years. Most of the bar’s offerings are small-batch mezcals in bottles with handwritten labels. What you try today may not be available at all the next time you visit. What has changed in the past year or two is Bósforo’s visibility. Once a bar that was really only for locals in the know, Bósforo is now visited by mezcal lovers from all over the world. If you’re a fan of the spirit—or you haven’t yet tried it and would like to—Bósforo is worth a night out in the Centro.

“Puerta del Diablo,” or “Devil’s Door” has a dark history; it was a site where acts of torture were committed during the civil war. History can feel heavy here, to be sure, but Salvadorans are reclaiming this beautiful spot, which has stunning views of mountains and the Pacific Ocean.

Fly by Jing is chef Jenny Gao’s pop-up supper club, where 10 lucky diners get to sample 10 to 15 courses of “Sichuan soul food.” Gao was born in China but raised in Toronto, and her dinner menus reflect this East-West tension. Imagine a Chinese-Italian fusion dish with organic black pork dumplings over fresh pasta, the bowl topped with a cured egg-yolk. Dinners happen twice a month and cost about $77, including one cocktail, beer, and wine. Subscribe to Gao’s email newsletter to scoop up tickets to the next culinary event; seats sell out fast.

One of the most convivial Garifuna dining spots in Hopkins is run by the entrepreneurial Tina, born and raised in the village. Sample local dishes, such as the breakfast fry jacks, and Tina’s Garifuna hudut—snapper simmered in a seasoned coconut stew, with a side of mashed plantain. You’ll also find a variety of surprising daily specials, including curries and lobster cooked several ways, and small bites like quesadillas. Locals come in and out all day. There are Friday evening Garifuna drumming sessions in the open-air thatched restaurant.

Travelers should visit Taronga Zoo as much for its harbor views as for the 4,000 resident animals (who get to see them all day long). Ferry 15 minutes from Circular Quay and take an optional Sky Safari cable car, included in the ticket price, and you’re in an exotic land of giraffes, elephants, and bongos as well as native echidnas, wombats, and Tasmanian devils. Wildlife tours, zookeeper talks (including impressive bird shows), and special events such as the Twilight at Taronga summer concert series are on the calendar, and a tented camp accommodates overnight guests who help feed select animals before a sunset dinner set against the Sydney Opera House and Harbour Bridge. Tent cabins feature decks that lure campers out of bed for sunrise.

This San Salvador-based gallery, opened in 1985, is always worth a visit, given its variety of paintings and sculptures by Salvadoran and other Latin American master artists. Check to see if your visit coincides with its annual “Latin American Painting and Sculpture Show”, which attracts critics and collectors.

Las Flores is a surfers’ beach, with whipping waves and a break point, as well as a hippie vibe—you can even camp on the beach (though notifying the POLITUR, the tourist police, of your intent to do so is recommended as a safety measure). Surfing is only recommended, however, for advanced and expert boarders.

The Beauregard-Keyes House stands out in a neighborhood—the French Quarter—already filled with standout buildings. Built in 1826, it’s a superb example of the then-newly-popular Greek Revival style, with its bossy pediment and sweeping granite stairs, which displaced the more austere Creole style. It’s been home to an illustrious roster of residents, including legendary 19th-century chess player Paul Morphy (born here in 1837 and world champion before he turned 20) and Confederate General P.G.T. Beauregard after the Civil War. Next door and visible even if you don’t take the guided tour is a small, walled parterre garden, restored to the formal style of the middle 19th century.

Bangkok’s most iconic site is a massive palace complex that served as the royal residence until 1925. Of its many buildings, the one with the most architectural interest is Chakri Mahaprasat. It was designed in 1882 by British architects, in a style that could be described as traditional Thai meets Italian Renaissance. Nearby is the 1784 Wat Phra Kaeo, or Temple of the Emerald Buddha, Thailand’s most sacred Buddhist place of worship. Go inside to see the Emerald Buddha, carved not of emerald but of semiprecious green stone, robed in gold and just 66 centimeters (26 inches) high.