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Driving between Globe and Show Low in the White Mountains east of Phoenix, US 60 curves and descends dramatically into the Salt River Canyon. Some call it the ‘mini Grand Canyon.’ The highway snakes down some 2000 feet before climbing back up... Spring brings snowmelt and whitewater rafting...by late summer, the monsoon rains are keeping the river muddy and turbulent...Several parking areas allow you to pull off the two-lane road; breathe in the views, stretch your legs on Apache land.

This is the neighborhood spot for the entire town of San Sebastián under the age of 40. Whether it’s an 8 o’clock shot of espresso, a mid-morning toast with tomato and olive oil, or a beer at 7pm, this place is always hopping with people. It’s the perfect place for conversation, people-watching, and Wi-Fi. Their toast and their homemade cakes are outstanding.

Bernal Heights is one of my favorite neighborhoods in San Francisco. It’s a little off the beaten path, but on a clear day the park at the top of the hill offers an amazing view of the city and the bay. On a foggy day, the park feels like the setting of The Hound of the Baskervilles. Did I mention dogs are allowed off-leash?

Just 33 miles northeast of Avignon, the town of Vaison-la-Romaine is home to some of France’s most significant archaeological finds. The Ouvèze River flows through the village, creating two separate banks. On the left, a medieval town features enchanting fountains, houses built into the sides of cliffs, a towering belfry, and the ruins of a 12th-century castle. On the right, the new town surrounds an ancient Roman village, complete with preserved dwellings, a theater from the 1st century C.E., and a Gallo-Roman bridge. Amid the Puymin and La Vilasse archaeological sites, you’ll also find the imposing Our Lady of Nazareth Cathedral (built in the 11th and 12th centuries) and the St. Quenin Chapel (with an apse dating back to the 13th century). A 9-euro (around $10) pass grants 24-hour access to all the sites with guided tours if desired, but you can also just wander the cobblestone streets for free, discovering ancient doorways, striking facades, and hidden statues as you go.

Remote and difficult to access, this three-mile beach on the Dominican Republic’s southwestern Caribbean coast (15 miles from Pedernales and close to the Haitian border) is also blissfully uncrowded. Playa Bahia de las Águilas, which translates to “Bay of Eagles,” can only be reached via a four-wheel-drive vehicle on an unpaved road, or a 15-minute speedboat ride from the little village of La Cueva at Cabo Rojo. Once there, however, you’ll discover a pristine beach, bordered by rocky cliffs and free of any hotels or restaurants—the beach is located in the Jaragua-Bahoruco-Enriquillo Biosphere Reserve, so building is forbidden. Turquoise water laps the white sand, while well-preserved coral reefs wait just offshore. Don your mask and snorkel to see starfish, sand dollars, and maybe even a manatee. Also remember to bring water and sunscreen as there’s virtually no shade, and pack lunch or plan to eat in nearby La Cueva.

Built in 2009, Vdara, a condo-style, all-suites hotel, is a tower of serenity in a neighborhood not known for it. Despite its location, at CityCenter, just off the Las Vegas Strip, Vdara has no casino, no celebrity-chef restaurants, no glittering stage productions, no over-the-top pool and nightclub scene, and—like its neighbor, the Mandarin Oriental Las Vegas (but rare for Las Vegas) no smoking permitted anywhere on the property. What it does have, worked into its minimalist, contemporary design, are spacious rooms, kitchenettes, washers and dryers, and a residence club–like feel that puts many guests in no hurry to leave. At 1,495 suites, the Vdara is too big to be called a boutique hotel, but with a high level of service (pool cabana reservations, anyone?), its size isn’t a liability.

The thermal hot springs in Rincón de La Vieja at Rio Negro (Black River) may not be as well known as those in the Arenal area, but we had the pools and surrounding forest to ourselves. From where we stayed at the Hacienda Guachipelin Rincón de La Vieja, the springs were accessible by horseback or vehicle, followed by a short hike and crossing a rather dubious hanging bridge. The pools are heated by the Rincón de La Vieja Volcano, so you definitely want to test the steaming water. There are seven pools to sample of different shapes, sizes and temperatures. The first pool was too hot to plunge more than our toes into. And the pool that was “just right” was the last one, which happened to be ideally situated next to the churning river. After two days of horseback riding, hiking, canyon ziplining and rappelling, it was great to unwind at this private oasis. If a rainforest/volcano adventure beckons you, I recommend staying at Hacienda Guachipelin Rincón de La Vieja and getting an adventure pass from Adventure Tours--both are at Rincón de La Vieja National Park.

Lions and tigers and bears…oh my, this museum has everything for the aspiring naturalist. Examining the relationship of human and animal throughout history, original displays of classic and contemporary art mingle with taxidermic animals, rifle collections, and archives in a 17th-century mansion. Visitors, especially kids, will love opening the wooden drawers to find contents like scat and paw-print samples, or hunting down a trompe l’oeil mousehole. Founded by the François Sommer Foundation, the museum is committed to promoting the global discussion about our environment. The result is a compelling selection of temporary exhibitions, conferences, and events that change with the seasons.

Inaugurated in 1912 by its namesake, the Spanish regent Maria Cristina, this belle epoque landmark has welcomed international elite to its gilded halls from day one. Designed by the same architect behind the Ritz in Paris, the hotel has long been a favorite of celebrities during the San Sebastián Film Festival (Bette Davis was, notably, a fan). A $25 million renovation in 2012 only cemented its status as the city’s most luxurious hotel. With three of the city’s most elegant eateries (including a favorite see-and-be-seen bar), panoramic views of iconic belle epoque buildings and the Urumea River from the many terraces, and signature Luxury Collection concierge service, the Maria Cristina still feels fit for the aristocracy who frequented it in the city’s beach-destination heyday. Spacious and decadent rooms with an updated belle epoque style, as well as a central location within walking distance of many of San Sebastián’s Michelin-starred restaurants, only sweeten the deal.

Housed in the monastery of San Marco, this museum pays homage to the delicate, spiritual work of Fra Angelico who lived and worked here as a monk from 1435-1445. Some of his most celebrated paintings and frescoes are on show here: the famous Annunciation (as reproduced on many a Christmas card) is at the top of the stairs on the first floor and the great Last Judgement alterpiece is in the Pilgrim’s Hospice. He painted frescoes in the corners of the main cloister and also decorated the monks’ tiny cells with the help of his assistants. This is one of my favorite museums in Florence...don’t miss it! Photo by Gianluca Moggi

The Blue Star Contemporary Art Museum is the first and longest running venue for contemporary and modern art in San Antonio. It features a plethora of exhibitions each year and always has something going on at the museum. It also hosts concerts and performance art events. The museum is a great place to visit and has had a significant impact on the surrounding communities and the city of San Antonio. One of the best things about the museum is that it’s accessible from the River Walk trail network and can be reached from downtown on a short bike ride. It’s located in a great neighborhood with no shortage of activities, so it’s worth the trip even if you aren’t a contemporary art lover.

This property is now the Waldorf Astoria Las Vegas.

With a level of service that the huge hotels cannot come close to, the 392-room Mandarin Oriental is one of the rare, non-casino luxury hotels that provide an almost residence-like respite within steps of all that makes Las Vegas Las Vegas. Located midway along the Strip at CityCenter—an address it shares with the megaresort Aria and the Shops at Crystals—it is Asian-influenced in its decor, its service, and its Zen-like serenity. Business guests favor it, especially those who can afford the China-size suites, but so do deep-pocketed families. The best check-in-with-a-view in all of Las Vegas happens at the 23^rd-story Sky Lobby, whose Las Vegas Strip panoramas can be enjoyed just off the lobby, in the Mandarin Bar or further down the floor, at Twist restaurant. Spectacular Strip and city views are a theme throughout the hotel; a whirlpool with a view, anyone?

Opened in 2010, the Design Museum Holon is the first museum in Israel dedicated to design. The iconic building, which quickly became a city landmark, was designed by acclaimed architect Ron Arad. By mounting exhibits on historical and contemporary design from Israel and around the world, the museum aims to inspire and challenge the design community, as well as the general public’s perception of design and the way it impacts their lives. For professionals in creative industries, students, and design enthusiasts, the museum is a vital and dynamic resource. The building includes galleries for temporary exhibitions, an archive, the Design Lab, and Collection Windows.

Few airports put as much thought into traveler’s well-being as San Francisco International. The Berman Reflection Room, one of many unique spaces, provides, “A center for quiet self-reflection and meditation.” Free from distractions—technology, talking and noise—here you can just take a moment to decompress. Easily accessible, pre-security in the main international hall, it can be a meaningful stop before a long journey or after saying goodbye.

The best of several great Atlantic beaches around Punta Rucia, Playa La Ensenada is made up of a fishing village and 4.5-mile stretch of sand with calm, crystal-clear water. Here, you can snorkel around submerged reefs in waist-deep water, or take a 12-minute boat ride through mangroves to a dreamy sandbar (named Cayo Arena but also called Cayo Paraiso, or Paradise Island) to see even more colorful fish. The size and shape of the sandbar change depending on the currents and season, so you’re always in for a bit of a surprise.