Fashion designer Silvia Tcherassi managed to make this 250-year-old mansion feel airy and ethereal. Situated in the center of Old Town Cartagena, the colonial building features understated decor that emphasizes sheer fabrics, soft colors, and natural wood and stone. The property is divided between the 42-room hotel and spa, and Mansion Tcherassi, which holds seven rooms with more impressive decor and features such as restored original stone walls and private balconies. Stone walls reappear in the Italian restaurant, which extends to a cozy patio facing a plunge pool and vertical garden made of thousands of local plants. There are four pools in all as well as a roof deck overlooking Cartagena and the sea in the distance. A casual rooftop restaurant serves seafood alongside even more incredible city views. After a day exploring the colorful historic buildings of Old Town, a treatment in the traditional Chinese medicine–inspired spa is worth indulging in.