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Located in the small river town of Hannibal, the Mark Twain Boyhood Home & Museum is actually a cluster of eight buildings that pay homage to one of America’s most celebrated authors. Visitors can tour Mark Twain’s Boyhood Home & Garden—a designated National Historic Landmark—to see where Samuel Langhorne Clemens grew up and the real adventures of Tom Sawyer took place, then pop into the Interpretive Center to view a timeline of his life and several interactive exhibits. Also worth checking out are the Huckleberry Finn House (where Tom Blankenship grew up), the Becky Thatcher House (featuring a museum dedicated to Laura Hawkins and childhood in the mid-1800s), the J.M. Clemens Justice of the Peace Office (where Twain’s father held court), and the Museum Gallery (home to 15 Norman Rockwell paintings and treasured Clemens family artifacts). Before heading out, be sure to pose for a family photo in front of the Tom & Huck Statue, which sits at the foot of Cardiff Hill.

For 20 years now, the Spring Mountain corridor north of the Las Vegas Strip has been a hotbed of hot pots—and every other Asian dish under the desert sun. When celebs such as Anthony Bourdain and Penn Jillette raved about the real-deal northern Thai cuisine at Lotus of Siam, chowhounds followed. Tell your friends you’re finally making the trip out to the strip mall and they’ll tell you to avoid the items you can order from the takeout joint at home: no pad thai, no chicken satay. They’re right. Dive into the last page of the menu, the one about dishes from Northern Thailand, then entrust your tastebuds to the award-winning hands of Chef Saipin Chutima and try her larb or the jackfruit curry, anything with ground pork sausage, the khao soi (egg noodles and meat in a coconut curry sauce), the nam prik ong (a chunky mix of pork, tomato, and red chili, served with lettuce and raw vegetables), or the whole fish with chilis. The food is spicy, yes, and the afterburn is serious, but the depth of flavor is sublime enough to make you weep with regret the next time you have to call your local takeout place for delivery.

The Eastern Market, now a National Historic Landmark, opened in 1873 to serve the Capitol Hill neighborhood (an 1805 version, located down by the Navy Yard, was a casualty of the War of 1812). The brick market hall, packed with butchers, bakers, vegetable markets, cheese vendors, flower kiosks, and a lunch counter, is bright and charming. Under the shed roof outside, additional local produce is displayed and sold. On weekends, booths selling vintage goods and handmade jewelry, housewares, and clothing do a brisk business down the center of 7th Street. Crowds spill out of the cafés, taco joints, and bagel shops occupying the first floors of the row houses along the block, adding to the lively mix at the market.

Completed in 1916, this Italian-inspired villa on Biscayne Bay was the home of the early 20th-century industrialist James Deering and is now a National Historic Landmark. The house was modeled after historic villas and country estates in the Veneto region of northern Italy. The heart and main living area of the house is the Courtyard, which was originally open to the sky. Diego Suarez, who had worked in Florence, designed the gorgous formal gardens with classic Italianate flair, but modified for the heat and humidity of southern Florida. Thousands of varieties of orchids flourish in the greenhouse, while subtropical trees, palms, and low hedges highlight the lines of the gardens’ layout.

Taking just the ‘right’ wrong turn on a visit to Pike Place Market can land you in Post Alley, where spearmint, wild cherry, and tropical punch bubble gum drizzles down the window panes and grape, peppermint, and lemon ice gum-cicles form from sills. It may be one of the lesser-known Seattle tourist attractions, but it certainly makes a big impression with plenty of chaotic color on a rainy day. And if you’re a gum chewer, be prepared to stick a drop of your own favorite flavor to leave a colorful mark on the city.

I fell in love. I fell in love with the town of Marfa. Safari tents. Stand alone bathtubs. Vintage trailers. Twinkle lights. Hammocks. An off the beaten path campground takes you to another world. You can choose to stay in one of their hip vintage trailers, eco-friendly safari tents, or in one of two teepees. The place fills up so all that was left was the safari tent. I felt like I was in a part of Moonrise Kingdom. It takes up 18 acres in Marfa, Texas and it has a place where they host live music, a communal kitchen, a shaded nook full of swinging hammocks, a community lounge and a small little shop filled with unique finds. It’s a place that just steals your heart and makes you wonder when you can come back.

With headquarters in Portland, Oregon, the Ace Hotel brings a dose of Pacific Northwest cool to the Flatiron District of Manhattan. Located in a turn-of-the-century building, the Ace has become a hub for stylish visitors and freelancing New Yorkers—locals often set up shop in the hip lobby to work and sip Stumptown coffee. The aesthetic is laid-back yet creative, with fun local art, free Wi-Fi, and quirky touches like tabletops made from discarded Hubble telescope lenses. The Ace is unpretentious and inviting, with a social and interactive lobby and two destination restaurants. Rooms range from small bunk rooms to spacious loft suites—offering a match for a variety of price points.

Star chef Richard Sandoval recently opened Toro Latin Kitchen + Bar in nearby Punta Ballena. Try the spicy grab quacamole and the beef chicarron with a strawberry basil caipriñha. Get our complete list of Where to Go 2016 vacation ideas here.

It is easy to indulge yourself without too much guilt in San Miguel—walking the town’s hills burns up plenty of calories. The restaurant Cumpanio operates three local bakeries, each called Panio (pictured here), which make out-of-this-world croissants, tarts, and cakes. San Miguel’s longtime stalwart bakery Petit Four serves many more tasty options than the namesake sweets. Enjoy baked goods served family-style at a large community table at Robin’s La Mesa Grande. Don’t worry when La Buena Vida sells out of its famous orange doughnuts, because more are made throughout the day. You can find a couple of the best purveyors of sweets with your eyes: Panadería El Maple is known by its Canadian maple leaf sign, while everyone calls La Colmena “The Blue Door Bakery,” for its impossible-to-miss entry.

Gottfried Semper and Karl von Hasenauer may not be household names abroad, but in the Vienna of Franz Joseph’s time they were towering architects. The duo was responsible for the soaring cupolas and sweeping staircases of two stunning mirror-image cultural institutions on the Ringstrasse. In the Kunsthistorisches (Art History) Museum, famous stairwell-roof frescoes are by Gustav Klimt, and the rich assemblage of works includes Pieter Brueghel’s Tower of Babel, Caravaggio’s David with the Head of Goliath, and works by Dürer, Raphael, and Velázquez. The sister Naturhistorisches (Natural History) Museum is home to one of Europe’s oldest pieces of art: the famous Paleolithic goddess figure known as Venus of Willendorf. There are also displays that range from insects to dinosaurs and flora and fauna collected worldwide.

In operation for almost 160 years, this renowned Belle Époque resort on the shores of Lake Geneva in Lausanne is steeped in important history and culture. The treaty that broke up the Ottoman Empire was signed here in 1923, and guests have included everyone from Charlie Chaplin and Gary Cooper to Rod Stewart and Nelson Mandela. From 2012 to 2014, the hotel received a nearly $30 million makeover, helmed by famed interior designer Pierre-Yves Rochon, which complemented the timeless elegance of all 168 rooms and suites with such luxuries as Murano glass chandeliers, expansive mirrors to bring the views indoors, and entertainment screens discreetly embedded in bathroom mirrors. There are four restaurants on the property, most notably the exquisite Anne-Sophie Pic, which has two Michelin stars. In the summer months, the hotel also serves dinner on its own turn-of-the-century, steam-powered paddleboat as it plies the waters of the lake. The state-of-the-art spa, offering a wide selection of restorative treatments, opens up onto the resort’s 10-acre park and includes separate saunas and hammans for men and women, a Jacuzzi, two heated pools (one indoor, one out), and two tennis courts.

The Bonsecours Market is hard to miss, whether you are walking around Montréal’s historic center or looking at the skyline from the harbor. A silver dome caps the long building, which dates from 1844 and was modeled on Dublin’s Customs House. It looks more like a stately civic building than a market, and in fact it was Montréal’s city hall for a while, as well as the seat of Canada‘s parliament for one session. After serving as the central market of the city for nearly a century, it closed in 1963 and was largely abandoned until 1992, when it reopened as the home of a visitors’ center for Montréal’s 350th anniversary. Today it houses a dozen or so boutiques featuring works by local designers, as well as a few restaurants that make for good pit stops on a day of sightseeing.

Located in a square by the same name (Plaza El Salvador del Mundo/The Savior of the World Plaza), this monument, installed in 1942, depicts Jesus standing atop a globe, is an iconic image in El Salvador’s capital city, San Salvador. Note that the plaza also has a statue devoted to the beatified priest, Óscar Romero.

San Miguel is known as a community of artists, but to fully appreciate that understatement, every traveler should get closer to the city’s arts community. This village is a place where many have reinvented themselves as the next Picasso or Basquiat. First stop? The art galleries at Fábrica la Aurora, where visitors browse, shopping to add to their collections, with choices from the genres of painting, drawing, and sculpture. Longtime local favorites include Peter Leventhal—whose Rubenesque nudes adorn many a wall across the globe—and his wife, multimedia artist Terra Mizwa; abstract artist Merry Calderoni; and Annie Evans, whose sculptures of devilish women are mesmerizing. Art galleries also abound in the Centro and nearby San Antonio district. Events calendars detail monthly art walks.

The best of Brazil is only a short walk from Cabo San Lucas’s downtown tourist heart. Madeira Bistro, a burnt-orange corner joint, features a wide entrance and wall made nearly entirely of windows. The airiness invites breezes in and allows the intoxicating aroma of the rodízio-style grilled meats to waft out. Here, round after round of rib eye, hanger steak, top sirloin, and other preparations are served, along with sides of basil mashed potatoes, coleslaw, sweet potatoes, and more. The food keeps coming until you cry uncle. The knowledgeable staff is there to help with pairings and perhaps wheel you out.