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Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

Originally built to serve the area’s fish canneries, the Historic Requa Inn, at the base of the Klamath River, is one of the few small hotels right near Redwood National and State Parks. You can come for dinner even if you’re not staying at the inn, which is run by a local family. They offer a prix fixe menu Wednesdays through Sundays from April 1 to October 31. The only seating is at 7 p.m., and what you get is a communal, family-style meal: A small group of people sits around a table and shares a selection of seasonal Californian dishes, which are all crafted using ingredients sourced from a nearby organic farm. (Think of it as having dinner with your family, just tastier.) Make a reservation ahead of time, since spots are limited. Visitors can also pick up a picnic lunch here if they order one 24 hours in advance. Although an old establishment, it’s well-kept; guests will find there is no TV or phone in their room, which provides the perfect excuse to sit outside and enjoy the water going by.

Originally laid out during Spanish rule, the Alameda Central was Mexico City’s first municipal park, at one time reserved for the elite. Today it’s a well-manicured garden for all, especially popular with working-class crowds on Sundays. Its willow-lined lanes lead to old-fashioned statuary, fountains, and a gazebo (where something’s always going on), as well as a rotating calendar of contemporary sculpture exhibitions. On the park’s western edge and occupying a beautifully restored art deco structure, the shopping and design center known as Barrio Alameda houses edgy boutiques, a chic guesthouse, and trendy restaurants whose outdoor seating is a people-watcher’s delight. Duck in for a glimpse of how the city center continues along its gentrifying course.

Total immersion is the draw of the Ritz-Carlton, Laguna Niguel, which sits on a bluff 150 feet above the Pacific’s craggy coastline. The hotel delivers Ritz-Carlton’s trademark luxury—two pools with bucolic garden views, beach butlers on the sand—but also an authentic sense of place. Naturalists lead whale-watching and snorkeling excursions, as well as an ocean-inspired art program that was developed by marine-life artist Wyland. Spa treatments include seaweed wraps, marine collagen facials, and a foot massage inspired by the rhythm of the ocean. Even the resort’s marble-bedecked interiors integrate the environment, including a sculpture in the lobby by artist James Aarons made of 225 ceramic and gold pieces inspired by American cliff swallows, which migrate through the area. Shuttles take guests to and from the swimmable, surfable Salt Creek public beach below. Meals at the six restaurants are indulgent but never fussy, whether it’s pasture-raised beef and artisanal cheese at enoSTEAK, or pan-seared scallops with morita-glazed pork belly at the pan-Latin restaurant Raya. Pro tip: Before the sun dips below the horizon, grab a spot by a fire pit at the lounge 180blu, order a tamarind-togarashi margarita, and enjoy the views of the Pacific.

In a country that has more cows than people, you can’t visit Argentina without shopping for leather goods. Prune opened its doors in 1999 and is one of Argentina’s premier brands for quality leather goods that are stylish and great value. They sell European-inspired handbags, clutches, leather jackets, belts and shoes. You can find Prune shops in both Palmares Open Mall and Mendoza Plaza Shopping in Guaymallen.

If you’ve never been to the Marin Headlands, you MUST go! The views are stellar, but make sure you get there early (well, early enough to get there before all the tourists!) Ht up the headlands for a nice hike and view and then drive to Bar Bocci in Sausalito for lunch or dinner. You won’t be disappointed.

In recent years, this pretty neighborhood, located just five minutes north of downtown Orlando, has become a dining, shopping, and entertainment destination in its own right. Edgewater Drive is lined with restaurants, shops, and offices, while the surrounding residential areas feature historic bungalows, Craftsman-style homes, brick streets, and lakefront views. Favorite eateries in the neighborhood include Jade Sushi & New Asian and K Restaurant, which is nestled in a cute old house. While there isn’t a college nearby, the area gets its moniker from streets named after famed universities like Princeton, Dartmouth, and Harvard.

Baja California Sur’s capital deserves more than a day trip. The cosmopolitan city is home to some of the peninsula’s finest restaurants, and its beaches rival any in the world. Ensenada Grande, on Isla Partida, is part of the Espíritu Santo Archipelago and is, in a word, stunning. Golden sands give way to clear waters that are framed by volcanic formations (ask your guide to point out “La Máscara”). On the mainland, visit Balandra, a lovely white-sand beach whose waters shimmer a vibrant turquoise. It’s famous not only for its splendor but for the unusual mushroom-shaped rock known as El Hongo, as well. El Tecolote doesn’t quite have Balandra’s beauty, but it offers much more in the way of activities. Camp, grab a bite, and start here before heading on to an Espíritu Santo adventure.

In Rupit, Stone cottages with orangey-red terracotta roofs perch around a stream, half-hidden by the mountainous green hills. An hour and a half drive from Barcelona, walk around this beautiful, if tiny village (approximately 340 residents). Pose for pictures in the dovetailed doorway of the Smithy, and carefully cross its hanging wooden bridge, but remember, it will only support the weight of 10 people at a time. For sweeping views of the village, hike to St. Joan de Fàbregues, a Romanesque building perched on a hill.

This dramatic two-tier waterfall, whose name translates as “Golden Falls,” a reference to the shimmering mist that sometimes appears around the falls, is one of Iceland’s most famous—which is saying something in a country abundant with waterfalls. Saved from oblivion during the 1920s (foreign investors wanted to dam the falls to create hydropower), the waterfall lies in a canyon on the Hvítá river and is backed by scenic snowcapped peaks. It’s possible to follow the falls as they flow downstream through the canyon, either via a walking trail or on a rafting trip, though it’s worth noting that the paths are wet and can be slippery. The visitor center has a canteen that serves up surprisingly tasty local dishes like lamb soup; there are also a gift shop and a local exhibition centered around traditional life in the area.

Chef Joshua McFadden is Portland’s “vegetable whisperer.” That’s no small accolade in a town where vegans roam free and farm-to-table is table stakes for most high-end restaurants. Tusk, his Middle Eastern–inflected restaurant on Burnside Street, turns out small plates under the watchful eye of his business partner, chef Sam Smith. Each dish is near reverent of its ingredients, with “Vegetables, Fruits, Grains” literally at the center of the printed dinner menu. Brunch at Tusk is a more eclectic affair, and also one of Portland’s hottest weekend seats. The bright space even makes the wait for a table a pleasant experience and one well worth the time it takes for the chance to taste the creations of one of Portland’s premier chefs.

Home to warehouses and bustling trolley stops in the 1920s and ’30s (with the warehouses becoming artists’ studios and storage facilities in the ’70s), these few blocks in South Dallas’s Oak Cliff neighborhood were designated a National Historic Landmark in 199O—right around the time the area was experiencing a decline. In the new millennium, however, there’s been a revival: Today the area’s brick buildings and charming former homes hold over 60 independent shops, restaurants, bars, cafés, and galleries. Grab a coffee or glass of wine and browse the tomes at the Wild Detectives bookstore, shop for furniture and local artwork at Neighborhood, and find unique gifts and design items at Bishop Street Market and We Are 1976. Foodies also flock to top spots like Hattie’s for Southern low-country–inspired fare; the much-acclaimed (and often hard to reserve) Lucia for Italian fine dining; Eno’s Pizza Tavern for thin-crust pies; Tillman’s Roadhouse for Texas- and Southwest-flavored favorites; and the legendary Lockhart Smokehouse for pit BBQ. Save room for artisan sweets from Dude, Sweet Chocolate (which has garnered national acclaim) and a slice of fresh-from-the-oven pie from Emporium, where the menu changes seasonally. With the area now firmly enjoying “features on travel TV shows” status, and private residences still lining the side streets, parking here can be tricky—especially on the weekends, or during a festival or one of the regular wine, art, or jazz nights.

Kiyomizu-dera on Mount Otowa is one of the most famous temples in Japan, a place that appears in every sequence of Japanese travel photos. The landscape is all cherry trees and forest; it is among Kyoto‘s loveliest spots. The current structure dates to 1633 and is one of 33 temples on a pilgrimage circuit in the Kansai region dedicated to Kannon, the Buddhist goddess of mercy. The circuit runs from the south of Wakayama north to the Sea of Japan. You’ll see pilgrims carrying nokyo-cho—books stamped to record the visit—and monks busily inscribing in calligraphy. The temple, set against a steep hill and constructed on huge pilings, is a UNESCO World Heritage site.

Nothing is a more powerful symbol of the City of Light than the Eiffel Tower. Designed by Gustave Eiffel for the 1889 Paris Exposition, it’s one of the world’s most-visited monuments, with nearly 7 million people ascending the 1,062-foot wrought-iron structure each year. Glass elevators spirit you to the top—hardy souls can take the stairs part of way—where in addition to unparalleled panoramic views of Paris, you can toast your arrival with a glass of bubbly at the Champagne bar. Evenings there’s a grand light show: every hour on the hour, the tower sparkles for five minutes with 20,000 bulbs.