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Painted by Michelangelo between 1508 and 1512, the frescoes on the Sistine Chapel ceiling are considered some of the finest art ever produced. These religious paintings include nine scenes from the Book of Genesis, of which The Creation of Adam is undoubtedly the most iconic.

When the Last Bookstore debuted in 2005, the name was meant to be ironic. Now, in a world of Kindles and iPads, digital books (or at least digital bookstores) are the norm, and brick-and-mortar establishments such as the Last Bookstore are a dying breed. That hasn’t stopped this Downtown L.A. icon from growing. The shop still buys, sells, and trades new and used books and vinyl records just as it did when its doors first opened over a decade ago, and it shows no signs of stopping anytime soon. Come in to browse the store’s impressive collection, to hang out for an afternoon, or to catch author talks and more. The Last Bookstore puts on some killer events, and past speakers have included the cast of Portlandia, How to Kill a City author Peter Moskowitz, and Holocaust survivors. Oh, and they occasionally give away free concert tickets on their Instagram account, so it’s worth a follow even if you’re not a die-hard bookworm.

Maxxi, Rome’s first major contemporary art museum, cost €150 million and took renowned architect Zaha Hadid 10 years to complete. The result—a vast, bold space with exhibits on architecture and art—proves that modern Rome can produce masterpieces, too.

But it’s not just the building that’s worth visiting. Inside, visitors can explore a rotating set of art exhibitions dedicated to paintings, sculptures, and more from the 21st century. The museum is open Tuesday to Sunday from 11 am – 7 pm. It is closed on Mondays. You can get tickets in advance online.

Yeah Baby! The Strip might get all the attention, but if you want the real Vegas the only place to go is Fremont St. With its enclosed light show of a ceiling, freak show of people watching, and rock ‘n’ roll show of live entertainers you could be there for hours. Of course, it has casino or two should you want to make a wager, but my bet is that you’ll be fully occupied just taking it all in.

A UNESCO World Heritage site, this 1,700-year-old palace sits on the Adriatic seafront, serving as the focal point of Split. It was built by the Roman emperor Diocletian as a seaside retirement home and has served as a refuge for many a conqueror over the centuries. Today, some 2,000 locals reside within the compound’s thick walls, making it a lively urban quarter. Getting lost in the labyrinth of surrounding streets is the best way to explore downtown Split—as you meander around, you’ll stumble across lively cafés and shops tucked into millennia-old buildings. Be sure to check out the Peristil, an imperial square framed by two colonnades, where Diocletian used to address the public. Towering above the square is Split’s major landmark—a 187-foot-tall belfry that you can climb for panoramic views of town.

Routinely crowned the city’s top seafood restaurant, Blue Water Cafe is also among the continent’s best. After honing his skills at Michelin-starred restaurants in Europe, executive chef Frank Pabst opened this Yaletown classic to marry fine-dining techniques with local, sustainable ingredients. Eventually, the restaurant became a founding member of the Ocean Wise program, which helps consumers make ocean-friendly seafood choices. When visiting, you can belly up to the bar—which boasts more than 200 whiskeys and 1,000 wine labels—or reserve a table in the elegant brick-and-beamed dining room, housed in a heritage warehouse. Come summertime, however, you’ll want to head straight to the patio for sushi and premium sake. Fancy a splurge? Go for the seafood tower, which showcases the bounty of British Columbia.

In other cities, Schloss Belvedere would be the grand attraction: The baroque palace turned museum is a UNESCO World Heritage site, and its French-style gardens, enormous pools, and upper and lower pavilions are stunning. But in Vienna, a city that’s chockablock with majestic palaces and marvelous art institutions, the Belvedere winds up being underappreciated by visitors. Formerly the summer palace of the French-born military commander Prince Eugene of Savoy, the early-18th-century palace was designed by Johann Lucas von Hildebrandt, one of the most celebrated architects of his day. Works in the building’s collection range from baroque masterpieces to 20th-century treasures such as Gustav Klimt’s The Kiss as well as pieces by Oskar Kokoschka and Egon Schiele.

Captain Dave’s ocean safaris offer visitors a different way to see Laguna. Departing from Dana Point, the cruises take place on a high-tech, high-speed catamaran equipped with underwater viewing pods so guests can see marine life up close. The boat also features three tram nets on the bow, offering prime views of everything from blue, humpback, and fin whales to orcas, dolphins, and even great white sharks. Cruises are limited to 49 people so everyone gets a front-row seat—plus Mrs. Captain Dave’s legendary triple fudge brownies that she bakes fresh for every trip.

Nick’s is a Southern California institution, with coastal locations in Long Beach, San Clemente, Manhattan Beach, and Pasadena. The Laguna outpost has the others beat, however, thanks to its perch just across the street from Main Beach. Diners can head here after a long day in the sun for delicious takes on classic American dishes, from buttermilk fried chicken and San Francisco cioppino to rib eye melts and cheeseburgers with Thousand Island dressing. Whatever you choose, pair it with a house cocktail (you can’t go wrong with the jalapeño-watermelon margarita) as you watch the sun set over the Pacific.

Located right on the Pacific Coast Highway, Watermarc is a people-watcher’s dream, with an oversize front patio and large windows overlooking Peppertree Lane. Grab a window seat if you can, then dive deep into the extensive wine list, which features 239 varietals perfect for pairing with the wide range of “grazing plates” on offer at dinner. Order dishes like sizzling shrimp, cod-and-potato croquettes, ahi watermelon skewers, and charred octopus to share with the table, then pick an entrée like day-boat scallops with lobster risotto for yourself. The menu here goes well beyond seafood, but while you’re staring at the ocean, you might as well try her delicious offerings.

This restaurant feels like you stepped back in time - think Mexico in the 70s. The story goes - it all began in the VW van in Playa del Carmen. Tacombi used to sell tacos out of the van, and now he has a nice, cozy spot in Soho where the van is parked. It’s a garage with lights strung in the air. It just feels cool to be in. The design is great, but the food is even better. Virtually any tacos you order are wonderful. I also recommend the guacamole appetizer - yum! And don’t leave without ordering a drink.

Because it’s a major cruise port there are plenty of tacky restaurants on St. Thomas, but it doesn’t take a lot of effort to get under the skin of the island and find places where the locals eat. One such restaurant, Gladys’ Cafe, serves up traditional Caribbean fare and is known as one of the best on the island. Skip the a la carte menu and instead get one of the lunch plates including curried chicken or goat served with red beans and rice, mac and cheese and fried plantains.

Don’t let the name or menu fool you. This is neither a bakery nor the wings and burgers joint the menu might have you think. Rather, it’s a lively bar in the otherwise quiet city of Launceston that attracts vegans and meat eaters alike. Vegans and “vegos” come for the shrub burger (with fried pumpkin, eggplant, and vegan lemon aioli) or the veggie enchiladas. Carnivores swear by the “sanga” (sandwich) with slow-roasted pork shoulder doused in whiskey barbecue sauce and topped with coleslaw and apple peach chutney. An Aussie craft beer or Baileys and butterscotch espresso martini on the side patio, strung with faux ivy, isn’t too shabby either. The best times are had on live music and DJ nights, when the bar buzzes late.

A quick bus ride from the city (or a refreshing end to the Bondi to Coogee Coastal Walk), Coogee Pavilion is one of the most happening beach bars in Sydney. The downstairs area is home to a wood-fired pizza oven, oyster bar, juice stall, and kids’ zone with giant Scrabble, pétanque, ping pong, and nautical books, while the breezy rooftop features four different bars, outfitted with love seats and wire-frame stools for taking in the breathtaking bay views. Aussie wines and beers plus fruity cocktails shaken with house-made juice pair with Mediterranean-themed tapas like chargrilled lamb chops and blistered Padrón peppers.

There’s truly no other place in the world like this unique and disturbing museum. It’s probably best that photography is strictly prohibited inside, because that might spoil the bizarre surprises that wait for those who haven’t been yet. The Mütter is a medical museum in Center City that’s part of the College of Physicians of Philadelphia. Be forewarned: Its world-renowned collections are often somewhat disquieting—biological oddities, anatomical and pathological specimens, wax models, and antique medical equipment. (Wooden cabinets in one gallery hold drawers full of objects that people have swallowed!) The gift shop may be the most interesting museum store you’ll ever visit, and might be the only place that sells conjoined-twin cookie cutters.