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For the location of their first independent hotel, Atelier Ace (the creative arm behind the buzzy Ace Hotel Group) chose Panama City’s historic Casco Viejo, a once gang-ridden neighborhood now teeming with trendy restaurants, cafes, and wine bars in 16th- and 17th-century buildings. The American Trade Hotel occupies a stately property on Plaza Tómas Herrera, complete with 50 minimal-chic rooms and suites outfitted in Frette linens and custom, reclaimed-wood furnishings. Plush “Jardin” suites open onto a private garden courtyard, while others feature vaulted ceilings or views of the Gulf of Panama. On-site dining and drinking options abound, ranging from Café Unido for pour-over coffee made from Panama Geisha beans, to a jazz club created by Grammy-winning Panamanian jazz pianist and composer Danilo Perez.

Famous for being Southern Germany’s hub of the Enlightenment during the late 18th century (Hegel and Hoffmann both lived here), Bamberg is also home to a superbly preserved medieval town center, which was declared a UNESCO World Heritage site in 1993. Here, visitors find an endless array of architectural styles, from Gothic and Renaissance to Baroque and neoclassical, all spread through three distinct areas: the episcopal town, the island town, and the market gardeners’ town.

The Romanesque-Gothic cathedral of St. Peter and St. George is Bamberg’s most prominent building (it’s home to the famous Bamberg Horseman statue, the tomb of Henry II and Cunigunde, and the only papal grave in Germany), but the New Palace and the Alte Hofhaltung Palace are also must-sees, as are the town hall, the tanners’ cottages, and “Little Venice,” a former fishermen’s village with half-timbered houses and tiny gardens. If you’re a suds fan, be sure to sample Bamberg’s famous smoked beer before leaving.

Opened in 1950, the Jamaica Inn is one of the oldest and most gracefully aged of the classic Jamaica luxury resorts. It sits on its own private beach, which is rare in Jamaica, and each of the 52 suites and cottages has a Caribbean view. It is a timeless place, which may be why there are no TVs, radios, or clocks in the rooms, with a quiet serenity about it that may have been the appeal to such guests as Marilyn Monroe, Ian Fleming, and Katharine Hepburn. The grounds are immaculately kept, and the dining is as romantic as starlight and live music can make it. But the standout feature is that each suite has an oversize covered veranda that guests could literally live on. On it, they’ll find a full-size sofa, wingchair, breakfast table, coffee table, and, should one want to write home about it, writing desk.

Wynand Fockink founded his namesake distillery on this narrow alleyway off Dam Square in 1724 (and the building is even older, dating to 1679); some 70 varieties of jenever (Dutch gin), fruit brandy, and liqueur are still produced here today. In the small, beautifully preserved tasting tavern you can learn about—and more importantly, sample—both oude (old) and jonge (young) jenevers, as well as classic Dutch liqueurs like Bruidstranen (bride’s tears), an orange-flavored cordial with flakes of silver and 22-karat gold. Let the bartenders guide you on the traditional method: Bend down and slurp from the tulip-shaped glass—no hands allowed! You can also sign up for a one-hour tasting session and tour of the distillery; the cost is €17.50 (about $20).

Yes, Angelina on the Rue de Rivoli (around the Tuileries Garden and the Louvre) is a tourist spot, but it is still one of the best places in Paris for hot chocolate. Their menu of pastries and other small dishes is good, but don’t miss out on the hot chocolate. It is also a fun place to people watch, as there is a mixture of tourists, diplomats and government workers, and grandes dames who frequent the cafe to get their sweet tooth fix. Sit as table 11 (3rd from the back against the mirror) and you’ll sit where Coco Chanel took her hot chocolate nearly every day.

Reservations required—and no wonder. The tours at the Neon Museum sell out months in advance. A walk through the museum’s famous “Boneyard” (where neon goes to die) is fascinating, from motel row to the first integrated casino (one that shut almost as soon as it opened), and the Stardust, with its nuclear testing-inspired font. All of this comes alive thanks to the museum’s famous docents, all art history buffs with loads of family history or other personal anecdotes.

The trek to the HOLLYWOOD sign may be the most famous L.A. hike to outsiders, but if you’re looking for downtown views, celebrity sightings, and a typical L.A.-style glamour hike (not necessarily strenuous, but very fashionable), the 3.3-mile Runyon Canyon loop is your best bet. You’ll still get a great view of those giant letters, but you’ll also be able to spot the who’s who of the Hollywood Hills, with plenty of locals out on their routine pre-Sunday-brunch ritual. (And there are lots of grade-A brunch spots nearby, such as the Griddle Café, if you too are in search of a pancake-heavy menu.) The trails are dog-friendly, and dog-loving Angelenos take full advantage, so your pooch will have no shortage of company if you decide to bring him along.

Las Ventanas al Paraíso represents the epitome of luxury, with gorgeous, gigantic rooms featuring traditional crafts, handmade mosaic headboards, and classy furniture and accents. Balcony railings are awash in pink blossoms of bougainvillea. Some rooms take amenities further still, with private kitchens and wine cellars, as well as personal butler service. The property is set between the desert and the sea, and common areas, such as pools, have exceptional ocean views. Service is ultra-attentive, as one would expect at this price point, and guests rave about on-site restaurants and dining, especially in La Cava, the resort’s private wine cellar. Concierges can assist with planning a host of excursions and experiences, from cooking classes to whale-watching trips.

A city as ancient as Istanbul has many layers of history, and you’ll have to go below the surface to see the Basilica Cistern, the largest of the underground cisterns. Built in the sixth century for the Byzantine emperor Justinian, the atmospheric reservoir is supported by 336 columns, many of which have been repurposed from other ruins over the centuries. The Medusa-head column bases are a favorite to photograph, along with the carp that swim silently in the dimly lit waters. The cistern is located between the Blue Mosque and Hagia Sophia, and the best time to visit is simply whenever the line looks short, especially on a hot summer day—it’s always cooler underground.

Visitors flock to Búzios for the simple pleasure of strolling up and down the Rua das Pedras, the main cobblestone street, as well as the promenade named for Brigitte Bardot, where they can admire fishing boats and pleasure craft in the small bay. The town overflows with historic homes and fine chapels such as Nossa Senhora Desatadora dos Nós (Mary, Untier of Knots) by Praia de Geribá, or Geribá Beach, as well as the spare 17th-century Igreja de Sant’Anna (Church of Sant’Anna), which is on a hilltop.

Located about an hour from Medellín, Santa Fe merits a detour for its lovely, well-preserved colonial architecture. The town was Antioquia province’s capital before Medellín, from 1584 until 1826, and time seems to have stopped here amid cobblestoned streets and whitewashed structures. Horseback tours lead to nearby waterfalls and the Cauca River.

Tsukishima is a neighborhood best known for one of Tokyo’s local dishes, monjayaki. This casual dish is similar to Osaka’s savory okonomiyaki pancake but with much more liquid, making it great fun to cook. Diners are seated around a hot iron grill and prepare their own monjayaki after the staff help you with your first one. An ice-cold beer hits the spot as the table heats up. There are a variety of flavors, like seafood, pork, or house styles. A popular combination is mochi, mentaiko (spicy roe), and cheese. At night the main street is open only to pedestrians and is an interesting area to wander and explore.

Jamaica’s primary public art museum, the largest of its kind in the Caribbean, is a key part of the island’s history. Established in 1979, it houses more than 2,000 pieces ranging from pre-Columbian works to those of contemporary Jamaican artists and also mounts temporary exhibitions on various aspects of Jamaica’s history and culture. The collection continues to expand and now includes videos, graphic designs, and street art. Guided tours are available, and there’s an on-site coffee shop and gift store.

On the desolate site of the 2010 World Expo, the Chinese government has transformed an old power station into an artistic gem. Power Station of Art (PSA) is the first state-owned contemporary art museum in China, so while that precludes shows that might be deemed too avant-garde, it also means admission to the big-name exhibitions is heavily subsidized—and sometimes even free! In addition to hosting the Shanghai Biennale, the museum puts on shows running the gamut from modern Danish design to punk rock history and works by Shanghai street artist JR.

At street level, the Capuchin monastery might seem like many other historic churches in Palermo. But once you go below ground, you’ll encounter the most unusual and macabre display in the city. More than 8,000 mummified bodies are interred in its catacombs, some stacked on wooden shelves, others standing or hanging upright along the walls. The oldest resident is a friar named Silvestro da Gubbio, who dates from 1599; among the more recent arrivals is two-year-old Rosalia Lombardo, who died in 1920 and is so eerily well preserved that she’s been nicknamed Sleeping Beauty.