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Scottsdale has been a resort destination since the 1920s when painter Jessie Benton Evans turned her adobe home into a tearoom and guesthouse known as the Jokake Inn. You’ll find many of the world’s big-name brands here, along with a collection of smaller, independently owned properties.

If you are more interested in the night life of Lisbon, I highly recommend to stay in the area of Barrio Alto, known as the nigh-life and entertainment district of Lisbon. One of the most beautiful hotels in Barrio Alto is LX Boutique Hotel, which was a historic building, that turned into the current hotel. Each floor in the hotel is designed and dedicated to a concept related to Lisbon; One floor is dedicated to the fado music, another floor is dedicated to the Tagus river, and others are dedicated to Barrio Alto, the Seven Hills of Lisbon, and Fernando Pessoa, one of the greatest poets of Lisbon. If you are looking for a great night hang out, just cross the street to Pensão Amor, one of my favorite bars in the city. LX Boutique Hotel, Rua do Alecrim 12, Lisboa

To the west of Santiago’s historic heart of downtown, here the Chilean capital was founded at present day Cerro Santa Lucía with its lush garden. Now a trendy neighborhood, here top restaurants, bars, cafés, boutiques, parks, and stately apartment buildings make up this happening area around Lastarria street.

Forget about generic buffets and cheesy nightlife options, or destinations solely located in a region’s tourist zone. Today’s best all-inclusive resorts can be mega but still feel intimate—thanks to fine dining restaurants with a la carte menus and perks like designer fashion shows and top shelf liquor. Our list also highlights some less traditional, boutique picks both on and off the beach, offering eclectic and exclusive all-inclusive adventures.

If you plan to visit Yellowstone National Park in the summer—when grizzly bear sightings, hot spring treks, and Grand Teton Mountain vistas are at their peak—remember to reserve a room far in advance. With their guided tours and unparalleled access to nature, these lodges fill up fast.

With luxury resorts, quaint motels, condo rentals, and campgrounds, the Big Island offers a wide variety of accommodations. If you’re looking for high-end resorts, the Kona area on the west side of the island is your best bet, while travelers who prefer a low-key condo or B&B will be better off on the eastern Hilo side. Be sure to book in advance, especially during events such as the Ironman Race in September and the Merrie Monarch Festival in April.

Genoa may get overlooked for more famous Italian cities such as Venice, Rome, and Florence, but it’s a hidden gem for those in the know. The art deco icon, Meliá Génova, makes for a great base for exploration or for a touch of nostalgia book a stay at the Excelsior Palace, home to Italy’s first casino. For a truly grand Italian seaside experience, a classic Ligurian villa overlooking the waters of the Riviera di Levante.

You don’t have to sleep on the ground after a day spent exploring the Grand Canyon’s rim trails on foot or by air via helicopter tour. We’ve rustled up a passel of our favorite national park lodgings so you can spend time where it counts: planning visits to the skywalk and Hopi House.

There are more restaurants in Tokyo with Michelin stars—230—than any other city, making Tokyo an unrivaled culinary capital. The city’s range of restaurants is astonishing, from traditional Japanese cuisine to French fusion and beyond. There are also, of course, sushi restaurants where you can try sea urchuin, traditional kaiseki, tasting menus, haute cuisine spots that rely on seasonal ingredients, and so much more. Quick tip: Michelin star or not, it’s a good idea to check in with your hotel’s concierge about your restaurant of choice to make a reservation. Many fine dining restaurants have only a few, very coveted tables.

Berlin, the urban center of Germany, caters to anyone’s interests. If you’re a history buff, visit Museum Island, a UNESCO World Heritage Site in the River Spree consisting of five museums, including the Museum of Islamic Art. If there’s time, take a tour of Brandenburg Gate, the city’s most famous landmark. For art lovers, the East Side Gallery can’t be missed. If you’re traveling with family, be sure to spend time in Prenzlauer Berg, which has children-friendly cafes, shops, and playgrounds. There’s also a popular flea market there on Sundays.

If you’re in the market for designer duds, Cancun and Playa del Carmen offer shopping centers full of upscale boutiques, familiar American brands, and Mexican department stores.

Just north of the city center, Isola is Milan’s slightly offbeat, somewhat hipster, and completely all-natural neighborhood. On any given day, its vibe is friendly and local. The area offers amazing boutiques and specialty stores, boasts the best barber in the city, and features colorful street art.

Mexico City has no dearth of luxurious boutique hotels, but Las Alcobas is a special option. Designed by famed firm Yabu Pushelberg, the hotel is full of gorgeous details, from hand-stitched leather wall coverings to a spiral staircase that surges up from the lobby. Upon arrival, guests enjoy a welcome drink as a bellman leads them to their room; explains the technology that controls the light, sound and temperature; and offers them a selection of handmade soaps. Once settled in, they can lounge in plush robes on their goose-down comforters while sampling snacks from the minibar. For a heartier meal, Las Alcobas offers two excellent restaurants. Just outside the hotel’s front door, there’s also Presidente Masaryk, Polanco’s main avenue full of restaurants and high-end boutiques.

Any visit to Copenhagen will keep you busy and full—the Danish capital boasts 22 Michelin stars in 17 restaurants. Supplement feasting on Nordic cuisine with exploring the city’s modern architecture, like the Black Diamond, which has stunning views of the river. It’s an extension of the Royal Library and named for the black granite cladding and irregular angles. The Copenhagen Opera House is another landmark worth checking it: It’s one of the most modern (and expensive) opera houses in the world. The limestone structure is surrounded by canals, giving the impression that the building is situated on an island.

Canals, culture, and cannabis are just a few of the reasons Amsterdam, the capital of the Dutch Golden Age, remains one of Europe’s most popular cities. Two of the must-visit Amsterdam museums include the Anne Frank House and the Van Gogh Museum. After visiting one or both, step into one of the hundreds of coffee shops—legal marijuana dispensaries—with the more well-known ones located in the Red Light District.