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Housed in the monastery of San Marco, this museum pays homage to the delicate, spiritual work of Fra Angelico who lived and worked here as a monk from 1435-1445. Some of his most celebrated paintings and frescoes are on show here: the famous Annunciation (as reproduced on many a Christmas card) is at the top of the stairs on the first floor and the great Last Judgement alterpiece is in the Pilgrim’s Hospice. He painted frescoes in the corners of the main cloister and also decorated the monks’ tiny cells with the help of his assistants. This is one of my favorite museums in Florence...don’t miss it! Photo by Gianluca Moggi

The first Smithsonian affiliate in the Northwest, this superb museum chronicles the Asian Pacific American Experience. Among its most poignant exhibits is the Letter Cloud installation: old hotel walls frame tales of aging far away from home. It also offers walking tours of the surrounding International District, including Touch Of Chinatown, which visits the elegant Kobo gallery and Uwajimaya, one of America’s largest Asian grocery and gift stores. Stop into the nearby Panama Hotel, home to a teahouse and the nation’s only intact sentō (Japanese public bathhouse). Lockers and marble baths still stand in the basement, which harbored the belongings of Seattle’s 7,050 Japanese-American residents imprisoned in WWII internment camps—the basis for Jamie Ford’s best-selling novel Hotel On The Corner Of Bitter And Sweet.

For a little old-school San Telmo atmosphere, you can’t do much better than this classic corner bar. Dating from 1864, the antique building started out as a pulpería (general store), the seedy center of a gambling ring and even a brothel before it was converted into the popular restaurant and bar it is today. On your way in, check out the antique cash register and the gorgeous vitraux (stained glass) over the long bar: it’s no wonder this place has been used as a film set several times over. Then pull up a chair at one of the rustic wooden tables, preferably by the windows for maximum people-watching potential. If it’s morning or time for merienda, ask for a cortado with medialunas; otherwise, order an ice-cold chopp (draft beer) and a monster-sized lomito (steak) sandwich.

The Southernmost Point buoy, at the corner of Whitehead Street and South Street, marks not only the spot for the southernmost point of the continental United States but also the distance (90 miles) to the next country, Cuba. The buoy, installed by the city in 1983, is visited by thousands of people each day. (Before the buoy, a small sign stood at the spot alongside a line of seashells for purchase.) Taking a photo in front of the buoy is imperative for a first visit to Key West, so bring a tripod, or ask a stranger to snap a few shots. Buskers play music, and street vendors sell food and goofy souvenirs and slash open coconuts to drink.

Delmonico’s, which sits on a distinctive triangle-shaped corner near Wall Street, opened in 1837 as the first fine dining restaurant in the U.S. It was the first establishment to have a printed menu, separate tables, and tablecloths, and it was the first restaurant that allowed women to congregate as a group. It has invented famous classics such as Delmonico Steak, Eggs Benedict, Baked Alaska and Lobster Newburg. Entering from the streets of the financial district, you step into a different era. This is serious old-school dining in a landmark steakhouse. Mahogany coffered walls, fancy chandeliers and roaring 20’s-era murals seem to scream for a cold martini and a rare steak. Morgan, Carnegie, Vanderbilt, Rockefeller - they all passed through here in their time. It’s pricey, so save this for a special occasion and find a quiet time to visit. 56 Beaver Street www.delmonicosny.com

If you want to vacation like British royalty, visit the mosquito-shaped island of Mustique, which Naomi Campbell, Mick Jagger, and Princess Margaret have all called their home away from home. Once on land, there’s no better place to stay than the Cotton House, a private retreat that feels like the lap of luxury. Set on 13 acres of cerulean beachfront and gardens thick with jasmine and frangipani, the 20 rooms and suites are awash in neutral hues inspired by their surroundings, with wicker pendant lighting, ikat throw pillows, and breezy mosquito nets over the beds. Explore the coral reefs near the shoreline in a glass-bottom kayak, or improve your backhand with help from the resident tennis pro. After a day of sun-soaked adventure, dine on fresh-caught specialties (pan-seared barracuda, Caribbean-style sushi) at Veranda restaurant, then retire to the Great Room, a colonial-inspired lounge offering rare and local rums.

This quaint neighborhood corner joint, on Charleston’s rapidly gentrifying Westside, serves Charleston food with a French accent. That’s not nouveau fusion-and-foams French—it’s rich old-school braises, and buttery, mounted sauces over braised local fish and pork ribs. Although the fancier entrees shine, it’s hard not to defer to the tempting double burger with pickled lunchbox peppers, or the French dip with its fall-apart brisket and intense au jus. Start with artichoke heart au gratin dip, the crab gnocchi with smoked bacon lardons, or a salad made with pears, figs, burrata, and toasted pine nuts. Pair everything with an excellent wine list and local beers. The best seats in the wood-ceilinged, cozy dining room overlook the kitchen (and can be reserved), where conversation with the cooks is welcome.

Before taking the train to Rome, we picked up a spread of antipasti at Peck, a vast and pristine food shop in Milan. In addition to a huge selection of cheeses, fruit, salumi, and bread, Peck sells prepared specialties like meatballs, potato croquettes, and caprese salad.

Why we love it: A charming European-style inn right in downtown Clayton

The Highlights:
- The kind of friendly service you only get at small hotels
- Complimentary breakfast with farm-fresh eggs and country bacon
- An outdoor patio with fire pits and heat lamps for colder weather

The Review:
Housed in a Tudor Revival–style building from 1926, the Seven Gables Inn sits in the heart of downtown Clayton, surrounded by quaint boutiques, galleries, and restaurants. It stands out among the surrounding buildings, however, for its sloped roofs, large chimney, narrow windows, and decorative half-timbering. Developer Restoration St. Louis recently bought the property and set about revamping the interiors, so now all 32 guest rooms and suites merge historic charm with modern luxuries (think hardwood floors and stately wall coverings complemented by Bissinger’s chocolates, Jonathan Adler bath amenities, and plush robes).

Mornings here start with a complimentary breakfast of homemade pastries, farm-fresh eggs, and country bacon—a nice touch, as are the warm cookies at check-in and the evening cocktail reception, held Monday through Thursday. The charming courtyard is the perfect place to enjoy an afternoon break, while the Restaurant at Seven Gables is ideal for when you’re craving a cozy setting and upscale pub fare like chicken pot pie and filet mignon.

Along the glittery street of Collins Avenue in South Beach is the Raleigh Hotel, a smart and stylish blend between sparkling lights of Miami and the rich history that old Florida is known for. Immerse yourself in the calming and relaxing vibe of the hotel from the moment you enter the the lobby. Sip a martini at the bar that has been serving shaken cocktails for nearly 50 years.

Take a seat on one of the plush couches and get into the luxurious and sensual atmosphere that keeps South Beach at the top of its game. If you are hungry, make your way to the outdoor restaurant, Restaurant Michael Schwartz located along the twinkly lit bar on the patio. Chef Michael Schwartz helms the kitchen, using farm fresh ingredients and local seafood.

Once you are finished sampling the variety of specialty cocktails with fresh smoked herbs and prime liquors along with crispy crab cakes and shrimp toast, head to the expansive pool patio, which seems to go on forever. It is commonly known as the most famous pool in Miami.

The Raleigh is most well known for hosting Miami Swim Week, where the top names in fashion will sit along the twinkling trees and poolside cabanas to view the next seasons swimsuit trends.

You’d think that having a Meilleur Ouvrier de France (a prestigious crafstman title) at the helm of a restaurant would imply steep prices, but at Semilla, you’re in for both a great meal and a great deal. The international influence is strong here, where Ferrandi-trained chefs serve up modern interpretations of classic French dishes from an open kitchen. The crowd is mixed, the service is smooth and attentive, and the bread, an important element to any meal in France, is rustic and hearty—baked fresh in the adjacent sandwich shop run by the same owners. But the most unique aspect to the menu at Semilla is the option of half-portions on a selection of dishes. The menu changes daily with meat, fish and veggie options available for every kind of eater. Open seven days a week but be sure to call ahead for a reservation.

Even now I’m craving their guilt-free collection of tapas-style breakfast miniatures. You can expect to find little croissants stuffed with jamon, light pastries topped with berries, and fresh squeezed orange juice. It’s simple, inexpensive, and quick—nothing fancy but perfect for a snack. I should note it’s a chain but it’s where the locals go, so don’t write it off and pop in when you see one. Tip: Grab a little tile to your right when you walk in, order at the counter and they’ll write on it. If you’re like me, you’ll go back for more so bring it up with you for round two. Then pay when you’ve finished.

Why we love it: A condo-style property near Pier 60 that’s perfect for traveling families

The Highlights:
- Spacious, residential-style rooms with kitchenettes
- A kids’ club for children and rooftop cantina for adults
- A prime location steps from the Gulf and Pier 60

The Review:
Steps from the ocean and famous Pier 60 stands the flamingo-pink Hyatt Regency, favored for its friendly, attentive service. A residential-style property, the hotel boasts 287 generously sized rooms and suites, complete with some combination of walk-out balcony, kitchenette, dining table, living area, and workspace. Also on site is a 24-hour gym, a serene spa with sun-warmed shell massages, and a heated pool on the eighth floor overlooking the beach.

Though rooms here cater to those who like to prepare their own meals, the hotel still shines with dining options. Guests can start the day with freshly brewed coffee and pastries from the grab-and-go Market and end it with a handcrafted cocktail at Off SHOR or the Latin-inspired Tropicana Rooftop Cantina (order your drink in a souvenir glass and it will come in a coconut carved into a monkey’s head). For dinner, there’s SHOR American Seafood Grill, which boasts a spacious patio and regional seafood dishes like whole local snapper and line-caught Florida swordfish.

College-town hiking aficionados usually know where to eat, so when the guys up the street at Babbitts Backcountry Outfitters told me this was one of the best places in town for weekend brunch, I went. A lunch-and-dinner place during the week, Criollo Latin Kitchen opens up on weekend mornings with offerings from blue corn pancakes to pork belly tacos, with poblano cheddar grits, sweet ancho chili sausage gravy, and Haitian ‘ti-malice'-inspired relish to go with eggs over easy. And along with the artists’ paintings that change monthly, the food is “local” as well—the menu and the chalkboard on the wall will let you know the ranches and farms in Arizona and Colorado that are the sources for Criollo’s organic ingredients. On this particular morning, I had the “huevos motuleños,” the Yucatán’s version of “huevos rancheros.” And get some bacon—it’s hearty, comes from Black Mesa Ranch in the White Mountains, and will make you want to bring the word “toothsome” back into popular usage. Even if you’re just passing through Flagstaff on your way to the Grand Canyon, or driving from Albuquerque to Los Angeles, Criollo is worth a stop. It’s just a block north of historic old Route 66 downtown. (Criollo is owned by the same folks who opened the nationally-renown “Brix” just up the street—Flagstaff is becoming a restaurant mecca—and its newest sister restaurant is “Proper,” way down the road in Tucson. “Taco Tuesday” evenings with inexpensive margaritas can be crowded.)

The Heladería de Lares, a 45-year-old family business, sells about 50 unusual flavors of ice cream up in the mountains. Salvador Berreto, known to the locals as Yinyo, founded the shop to commemorate the Grito de Lares, a battle for freedom that had taken place exactly one century before. Yinyo started with corn, a flavor at the heart of the Puerto Rican diet and the current bestseller. Other flavors are cod, coquito (the Puerto Rican version of eggnog), and rice and beans. Fortunately, you can taste two flavors before deciding what to buy, and the ice cream is cheap, so you can stock up. Every weekend, people form what locals like to call lines, but are really boisterous blobs extending half a block down from the shop’s entrance. While eating, people skim through newspaper clips about when Denise Quiñones, a girl from Lares, won a Miss Universe pageant, or study photos of the 1945 Fuego de la Candelaria (a fire in Lares). After reading about the history behind Lares’s anthem and running their hands over the guiro (a musical instrument played by scraping its serrated surface), people often wander outside to the Plaza de la Revolucion. Here, on a typical Sunday, artisans sell paintings of the three magi (the Puerto Ricans’ second Santa) and of flamboyanes (the national trees with orange flowers). If you have doubts as to whether it’s worth it, just ask Bill Clinton and his daughter Chelsea. In 2008, Clinton forced $100 into the hands of Yinyo’s son for a mango ice cream.