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Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

Once a separate municipality, San Ángel—in the city’s south, nestled into its western foothills—is a leafy, genteel enclave whose relative isolation adds a soigné feel (for better or worse) you won’t find in neighboring Coyoacán. Ground zero for promenading is quaint Plaza San Jacinto, whose cute parish church (and beautiful cloister garden) is a sort of spiritual last stand amid the surrounding area’s high-toned consumerism. That said, the plaza’s true spirit comes alive Saturdays, at the so-called Bazar Sábado, an artisanal market that fills the area with stall after stall of handmade jewelry, textiles, crafts, and accessories, plus a great deal of art—some finer, some less so—in styles that go from hippie to haute. Strolling musicians and performers add to the carnival atmosphere.

A true desert outpost, the Peruvian town of Mancora enjoys the most sunshine hours of anywhere in the country. Unlike the rest of Peru the water is warm enough to surf without a wetsuit, a welcome complement to an area already featuring some of the best waves in South America. Hemingway knew what he was doing when he set up shop in nearby Cabo Blanco, an authentic fishing village where the ceviche is some of the freshest on the planet and the days pass with a simple peacefulness unique to many coastal escapes. While outdoor activities abound around Mancora, from kitesurfing to fishing to morning yoga sessions, on this particular morning the to-do list consists of nothing more than a good book, a cold drink, and watching whales splash on the endless horizon.

Get down and dirty on an unforgettable spelunking experience at the Venado Caves, 45 minutes from La Fortuna. The caves were formed some 15 to 20 million years ago by tectonic shifting and erosion from underground streams. In them, you’ll see stalagmites and stalactites galore, and get the chance to check out colorful frogs and fascinating marine fossils and learn about the bat communities hanging right over your head. The experience is real (and really humid)—so wise adventurers bring insect repellent, knee pads, and an extra change of clothes. Waterproof your camera, too.

If the city has you overwhelmed, whether by its chaos or its abundance of choices, and you want to take refuge in the familiarity of a hotel bar, you can’t do much better than St. Regis’s King Cole Bar. Sit inside at the bar or on one of its loungers and enjoy live music with your drink, or—better yet—head out to the terrace, where you can watch traffic zip by on the city’s main avenue, Paseo de la Reforma. You’ll also be looking out upon the Diana the Huntress fountain, a snapshot-worthy landmark in this city that has no shortage of them. In fact, you can also see the Angel of Independence statue and Chapultepec Castle from here. As for drinks, the must-try is the Sangrita Maria, a blend of mezcal, sangrita, and pasilla chile puree. Every St. Regis bar creates a signature cocktail, and this one is definitely representative of Mexico City. If you’re a smoker, ask to see the bar’s cigar selection.

In the southwest of Providenciales, this national park encompasses the tranquil Chalk Sound lagoon, a large expanse of shallow water connected to the ocean by a small channel. Check out the fringe of jagged limestone, called ironshore, along the shorelines of the lagoon and its small islets. You can rent a car and explore scenic Chalk Sound Drive, or you can stop at Las Brisas Restaurant to rent kayaks for a paddling adventure. See if you can spot stingrays and small sharks finning through the water, or the local rock iguanas foraging on the islands.

When visiting this dramatic, narrow beach in the wealthy La Jolla enclave, take time to admire—and photograph—its single surf shack. One of San Diego’s most important surf-culture icons, the wooden palapa is actually a designated historic landmark, built in the 1940s by soldiers and surfers who served in World War II and reconstructed as recently as 2016. Windansea is also known for its pounding, experts-only surf break; you should attempt it only if you’re experienced, but it’s just as fun to watch from atop the beach’s smooth sandstone rocks. For some peace and quiet, sunbathe in one of this stretch’s secluded pockets.

Within the 18th arrondissement in Paris France, high atop the city, resides the wonderfully beautiful, hilly neighborhood of Montmartre. This diverse and eclectic section of the city can be a bit busy with tourists, but the views of Paris and the splendor of the Basilica of the Sacré-Cœur are certainly worth it. Riding the funicular is rather novel, but not necessary if you’re willing to climb the 300+ steps to the summit. This is an area to be explored on foot, as is nearly all of Paris. The shops, theaters, and forever famous Moulin Rouge should not be missed. The streets are intimate, the shops unique, and the overall feel of this place speaks of a youthful, colorful Paris.

One of the most famous restaurants in Venice, the Michelin-starred Da Fiore occupies an understated-yet-elegant space in what was once an old Venetian tavern. The food is a modern take on traditional Venetian, with lots of fish and seafood, but the menu changes constantly based on what is fresh and locally available. Everything is wonderfully prepared with a lovely fusion of flavors and textures and comes out perfectly plated. There’s also an excellent wine list. You can order à la carte or choose a six- or seven-course tasting menu at dinner.

Colombians from the Caribbean coast, known as Costeños, are immensely proud of their cultural, musical, literary, and historical heritage, all of which are on display at this interactive museum. The country’s famous shore stretches from the jungles bordering Panama up through the historic cities of Cartagena, Barranquilla, and Santa Marta, all the way to the deserts of La Guajira. Multimedia exhibits here offer insight into the region’s indigenous cultures, and into the varied musical expressions that have emerged along the long coastline.

This 2.5-kilometer (1.5-mile) promenade along the vast Guayas River is part public park, part urban playground filled with restaurants, cafés, shops, a clock tower, an IMAX theater and even a Ferris wheel. From the docks, small boats leave on river tours or head to Santay Island, a wildlife refuge on the eastern side of the river. At La Rotonda, a statue of Simón Bolívar and José de San Martín commemorates their meeting in Guayaquil after the liberation of Ecuador from Spain.

La Piazzetta is known as the place to see and be seen while on glamorous Capri. The small square, officially the Piazza Umberto I, is the center of everyday Caprese life and is dominated by a unique freestanding clocktower that chimes every 15 minutes. For the best seat in town, head to Bar Tiberio, which sits just beside Santo Stefano cathedral. You will have a view of striking Monte Solaro, as well as all of the comings and goings from the funicular and along the shopping streets.

High atop Montmartre is this distinctive white church, Sacré-Cœur, or “sacred heart.” Constructed of travertine stone (the same used in the Arc de Triomphe), the Roman Catholic Church took nearly 40 years to complete and five more years to be consecrated (in 1919). If you choose to approach the church from below, it’s around 100 steps, and if you want to climb up into the dome, it’s another 270. Your reward for all that exercise is a stunning view of Paris unfolding below. Also worth noting: the basilica’s campanile houses La Savoyarde, the largest bell in France, weighing in at 19 tons.

Head to a place that succeeds in squeezing many centuries’ worth of artifacts from multiple civilizations into a manageable—and beautiful—17th-century mansion: the Museo de Arqueología UNT (National University of Trujillo Museum of Archaeology, Anthropology and History), housed in La Casa Risco. You’ll find remnants of the Chimu, Mochica and Incan empires in the form of jewelry, clothing and ceramics, as well as displays that explain the rise and fall of these civilizations.

Sydney’s 158-acre botanic garden, which hugs the harbor between Mrs Macquarie’s Chair and the Sydney Opera House, is home to nearly 9,000 plant species. Depending on the season of your visit, you might seek out spring peaches and wisteria or tropical orchids and summer lotus flowers. On any occasion, don’t miss descendants of the 200-million-year-old Wollemi pine, a dinosaur of a conifer only discovered in 1994. The gardens are also studded with sculptures from historical statues to modern works by Bronwyn Oliver, Paul Selwood, and Keld Moseholm. The quartz-and-sandstone Wurrungwuri depicts an Aboriginal shield once used by the traditional owners of this land. Tours are offered throughout the year, including a 1.5-hour Aboriginal history tour on the food and medicinal properties of native Australian plants.