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A cultural hub for Turkish and international art, Istanbul Modern opened in 2004 as a permanent home for the contemporary Istanbul Biennial. The 8,000-square-foot warehouse sits along the Bosphorus next to the Golden Horn, a historically important port for thousands of years. The water views rival the exhibitions for your attention and appreciation, and the museum has an excellent restaurant and terrace to take advantage of the location. Back inside, the permanent collection shows contemporary and modern artists from Turkey, with rotating exhibitions of photography, design, and new media. The downstairs cinema has several screenings a week of films that complement exhibitions or feature distinctive work, often accompanied by panel discussions. The gift shop is one of the best places to buy unusual and beautiful souvenirs such as upcycled jewelry and kids’ coloring books of museum art.

Perched on a steep hill in the lovely neighborhood of Alfama, you will in no doubt leave with a great souvenir or gift. Sellers throw down blankets or rugs in rows and sell a variety of hand-made goods, antiques, books, clothes, military objects, etc. I took home two wonderful brass bottle openers and a couple of old world maps. Getting to the market is easy and the trip there is quite beautiful; take the Tram 28, or Tram 12 up the hill through the tight, and narrow neighborhood streets (becos). After you’ve spent all of your Euro, take a short walk over to the Santa Engracia Church, Museum of Decorative Arts, or the National Pantheon. Oh, and don’t forget to take in the views and snap a few pictures.

Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

A true desert outpost, the Peruvian town of Mancora enjoys the most sunshine hours of anywhere in the country. Unlike the rest of Peru the water is warm enough to surf without a wetsuit, a welcome complement to an area already featuring some of the best waves in South America. Hemingway knew what he was doing when he set up shop in nearby Cabo Blanco, an authentic fishing village where the ceviche is some of the freshest on the planet and the days pass with a simple peacefulness unique to many coastal escapes. While outdoor activities abound around Mancora, from kitesurfing to fishing to morning yoga sessions, on this particular morning the to-do list consists of nothing more than a good book, a cold drink, and watching whales splash on the endless horizon.

Formerly known as Bastakiya, the Al-Fahidi Historical Neighborhood was preserved in the mid-2000s amid the city’s rush to modernize. As you wander around this district off Dubai Creek, you’ll see teahouses, art galleries and private homes on narrow pedestrian alleys. The area was settled in the 19th century by Arab merchants from Persia. In those days, wind towers called barjeel were used as a form of air-conditioning.

A visit to the Palazzo Mirto offers the rare opportunity to see the interior of a classic Palermo palace as it was during its extravagant heyday. Located in the historic Kalsa district, Palazzo Mirto was home to the prominent Filangeri family for 400 years; the last remaining member donated the palace to the city in 1982. The vast library, the Chinese smoking room and the cavernous ballroom still have their frescoes, chandeliers, tapestries and opulent furnishings intact.

Kiyomizu-dera on Mount Otowa is one of the most famous temples in Japan, a place that appears in every sequence of Japanese travel photos. The landscape is all cherry trees and forest; it is among Kyoto‘s loveliest spots. The current structure dates to 1633 and is one of 33 temples on a pilgrimage circuit in the Kansai region dedicated to Kannon, the Buddhist goddess of mercy. The circuit runs from the south of Wakayama north to the Sea of Japan. You’ll see pilgrims carrying nokyo-cho—books stamped to record the visit—and monks busily inscribing in calligraphy. The temple, set against a steep hill and constructed on huge pilings, is a UNESCO World Heritage site.

One of New York’s loveliest historic districts, Brooklyn Heights sits along the East River to the south of the Brooklyn Bridge. Its streets are lined with beautifully preserved and restored 19th-century town houses while a promenade along its western edge offers views of the skyline of downtown Manhattan—especially stunning when the sun is setting over New York’s harbor. Simply wandering its streets, you’ll feel transported back in time, but there are some buildings of special interest you may want to seek out. The celebrated 19th-century preacher Henry Ward Beecher (brother of Harriet Beecher Stowe) presided at Plymouth Church (57 Orange St.). Truman Capote finished Breakfast at Tiffany’s and wrote In Cold Blood during the 10 years he lived at 70 Willow Street, and novelist Thomas Wolfe lived at 5 Montague Terrace from 1933 to 1935. Grace Church (254 Hicks St.) and St. Ann & the Holy Trinity (157 Montague St.) are outstanding examples of 19th-century Gothic Revival architecture. After you are done exploring, Atlantic Avenue, which marks the southern edge of the neighborhood, and Montague Street have a number of restaurants to choose from if you are ready for a meal.

This Alpine area in Appenzellerland sits at an altitude of more than 5,000 feet and is home to the much-photographed Aescher-Gasthaus, Switzerland’s version of the Tiger’s Nest Monastery. The 19th-century guesthouse was constructed directly into a jagged cliff face and while guests can no longer stay overnight, it’s a popular place for a meal. The cable car to Aescher departs from Wasserauen, and then a 20-minute hike passes ancient Wildkirchli caves that were once home to prehistoric bears and, later, 16th-century hermits. There’s also a grotto chapel built right into the stone, a small museum, and a sheep farm on some seriously steep meadow terrain.

Nişantaşı is the posh “Upper East Side” of Istanbul, home to the priciest designer boutiques and old-fashioned couturiers, especially along Teşvikiye and Abdi İpekçi streets. Beymen department store was Turkey’s first luxury retailer and remains a one-stop shopping destination for international and Turkish designers; take a seat outside its sidewalk café to see the fashionable set preen. For a peek at the old-money Istanbul chronicled in Orhan Pamuk’s book The Museum of Innocence, find Hak Pasajı, a shopping arcade just a few steps from the City’s Nişantaşı shopping center. Along with jewelry stores, stationers, and shoemakers, you’ll find Orlando Carlo Calumeno’s shop, a veritable treasure trove of authentic Constantinople relics ranging from French postcards of the old Pera district to museum-quality Ottoman army items.

Taf Coffee started out as a family-owned coffee roastery in the 1990s then quickly moved beyond Greek brews to becoming Athens’ main source for international gourmet roasts. Owner Yannis Taloumis opened the doors to Taf Coffee (a sit-down café) in 2009 and the family’s brand been going strong ever since, recently expanding to Taf Points, a mini-espresso bar concept in Athens and points beyond. The café, at the edge of the funky Exarchia district, is a haven for coffee aficionados interested in a wide variety of brews made by international-award-winning baristas. (Yes, traditional Greek coffee is still on offer.)

Sandwiched in between the Railyard District and the plaza, this breezy brick-and-adobe-exposed Mexican-inspired spot features a sprawl of folk art, majolica tiles, distressed windowpanes, and leather banquettes. There’s a range of diverse delights on the menu: duck carnitas, marrow tacos, grilled whole sea bass and, for vegetarians, cauliflower Frito tacos topped with Marcona almonds, raisins, and Spanish olives. For a side dish, order the warm Mexican street corn, known as esquites. To sip, it’s all about house-shaken tequila, smoky mezcal cocktails, and classic Mexican brews like Sol and Bohemia.

An Old World grande dame of the 19th-century tradition, the InterContinental Amstel Amsterdam presides over the Amstel River from its waterfront perch at the eastern edge of the original city. An imposing example of a Dutch take on French Renaissance Revival architecture of the period, the hotel—known initially as the Amstel Hotel—was conceived of by well-to-do Amsterdam doctor Samuel Sarphati to attract wealthy Grand Tour–goers to the struggling city. Since then, dignitaries from Queen Elizabeth II to former President Bill Clinton, and celebrities from Audrey Hepburn to George Clooney, have entered the imposing lobby—with its grand staircase, marble columns, and gilded chandeliers—and taken up residence in its opulent suites.

While in its latest iteration the hotel has updated itself in all the right ways, it still offers each guest the superlative but understated service that such royals (of both state and silver screen) would expect, down to the private butler service that comes with each room. The current French-inspired decor channels the building’s original architecture and includes romantic hand-drawn wallpaper in bedrooms. The unfussy, seasonal cuisine and craft cocktails in the restaurants and bars infuse the traditional space with modern sensibilities. Even the health club has its feet in both past and present: The thoroughly modern facilities were inspired by one of the forefathers of physiotherapy, who took up residence in the hotel and treated such distinguished clients as Empress Elisabeth of Austria there.

Hilton’s reentry into the heart of Paris is nothing short of majestic. After a $50 million design overhaul, the 125-year-old hotel, made for the 1889 World’s Fair, has been revived to its 19th-century splendor with a contemporary twist. Formerly the Grand Hotel Terminus and the Concorde Opéra Paris, the property’s landmark status—with its Haussmannian facade and elegant public spaces—demanded it be painstakingly preserved. Among the restored, original elements, the most awe-inspiring are the Corinthian columns, chandeliers, balustrades, hand-painted frescoes, and marble and mosaic tiling. Fortunately, the bar takes pride of place among them, making it the ideal spot to start your stay with a cocktail or glass of wine.

The style in each of the rooms breaks with the traditional stark-white modern codes of most business hotels. Here it incorporates warm accent colors and textiles. With few heritage elements left to preserve, the sense of place is woven in with custom etchings of iconic Paris scenes hung behind each bed. But you won’t be spending much time here, as the action happens in the grand salon.

The lines are long (expect to wait at least an hour) at this young barbecue joint tucked inside the Dallas Farmers’ Market—but the tender, perfectly smoked meats are worth the wait says Daniel Vaugh, barbecue editor of Texas Monthly. “They have incredible brisket and giant beef ribs,” he says. Watch for a brick-and-mortar outpost slated to open this spring—menu standbys like bacon-and-chile-flecked mac and the “trough” meat-sampler, pictured here, are sure to make an appearance.