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The cathedral, usually called the Duomo, is Florence’s most recognizable building. You are able to catch glimpses of its magnificent red-tiled cupola from just about anywhere in the city center. Construction on the church complex began in 1296 and the work—Brunelleschi’s dome and his Baptistery, and Giotto’s bell tower—was completed in 1426. The interior of this architectural is reserved in contrast with the exterior’s marble Gothic facade and its green, pink, and white stripes. Climb the 463 steps up into the dome for a close-up look at Giorgio Vasari’s fresco, The Last Judgment, and a bird’s-eye view of the city.

Pearl was founded in 1881 as a traditional brewery. These days, however, the bustling complex is less about beer than its 15 restaurants, dozen-plus retailers, and numerous family-friendly events, including a twice-weekly farmers’ market. Start with lunch at La Gloria, chef Johnny Hernandez’s nod to interior Mexico, followed by dessert at Bakery Lorraine, where you’ll find an enticing rainbow of Parisian-style macarons. If you’re in the mood to shop, pick up a tailored guayabera from Dos Carolinas, or a piece of handcrafted jewelry from Ten Thousand Villages. Pearl Brewery is even home to Hotel Emma, a true gem in San Antonio’s boutique-lodging scene, in case you don’t want to leave.

Nestled on beautiful Playa Dorado in Puerto Plata, this elegant hotel features 50 stylish suites, complete with neutral decor, flowering orchids, and private furnished balconies. Some suites can be connected, but for even more space book the penthouse, which includes three bedrooms, a large living room, and a freestanding outdoor tub. In addition to a pristine beach, Casa Colonial boasts a sleek rooftop pool, a restaurant that serves fine French-Caribbean cuisine, and a spa with a treatment gazebo above a tropical pond. When staying here, don’t miss the chance to explore Puerto Plata and its charming main square surrounded by Spanish colonial and Victorian buildings, as well as the more-than-500-year-old remains of Fort San Felipe. Fifteen minutes from the resort, you can also swim in freshwater lagoons in El Choco National Park.

An exploration of Tlaxcala can begin and end in the Plaza de la Constitución, the zocalo in the old town center. Within walking distance are the Plaza Xicohtencatl, often full of crafts and food stalls, the Ex-Convento Franciscano de la Asuncion (built in the 1530s and one of Mexico‘s earliest monasteries and cathedrals, boasting a visually spectacular interior within its stone walls), several intriguing museums, and the municipal market. Around the zocalo itself you’ll find a colonial-style arcade of restaurants, cafes, and shops, the government building with an interior courtyard painted with historic murals, the Hotel Posada San Francisco an appealingly intimate bar, and plenty of places to park yourself and kick back in the shade. Ninety-five percent of the tourists you’ll encounter will be Mexican.

In early April, I spent a week on a yoga retreat at Amansala in Tulum, Mexico. We had four hours of yoga and Pilates practice a day, and I spent the rest of my time on the beach, swimming in the ocean, reading books (I finished Gabrielle Hamilton’s excellent memoir, Blood, Bones, and Butter), drinking coconut juice, and snacking on delicious homemade tortillas, salad, salsas, and guacamole. At night we ventured out to explore, and discovered a wonderful new open-air restaurant called Hartwood, where I wish I could eat every night.

What is more romantic than an intricate and well-used Spanish fan? Fans are a highly personal item, and like perfume, one should only use the best they can find (or so my mother always said). For the royal minded there is only one choice, Casa de Diego. Founded in 1858, this a business steeped in international approval, and the generations have been privileged to create masterpiece shawls, umbrellas, and of course fans for royal families all over the world. Proudly facing the Puerta del Sol is the window display of fans, giving only a glimmer into the magic on the other side of the doors. Right outside is the hustle and bustle of city center, but inside the shop you are transported to a haven of beauty. Take home a piece of Spanish tradition with you, and smile every time you fan yourself, remembering Madrid.

Anyone with an iota of interest in art will certainly visit the Prado while in Madrid. But be sure to save some time to visit another nearby museum, where there’s something wonderful to see before you even get inside. Just a 5-minute walk down Paseo del Prado you’ll find the CaixaForum Madrid, with its awe-inspiring vertical garden. From a distance, you might even think you’re looking at a mural there on the wall, but as you approach, the lush greens and earth tones come to life with varying textures that are luscious and welcoming. A masterpiece where nature is the medium!

For traditional Mexican handicrafts, Mercado Coral Negro is the easiest place to find all your wares. Here you can purchase jewelry, mayan relics, and unique creations from all over the region. The most beautiful items are the embroidered garments created from local cotton and dyed using traditional methods.

Georgia O’Keeffe called the grouping of weathered rock outcroppings near Abiquiu “The White Place” and immortalized it in paintings. The land is so arid, and so little changes in New Mexico, that the location and signature V shape have survived. A great hike, close to Abiquiu. Cowboys and Aliens was also shot nearby!

Baja Beans Roasting Company purchases beans from a family farm in Puebla and roasts them in a vintage coffee roaster in Todos Santos. Order a latte to sip in the café’s garden patio, or buy a bag of beans to bring home. Baja Beans Roasting Company, 52/(01) 612-167-3139. This appeared in the March/April 2012 issue.

Ducking into the Matador in the alphabet district is a great way to tour the Mexican culture through its tequila and mezcal heritage. Touting over 100 tequilas in a variety of vintages, you’re likely to become a bit overwhelmed by the depth and complexity. This anxiety is generally relieved after a couple of shots. Staff are keen on giving solid recommendations based on your preferences. There are “flights” of tequila to introduce you to the subtle characteristics of this oft-misunderstood beverage. Be daring and undaunted by the task at hand, and try to sip, not shoot. Salt & lime optional. The space is anchored by a large fire pit that is cozy in the winter months. Huge windows open during summer to bring the outside, in. The menu is focused and leans toward the California interpretations of Mexican cuisine. The pork dishes are a bit more traditional, while the fish tacos have a NW flair. The carne asada is nicely done, and there are veggie and gluten-free options all over the menu. Happy hour is a big draw with lots of great dishes and featured drinks on the cheap. While being part of a small chain of restaurants might seem one-dimensional, Matador promotes local sourcing on ingredients and lets each store have its own personality. NW Portland is a great neighborhood for exploring, and a tequila flight at the Matador is an entertaining way to get the party started.

This historic bakery in Campo de’ Fiori serves good pizza bianca and excellent pizza rossa, as well as assorted slices, cookies, and pastries. The neighboring annex across the alley (Vicolo del Gallo 14) serves sandwiches and baked goods. Drop in during August and September for a taste of the seasonal treat pizza prosciutto e fichi (pizza bianca filled with savory slices of prosciutto crudo and sweet, overripe figs).

Cuatro Cienegas has got to be one of the coolest places on the planet earth! It is certainly not like any other place or ecosystem I have ever visited and I would have never imagined you could find paradise in the middle of the Chihuahuan desert. “Cuatro Cienegas” means “four marshes” in Spanish and at one point in history this place was a wetland. The pools, called pozas, are scattered throughout the desert around the town. Some of the pools are warm and some of them are freezing cold! They are a blast to swim and snorkel in! Cuatro Ciénegas is an official Mexican biological reserve because the ecosystem has unique fauna and flora that can’t be found any other place in the world! NASA stated that the biological reserve of Cuatro Cienegas could have strong links to discovering life on Mars, since the adaptability of bioforms in the region was unique in the world. How far out is that? Some refer to Cuatro Cienegas as the “Galapagos of Mexico”. Be sure you also check out the Gypsum Dunes that are also located here. This place is a geologist’s dream! I would recommend staying at Quinta Santa Cecilia during your visit, and although many of the pozas are mapped and marked you are better off hiring a local guide to take you to the best spots. Cecilia or the management of your hotel can assist here. The drug battles in this part of Mexico continue to dominate the press, but we did not feel unsafe during our visit here.

Get a bird’s-eye view of Laguna and its famous sunsets at the Rooftop Lounge, which sits atop La Casa del Camino hotel. Drinks here include a lengthy list of red, white, and sparkling wines as well as specialty cocktails like mojitos in strawberry, mango, and ginger flavors. To pair with your sips, there’s a range of small bites, from barbecue meatballs with blue cheese slaw to bacon-wrapped dates and coconut-breaded shrimp. Just be sure to come prepared with sunglasses and a hat, as shade is limited, and bring your four-legged friend—the bar is dog-friendly.

Located at the Casa del Mar Beach Resort, this casual, indoor-outdoor restaurant starts serving breakfast at 7:30 a.m. and stays open until 10 p.m. Whether you visit morning, noon, or night, you can look forward to everything from local fish to oversize salads and hearty sandwiches. Cocktails are another specialty—in fact, the restaurant hosts happy hour three times a day with two-for-one drink offers. Other nightly specials popular with both visitors and locals include all-you-can-eat ribs on Tuesdays and karaoke on Wednesdays, made all the more fun by the breezy location and ocean views. Die-hard sports fans don’t even have to miss the game, since the restaurant tunes its TVs to whatever patrons request.