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Reservations required—and no wonder. The tours at the Neon Museum sell out months in advance. A walk through the museum’s famous “Boneyard” (where neon goes to die) is fascinating, from motel row to the first integrated casino (one that shut almost as soon as it opened), and the Stardust, with its nuclear testing-inspired font. All of this comes alive thanks to the museum’s famous docents, all art history buffs with loads of family history or other personal anecdotes.

Two hours from Rio de Janeiro, off the coast of Angra Dos Reis, Ilha Grande makes for a spacious retreat for two or an epic group vacation. The private island’s six-bedroom house comes with kayaks and stand-up paddleboards, plus a staff ready to whip up caipirinhas at all hours of the day.

Jerusalem’s Yad Vashem ensures that the magnitude of the Holocaust’s injustices are never forgotten. Visiting the museum is an educational, as well as emotional, experience and should not be rushed. The museum is dedicated to researching the phenomenon of the Holocaust and genocide in general, with the hope of avoiding it in the future. Exhibitions present the history that led up to the Holocaust, as well as the related events during and after World War II, featuring personal stories, historical artifacts, films, and photographs. It also highlights the bravery of underground movements, uprisings, and the non-Jews (the Righteous Among the Nations) who saved Jewish neighbors, children, and families from certain death. Outdoor gardens contain several monuments, including a haunting children’s memorial and commemorative sculptures. Guided audio tours are recommended.

No matter how many postcards you’ve seen of Rome’s iconic Colosseum, you just don’t get it until you pass beneath its crumbling arches. Built by Emperor Vespasian in 72 C.E., the huge amphitheater held 50,000 spectators and marked its opening with 100 days of brutal spectacles like gladiator combat and animal fights. The Colosseum was in use for four centuries, and now you can tour the ruins. Walk through the Hypogeum, an intricate series of tunnels and elevators originally used to transport animals, slaves, and gladiators, to the performance above, or take a moonlit tour to have one of the world’s most storied structures all to yourself.

This covered food market dates back to 1786 (there has been a market on the site since 1610) and today it’s a bustling indoor food market with everything from fresh fish to spices, cheeses, oils and homemade cakes on sale. It’s also a hub of social activity for the city, where people meet for a shop and a chat. Wander around the market to sample some of the region’s best produce – from the fresh fish landed on the pier at east Cork fishing village Ballycotton (Ballycotton Seafood Ltd) to the Toonsbridge Buffalo Mozzarella from The Olive Stall. Farmgate Café on the market’s upper balcony level looks over the market hall and is a great place for people-watching and soaking up the atmosphere while tucking into fresh oysters or seafood chowder, or coffee and cake.

Sure, Faneuil Hall and Quincy Market make up the most touristy part of Boston, complete with street performers, a light show, and the obligatory Yankee Candle store and Cheers restaurant; we nonetheless defy you to stay away. This part of the Boston waterfront has thrived on commerce since colonial times: Faneuil Hall was crowded with merchant’s shops as early as 1743, and the larger Quincy Market was added in 1824 to provide more space (it also was the site of speeches by Samuel Adams and other early patriot leaders). If you’re looking for a Red Sox hat or a “Boston Strong” T-shirt, you’ll find it here.

Arriving in Dublin on the morning of St. Patrick’s Day is like experiencing the calm before the storm. The cobblestone streets of Temple Bar are quiet and nearly empty, and bicyclists can cycle through the narrow streets with ease. This is the time to have breakfast while devising a plan: Do you want to find a place near the parade route? Should you claim a table at a pub? We filled up on eggs and coffee at Elephant and Castle in Temple Bar, and then saw the end of the parade. By noon, streets were clogged with people from all over the world -- singing in the streets, painting shamrocks on strangers’ faces -- and pubs rang out with traditional Irish songs. Don’t be shy if you don’t know the lyrics, since there’s a good chance you’ll hear the songs again. Have a Guinness (or two) and join in!

Visiting the Strip? Save time for its spas. One of my favorites: Qua, at Caesars Palace. The Roman baths make you feel like you’ve left Las Vegas behind, and the snow room is worth a (quick -- it’s cold!) stop. Then the treatments are out of this world. On my most recent visit, I got the Nagomi treatment, on the mini-menu for the new Nobu boutique hotel inside Caesars. It included a therapeutic massage and excellent facial with a new fizz-like layer that worked on my skin. I couldn’t think of a better way to start my day.

The Roman Forum is where ancient Rome began. The sprawling archaeological park gives us just a hint of what the Roman Empire once was—a dominant and diverse society. The Forum itself was the political, social, religious, and commercial focal point for the Roman Republic and eventually the whole Empire—for the most elite members of society as well as the common plebs. Walking through the Forum is a walk through history, from its beginning as a valley with small hilltop communities (8th century B.C.E.) to its rise as the capital of an empire. The ruins of basilicas, temples, public forum spaces, and shops can be explored, and the adventure leads to Palatine Hill, an area of high-society patrician homes including the house of Caesar Augustus.

Built by Kaiser Wilhelm I in the late 19th century as a gesture to parliamentarians, Berlin’s famed Reichstag came into its own during the Weimar era—Germany’s first attempt at democracy. The parliament building burned under mysterious circumstances in 1933, leading to the suspension of civil rights and Hitler’s ensuing dictatorship. Seized and shot to pieces by Soviet troops in 1945, then abandoned during the city’s division, the traumatized building reentered public life when the German government returned to Berlin following reunification. Today the Reichstag stands proud, topped by a glass dome designed by British architect Sir Norman Foster as a symbol of political transparency. Going inside the dome is very popular; you can look down on plenary sessions as well as admire sweeping city views.

The central hub of downtown Amsterdam is Dam Square, and it’s been at the heart of the city’s history since the 13th century. Today, the open-air public space is ringed by shops and restaurants and packed with people, including street performers and tourists en route to nearby attractions like the Royal Palace, the National Monument, and the Nieuwe Kerk (New Church), where you can catch a horse-drawn-carriage tour of the city.

The unofficial symbol of St. Louis, the Gateway Arch is the tallest man-made monument in the United States, rising 630 feet into the air. It sits at the center of Gateway Arch National Park, which was established in 1935 to commemorate Thomas Jefferson’s vision of a transcontinental America. In 2018, the park emerged from a five-year, $380 million renovation, which added a grassy pedestrian walkway over the interstate as well as a revamped museum with new exhibits about the construction of the arch and how the expansion of the United States affected Native American communities. Tour the new sites, then take the four-minute, vertigo-inducing tram to the top of the arch, where you can see up to 30 miles east and west on a clear day.

Among vacationers who’ve been coming to Grand Cayman forever, there’s a whole faction that essentially camps out at Rum Point all day every day, and you’ll understand why as soon as you see the place. Tucked away, super low-key, and graced with a ridiculously photogenic pier—its perfectly weathered planks cutting a striking figure against the tranquil, turquoise surroundings—this beach is the ultimate spot for settling into a lounger or hammock between water-sports outings. Rum Point’s namesake booze—which used to wash ashore by the barrel, according to legend—is available in all manner of cocktails here, of course. But order at least one mudslide at its spiritual birthplace: the beach’s beloved Wreck Bar.

Long considered one of the top hotels on Oahu, the Kahala has always been a particular favorite among the type of guests who travel with their own security detail. A number of past U.S. presidents, plus kings, queens, princesses Grace and Di, a handful of Nobel Peace Prize winners, rock stars, and movie stars, all have slept under its venerable roof at some point during the hotel’s 50-year history. The see-and-be-seen set moved on long ago, but privacy seekers still make a beeline here. They’re drawn less by the property’s fabulous beach (though that’s reason enough to stay here) than by its exclusive location—in a well-fortified cul-de-sac in the ritzy Kahala neighborhood. But there’s a warm and fuzzy side to the hotel, too. A pod of dolphins has full-time residency in the hotel lagoon, and visitors of all ages can swim with them (for a fairly steep fee). Rooms have a preppy beach house vibe—raffia ceiling fans, linen loveseats—and many come with heart-stopping sea views.

The Villa Grimaldi Memorial and Park for Peace occupies the site of a former interrogation and extermination center operated under Chile’s 1970s and ’80s-era military dictatorship. A wall lists the names of the prisoners who died here, and there’s a garden with a rosebush for each woman executed or “disappeared” that was inspired by survivors’ stories of being able to smell the roses outside their cells. Willows convey sadness engendered by the unspeakable crimes committed on the property. (Only the foundations of the original estate remain, but a model can be viewed.) A focal point of the garden is a gigantic tree that was burned down but somehow survived and grew back to its present-day height of more than 50 feet, a symbol of the indomitable human spirit.