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Work your way from Excelsior’s top floors (slinky Chloé dresses, Balmain leather jackets) to the main floor (watches, speakers, a sea of colorful iPad cases), then down to the subterranean floors for the impressive wine shop and restaurants.

My friend Andy says you can’t go to Milan without having an evening in Brera, the tiny artsy area adjacent to Milan’s fashion center. Bar Brera is the hangout of choice for expensive liquor and people watching.

Milan invented the art of bel cafè, the pedicured bar for a delicious morning coffee or afternoon aperitivo. Passerini has a delicious selection of pastries for mornings and afternoons, and is the ideal hideaway for an aperitivo in the city center.

Artist Dan Flavin’s last installation is the Church of Santa Maria Annuciata in Chiesa Rossa, fondly known as simply Chiesa Rossa. Flavin’s light installation is a technicolor dream of electric hues across the main nave and central apse.

The modern minimalism of Le Méridien Chambers boutique hotel is accented by all things art. Graffiti-covered stairwells and hallways lead to rooms, each with their own original piece of art by the likes of Brits Damien Hirst and Gary Hume. Located in the vibrant Theatre District, entertainment from live music to stand-up comedy is just outside the door. As a guest, you’ll be granted free admission to the popular Walker Art Museum one mile away. Aside from the art, there are thoughtful amenities like the rain shower and heated floors, and fresh Italian cuisine at the hotel’s Marin Restaurant & Bar.

Immediately adjacent to Loews Regency, the Sant Ambroeus Coffee Bar is one of the latest outposts of this popular group of New York, by way of Milan, restaurants. The original Milan restaurant opened in 1936, and there are now three others in Manhattan, as well as one in Southampton. The Park Avenue coffee bar has an Italian art deco decor, bringing a little bit of Milan’s style to the neighborhood, and several outdoor tables. Choose from a panini or one of Sant Ambroeus’s famous pastries.

Walking through the narrow streets of Boston‘s North End might have you thinking about a delicious Italian meal. Take the time, however to explore the area on Hanover Street where the surrounding brick buildings suddenly give way to a park where Paul Revere stands guard. Commemorating his ride to warn the colonists of the impending British Invasion, the statue stands in front of a small park leading to the famous Old North Church. The setting is a perfect spot to relive the beginning of the American Revolution, and after exploring, leaves you in a location filled to the brim with restaurants and cafes to recharge before moving on.

An ivy-covered, 17th-century mansion near the beautiful Place de Vosges is now the site of an intimate, five-star hotel. A favorite of sophisticated travelers who value privacy over hype, Le Pavillon de la Reine (named “Reine” in homage of a stay by Queen Anne of Austria) features striking interiors that blend original architectural details and aristocratic portraits with bright colors and contemporary furnishings. The 56 rooms and suites are similarly posh, with touches like patterned wallpaper and textiles, antique chandeliers, marble mantles, and flower-filled window boxes, plus luxe Codge bath products.

Set on St. Lucia’s westerly Anse Cochon beach, Ti Kaye is a secluded, adults-only oasis that feels worlds away from the rest of the island. Each of the 33 cliffside, gingerbread-style houses feature outdoor showers and verandas with double-wide hammocks, and some even include plunge pools. Since there are no TVs, the focus remains squarely on the picturesque beach, home to a PADI diving center, crashing waves, and breathtaking sunsets. The same is true in the resort’s two open-air restaurants (don’t miss the banana pancakes at the beachfront grill) and treetop spa. Rum connoisseurs can schedule a tasting in Ti Kaye’s wine cave, but if you crave a rowdier scene after all the relaxation, know that it’s a 20-minute drive to the nearest fishing village—you’ll want to make the trek on Friday nights though, when Anse La Raye hosts its weekly street parties.

Tucked off the casino floor, the Bellagio Gallery of Fine Art holds its own when it comes to well-established works of art. The gallery is small compared to the massive museums found in the likes of Paris and Washington, DC, but it is more than adequate for its intentions. In the city, few places are as quiet and thoughtful as the BGFA. Partnering with fine art institutes from around the world, the BGFA features a couple rotating exhibits each year. Past exhibits have featured work by Andy Warhol and Monet as well as Fabergé pieces.

Union Station is as stunning as it is rich in history, and continues to be a vital hub for L.A. rail, metro, and bus transport. On the outside, the building resembles an art deco riff on the old California missions; inside, the inlaid travertine and terra-cotta floors show the sort of detail work so rare in modern depots. Local tip: Settle into one of the giant leather chairs in the cavernous waiting room and immerse yourself in the city’s seedy side with Chandler’s noir classic, The Big Sleep. (Without a ticket you can’t enter the waiting room, but you can at least enjoy the Navajo patterning on the station floors.)

“Buongiorno, Signor Farley,” said Umberto, the head waiter at Hotel Missoni’s Cucina restaurant. By the beginning of the third day of my stay, the staff knew my name. And what I drank with breakfast. An espresso doppio was delivered to my table a minute later. “Prego,” the server said.

You’d think I was in Italy. In fact, I was 2,500 miles southeast of the country’s heel, in the capital of diminutive, oil-rich Kuwait. Opened in spring 2011, Hotel Missoni, owned by the eponymous fashion and home furnishings house, is one of many designer-conceived hotels that have popped up around the globe.

I have to confess: I have a complicated relationship with fashion. Maybe it’s related to my childhood. (Isn’t everything?) In the seventh grade, I wore a T-shirt to school that read, “My Son Is in the Navy.” My trend-conscious peers, who clearly had no sense of irony, laughed at me until the final bell rang. When I wore bowling shoes to high school, I was similarly mocked. How would I do in a hotel designed by a couturier?

I was picked up at the airport in Kuwait City in a Maserati (a complimentary perk for all Missoni guests). Not a bad start.

The property (like its sister hotel in Edinburgh, which opened in June 2009) is the brainchild of the Missoni family matriarch, Rosita. The hotel’s 169 rooms were designed to feel like her home. Compact Hans Wegner wishbone chairs and tuliplike Eero Saarinen–designed tables rest on hardwood floors, and everything—espresso cups, towels, even the swimming pool—displays the colorful striped patterns Missoni is known for. Generous helpings of turquoise, gold, and beige are splashed throughout the hotel to evoke the bayfront landscape outside, and every room looks out on the ever-expanding Kuwait City skyline. Like many things Italian, the hotel is simple and comfortable.

The Missoni team, which is fine-tuning its approach before opening hotels in larger markets, learns fast. There are no design hotel clichés here: no faucets with the function designed out of them, no overly formal staff. “Are those Camper shoes?” a waiter asked me one day at breakfast. I nodded. “Like bowling shoes,” he said. “Very cool.” Here, it seemed, fashion and I got along great.

965/2577-0000, from $414. This appeared in the September, 2012 issue.

Visiting the Strip? Save time for its spas. One of my favorites: Qua, at Caesars Palace. The Roman baths make you feel like you’ve left Las Vegas behind, and the snow room is worth a (quick -- it’s cold!) stop. Then the treatments are out of this world. On my most recent visit, I got the Nagomi treatment, on the mini-menu for the new Nobu boutique hotel inside Caesars. It included a therapeutic massage and excellent facial with a new fizz-like layer that worked on my skin. I couldn’t think of a better way to start my day.

Reporting live from Upper Mustang: We’ve successfully hiked in and out of this remote, inaccessible region in north-central Nepal over terrain that was variously bleak and spectacular. We traversed rocky, sandy trails (I use that word loosely) through shale and limestone cliffs with only the occasional, teasing glimpse of a snow-covered peak. On the 7th day of walking 6-7 hours per day, the weather turned against us and we battled howling winds and freezing rain for the better part of an afternoon. Over the past week your faithful reporter has endured blisters, sunburn, intestinal parasites, an upper respiratory infection and a mild concussion (damn monastery door frames built for short people). Despite the aforementioned maladies there were some really bright moments along the way and the Tibetan/Nepali families we stayed with welcomed us into their humble kitchens and homes. I return to modern city life with a renewed appreciation for the simple comforts of indoor plumbing and reliable electricity. [Pictured: a herd of goats grazes at 4010 meters over Nyi La Pass - the highest point in the Kingdom of Mustang.]

This delightful gallery is housed in one of Marrakech‘s elegant Saadian town houses, all creamy white plaster walls and subtle bejmat (unglazed terra-cotta) tiled floors. It’s the perfect setting for what began as owner-creators Hamid Mergani and Patrick Manac’h’s private and extensive collection of photographs that document scenes and portraits of Moroccan life over the past century. Today the foundation encompasses a whole lot more, with numerous collectors and photographers such as Daniel Chicault, Ana Muller, and Jean-Pierre Évrard donating or loaning from their own collections. There’s also a terrific little café on the roof for traditional Berber cooking and splendid views of the Atlas Mountains.