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The roots of this Mediterranean Revival-style boutique hotel go back to 1914, when a local grocer created the tropically inspired property to house his visiting vendors. Nearly a century later in 2010, hotelier and style guru Liz Lambert added the place to her mini-empire, reviving the grounds that still feature magnolia, palm, and cypress trees planted by the original owner. Set on a quiet section of the River Walk near the museum corridor, the restored building (which is on the National Register of Historic Places) houses 27 guest rooms decorated in a designer-meets-flea market aesthetic, with bright pops of color and plenty of personality. All are pet-friendly, and feature stocked SMEG fridges, Red Flower bath amenities, custom serape bathrobes, and complimentary coffee and Wi-Fi; suites have sitting areas, terraces, or other perks. Room service comes from the in-house Ocho restaurant, but it’s better to head down and eat there in person to take in the cheery setting, river views, pan-Latin menus, and cocktails that highlight rum (as a nod to Havana) and tequila (an homage to San Antonio’s Mexican roots). A regular calendar of happy hours, musical performances, and cultural events round out life at this vibrant hotel.

Hands down the best place to stay in Mexico City’s Centro Histórico is the aptly named Downtown. Located inside a restored 17th-century casona (mansion), the hotel shares its property with a select group of Mexican businesses, including a chocolate boutique and a mezcal bar, as well as restaurants, cafes, and fashion and jewelry ateliers. Appropriately, rooms evoke a bygone era, with low lighting, brick ceilings, and tile floors somewhat reminiscent of a monastery. Amenities are spare but select (C.O. Bigelow toiletries, for starters), and service is unobtrusive but attentive. After a day spent exploring the city, head to the rooftop pool and bar, where you can sunbathe on a bright yellow chaise lounge or sit under an oversized umbrella while waiting for your cocktail to arrive.

Hailed as one of the country’s first true boutique hotels, Hotel San José started its life as a 1930s tourist court and became a 1950s roadside motel before falling into disrepair in a bad part of town. In the mid-1990s, Liz Lambert bought it and transformed it into a minimalist, mid-century–inspired hot spot, the first of her distinctive Bunkhouse hotels, and the South Congress neighborhood changed with it. Although it’s now a must-visit for out-of-town hipsters (and its bar a hangout for trendy locals), the hotel stays true to its roots; a majority of the furniture was made by local artisans from reclaimed wood and Texas leather, the three most affordable rooms have a shared bath, and Lambert’s experience renovating the hotel and contributing to the neighborhood’s gentrification prompted her to make the documentary The Last Days of the San Jose.

Nowadays, SoCo is Austin’s hottest neighborhood, and Hotel San José is in the heart of the action, hosting local and touring bands in its courtyard and parking lot, and offering some of the city’s best coffee at Jo’s, its affiliated café. Plan to spend at least one evening making new friends over Shiner Bocks at the long tables in the courtyard lounge.

Why we love it: A wellness-focused stay where relaxation comes first

The Highlights:
- A staff nutritionist who can create customized menus before your arrival
- Suites with outdoor clawfoot tubs for alfresco bathing
- Yoga mats available in every room

The Review:
If you’re dreaming of making your wellness fantasies a reality, Sanará checks all the boxes. In addition to minimalist white interiors that encourage meditation—or, at the very least, tranquility—the boutique resort offers daily morning and evening yoga sessions, vegan meals made with locally sourced produce, and organic bath products crafted on site. Even the mosquito spray is biodegradable (but don’t worry, the 17 guest rooms have air conditioning). Though there’s no pool on the grounds, the resort is steps from a white-sand beach kissed by lapping waves and dotted with shady loungers. If you’re in need of even deeper relaxation, Sanará’s five serene treatment rooms set the tone for crystal healing, Mayan-inspired remedies, and bio-magnetic therapy, as well as soothing facials and massages.

Originally constructed in 1886, the building for this elegant five-room boutique inn went through a few different iterations as a private home and a small hospital before earning its National Historic status in the 1970s. But about 50 years ago when the hospital shut down, it fell into disrepair. Enter new owners Dina and Richard Dwyer. World travelers themselves, the Dwyers brought their expertise in design and construction and spent about four years renovating the building, which they opened in fall 2018. The property has an onsite pool, an outdoor fire pit, and is a short walk to shops and restaurants in downtown Calistoga. Guest rooms are elegant, with plenty of natural light, and bathrooms feature high-tech Toto toilets—all wonderful to return to after a day exploring Napa Valley. Breakfasts are a delight, too: ingredients are fresh (you might even get some herbs from their garden!) and Dina takes pride in highlighting local and regional purveyors. The beautifully appointed living and dining room—as well as Richard and Dina’s welcoming hospitality—will make travelers feel right at home.

A city within a city, Makati is Manila’s poshest shopping, business, and nightlife district. At the Makati Shangri-La, guests have amazing access to—and respite from—all of the above, including the malls that have made the neighborhood a retail pilgrimage site. After settling in, walk over to Glorietta, where you’ll find everything from high-end beauty boutiques to a family-run pawn shop and multiple Starbucks for good measure. Some of Manila’s best restaurants are also located in Makati, but the Shangri-La’s own Shang Palace is so beautiful and beloved, you won’t want to miss the experience if you have even the slightest interest in Cantonese food. As for the aforementioned breathing space on the guest floors, it starts with the waterfall you’ll pass en route to your room and ends with the custom-appointed bed in your plush, spacious surroundings. Go for one of the Deluxe Suites and you’ll also enjoy panoramic views of the bustle you’ve just left behind.

The first hotel to arrive in Denver‘s up-and-coming River North Art District (RiNo), The Ramble brings even more style to the increasingly trendy neighborhood. Accommodations in the 50-room boutique hotel feel both design-forward and homey thanks to antique Persian rugs, a cool color palette, and rich textures. Personal iPads make room service orders easy, and the mini-bar is stocked with carefully chosen snacks (gluten-free vegan protein bars, organic peanut butter cups). As notable as the rooms themselves are, the drinking and dining offerings—all provided by acclaimed New York bar Death & Co—are the real story. For those many days of Denver sunshine, grab a seat in The Garden, an open courtyard space. An intimate 20-seat bar with a cocktail tasting menu overlooks the lobby restaurant, where dinners feature small bites as well as family-style fare. And at the event space Vauxhall, a dedicated bar will host events like film screenings—and, of course, Broncos game viewings.

In the 1920s and 1930s, this heritage-listed property on tree-lined St. Kilda Road was an automobile showroom that sold the ultimate status symbol—the Rolls-Royce. Now it peddles another sort of luxury good: the boutique hotel stay. In the lobby, the Royce Hotel honors its Art Deco past with an arched ceiling in imitation hammered gold and lovingly restored wrought-iron chandeliers, but a zebra rug and curved mirrored walls anchor the design in the present. Some of the property’s 100 rooms and suites feature two levels and soaring bay windows, while others have kitchenettes, spa baths, and balconies with views of the city skyline, but you’ll want to venture out for the contemporary Australian specialties, including grilled steaks prepared from a selection of local grass-fed beef, at the hotel’s chic 100-seat restaurant Dish. Central though it is, there’s no lack of green space nearby: The hotel is situated between the sprawling Royal Botanic Gardens and Fawkner Park, while buzzy South Yarra is just a 15-minute walk away.

On a tree-studded peninsula between Monaco and Nice, this whitewashed luxury boutique hotel features 28 rooms and suites with a serenely chic vibe (think crisp white linens and richly patterned textiles, contemporary art and modern streamlined furnishings). A third of the units reside in the hotel’s main building, a mansion that dates back to 1889 but was fully restored and updated in 2003, and three additional rooms designed to resemble ship cabins are built into a wall with direct views onto the sea; the rest of the accommodations are housed in a quiet Italianate structure and a separate edifice at the edge of the property. Cap Estel’s Michelin-starred restaurant highlights seasonal ingredients, many of which are sourced from the on-site gardens. Guests who come to disconnect from the jet-set scene can relax in the hammam or waterside sauna, or with a massage and dip in the saltwater pool, though many guests would just as soon head straight into the azure waves of the Mediterranean, accessed through the hotel’s private beach.

A city crammed with ambitious young staffers willing to work long hours in hopes of shaping the country, Washington is a place that works hard and plays hard. One of the newest additions to its burgeoning boutique hotel scene, the Graham—its name a tribute to inventor Alexander Graham Bell—honors that tradition in retro-inflected style. The rooftop bar is a glam scene where the beautiful and powerful come out to play against the backdrop of the Washington Monument and Jefferson Memorial. The sultry downstairs restaurant–cocktail bar plays on the neighborhood’s historic aesthetic and the Mid-Atlantic region’s cuisine to attract discerning locals and visiting lobbyists. Rooms—mostly suites, of course—are pleasantly trendier than the District is used to, but bold pops of color and midcentury-inspired lines are balanced out by patterned wallpaper and elegant marble bathrooms that add a familiar dose of homey Southern style. Throw in a just-off-M-Street location, and the Graham just might be the quintessential Georgetown hotel.

Located in the Gaslamp Quarter, the recently constructed Hotel Indigo San Diego toes the line between hip and historic. The eco-chic boutique property prides itself on achieving LEED certification and boasts such unique features as a 4,000-square-foot green roof and a business center with Macs and iPads. History plays out in the hotel’s neighborhood story: an ode to the Wild West and the founding of San Diego.

Boldly designed rooms are outfitted with modern cherry blossom linens, vibrant murals, and oversized cushioned headboards. Clean up with Aveda bath products in your spa-inspired shower, and wake up to your own music thanks to an in-room iHome docking station. High-definition flat screens with premium cable and free Wi-Fi throughout the hotel mean you can stay as connected as you wish. At sunset go up to Level 9 Rooftop Bar for stunning city views and craft cocktails. Daily happy hour from 3:30 to 6:30 p.m. sweetens the deal.

For its much-anticipated first outpost outside London, the hip Hoxton boutique hotel brand—named for the trendy hipster neighborhood of its first hotel—chose five 17th- and 18th-century townhouses (including a former mayoral residence) on the canals of the Dutch capital. The brand has a formula that works, but rather than impose its signature style on another city—colonial-style, if you will—the designers have done it the other way around, imposing the buildings’ architectural styles and the city’s aesthetic on the brand. Original parquet floors, beamed ceilings, and wood paneling infuse the midcentury leather furnishings, geometric mirrors, and creatively patterned subway-tiled bathrooms with a Dutch feel, while the turquoise of the canal outside is reflected in the paint. Two rooms have original ceiling frescoes, and five have (non-working) fireplaces. In the ways that count, The Hoxton is true to its brand, such as bespoke toiletries, a scenester restaurant, a trendy bar, and its signature daily breakfast bag with a banana, granola, and orange juice.

Southern charm and Asian aesthetics meld seamlessly at the Mandarin Oriental, located on 15 floors of a high-rise building in the tony boutique-filled Buckhead neighborhood. Beyond a striking marble lobby, the 127 rooms feel like home—albeit a luxurious one—thanks to interiors by renowned architect Robert A.M. Stern. Plush carpets, large working desks, velvet-upholstered armchairs, and high definition LED televisions join bathrooms finished in black-and-white marble, with twin vanities, sunken tubs, and Atelier Cologne bath products. Whether you want to swim laps in the 60-foot swimming pool or simply unwind in the private English garden, the hotel is like a cocoon from the outside world; guests of the spa are welcomed with seasonal tea and an o-shibori, a Japanese steamed towel, before indulging in their massages and facials. But should you need to leave the bubble, the shops in Lenox Square are walking distance from the hotel, and free car service is available to take you within a two-mile radius.

Posada Borravino is tucked away along one of Mendoza’s oldest poplar-lined streets in the city’s Chacras de Coria neighborhood. The country inn has eight distinct guestrooms that offer a peaceful respite in a quiet Mendocenean neighborhood. The hotel’s design is simple but elegant. Rooms feel clean and refreshing with rustic yet stylish furniture, patina walls, and high, white-washed wooden ceilings.

A boutique hotel experience in every sense, here guests frequently mingle in the sun-drenched living room and cultivate friendships over bottles of malbec and long evening asados (barbecues). The back garden provides an inviting place to enjoy a good book, dip in the small swimming pool, or simply soak up the tranquil atmosphere. The staff is friendly and knowledgeable about what to do and see in Mendoza—from winery tours to adventure activities. In the evenings, Posada Borravino is lit up by dozens of scented candles, creating a magical ambience that casts a rosy glow on your entire stay.

Though it’s technically part of Eilat and connected to endless local activities via a beachfront promenade, the 375-room Dan feels like an ecosystem unto itself, complete with multiple waterfalls, pools, restaurants, and even squash courts, plus a spa, salon, and disco. Not your average megaresort, the venerable lodging was designed by globetrotting interiors guru Adam Tihany, who grew up just a few hours away in Jerusalem. For the full effect, consider one of the new rooms or suites, which feature muted, desert-chic décor, but know that any room will come with the most important amenity—views of the Red Sea. When you’re ready to leave the property, a whole menu of snorkeling and diving excursions awaits, as does Eilat’s Underwater Observatory Marine Park. The hotel is also happy to arrange jeep tours through the desert (don’t miss the Red Canyon and Solomon’s Valley) and visits to the International Birding and Research Center Eilat, known for its flamingo pools.