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Painted by Michelangelo between 1508 and 1512, the frescoes on the Sistine Chapel ceiling are considered some of the finest art ever produced. These religious paintings include nine scenes from the Book of Genesis, of which The Creation of Adam is undoubtedly the most iconic.

Occupying a prominent space between Brandenburg Gate and Potsdamer Platz, this memorial (also known as the Holocaust-Mahnmal, or Holocaust Memorial) has almost 3,000 gray oblong pillars (stelae), arranged at varying heights, that form a kind of labyrinth intended to reference the disorientation felt by Europe’s hunted Jewish population. Designed by New York architect Peter Eisenman, it opened in 2005. The effectiveness of the labyrinth is arguable; you may see groups of teenagers playing tag and picnicking on and among the blocks. However, there’s no denying the power of the site’s underground information center, which relates some of the life stories of Holocaust victims. Several other smaller but related memorials are nearby, dedicated to homosexuals, gypsies, and victims of National Socialist euthanasia killings.

Set in a row of shophouses—traditional double-use structures with a storefront on the street level, the owner’s residence on the floors above—the New Majestic Hotel is a small gem in Chinatown filled with quirks and contrasts. Colonial design is plentiful, from the vintage Compton fans in the lobby to furniture from the 1920s–1960s throughout. The rooms are a little more free-form. They range from suites with their own urban gardens to attic-style spaces with loft beds and 20-foot ceilings. Then there are the five rooms in which Singapore artists were told to unleash their creativity (Work, one of these rooms, looks like temporary housing, with plywood sections everywhere). Pieces by local emerging artists include murals with hidden messages or displaying pop art influences. The bottom of the rooftop pool has small portholes that look down onto the Majestic Restaurant, one floor down.

Many temptations are under one roof at the Langham, New York, Fifth Avenue. This polished hotel bucks the trend of tiny Midtown hotel rooms with spaces that begin at 420 square feet and stretch up to apartment-style accommodations with full kitchens—an ideal setup for families. The style is modern and refined, from the sweeping staircase that connects the lobby to the Michelin-rated Ai Fiori restaurant of chef Michael White on the second floor. The hotel doubles as an art gallery for the work of American artist Alex Katz, whose bold figurative paintings hang on the walls throughout the hotel. There’s also Chuan Body + Soul, a day spa based on the principles of Chinese Medicine.

A sense of discovery pervades at this innovative, open-air retail development in Culver City, which opened in 2016. Six buildings house first-to-market concept shops, pop-ups, and creative company headquarters. The place is constantly evolving, with a stylish lineup of businesses stepping in temporarily (St. Frank housewares, Charlotte Stone shoes) or permanently (Bird Brooklyn’s first West Coast outpost, Magasin men’s boutique, design shop Poketo). Be sure to hit some Southern California favorites, including The Edit by Freda Salvador and Janessa Leone, for shoes and hats, and Reservoir L.A. for an impeccable edit of local fashion brands. You’ll also find great iced coffee at Blue Bottle, acai bowls at São Acai, and tacos at the unmissable Loqui. Studded with cacti and succulents, as well as hanging chairs, the outdoor areas encourage leisurely shopping breaks. Keep an eye on the Platform’s schedule of events for outdoor concerts, film screenings, and food festivals. Pro tip: Put aside 35 minutes for an Aesop Express Facial at the cult Aussie beauty shop—it’s one of only four of the brand’s shops worldwide that offers them.

Opened by local restaurateur Lisa Wong in 1992, Rosario’s started as a neighborhood café, where San Antonio residents came to satisfy their Tex-Mex cravings. Today, it’s a city institution, known for its south-of-the-border specialties and house favorites. Don’t miss the tantalizing albondigas con arroz (Mexican meatballs braised in a spicy broth and served with rice and queso fresco), or the flavorful enchiladas Mexicanas (three queso-filled enchiladas smothered in a fragrant chile-infused sauce). And be sure to wash it all down with a perfectly crafted margarita.

Swiss contemporary artist Pipilotti Rist’s site-specific permanent installation piece, commissioned by the local bank, takes over an entire city plaza in her hometown. The plaza is draped in red carpet and paint, creating a space that’s an absurd take on the VIP concept. It’s fitting, then, that the “City Lounge” is located in the center of St. Gall’s financial hub of Bleicheli. It gives the illusion of spilling between the alleyways and seeping around corners, covering everything in its path, including fountains, benches, and even a sculpted Porsche. She worked with artist-architect Carlos Martinez to create the site in 2005, which was restored in recent years.

“Cuca” translates to vinegar in Indonesian, but this spot is anything but acidic. The atmosphere is a sweet blend of fine dining with friendly spaces that are stylish and contemporary as well as comfortable. Cuca’s menu concentrates on ingredients like just-caught seafood, fresh tropical fruits, and local vegetables and herbs. This local focus allows the chefs to create delicious, affordable meals while supporting area farmers. The menu is tapas style, with small shareable plates, perfect for leisurely lunches or dinners.

The concept of a New Moroccan cuisine has only been taken seriously in the motherland over the last couple of years, and only very recently in Fes. Chef Najat Kaanache, whose résumé includes stints at trendsetting restaurants El Bulli and Noma, opened Nur in September 2016. Designed by Stephen di Renza (creative director at the Jardin Majorelle boutique in Marrakech), the space has a monochromatic vibe that’s offset by stunningly beautiful plates of food that include innovations like duck confit on herb “meringue,” cured shark on Moroccan corn bread, and grass-fed beef adobo and potato hearts. This is a bright new chapter in Fes’s culinary evolution.

After 80 some odd years as one of Houston’s most lauded and refined hotels, the historic Warwick Hotel went from Bach to rock, when new owners gave it a slick makeover and renamed it Hotel ZaZa in 2007. A bold beacon in the Museum District, the dimly lit hotel is a virtual playground for adults, with daring decor, baroque details, and an outdoor pool with private piazza-themed cabanas. While it maintains much of its original 1920s architectural elegance and details, including Baccarat chandeliers, the interior walls are splashed with modern art and iconic editorial-photo shots of beloved celebs.

Many rooms and event spaces are themed, including the space-inspired “Houston, We Have a Problem” Suite and the Conspiracy Room, which nods to Prohibition. A recent refresh includes newly renovated 11^th-floor meeting rooms, new mattresses, new carpet, spa and fitness center upgrades (including treatment room tweaks and the addition of innovative infrared saunas), and new in-room flat-screen TVs. Bottom line: even an overnight stay feels like a true escape.

The largest and most storied of the Sydney Harbour islands, Cockatoo was once an Aboriginal fishing ground, a naval shipyard, a girls’ reform school, and a gruesome prison. Today, it offers fascinating walking tours, a casual café, and a number of events such as the Biennale of Sydney. When most visitors line up in the evening to catch the ferry home, those staying on the island are just setting off on a leisurely sunset stroll. They can watch the city light up from what feels like another world and then retreat to their campsite, canvas “glamping” tent, heritage home, or modern apartment until they wake up to birds and boats the next morning.

In the shadow of Buckingham Palace lies Fortnum & Mason, the department store with a royal warrant famed for its loose-leaf tea, luxury picnic hampers and sweet treats, including an excellent selection of macarons. You can buy all of these inside the store, as well as browse the gentlemen’s department, and cast your eyes up to the spectacular atrium, but the real highlight of a trip here is the afternoon tea, served in a gilded Diamond Jubileee Tea Salon, opened in 2012 for the Queen’s Diamond Jubilee. An accompanying piano player sets the tone: at high tea, you can expect a charming display of finger sandwiches, individual pastries and cakes from the cake carriage, and scones served with Somerset clotted cream and Fortnum’s lemon curd. The extensive champagne list is also not to be ignored.

Chef Thierry Blouet’s Café des Artistes made an immediate impression on the region when it opened inside the JW Marriott Los Cabos Beach Resort & Spa in Puerto Los Cabos. Blouet has spent more than a quarter century perfecting his Café des Artistes concept, one that blends gourmet French techniques with highly curated Mexican flavors. The results are magical: A tuna tartare is stacked delicately with pickled vegetables, avocado slices, and crispy fennel; pork belly is served with hibiscus and red wine sauce; and shrimp comes with a plum-habanero mole. The setting is equally striking: A sophisticated dining room opens to a terrace with breathtaking views of Cabo San Lucas Bay and, in the distance, city lights.

A short ferry-ride from Playa del Carmen, Isla Cozumel is a diver’s paradise. And while diving and snorkeling might be the main attraction here, the island and its town San Miguel de Cozumel offer a lot of land- and sand-based activities for the traveler as well. San Miguel de Cozumel’s main plaza is a peaceful spot to people watch, shop, and dine. Even though this town sees thousands of tourists a year and shiploads of cruise-goers dock here daily, it has managed to keep its charm and warmth. For some scrumptious grub, check out Kinta, a block or so off the main plaza on Avenida 5-- it offers up fresh seafood and traditional Mexican cuisine. The western side of the island is built up with beach clubs, where for a small fee you can enjoy their beaches and facilities-- Isla de la Pasión is one of these and boasts a gorgeous beach. The eastern side of the island is wilder and the surf too dangerous for swimming in most places, with the exception of Playa Chen Río. When you get tired of the beach, put on your Indiana Jones hat and travel inland to a minor Maya ruin, San Gervasio, which the ancient Maya dedicated to Ixchel, the goddess of fertility. Of course, this island was built around diving and you’ll see why once you hit the clear, turquoise waters and behold their technicolor reefs. Santa Rosa Wall and Palancar are two of the best dive spots. Dive shops abound for equipment rental, tours, and even certification lessons.

With his high-concept McCrady’s and his more rustic Husk—both in Charleston—chef Sean Brock transformed perceptions of Southern cooking from heavy, simple fare to a culinary tradition that is rich, complex, and filled with history. He worked with experts to resuscitate countless heirloom vegetables and grains lost to the agriculture industry, many of which reflect the region’s deep immigration roots (rice varieties from China; spices from Africa). He also changed the game with this simple rule: No ingredient north of the Mason-Dixon may enter the kitchen. Husk Nashville, which Brock opened in 2013, applies the same philosophy, but this time the menu is a nod to the bounty of inland Tennessee. In a 19th-century former residence in downtown Nashville, the James Beard Award–winning chef serves up his modern spin on classics such as pimento cheese, paired here with benne wafers, pickled jalapeños, and chipped beef. The Tennessee-raised pork prime rib, paired with cabbage, pecan butter, and molasses vinegar, is impossibly tender. Leave room for the vegetable plate, which highlights the best of the season’s produce.