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The English novelist D.H. Lawrence came to New Mexico to recuperate after being diagnosed with tuberculosis. This 160-acre ranch, gifted to him by Mabel Dodge Luhan, is where he started work on his novel The Plumed Serpent. He wrote underneath a tall ponderosa pine, immortalized by Georgia O’Keeffe in her painting The Lawrence Tree. Take a tour of Lawrence’s estate, including the famous tree, “standing still and unconcerned and alive,” as Lawrence once wrote.—By Edmund Vallance

Wealthy New York heiress Mable Dodge Luhan was a lifelong patron of the arts. D.H. Lawrence and Georgia O’Keeffe were among many artists and writers invited to stay at her house in Taos. These days, the picture-perfect adobe lodge (built in 1918) operates as a bed and breakfast-cum-art retreat. Hone your painting skills on a five-day course or bed down in “The O’Keefe Room” on the second floor, where Georgia slept during her frequent visits. —By Edmund Vallance

An ivy-covered, 17th-century mansion near the beautiful Place de Vosges is now the site of an intimate, five-star hotel. A favorite of sophisticated travelers who value privacy over hype, Le Pavillon de la Reine (named “Reine” in homage of a stay by Queen Anne of Austria) features striking interiors that blend original architectural details and aristocratic portraits with bright colors and contemporary furnishings. The 56 rooms and suites are similarly posh, with touches like patterned wallpaper and textiles, antique chandeliers, marble mantles, and flower-filled window boxes, plus luxe Codge bath products.

Opened in 2012, the Alpina is one of only two newly built, five-star hotels in Gstaaad in more than a century. Situated in a wealthy hilltop area in Oberbort, the hotel offers stellar views of the Bernese Alps (including the Spitzhorn and Oldenhorn) and the valley scenery of the Saanenland—as well as an impressive amount of discreet luxury. Built in traditional Swiss chalet style, the limestone-and wood-structure contains 56 rooms and suites that pair antique and artisan furnishings (wardrobes, tables, carved ceilings) with contemporary design pieces. All rooms have great views, though the higher the better; on the 5th and 6th floors, you’ll find the jaw-dropping, duplex Panorama Suite, with separate dining and working areas, and a fireplace. Furthermore, throughout the hotel’s public spaces, guests can see art by famous artists like Barbara Kruger, Tracey Emin, and Bosco Sodi.

The hotel facilities are some of the best in Switzerland, ranging from an authentically Cuban-style cigar lounge to multiple Michelin-starred restaurants. The hotel’s Six Senses spa spans a whopping 21,500 square feet and includes an 80-foot-long lap pool, while an immaculately landscaped garden, designed by French garden designer Jean Mus, brims with Alpine plants and corresponding fragrances in the summer.

Watching the sun set on Jamaica‘s west coast is a bona fide activity. The island’s red skies are a sight to behold. I have yet to experience a better Caribbean sunset than in Jamaica. From Montego Bay all the way to Negril--famous for having the best--to Whitehouse, get your camera and Red Stripe ready for the last hours of daylight. You won’t lack for choice of seafront bars or scenic spots--from the trendy Pier One in Montego Bay to the wooden shack watering holes along Negril’s West End cliffs. Wherever you end up, there’s a very good chance you’ll get hooked on this daily sunset viewing routine.

Designed by 19 of the world’s top architecture and design firms (three of which have already won the Pritzker Prize), the Hotel Silken Puerta América Madrid may be the world’s ultimate design hotel. A colorful, towering ode to the best of modern design, the hotel is unlike anywhere else, with each distinctive floor imagined by a different creative, including the likes of Zaha Hadid (her vision is an undulating space-age den of all-black or all-white rooms and smooth fiberglass surfaces) and Jean Nouvel (his gradient exterior is just the tip of a vibrant, imaginative iceberg). John Pawson imagined the Zen-like, all-wood lobby, while architect Teresa Sapey created what may be the world’s only whimsical, design-conscious parking garage, a brightly colored and well-lit space inspired by Paul Éluard’s poem Freedom, which adorns the building’s facade.

Despite each floor’s unique and avant-garde aesthetic, the Hoteles Silken group refused to compromise on luxury, guaranteeing top-notch service and every modern amenity one would expect from a five-star hotel. And don’t forget the acclaimed restaurant, two trendy bars (one on the rooftop, with postcard-worthy views), and the indoor rooftop pool.

If you are more interested in the night life of Lisbon, I highly recommend to stay in the area of Barrio Alto, known as the nigh-life and entertainment district of Lisbon. One of the most beautiful hotels in Barrio Alto is LX Boutique Hotel, which was a historic building, that turned into the current hotel. Each floor in the hotel is designed and dedicated to a concept related to Lisbon; One floor is dedicated to the fado music, another floor is dedicated to the Tagus river, and others are dedicated to Barrio Alto, the Seven Hills of Lisbon, and Fernando Pessoa, one of the greatest poets of Lisbon. If you are looking for a great night hang out, just cross the street to Pensão Amor, one of my favorite bars in the city. LX Boutique Hotel, Rua do Alecrim 12, Lisboa

Since its founding in 1903, the DMA (as locals call it) has grown to become one of the top 10 largest museums in the country, with a permanent collection of over 24,000 works culled from around the globe and spanning over 5,000 years of history. Works by boldface Western names like Renoir, van Gogh, Warhol, Rothko, O’Keeffe, and Wyeth lead to extensive collections dedicated to art and antiquities from Africa, Asia, and South America; in between, limited-run exhibits might focus on Native American works, Asian textiles, or emerging contemporary artists. In addition to hosting popular events that engage the whole family, the museum is also committed to supporting Texas artists via foundations and special programs, and offers a searchable Texas artists database to help spotlight these native sons and daughters. Dine on casual, gluten-free Mediterranean fare at the plaza-side Socca, or head to the ever-popular DMA Cafe—set in a striking atrium—for globally flavored dishes inspired by works in the permanent collection.

Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

Once a separate municipality, San Ángel—in the city’s south, nestled into its western foothills—is a leafy, genteel enclave whose relative isolation adds a soigné feel (for better or worse) you won’t find in neighboring Coyoacán. Ground zero for promenading is quaint Plaza San Jacinto, whose cute parish church (and beautiful cloister garden) is a sort of spiritual last stand amid the surrounding area’s high-toned consumerism. That said, the plaza’s true spirit comes alive Saturdays, at the so-called Bazar Sábado, an artisanal market that fills the area with stall after stall of handmade jewelry, textiles, crafts, and accessories, plus a great deal of art—some finer, some less so—in styles that go from hippie to haute. Strolling musicians and performers add to the carnival atmosphere.

An address won’t help you much on Burano. If you’re looking for a specific spot on this tiny archipelago off the Venetian coast, let color be your guide. According to legend, island homes were painted in vivid hues to help fishermen find their way in the fog as far back as the 6th century. While neon shades of blue, green, orange, and lavender may seem random, they’ve been determined by a regulated system for centuries. Even today, property owners must request permission and a selection of permissible colors from the Italian government before slapping a new coat of paint on their aging buildings. Visitors who make the 45-minute vaporetto ride from Venice to Burano are rewarded with a kaleidoscope of tropical hues and a serene island ambience that seems worlds away from the madding crowds in Piazza San Marco. While edible vestiges of its roots as a small fishing village remain in waterfront restaurants serving up heaping plates of frittura mista, seafood risotto, and spaghetti vongole, Burano is better known today for its hand-hewn lace and colorful homes. In the 15th century, its artistic prominence surged when island women began making the famed lace. Demand peaked after Leonardo da Vinci visited to shop for the Burano lace that covers the main altar of the Duomo in Milan. If you’re lucky enough to visit Burano during the pre-Lent Venice Carnevale, you may find new dimensions of color on its four canal-laced islands and picturesque footbridges. A multicolored palette of some 3,000 islanders provides a rainbow of backdrops for costumed revelers. Primping and posing, the fantasy personae inspire storms of clicks from photographers eager to capture the visual feast.

This late-19th-century city-owned seafood market, which was by and large abandoned after Hurricane Katrina, was reborn as an upscale food hall several years ago. The dilapidated structure was spruced up and the navelike interior painted an austere, modern white. Then a dozen or so food vendors moved in, serving as a sort of incubator for those with an idea but no desire to go the food-truck route. It’s a great place to swing by for lunch or a casual dinner—you can get craft cocktails and spend some time at the oyster bar, then browse the other offerings, which include crab mac and cheese at Fritai and alligator-sausage hash at Elysian Seafood.

Skip the hassle and haggling of street souvenir shopping—and be assured of the quality of the goods—at this government-run emporium stocked with examples of all of Rajasthan’s signature arts and crafts. It’s easy to get carried away amid the swirl of colors and textures, surrounded by hanging wooden puppets dressed in traditional garb, shelves lined with bright blue-and-yellow pottery, and stacks of block-printed and tie-dyed textiles. Larger items like rugs, trunks, and furniture (including bed frames, cabinets, and doors) will probably need to be shipped, while giftables like painted picture frames, carved figurines, pillow cases, brassware, and embroidered wall coverings should fit nicely in a second suitcase.

Another one of Tahiti’s “I can’t believe it’s real” spots is the Maraa Grotto: impossibly lush freshwater pools, small caves and the dripping grotto itself, ringed by ferns, which Paul Gauguin mentioned in his letters home (taking time away from his usual whining for loans; poor guy didn’t exactly live the life he painted). It’s frequently bundled with tours to Point Venus.

Located in historic downtown Williams, Arizona, just outside of Grand Canyon National Park, Red Raven Restaurant is cozy and casual with a brick exterior painted fire-engine red. The kitchen is small but sends out gourmet comfort food to diners seated in its high-ceilinged dining room. They tuck into dishes such as portabella and zucchini fries with a balsamic reduction sauce, broiled pork medallions topped with cilantro pesto and tempura-style broccolini, and a lamb and vegetable stew made with Guinness. Seating at this husband-and-wife–owned establishment is limited, so definitely call ahead.