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Why we love it: An apartment-style hotel designed by acclaimed architect Jean Nouvel

The Highlights:
- Individually decorated rooms with modern appliances created for longer stays
- A thoughtful mix of modern and historic design elements
- A rooftop lounge that looks out over the Roman Forum

The Review:
When the Fondazione Alda Fendi-Esperimenti acquired the Palazzo Rhinoceros—a 17th-century palace near the Roman Forum—and handed renovations over to Jean Nouvel, something special was bound to happen. The renowned French architect transformed the historic palace a stone’s throw from Rome’s birthplace on Palatine Hill into a 24-apartment sanctuary for guests staying anywhere from one night to one year.

The apartments—which all have kitchens designed for longer stays—each have their own unique layout with sliding steel walls so you can close off the living room from the bedroom, or create one massive space. Even though the use of steel materials and contemporary furnishings makes for a thoroughly modern atmosphere, Nouvel kept some old paint intact and installed window panels with photographs of the space before renovations to help tie the property to its historic location. For the best views in the building, head to the six-floor terrace, where you can take in the sunset over the Roman Forum with a cocktail in hand.

If there were ever a hotel with history, it’s the Singular Patagonia. Opened as a hotel in November 2011, the original building once served as a post-Victorian cold-storage factory built by the British in 1915 for the purpose of processing sheep’s wool and meat to be shipped back to England. Overlooking the waters of Last Hope Sound, the long, red-brick building is located just outside the town of Puerto Natales. After operating for almost 70 years as a factory, it was declared a national historic landmark before being transformed into a luxury hotel.

History is by no means forgotten. The hallways are still stocked with brightly colored machinery—from steam condensers to boilers and forges—all stamped with the name of the British city in which they were built: Derby, Birmingham, London, or Glasgow. Designed by Chilean interior designer Enrique Concha and local architect Pedro Kovacic, the 57 bedrooms stretch along a new wing that was added to the original buildings, and these rooms are furnished with Victorian-inspired furniture.

Located across the Tiber River from the Centro Storico, Trastevere is a kaleidoscope of ivy-covered buildings, complicated Italian history, and bombastic nightlife. The heart of the neighborhood is Piazza Santa Maria, a large square where street performers show off their stuff, and Porta Portese’s massive Sunday flea market. Film buffs can take a walk through the maze-like side streets for a glimpse of director Pier Paolo Pasolini’s early life before heading off to one of the neighborhood’s many bars for a craft beer or aperitivo.

Michelin-star chef, and virtually self-taught man, Francesc Rovira’s cafe and restaurant in sleepy Gombrèn is not centrally located for gastronomy enthusiasts to find. Far from Barcelona, but not too far to drive for a day, nestled in the Pyrenees - it is worth its own adventure. Rovira is one of many chefs who cooks with local ingredients and because mushrooms are so important to the region he cooks, mushrooms are one of his most well used ingredients. From the nearby forest at Montgrony he sources fungi in varying colors, shapes and sizes - only purchasing what he cannot pick himself because he is now known for the way he uses this ingredient. If mushrooms aren’t your thing, venture to Fonda Xesc anyway. The pumpkin soup with elderberry ice cream was a revelation in my mouth and the wine pairings were some of the best I’ve ever experienced. There’s no pretention in Rovira’s restaurant, only very good gastronomy.

Central Mexico’s Bajío region—San Miguel sits at its heart—is high mountain desert, with a landscape quite worthy of exploration. The 445-acre nonprofit nature preserve called El Charco del Ingenio—named a Peace Zone by the Dalai Lama in 2004—is a prime destination for nature lovers, thanks to miles of trails, an extensive botanical garden, and a fascinating wetlands preserve. Spend all day if time allows—an on-site café provides nourishment to keep you going.

The cobalt-blue-and-brick-red residence where now-legendary Mexican visual artist Frida Kahlo grew up—and at times lived with husband Diego Rivera—is one of the city’s most consistently packed attractions; buying tickets in advance is strongly recommended. That said, the visit is essentially (and justifiably) mandatory and offers fascinating glimpses into this extraordinary woman’s life and work. In addition to holding some of her paintings, the house also functions as a showcase for her library, astounding wardrobe, and collection of pre-Columbian artifacts; it additionally bears witness to her close association with left-wing politics. What’s more, the museum portrays the artist’s struggles with depression, marital infidelities, disability, and illness. The house’s garden—home to a modest café and mostly bashful felines—makes for a great breather before more strolling in the Coyoacán neighborhood.

To the northwest of central Copenhagen, much-photographed (though less frequently visited) Grundtvigs Kirke is notable as a rare example of a church constructed in the expressionist style. Architect Peder Vilhelm Jensen-Klint won a design competition for the church commission in 1913, but World War I delayed construction until 1921, and the structure was not completed until 1940. (Jensen-Klint was also responsible for the surrounding residential development.) Grundtvig’s monumental and severe exterior was inspired by traditional Danish churches, while the soaring interior is filled with light that pours through the clear windows on sunny days and illuminates the pale yellow bricks. A bit off the beaten path, the church is about a 20-minute bike ride from the city center. The trip takes longer if you use public transportation, so do as the Danes do and hop on a bike.

It was 1852 and Argentine society was so polarized, the country’s very existence was threatened. Thus, Club del Progreso was born as a gentlemen’s retreat whose noble goal was to unite the nation’s political factions through thoughtful discussion and cooperation, thereby ensuring Argentina’s progress. The club still hosts academic debates on issues of national interest, and its stately, wood-paneled dining room, hung with dazzling chandeliers, frames an elegant, historical setting for trying classic Argentine fare like roast suckling pig or revuelto gramajo (scrambled eggs with potato and vegetables).

Sicily is known the world over for its fruits, fish and wines. You’ll find these and other delicious edibles at the local markets. The Mercato Vascone (near the cemetery), Mercato Sant’Orsola and Mercato Zaera (on Viale Europa) are all open daily except Sunday until 1 p.m. On Sundays, you can visit the Mercato del Contadino (farmers market) at the Piazza del Popolo. Edibles you can take home include jams and preserves, vacuum-packed olives, olive oil, wines, dried fruits, pasta and cookies—Sicily has some of the best sweets in all of Italy.

There are now 35 locations of Eataly, the massive Italian food hall, around the world, with 18 of them in Italy itself. The New York City one at Fifth Avenue and 23rd Street, which opened in 2010, was the first in the United States (it’s been joined by others in Boston, Chicago, and Los Angeles, as well as by a second outpost in Manhattan, near the World Trade Center site at 101 Liberty Street). For connoisseurs of all things Italian, this is a must-visit—or, more accurately, a must-shop and must-eat stop. Covering more than 50,000 square feet, Eataly NYC Flatiron includes five different restaurants (plus occasional pop-ups) offering opportunities to graze on antipasti, fish, pizza, and other dishes. A popular rooftop beer hall is open all year round (thanks to space heaters and a retractable roof). While you will want to eat your gelato on the spot, there are also a number of stores where you can buy gifts from biscotti to olive oils to take home a little bit of Italy via New York.

Part of the revitalization of the city of Santa Marta is this new addition to its cultural offerings. The Tayrona Gold Museum (Museo del Oro Tairona), named after the Tayrona culture, which dates back to at least 100 C.E., has a fascinating collection of pre-Columbian gold jewelry and other artifacts, as well as displays about the region’s history. A centerpiece of Parque Simón Bolívar, the museum is located in the restored 16th-century former Customs House (Casa de la Aduana), one of the earliest buildings in Santa Marta and an important artifact in itself.

Cañón de la Zorra (Fox Canyon) and its 40-foot waterfall are just north of Santiago, a sleepy yet charming colonial-style town 35 miles north of San José del Cabo, across the Tropic of Cancer. The hike to the waterfall takes you through oases with endemic plants and gives you glimpses into a Baja outback that existed before the region became a popular tourism destination. There’s a great area for swimming as you admire the waterfall and multicolored granite cliffs. Tip: On your trip back to Los Cabos, stop by the Agua Caliente, Santa Rita, and El Chorro hot springs about five miles south of Santiago.

The classic, late-morning Mexican breakfast (quite good for hangovers) is typically spicy, abundant, and sophisticated in ways quite distinct from the brunches that have become synonymous with the urban weekend—think solid, cold beer instead of innovative mimosa iterations. But for one of the town’s signature Mexican breakfasts, in one of its lushest courtyard gardens, try the Yucatecan fare at La Casa del Diezmo. And if you just can’t shake where you came from, the eggs Benedict at Lavanda prove to be artistic creations indeed, akin to lotus-flower sculptures.

Not everyone gets to live across the street from the White House. Before the current Italian-Renaissance hotel was constructed in 1927, the prime real estate was occupied by the homes of two little-known American icons: John Hay—personal secretary to Abraham Lincoln, ambassador to the United Kingdom, and Secretary of State under both William McKinley and Theodore Roosevelt—and Henry Adams, Harvard professor and great-grandson of John Adams. Their houses were hubs of D.C. culture for decades at the turn of the last century, and so, when the Hay-Adams opened, it was only logical that the hotel would continue that tradition. Washingtonians play at the sultry bar scene, everyone from Amelia Earhart to the Obamas has stayed in its elegantly Old World rooms overlooking historic Lafayette Square and the White House beyond, and the hotel is known for its discreet and comprehensive, no-questions-asked service. Should guests need a ride to one of the District’s many important meetings, the house Mercedes drops off anywhere downtown, guaranteeing a first impression worthy of a luminary. Though if you insisted on the meeting coming to you, no Beltway insider would mind.

This hotel is on our list of the best hotels in Washington D.C.

Oaxaca’s Casa de la Ciudad is housed in a big yellow building just a couple of blocks from the Zocalo. On the ground level you’ll find the Andres Henestrosa memorial library which contains over 50,000 volumes, and some rooms that are used for temporary exhibits. Make your way across the central patio and up the steps to the second floor, where you’ll find, among other things, a room that has two very large aerial photos (about 12 square feet) of Oaxaca city on the floor. One of the photos was taken in 1990, and the other in 2006. They call this the “foto-piso” (photo-floor). It’s fun to walk over it and pick out landmarks and see how Oaxaca has changed over time. The Casa de la Ciudad often has exhibits dealing with urbanization and architecture, and it also hosts workshops, concerts and other events. It is open daily from 9 am to 8 pm, and admission is free.