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The former residence of Würzburg’s prince-bishops, this UNESCO World Heritage site is one of the most important Baroque palaces in Europe. It was—remarkably, given its scale and level of detail both inside and out—built almost entirely within a single generation. Court architect Balthasar Neumann oversaw the construction, while leading architects from Germany and France created the fabulous ornamentation. Woodcarvers, sculptors, and artists from Italy—including Giovanni Battista Tiepolo, regarded as one of the greatest fresco painters of the 18th century—also contributed to the design.

Rebuilt after World War II, the palace now features a bevy of architectural styles, from German and Viennese Baroque to French château. Inside, the White, Imperial, and Garden halls are can’t-miss attractions, as are the grand staircase and ceiling fresco by Tiepolo and the Mirror Cabinet. Before leaving, be sure to take a walk in the court gardens, which feature fountains, charming yew trees, and a group of cherub statues by Johann Peter Wagner.

This former royal palace is one of the largest museums in the world, and its art collection is considered one of the most comprehensive. It contains around 400,000 works, although—mercifully, perhaps—not all are on display at any one time. There are some pieces that never get taken off the walls. The Mona Lisa and her smile attract millions of visitors each year. Other must-see masterpieces include the sculptures Winged Victory of Samothrace and Michelangelo’s Rebellious Slave, and the Eugène Delacroix painting The Death of Sardanapalus. There’s no real trick to avoiding crowds at the always-packed museum. The best you can do is try to go in the off-season, early or late in the day, and on a weekday. Your chances of being alone with the Mona Lisa will still be slim to none, but you might be able to actually see that enigmatic smile behind the Plexiglas.

This leather workshop is hidden away in a former Franciscan monastery next to Santa Croce. The Scuola del Cuoio was originally founded to provide skills and work for some of the city’s orphans after World War II; masters and apprentices still produce wallets, purses, journals, and jackets. Take a quick tour of the beautiful cloisters, frescoed corridors, and workspace, or sign up for a full workshop and try your hand at making something of your own. Everything is crafted on-site using traditional methods. Be sure to get your purchases personalized with a gold-stamped monogram.

Chile en nogada is a poblano chile pepper, stuffed with peccadillo (shredded meat, aromatic diced dried fruit and spices), topped with a walnut-cream sauce and pomegranate seeds. This dish from Puebla is not often found on menus of Mexican restaurants in the U.S. It’s not even that common south of the border, except during the August-September season surrounding Mexican Independence Day. If you’re in downtown Tucson, however, you can try it at Penca. In a repurposed space with exposed brick and hip cocktails, this restaurant is also a worthy destination for brunch or late afternoon tacos. Choose from carnitas, fish, lengua, cabeza, nopales, carne asada, and more. The corn-tortillas are handmade right after you place your order. (The tortillas alone are almost worth the trip.) Mexico City is the inspiration. The food is fresh, and the scene is full of optimism: downtown Tucson is reinventing itself with a new streetcar for a live-work-play vibe. Taste and see how this desert city continues to evolve. (Penca has recently been named one of the best bars in the country. Start your meal here with a creative cocktail!)

The church of the mission of San Jose del Cabo is simple, both inside and out, but one of its charms is a special area where locals tie ribbons with petitions for divine intervention or expressions of thanks written on them. If you’d like to join in on the tradition and express your thanks, choose a white ribbon and write about what you’re grateful for on it. Then, tie it to the rack near St. Charbel Mahklouf, the somewhat obscure Lebanese saint who is believed to work miracles.

A local favorite, Bar La Ranita (Little Frog) is attached to the Hotel Rana Cansada (Tired Frog) and has been around since 1984. The ambiance is laid back, but the prices are affordable and the margaritas pack a powerful punch.

Founded in 2004, this exquisite Chinatown boutique sells unique jewelry pieces designed by Cindy Yokoyama. “I started as a painter and fell in love with abstraction,” she says. “Many of my pieces still reflect elements of this, including asymmetry.” She also plays with order and chaos, and mixes urban elements with natural organic ones beautifully. Expect seeds and shells mixed among metallics... and the azure hues of Hawai‘i’s sea and lush greens of its slopes. Of special note: earring sets where two teardrops complement each other, rather than matching—showcasing stones like lapis lazuli, fossilized coral, and bumble bee jasper.

Located on the island of Djurgården, this purpose-built maritime museum is an extraordinary sight: It houses the massive warship Vasa, which sank just minutes after launching on its maiden voyage in 1628. Raised from the harbor in 1961, it was painstakingly reassembled to its original glory. Head straight to the auditorium to watch a documentary about the salvage, and then slowly meander through the rest of the fascinating exhibits.

Rembrandt purchased this sizable former merchant’s house in 1639, when he was at the peak of his fame as a portraitist of the city’s elite. He lived, painted, and taught in the multistory building for nearly 20 years, and on the topmost floor—the site of his studio and workshop—crafted what is considered his masterpiece, the Night Watch. The home’s interior is not original but rather a faithful re-creation, based upon a room-by-room inventory conducted after the artist declared bankruptcy in 1656 and was eventually forced to leave. Be sure to catch the free daily paint-preparation and etching demonstrations; the former is particularly interesting to understand how difficult—and expensive—it was to acquire and process paint in that era. Though there are no Rembrandt paintings at this museum, you will find a large number of his superb etchings on view in the ground-floor exhibition space.

One of Playa’s newest hotels, Cacao is being touted as a “kicked-back, relaxed ‘hippie chic’ boutique, 60-room hotel. Conveniently situated on Playa del Carmen’s 5th Ave. in the heart of the destination’s fashionable restaurant, club and boutique scene it is also walking distance to the beach. Spacious, modern rooms and suites provide comfortable amenities, including bathroom toiletries by Italian fashion designer Missoni and distinctive touches by architect Rodrigo de la Peña. Dramatic architectural elements such as huge canvas accents in geometric shapes and a central court with a hyacinth lily pond combine with clean interior design and contemporary, bold color accents. The roof-top bar boasts innovative “coctelería” (mixology) experiences, along with spectacular views of the Caribbean and Cozumel Island as a scenic backdrop. Onsite Nibs Restaurant dishes up gourmet food in a serene setting, while a rooftop pool provides a refreshing escape

Just to the southwest of Tucson, on the San Xavier Reservation, sits the late XVIII-century Mission San Xavier del Bac, one of the finest examples of Spanish colonial architecture in the U.S. The combination of late Baroque and Moorish-inspired design is a beacon any time of the year, but on this winter day, the flooded fields worked some magic—panoramas of reflected landscapes are almost nonexistent in southern Arizona! The ‘white dove of the desert’ is the oldest intact European structure in Arizona, and it still serves as a parish church for the Tohono O’odham people.

This is a quintessential stop on any Grand Canyon itinerary. Constructed using native stone and Oregon pine, El Tovar Dining Room in El Tovar Hotel (which opened in 1905) is a longstanding landmark that’s hosted everyone from Theodore Roosevelt to Paul McCartney. The menu reflects regional Southwestern flavors and is filled with dishes showcasing local ingredients, such as the red chile tamale with adobo crema and the pork chops with apple-jalapeño chutney (inspired by the restaurant’s 1946 menu). Before you sit down to dinner, be sure to catch the sunset on the small outdoor patio. And definitely check out the wine list. There are plenty of tasty local varietals grown in regions all around Arizona.

This Cuzco corner presents a notable juxtaposition between ancient Incan and Spanish colonial architecture. Since the Incas worshipped their sun god, Inti, above all others, this temple in their imperial capital was the most important of the entire realm. It was here that they brought the idols of all peoples they assimilated, to offer them representation as they demanded allegiance in Cuzco. When the Spanish arrived, they tore down much of the temple and built a monastery on top of it. However, the walls that do remain provide stunning examples of pre-Hispanic engineering, particularly the rounded outer wall that can be seen from Avenida del Sol.

There is a staggering amount of artwork on display here. It is said that if you stood at each piece for just one minute, it would take you four years to see everything. Created by Pope Julius II in the early 16th century, the museums have expanded over the past 500 years to their current size of more than 12 acres! Highlights include the Borgia Apartments, the Raphael Rooms, the Gallery of Maps, and of course, the sublime Sistine Chapel.

At this luxury collection of six historic homes—some from the 16th century—guests can book a bedroom or an entire house, all within blocks of Santo Domingo’s most important attractions. You won’t find out which room or home you’ll be staying in until your arrival, but you’re sure to be pleased. Located in the heart of the Zona Colonial, the casas are exquisite. Two were part of former convents, one was a monastery, and another was once the private home of a famous Dominican fashion designer. Each one features unique decor and its own courtyard, and five of the six have private swimming pools. Upon check-in, you’ll receive a loaner iPhone to communicate with your house butler and the round-the-clock concierge team, who can help arrange excursions like culinary tours in the Old City and visits to one of the Caribbean’s largest organic cocoa producers.