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The beef goes back centuries, and will never be entirely resolved: what are the true origins of pisco, a grape-based, aguardiente distillate that became a national symbol of Chile…and Peru. To end the conflict, the people behind this bar and restaurant invented a new, independent republic dedicated to Pisco that is known as Chipe Libre. Inside a vast Lastarria mansion, this imaginary state unites lands in southern Peru and northern Chile, in obeisance to a sole monarch, pisco. The bar features a good 100 labels and cocktails like “Pisco’s in the Air,” made with lime juice, raspberry, papaya and basil; plus a full range of what are among Santiago’s best traditional sours. Standout food include the crunchy-seafood saltado (marinated and grilled beef strips), with mango, served on a sizzling grill; the joint’s star sandwich, El Presidente, is a solid slice of roast beef, fried egg, and shoestring potatoes. To avoid any sovereignty disputes, Chipe Libre flies its red-and-black, center-starred flag as the republic’s national colors.

The Blue Ridge Mountains stand in for the Black Forest at Grand Bohemian Asheville, a 104-room luxury property inspired by old-world Bavarian hunting lodges, complete with stag-antler chandeliers, rich velvet and brocade textiles, and a popular mascot in the lobby—a taxidermied wild boar named Zsa Zsa. In contrast to the more dramatic public spaces, rooms and suites are spacious and light with crisp white bedding and tufted headboards; almost all of the bathrooms have large tubs with shutters that open up to the sleeping area. In addition to the rare original artwork that’s scattered throughout the hotel, there’s a gallery featuring paintings, art glass, woodwork, and sculptures from local, regional, and international artists. George W. Vanderbilt’s Gilded Age castle is across the street, and the hotel is within walking distance of Biltmore Village’s popular restaurants and shops and only two miles from trendy downtown Asheville, making it a convenient jump-off for exploring the Great Smokies.

Situated just 40 miles from downtown Anchorage and the Ted Stevens Anchorage International Airport, this year-round resort feels worlds away, set deep in a glacier-carved valley off scenic Seward Highway. With 304 rooms and a dizzying number of amenities, it also feels like a world unto itself. There are eight dining and drinking options, a fitness center, a heated saltwater lap pool with mountain views, and a spa that provides Arctic mud facials. But guests come to Alaska to commune with the great outdoors, and Alyeska offers its fair share of world-class experiences, including the longest continuous double-black-diamond ski run in North America and more than 1,600 acres of skiable terrain. The staff can arrange excursions that range from heli-skiing and dogsledding tours in winter to naturalist-led walks and glacier cruises in summer. For breathtaking panoramic views, the resort even has its own 60-passenger aerial tram for whisking guests straight from the hotel up 2,300 feet to the top of Mount Alyeska.

Southern charm and Asian aesthetics meld seamlessly at the Mandarin Oriental, located on 15 floors of a high-rise building in the tony boutique-filled Buckhead neighborhood. Beyond a striking marble lobby, the 127 rooms feel like home—albeit a luxurious one—thanks to interiors by renowned architect Robert A.M. Stern. Plush carpets, large working desks, velvet-upholstered armchairs, and high definition LED televisions join bathrooms finished in black-and-white marble, with twin vanities, sunken tubs, and Atelier Cologne bath products. Whether you want to swim laps in the 60-foot swimming pool or simply unwind in the private English garden, the hotel is like a cocoon from the outside world; guests of the spa are welcomed with seasonal tea and an o-shibori, a Japanese steamed towel, before indulging in their massages and facials. But should you need to leave the bubble, the shops in Lenox Square are walking distance from the hotel, and free car service is available to take you within a two-mile radius.

Inspired by the famous Fox Theatre—the Moorish-style movie palace turned performance venue is just across the street—Hotel Indigo Atlanta Midtown strikes a musical note at every turn. The experience begins at reception, where the desk resembles a drum set and a collage of show tickets from the past 30 years decorates the wall behind it. Guest rooms riff on the theme with accent wall murals that make it look like you’re either attending a concert or starring on stage, but the overall vibe is playful comfort, with pops of green on the quilts, spa-like baths with Aveda products, flat-screen TVs, and free WiFi. If you find yourself hankering for soul food, the chicken and waffles at the on-site restaurant should do the trick, but don’t pass up a drink at the black-and-white bar counter, which looks like the keys of a piano and is backed by a wine display that evokes the inner workings of a jukebox.

In a new(ish) location overlooking the bay, this perennial Big Island favorite weaves local, organic, and free-range produce into culinary alchemy. Deceptively simple dishes dance on the taste buds; the rich umami of the mushroom potpie and the spicy ahi poke do a particularly fabulous fandango, along with the jalapeño-hamachi-belly sushi roll. The peppered beef carpaccio has a dedicated following, pairing soft grass-fed beef with sea salt and fried capers—as does the half-pound burger that comes topped with Gorgonzola. Even vegetarians can indulge here, starting with the cauliflower grilled with black-garlic aioli and moving onto a taro-quinoa veggie patty beside hand-cut fries. Make sure to save room for the legendary chocolate lava cake!

The café Saint-Régis, located on the quaint and quiet island of Ile Saint-Louis, just a few meters from Notre-Dame, is one of those cafés that make Paris what it is. Professional waiters in black-and-white uniforms tend from one table to another frantically, while locals talk all things fashion, philosophy, or politics, or quietly read an enthralling book by the window. While this scene was accurate 50 years ago and still is today, there are notable differences, technology-wise, as the café is equipped with free Wi-Fi. So laptops and smartphones abound, for the pleasure of Instagram users. Atmospheric, historic, cozy and, well, of course, pricey. That’s the Saint Régis. My favorite time to go? Right before sunset after a long stroll on the banks of the Seine in the winter, either outside under the warm lights or inside, away from the hustle. But regardless of the weather, it’s always a good time at St. Régis...

Fans of Georgia O’Keeffe should definitely book a stay at this quaint adobe hotel in her old painting grounds. Not only is there a well-stocked gift shop where you can buy O’Keeffe prints and books, the property arranges tours of her home and studio, and is located near the Ghost Ranch retreat center and the White Place rock formations, both of which the artist loved to paint. Wood-beam ceilings and New Mexico antiques adorn rooms. Request one of the cottages with wood-burning Kiva fireplaces, or if you come in winter and book economy like I did, you’ll likely get upgraded to a nice room with a gas fireplace. My best meal in New Mexico was also enjoyed here. I ordered trout stuffed with corn pancakes and a chardonnay from nearby Black Mesa winery. My partner’s chili rellenos with green chili and Monk’s Ale—brewed at the Christ of the Desert Monastery about an hour away—were also tasty. It was a lovely introduction to the beautiful state.

To begin to understand the true wilderness that occupies most of the southern tip of Florida, there is nothing like a visit the 734-square-mile wetland preserve of Everglades National Park. More than a national treasure, the park is a UNESCO World Heritage Site, deemed important to the greater culture of all of humanity, and is the largest tropical wilderness in the USA. Among the many and diverse species that dwell here are manatees, Florida alligators, American crocodiles, Florida panthers, and the state’s elusive black bear, in addition to several unwanted invasive species including Burmese pythons. From Miami, the best access point is Shark Valley, where you can ride a 15-mile loop through the park aboard a tram, climb an observation tower for panoramic views, and walk out to viewing decks to spot alligators, birds, and more. For the more adventurous, there are several outfitters who can take you deeper into the Everglades on kayaking tours to visit a pristine wilderness few people on the planet get lucky enough to witness.

Gothic and grand, this 18th-century former nobleman’s home stands proudly on the banks of the Grand Canal in the San Marco district. Venetian-born owner and interior designer (among her many talents) Francesca Possati has restored this historic home to its regal glory. She has worked with local artists to breathe new life into original woodwork, ornate trompe l’oeil ceilings, and silk wall hangings, resulting in a once-again polished and posh palazzo. The distinctly Venetian rooms—many with canal views—are styled with rich fabrics, bold wall coverings, and pristine period antiques and illuminated by Murano glass chandeliers. Of course, they’ve been updated with the latest modern perks (like Italian marble and whirlpool tubs in the bathroom).

Stroll the art-filled hallways, splurge for a tasting menu at the elegant restaurant, and watch the gondolas float by from the red-awninged terrace. La dolce vita, indeed.

The Aubrey sits at the edge of Barrio Bellavista, a few steps from Santiago’s bottle-green 1925 funicular (which takes visitors up to Cerro San Cristóbal) and just below the zoo (sometimes guests can hear the animals when they’re lying by the pool). Open since 2010, this 15-bedroom boutique hotel is housed between two 1920s mansions built by the same architect. The larger of the two houses once belonged to famed Chilean railway magnate Domingo Durán. Today, the hotel is owned by a Brit and an Aussie who spent $3 million and several years transforming it into its current state.

The bedrooms are split between the two mansions, and there’s also an outside block housing a few pool suites. A cobbled terrace runs between the restaurant and piano bar. The interiors are inspired by the early 20th-century art deco movement and feature statement art deco furniture, printed fabrics, and elaborate wallpaper.

One of the most widely sold mineral water brands in Argentina comes from Villavicencio, a private nature reserve located on the way to Uspallata, about an hour from downtown Mendoza. It is a historic route because General San Martin took it on his way to Chile to free Argentina from the Spanish crown. The road leading up to Villavicencio has a dizzying 365 curves and has been given the name “Camino del Año” or “Road of the Year”. On the reserve is a picturesque hotel and spa built in 1940, where the wealthiest families in Mendoza used to summer vacation, bathing in the crystal mountain waters and natural hot springs. Today, the hotel has been named a National Historic Monument. It’s closed to the public, but you can hike around the hotel and surrounding nature reserve. There’s a $25 peso entrance fee that includes a guided visit. It’s open from Tuesday to Sunday, 9:00 AM to 5:00 PM.

(Note: Google insists this is Kamuela, it is Kohala) The lava coast of Kohala on the Big Island is dramatic. Waves dash against the black rocks relentlessly until eons from now they will be sand. True, there are fewer white-sand beaches per square foot of land on the Big Island than others in the Hawaiian chain, but the island is huge. Beaches here often hold secrets, are the sources of legends, and are part of the circle of life for creatures indigenous to Hawaii. There have been lava flows since the ahapua’a land divisions were formed, but from the very tops of the mountains running to the sea, most beaches remain intact. One of my favorites is in a little inlets fronting the Mauna Lani Bay Hotel on Makaiwa Bay called Keiki Beach. Not for much swimming, it is a sandy-bottomed dipper’s delight or, as the name states, a place for children (keiki) to play in. A tree for shade, sand, tide pools to explore, a canoe house (hale) covering a koa canoe nearby, and a friendly turtle (honu) who feeds here are all part of what could be a perfect day. There is surf off the point in winter and snorkeling in other seasons. You might even want to rinse off and have lunch at the Mauna Lani pool restaurant. Parking is a good 15 minute walk via a trail. Follow signs to public parking off Mauna Lani Drive, bring water and beach gear, and get there early. Of course you could stay at the Mauna Lani Hotel and Bungalows too. http://www.maunalani.com/

Spend the night nestled under the Golden Gate Bridge in the most dignified of accommodations: the former living quarters of high-ranking officers in the U.S. Army. Cavallo Point is the result of the luxurious reimagining of a cluster of military lodges located within the Golden Gate National Recreation Area, just over the bridge in Marin County. Today, the 142-room hotel serves as a retreat for in-the-know travelers and locals looking for an easy, elevated escape from everyday city life. Original brick fireplaces and beamed ceilings mingle with modern finishes and furnishings, such as butter-soft leather sofas and whitewashed Adirondack chairs. The expansive grounds are meant to be explored on foot or bicycle. The Wellness Weekend package includes all meals, prepared with an emphasis on health at Murray Circle restaurant, morning yoga classes, guided hikes, a spa treatment, nightly wine receptions, and plenty of free moments to soak in the serene meditation pool—the very best kind of boot camp.

The site of the premier Academy Awards after-party in 1929, this historic Beaux Arts hotel on the edge of downtown was recently updated for the first time since the 1980s. Today, The Mayfair’s grand, monochromatic lobby features original stone columns, light marble accents, plenty of skylights amid lofty ceilings, and impressive arches and alcoves with gray-velvet seating scattered throughout. The chic M Bar at the back glows under a lit-up, seashell-like sculpture. Rooms and suites have panoramic views of the city skyline and feature patterned wallpaper, black-and-white photographs of the city, and striped canopies draped over the beds.