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Set on 18 literally green acres, this amenity-rich hotel feels like a secluded retreat among the towering pines, sprawling oaks, and manicured grounds—despite its proximity to the bustling Loop 610 and the Galleria. It affords so much peace and quiet, along with accessibility, that President George H. W. and Barbara Bush used the Houstonian as their home address while he was in office, and stayed on property during visits back to Houston.

The lobby has a warm, luxury lodge feel with soaring ceilings, wood details, and a massive stone fireplace. Guest rooms feel more elegant and traditional, with lavish textures and verdant floor-to-ceiling views. Every room has a 42-inch HDTV, complimentary Wi-Fi, a Keurig coffeemaker, and terrycloth bathrobes. (There are 67 concierge-level rooms that include daily continental breakfast, after-dinner sweets and cordials, plus additional services.) For the nature-minded, there’s a mile-long walking trail around the serene property.

The Evergreen Brick Works, a reclaimed quarry in the lush Don Valley, is a showcase for sustainable and green living, as well as for urban design. A community has been established in this once-derelict industrial site and former landfill. Toronto’s largest farmers’ market sets up shop on Saturdays, and spotlights food from all over the province. On Sunday, the market shifts its attention to crafts. A full schedule of activities and diversions make this a perfect weekend escape: There’s a children’s garden (with weekly programming), bike trails and rentals, and a hike that leads to a rewarding view of the city’s skyline.

American entrepreneur Jim Thompson, who began his Thai silk business here in the 1940s, built himself a residence in 1959 by assembling six traditional teak houses brought from other parts of Thailand. Today, Thompson’s former abode is a museum that displays his extensive collection of rare Asian art and antiques. The gift shop sells high-end silk clothing (including darling children’s wear) as well as bags, scarves and home goods such as cushion covers, plus postcards and books.

Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

Once a separate municipality, San Ángel—in the city’s south, nestled into its western foothills—is a leafy, genteel enclave whose relative isolation adds a soigné feel (for better or worse) you won’t find in neighboring Coyoacán. Ground zero for promenading is quaint Plaza San Jacinto, whose cute parish church (and beautiful cloister garden) is a sort of spiritual last stand amid the surrounding area’s high-toned consumerism. That said, the plaza’s true spirit comes alive Saturdays, at the so-called Bazar Sábado, an artisanal market that fills the area with stall after stall of handmade jewelry, textiles, crafts, and accessories, plus a great deal of art—some finer, some less so—in styles that go from hippie to haute. Strolling musicians and performers add to the carnival atmosphere.

One of Dalmatia’s most underrated cities, Šibenik is finally being recognized as an exciting coastal destination. Its medieval heart is a stone maze of steep alleyways dotted with charming squares and hidden cul-de-sacs, not to mention a pretty harbor and a seafront promenade lined with cafés. Crowning it all is the Cathedral of St. James, an architectural masterpiece incorporating style elements of both the Gothic and the Renaissance. The cathedral is said to be the world’s largest church built entirely of stone—most of which was quarried in the nearby Adriatic islands. Of particular note in this UNESCO World Heritage site: the frieze of 71 heads on the cathedral’s outer wall, which depicts 15th-century citizens of Šibenik with many different moods and personalities.

It’s not that vegetarians aren’t welcome at Costa Mesa restaurant Vaca. It’s that they may not feel the same unbridled excitement as those who enjoy expertly prepared meat and seafood. The innovative lunch and dinner hot spot owned by former Top Chef contestant Amar Santana celebrates Spanish cuisine, from Andalusia, Seville, Madrid, Barcelona, and the Basque region to be precise. The call at lunch is the $28 three-course prix fixe, which changes weekly. Dinner brings an almost paralyzing array of decisions: unparalleled dry-aged rib eye (the restaurant’s name, after all, is Spanish for “cow”), seafood paella, or a collection of tapas such as sea urchin with scrambled eggs, served in the spiky shell with caviar. To accompany it, pick from one of the three drinks on tap: a house vermouth, a red sangria, or a signature gin cocktail named after the restaurant. Tucked between the Segerstrom Center for the Arts and the South Coast Plaza, the restaurant is great for preshow dinner or post–shopping spree lunch. Pro tip: If you’re with a group, request a circular booth; if you’re a pair, go for the heated patio or the bar.

Parque de los Novios, in the center of Santa Marta’s colonial sector, is perfect for people-watching in the late afternoons when the tropical heat abates. Everyone from the gentry to the common folk—not to mention a plethora of brides posing beneath the gazebo—seems to treat themselves to a nice stroll around the park. Nearby restaurants and bars come alive after night falls, as do, of course, street artists and musicians.

We live in the age of artisanal everything, from chocolate and coffee, to, you guessed it, water. At Mexico City‘s Casa del Agua, staff produce and bottle “local water” on-site. The bottles—designed artisanally, of course—are charming souvenirs that you can use over and over again (with your own, less expensive water) once you’re home. Be sure to go to the second level of the shop to see the filtration process, and to the terrace level to see where the water is captured.

Shanghai Tower has a lot to be smug about. At 2,073 feet, it’s the second highest building on earth, topped only by Burj Khalifa in Dubai. Let the world’s fastest elevators whisk you to the 119th-floor observation deck at 67 feet per second. From up here, the Oriental Pearl Tower looks like a child’s toy, and the cruises gliding on the Huangpu River appear no bigger than model boats. While, from the ground, you have to crane your neck to see the tops of skyscrapers like the Shanghai World Financial Center and Jin Mao Tower, in Shanghai Tower you’ll be looking down on them. Like a boss.

Formed by water erosion 200 million years ago—and not by a meteor impact, as is often presumed—the Makhtesh Ramon is a geologic jewel amid the majestic landscape of Israel’s Negev Desert. The earth’s largest natural crater (makhtesh), the site offers a range of activities from horseback riding and jeep tours to mountain-bike trails and family excursions. At the visitor center in the city of Mizpe Ramon, guests can learn about the area’s unique flora and fauna, such as ibex; participate in special interactive exhibitions; and take in a panoramic view of the expansive crater, which measures 25 miles long and 1,600 feet deep, from the observation deck.

Adjacent to the eponymous hotel, this shopping center near the cruise ship terminal in Pointe-a-Pitre has several boutiques stocking colorful island-style jewelry and accessories, and beauty products. It is named after the 19th-century French poet and Nobel laureate who was born and raised in Guadeloupe. You’ll also find local shops surrounding the center selling textiles, arts and crafts, and souvenir trinkets.

Petra flourished more than 2,000 years ago, trading with Rome as an equal before being abandoned after a series of earthquakes in the 4th and 6th centuries C.E. It wasn’t until the 19th century, when European explorers “rediscovered” it, that the ancient city returned to the public consciousness. Now, visitors can walk down the narrow canyon of the siq to the city entrance—as dramatic an approach as any to a tourist attraction on the planet. The canyon opens up onto the carved facade of the Treasury, Petra’s most iconic site. From there, you can explore the cliffside tombs with their colorful bands of sandstone, the Street of Facades, and the amphitheater hewn from living rock. The ancient center lies some distance off, along with the splendid old Monastery, which sits at the top of a steep but rewarding climb. Consider buying a three-day ticket and visiting at different times of day to enjoy the changing light—early in the morning is best for the Treasury, while late afternoon is better for the Royal Tombs.

Hoshinoya Tokyo is a modern ryokan that gracefully stands between the Imperial Palace and the Journalism Center of Tokyo. Built upon the heritage of Japanese inns, this hotel exudes warmth and minimal elegance from every angle.

At first glance, I was drawn to the understated steel pattern of the facade that’s graphically new, yet mysterious ancient. Once inside, I was immediately soothed by the interior decor and furnishings crafted from the finest woods and fibers native to Japan. On each floor, there is an Ochanoma lounge where you can read or enjoy tea by the diffused light of the shoji screens. My favorite part of the ryokan is the hot springs on the top floor. If you have seen and love the Skyspace series from artist James Turrell, onsen is where you can truly feel connected to earth, water and sky.

I travel for the opportunity to learn and to see things anew. On the subject of Japanese aesthetics, the novelist Jun’ichiro Tanizaki writes “We do not dislike everything that shines, but we do prefer a pensive luster to a shallow brilliance, a murky light that, whether in a stone or an artifact, bespeaks a sheen of antiquity.” I read this as a young design student but it’s only until my stay at the hotel that I vividly saw this sheen of antiquity. I highly recommend Hoshinoya Tokyo for the finest amenities and a chance to experience the modern Japanese approach to beauty and design.

In reality, the 1,620-hectare (4,000-acre) Barro Colorado Island is a hilltop. Or, at least it was until the creation of Gatún Lake turned it into the largest island in the Canal Zone, one where the Smithsonian Institute operates a research center and gives morning tours. Ships sail tightly past the island, offering the chance to glimpse toucans, iguanas and bats that live among the 1,300 plant species and 381 bird species of this vital tropical woodland.