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There is a staggering amount of artwork on display here. It is said that if you stood at each piece for just one minute, it would take you four years to see everything. Created by Pope Julius II in the early 16th century, the museums have expanded over the past 500 years to their current size of more than 12 acres! Highlights include the Borgia Apartments, the Raphael Rooms, the Gallery of Maps, and of course, the sublime Sistine Chapel.

The Court, an off-the-radar lounge bar with front row seats to the Colosseum, is the perfect place to wind down in Rome. The bar overlooks the archaeological ruins of the Ludus Magnus (the site where the gladiators trained) and offers a view of sunset over the Colosseum, the world’s most amazing arena. The cocktails are the creation of mastermind Matteo Zed, one of Rome’s top bartenders, whose tasty Rising Sun (a gin, yuzu, and matcha cocktail) may well keep you at the bar until dawn.

“Ristorante da Ivo is where George Clooney famously likes to dine, but it’s still completely charming. It’s a tiny trattoria and very expensive, but the food is stunning. The kitchen is still family-run and it feels very local, not at all pretentious. You can get dressed up or go in jeans and a jumper. Do try the baccala, which is salted dried cod that’s been soaked in milk and whipped up with olive oil. It’s creamy and delicious.”

Read about more of McAlpine’s Venice favorites.

Perched like an eagle’s nest in the lower Alps, just steps from Italy, this 1930s landmark restaurant faces a stunning rainbow of blues in the expansive view of ocean and sky just beyond its vertiginous glass walls. Taking inspiration from his own heritage and his international kitchen staff, Italo-Argentine chef Mauro Colagreco is making a name for himself for colorful cuisine that plays with contrasts of flavor and texture. Dishes often include an uncommon ingredient—the chamomile broth, for instance, or a combination of oysters, pears, and caviar; the bread served with a poem. The food is both pretty on the plate and a pleasure for the palate.

This family-run bakery has been making cantucci (what you might know as biscotti) for decades. The clan’s patriarch, Roberto, mixes and rolls everything by hand in the back, using a recipe that he knows by heart—ask, and he will happily show you the original recipe, now splattered with egg whites and cocoa. Roberto’s delicate cantucci are far from the tooth-cracking kind sold at many places. If you are really lucky, a fresh batch of the dark-chocolate-and-pistachio variety may have just been pulled out of the oven when you arrive.

A local favorite on postcard-pretty Piazza della Passera in the Oltrarno neighborhood, Il Magazzino serves up delicious Florentine food with a special emphasis on offal. If you are up for it, there’s no better place to sample stalwarts of the indigenous cuisine in dishes such as grilled udder or classic trippa alla fiorentina, or tripe stewed in a tomato sauce topped with grated Parmesan. If offal’s not your thing, opt instead for the mouthwatering linguine with kale pesto. The great wine list offers some affordable choices.

Everyone seems to be talking about Chez Nous and, frankly, it’s easy to see why. A meal here feels like dining at your most fashionable friend’s place. The restaurant is tucked away from the main drag in a beautiful Charleston single house, with a handwritten menu that changes daily, with the chef taking inspiration from the daily market as well as the cuisines of Northern Italy, Northern Spain, and Southern France. If the weather’s nice, request a table on the porch or in the courtyard.

Isola has become Milan‘s hipster hangout, so you are going to want spend a lot of time here. Best way is sleeping over, and the Isola Apartments are key. Lots of light, minimal decor and all the trappings of home, the loft apartments are great for couples with kids or other kids of third wheels.

Start your day at Deus Ex Machina, a motorcycle store in an alley full of them, whose café is the perfect spot for a cappuccino and soft scrambled eggs while you ogle the Ducatis.

Camogli is a quick 30-minute train ride out of Genoa, making it easy for an evening out for cocktails and dinner. Leave from Brignole Station, and arrive in Camogli by 6:30pm so that you can get a seaside table at Bar Auriga for a perfect Aperol Spritz as the sun sets and the waves crash in.

If you come to Genoa in late winter, you will have to deal with many cool and rainy days. BUT, you will get the privilege of shopping the amazing (i.e. 40/50% off) sales. So it’s a toss-up! If you are looking for women’s clothing, Lo Spaventarasseri has beautiful, artisan options in a lovely calm environment - perfect for trying clothing on after the holidays of overeating!

Enjoy your Pasta Alla Norma (one of the most traditional Sicilian pastas with tomatoes and roasted/fried eggplant) like the Sicilians—straight from the eggplant itself! Find a gorgeous (and large!) eggplant in one of the many street markets in Cefalu, slice off the top, and roast it whole. When soft, scoop out the eggplant flesh, and fill it with the Pasta Alla Norma. A perfect one-dish-wonder.

Just be sure to get to the markets early for good produce.

The scents that go into Ortigia’s gorgeous bath and beauty products are inspired by Sicilian plants (orange blossom, Sicilian lime, pomegranate, almond) and evoke the essence of this exotic, southern Mediterranean island. Beautifully presented in exquisite packaging, the bath essences, soaps, body lotions, scents and scented candles are all made from natural products in Sicily. They make wonderful gifts (if you can bear to give them away, that is…).

The recipe for the delicious, tiny truffle-cream sandwiches at atmospheric old Procacci is a guarded secret but, oh boy, are they good, especially when accompanied by a glass of prosecco. Smart Florentine ladies-who-shop flock here for a pit stop between purchases, but it’s also popular for an early-evening aperitivo. Procacci is additionally one of the few places to buy just-harvested truffles in Florence: look out for them in November and December. Heap truffle shavings over fresh, buttered taglierini pasta or a simple scrambled egg—after only one bite, you’ll understand the attraction to these precious, musty-smelling delicacies.

Hop on the commuter train at Lido Station (next to the Piramide Metro stop) and make the 25-minute trip to Ostia Antica, Rome’s ancient port town and administrative center. The teeming city of up to 100,000 residents is relatively well preserved and allows visitors a peek into the daily life of ancient Romans. Walk the basalt streets, visit the Forum, descend into Mithraic sanctuaries, and peruse the market stalls, which were in use until around the 5th century C.E.