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Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

Located along the historic Chesapeake and Ohio (C&O Canal), this laid-back neighborhood bakery and coffeehouse is one of my favorite hangouts in D.C. Baked and Wired serves delicious food and drinks in a cozy atmosphere. The space is adorned with works done by local artists and photographers—as well as napkins scribbled with slogans, poetry, and pictures by visitors who wish to leave their mark. Owned by a husband and wife team, Tony and Teresa Velasquez, the shop has been whipping up handcrafted baked goods since 2001. To the delight of the young, the old, the college kids, hipsters, and the “power suit” crowd, the shop churns out a plethora of treats. You’ll find cupcakes (“cakecups”), brownies, cookies, pies, bars, muffins, cakes, quiches, breads, biscotti, and even “zilla bonez” (dog biscuits). They also serve the best coffees including Stumptown, Intelligentsia, Madcap, Barismo, and Ceremony. For tea, try the “Chaider"—a seasonal combo of chai and apple cider. Dine here like a local; upon entering, head to the left side for the baked goods (the “Baked” side) and then to the right for coffee (the “Wired” side). Signature baked goods include: — The Strawberry Cupcake: made from fresh strawberries mixed with vanilla cake batter topped with a swirl of pink buttercream (the local favorite). — Bee Stings: shortbread cookie topped with sliced almonds and honey. — OMG’s caramel s’mores: a layer of graham cracker crust followed by caramel, marshmallow, and chocolate.

Hillside Farmacy is a farm-to-table restaurant in Austin built around a pharmacy theme. While it may sound odd, the execution is brilliant, with incredible food and wonderfully eclectic design. The restaurant space was formerly the home of a 1920s pharmacy owned by Austin‘s first African-American pharmacist. The decor features authentic apothecary items (from a different 1920s drugstore)—a vintage collection of medicine bottles, antique cash registers, tin ceilings, and wooden cabinets. But it’s the “F” in the deliberately misspelled Farmacy that nods to the emphasis on simple, fresh food. The restaurant works with local food purveyors and regularly changes the menus around the highest-quality seasonal ingredients. Local cheese, homemade pate, artisinal breads and pastries, raw bar, charcuterie are all available here. Dishes include bangers and eggs, buttermilk bisquits and gravy, and bison tartare. Other perks include an old fashioned soda counter and a shaded outdoor patio. If I were a local here, this would definitely be one of my favorite go-to places.

No, you don’t have the wrong address—this is indeed a downtown office building and parking garage. But don’t be alarmed. Walk through the door, and Café Poca Cosa’s stylish interior tells you immediately that this is no boring strip mall Tex-Mex joint. Neither, fortunately, is it an overly precious nouvelle-cuisine bore. It’s been voted “Best Mexican” in Tucson by locals, who know that chimichangas were born in this desert town. That said: you’ll find no chimichanga combo-plate here. Chef-owner Suzana Davila changes the chalkboard menu twice a day. Her concentration is on fresh ingredients and innovative dishes that translate regional cuisines rather than betray tradition. National publications have sung her praises, but Ms. Davila still checks on her own customers and eats lunch in the dining room with everyone else. She’s a self-taught native of Guaymas who can concoct over two dozen varieties of mole. Complex sauces, refreshing drinks (such as pineapple-basil agua fresca), and Baroque masks in red niches await you. Come for a late lunch on a weekday if you want to avoid the justifiable crowds. Have an open mind (and mouth), and discover how great contemporary Mexican cooking can be. Tucson can be proud of its plentiful taco trucks and Sonoran hot dog stands, but Poca Cosa celebrates the variety of Mexican cuisine for when you want to sit down in style. Buen provecho!

This colorful, photography-friendly collection of the one-eyed glass artist’s work is more than just another tourist attractions. The Northwest room, with its ceramics, textile art, Pendleton blankets, and photography of Native Americans, is a nod to the traditional arts that inspired Chihuly’s work. Playful, brightly colored glass is everywhere: oversized spheres piled into a rowboat, sea creatures and undulating glass ribbons that evoke the movement of the ocean, and fanciful “flowers” in the outdoor garden. The gift shop is large, with a nice selection of gifts, novelties, and Pendleton blankets. King County residents get a $4 discount off admission. Great for visitors, residents, and anyone who has a nice digital camera they’re itching to try out.

On a recent visit to Asheville, North Carolina, I was anxious to try some of the great restaurants I’d heard about. In the end though, my husband and I found ourselves gravitating back to the same restaurant over and over again - breakfast, lunch, and dinner - because it was absolutely delicious. We just couldn’t resist it. Tupelo Honey is a must if you’re in Asheville looking for some incredible Southern comfort food. This macaroni and cheese was probably the best I’ve ever tasted - rich and creamy, with delicious bits of bacon and other wonderful ingredients mixed in. Definitely not a diet food but worth every calorie!

Is Bar Agricole the best bar in the city? It’s certainly in the top five, based on the groundbreaking cocktail program developed by bartender and owner Thad Vogler; the award-winning architecture and interior design by local favorite Aidlin Darling; and a daring menu centered around produce from nearby organic and biodynamic farms. Vogler used to bartend in Tokyo, and his obsession with Japanese precision shows. You’ll see influences of that in the hand-cut ice cubes he uses, and in Agricole’s glassware and aprons (all from Japan). The bar stocks a limited selection of 20 or 30 spirits, almost all small batch, and with a special focus on rum. Come for drinks, come for dinner, or come for brunch: the midday menu highlights include ricotta doughnuts with quince marmalade and a chicory salad with fuyu persimmon and house-made vinegar. Pro tips: In winter, book the private dining room (nicknamed the Grotto) for a seated, though still laid-back, dinner for up to 32 people; for an outdoor event, Bar Agricole’s covered and heated patio is perfect for larger, more casual groups. For lessons in liquor, check out the private spirits tastings that Vogler offers through IfOnly.

Montevideo’s Ciudad Vieja, or Old Town, is located on a peninsula separating the Río de la Plata from the harbor. It has the orderly grid typical of many Spanish cities in the New World. Until 1829, the Ciudad Vieja was walled though today only one gate (the Puerta de la Ciudadela) remains of those defenses. This section of Montevideo is home to many of the city’s most famous historic buildings, including the cathedral and the Cabildo, which today houses the city’s archives.

Ask anyone you know who grew up in the Bay Area about the Exploratorium, and they’ll likely be able to share stories of class trips and seeing their hair stand on end at an installation about electricity or fun-house mirrors that taught about optics and visual perception. This is not, however, a museum simply for kids—though curious kids will definitely be entertained while learning. Instead, its exhibits aim to raise the scientific literacy of visitors of all ages, by providing engaging, amusing, and hands-on experiences. Long housed at the Palace of Fine Arts, the Exploratorium opened in its current, and much larger, space on Piers 15 and 17 in 2013. One advantage of the new waterfront location is the North Gallery and its outdoor spaces, focused on environmental phenomena like the wind, rain, and tides. The completely dark Tactile Dome and the disorienting Monochromatic Room may prove not just the highlights of your visit to the Exploratorium but the most memorable, or at least strangest, moments of your time in San Francisco.

Visiting the Strip? Save time for its spas. One of my favorites: Qua, at Caesars Palace. The Roman baths make you feel like you’ve left Las Vegas behind, and the snow room is worth a (quick -- it’s cold!) stop. Then the treatments are out of this world. On my most recent visit, I got the Nagomi treatment, on the mini-menu for the new Nobu boutique hotel inside Caesars. It included a therapeutic massage and excellent facial with a new fizz-like layer that worked on my skin. I couldn’t think of a better way to start my day.

Make the Gibraltar shopping circuit: Admire unique wares made by local craftspeople at Gibraltar Arts and Crafts in Casemates Square. On Main Street, stop and smell the handmade soap and beauty products at Gibraltar Soap. Then browse the quirky paper goods and kitsch crafts at All Wrapped Up or find the perfect accessory at the Silver Shop.

Some people dream of private islands with snowy sand and palm trees. Others fantasize about sleeping in a John Lautner house. For the latter, nothing beats this remote 1947 compound of luxury “living units” designed by the Frank Lloyd Wright protégé, the only Lautner residence open to public bookings. All concrete, redwood, glass, and steel, the four flats, which sleep two adults each, are distinctly designed with vintage furniture, organic cotton pillow-top mattresses, Heath Ceramics–tiled showers, and contemporary kitchens. Spend the day sunbathing from your private patio and cooling off in the saline plunge pool, and stargaze from the skylight above your bed at night. The micro-resort is self-catering, but that makes it all the more special—instead of eating in a restaurant, up to 12 people can dine under a communal redwood pergola; arrangements can be made for private chef dinners there, too. A hidden speakeasy-inspired bar for guests of the Ranch House (this additional accommodation, not a Lautner, sleeps four) only fuels the retro fantasy. Plan ahead: Weekends fill up months in advance.

Pastry chef Kelly Fields does complicated things with simple ingredients at her modern bakery and eatery. It’s part of the restaurant group overseen by local star chef John Besh, so it’s no surprise that it’s drawn nods from the James Beard Foundation, among others, for its delectable biscuits, corn bread, and more-involved dishes like crawfish and grits. Located in the sleek new district of mid-rise condos and apartments a couple blocks north of Lafayette Square, Willa Jean makes a great spot for a lazy breakfast or brunch—reservations are all but essential on weekends. It’s local knowledge that it’s also open for dinner and that the quality at that time of day remains high, with varied delicious dishes like braised lamb pasta and beer-can chicken (plus, it’s easier to get in).

The Kuşadası Bazaar actually consists of two bazaars. The Grand Bazaar is a vast collection of small stores and is the second-largest bazaar in the country, after Istanbul’s. The Orient Bazaar is an open-air alternative. Savvy shoppers will be able to find bargains on everything from Turkish towels to designer knock-offs, but be prepared and know that haggling is expected and the pressure to buy can be intense.

St. Kitts’ water taxis—basically anyone with a boat willing to make the crossing to Nevis—will drop you right on this beautiful stretch of sand, making Oualie Beach the perfect day trip. Once on land, head to the Oualie Beach Resort, where you can hang with guests and locals at the on-site restaurant and bar. If you’re feeling adventurous, ask the bartender for a sample of one of the house-infused rums, made with a variety of local plants and herbs. Afterward, walk down to the beach, where you’ll find watersport vendors and even a small spa for some additional relaxation.