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There is a staggering amount of artwork on display here. It is said that if you stood at each piece for just one minute, it would take you four years to see everything. Created by Pope Julius II in the early 16th century, the museums have expanded over the past 500 years to their current size of more than 12 acres! Highlights include the Borgia Apartments, the Raphael Rooms, the Gallery of Maps, and of course, the sublime Sistine Chapel.

The Court, an off-the-radar lounge bar with front row seats to the Colosseum, is the perfect place to wind down in Rome. The bar overlooks the archaeological ruins of the Ludus Magnus (the site where the gladiators trained) and offers a view of sunset over the Colosseum, the world’s most amazing arena. The cocktails are the creation of mastermind Matteo Zed, one of Rome’s top bartenders, whose tasty Rising Sun (a gin, yuzu, and matcha cocktail) may well keep you at the bar until dawn.

“Ristorante da Ivo is where George Clooney famously likes to dine, but it’s still completely charming. It’s a tiny trattoria and very expensive, but the food is stunning. The kitchen is still family-run and it feels very local, not at all pretentious. You can get dressed up or go in jeans and a jumper. Do try the baccala, which is salted dried cod that’s been soaked in milk and whipped up with olive oil. It’s creamy and delicious.”

Read about more of McAlpine’s Venice favorites.

Perched like an eagle’s nest in the lower Alps, just steps from Italy, this 1930s landmark restaurant faces a stunning rainbow of blues in the expansive view of ocean and sky just beyond its vertiginous glass walls. Taking inspiration from his own heritage and his international kitchen staff, Italo-Argentine chef Mauro Colagreco is making a name for himself for colorful cuisine that plays with contrasts of flavor and texture. Dishes often include an uncommon ingredient—the chamomile broth, for instance, or a combination of oysters, pears, and caviar; the bread served with a poem. The food is both pretty on the plate and a pleasure for the palate.

This family-run bakery has been making cantucci (what you might know as biscotti) for decades. The clan’s patriarch, Roberto, mixes and rolls everything by hand in the back, using a recipe that he knows by heart—ask, and he will happily show you the original recipe, now splattered with egg whites and cocoa. Roberto’s delicate cantucci are far from the tooth-cracking kind sold at many places. If you are really lucky, a fresh batch of the dark-chocolate-and-pistachio variety may have just been pulled out of the oven when you arrive.

Everyone seems to be talking about Chez Nous and, frankly, it’s easy to see why. A meal here feels like dining at your most fashionable friend’s place. The restaurant is tucked away from the main drag in a beautiful Charleston single house, with a handwritten menu that changes daily, with the chef taking inspiration from the daily market as well as the cuisines of Northern Italy, Northern Spain, and Southern France. If the weather’s nice, request a table on the porch or in the courtyard.

Isola has become Milan‘s hipster hangout, so you are going to want spend a lot of time here. Best way is sleeping over, and the Isola Apartments are key. Lots of light, minimal decor and all the trappings of home, the loft apartments are great for couples with kids or other kids of third wheels.

Start your day at Deus Ex Machina, a motorcycle store in an alley full of them, whose café is the perfect spot for a cappuccino and soft scrambled eggs while you ogle the Ducatis.

If you come to Genoa in late winter, you will have to deal with many cool and rainy days. BUT, you will get the privilege of shopping the amazing (i.e. 40/50% off) sales. So it’s a toss-up! If you are looking for women’s clothing, Lo Spaventarasseri has beautiful, artisan options in a lovely calm environment - perfect for trying clothing on after the holidays of overeating!

Camogli is a quick 30-minute train ride out of Genoa, making it easy for an evening out for cocktails and dinner. Leave from Brignole Station, and arrive in Camogli by 6:30pm so that you can get a seaside table at Bar Auriga for a perfect Aperol Spritz as the sun sets and the waves crash in.

Enjoy your Pasta Alla Norma (one of the most traditional Sicilian pastas with tomatoes and roasted/fried eggplant) like the Sicilians—straight from the eggplant itself! Find a gorgeous (and large!) eggplant in one of the many street markets in Cefalu, slice off the top, and roast it whole. When soft, scoop out the eggplant flesh, and fill it with the Pasta Alla Norma. A perfect one-dish-wonder.

Just be sure to get to the markets early for good produce.

Hop on the commuter train at Lido Station (next to the Piramide Metro stop) and make the 25-minute trip to Ostia Antica, Rome’s ancient port town and administrative center. The teeming city of up to 100,000 residents is relatively well preserved and allows visitors a peek into the daily life of ancient Romans. Walk the basalt streets, visit the Forum, descend into Mithraic sanctuaries, and peruse the market stalls, which were in use until around the 5th century C.E.

Once the bayside palazzo of a shipping magnate, the recently restored Romeo juxtaposes antique and modern art in a world-class collection. Fabrics, serving pieces, and porcelain by Hermès, Andrée Putman, and J.L. Coquet complement the Kenzo Tange–designed facade of undulate glass. Doubles from $240, 39/081-017-5001. Read Tom Downey’s “Tailor Made in Naples.”

Sometimes called “Milan‘s Sistine Chapel” because of its profusely--and beautifully-- decorated walls and ceilings, San Maurizio al Monastero Maggiore is well worth a visit. The Renaissance paintings commissioned by the Sforza family (the primary sponsors of Leonardo da Vinci), adorn the walls of a cloistered convent founded for noble ladies in the early 16th century. Built on an ancient Roman site, the church was built and decorated in stages over several centuries, every interior wall covered in luminous colors befitting the pomp of Lombard aristocratic taste. In particular, frescoes by Bernardino Luini, student of da Vinci, blend the sacred and the profane, using members of the court as models for portraits of saints. Most of the numerous religious and secular works of the Milanese painter have been lost, so San Maurizio is the best place to see his works. To get the most out of a visit to this little gem of art history, go with a knowledgeable guide. My husband and I toured historical Milan with Ludovic Goudin of Walks of Italy, who offer a variety of tours in Milan. San Maurizio was just one of the fascinating places we visited!.

Why we love it: An art-filled property that could only exist in Boise

The Highlights:
- Themed guest rooms that look great on Instagram
- An award-winning Italian restaurant
- An impressive art collection that lends a local feel

The Review:
Some upscale hotels feel impersonal, but not the 110-room Inn at 500 Capitol, which approaches interior design with refreshing whimsy. Its 57 themed rooms highlight various hobbies and interests, from the “Flicks Room” with movie star portraits and velvet ropes, to the “Best Friend Room” with dog sculptures and wildlife art. Even the “Standard” rooms are anything but, thanks to gas fireplaces, private balconies, and daybeds built beneath picture windows overlooking the Boise skyline. Hotel staff restock each room’s complimentary snack bar as it’s depleted, and more goodies await in the lobby, including complimentary beer and wine.

Making the inn even more desirable is Richard’s, the on-site restaurant run by Boise icon and James Beard–nominated chef Richard Langston that serves masterful renditions of classic Italian pastas and meats paired with Idaho-grown produce. The hotel also doubles as an art gallery (owner Brian Obie is an avid collector and painter in his own right), with a rotating array of works on loan from the Boise Art Museum, plus permanent pieces by Boise artist JanyRae Seda in the lobby. The kaleidoscopic chandelier that hangs above the entryway and the colorful sconces that fill the hotel are the work of another local artist, Filip Vogelpohl, while the stand of sculpted trees outside—a collaboration between Boise artists Ken McCall, Mark Baltes, and Leslie Dixon—turns the hotel’s doorstep into a city landmark.