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Founded in the 9th century, Santa Maria della Scala was one of Europe’s first hospitals. It was also one of the first hospitals anywhere to disinfect its equipment and only stopped taking in patients in the 1980s. (The writer Italo Calvino died here in 1961.) The early history of the hospital is illustrated in the 15th-century frescoes decorating the walls of the Pilgrim’s Hall, and there is a fascinating archaeological museum housed in the labyrinthine basement rooms.

Adobe streetfront: door...window...sky. Color. Much of Tucson, like most western U.S. cities, is devoted to strip malls and parking lots, but the historic core still has blocks of 19th-century Sonoran-style row houses. In the 1960s, acres and acres of the Barrio Viejo was razed, but fortunately not all of it. Today it’s a combination of gentrification and the pleasantly decrepit: attorney’s offices, student rentals, and family homes share this yard-less streetscape in a bilingual neighborhood. In reading about the history of the neighborhood, I came across this description, written back in the 1930s by Dr. James Harvey Robinson of Columbia University, who was visiting Tucson for the first time: “But this cannot be the United States of America, Tucson, Arizona! This is northern Africa - Tunis! Algiers! - or even Greece, where I have seen as here, houses built flush with the sidewalks with pink, blue, green and yellow walls, flowers climbing out of hidden patios and overall, an unbelievable blue sky. And the sweet-acrid smell in the air? Burning mesquite. Lovely! And the people - charming. But all this is the Old World, not America.” The Barrio Viejo is perfect for a bike ride. You do feel as if you’ve left reality-TV-obsessed Gringolandia...if only for a few blocks...

Before cotton reigned supreme in the South, tobacco was the money-maker. Planters channeled their profits into increasingly ornate homes, and one of the best examples of this post-Revolutionary architecture can be found in the Harrisburg district of Augusta, Georgia. Between downtown and the Augusta National Golf course (where The Masters takes place every April) is the Ezekiel Harris House, dating from the 1790’s. In later years, the area around the Harris House would become known as Harrisburg, before becoming incorporated into Georgia’s second-oldest city. The South’s first industry grew up nearby after the Augusta Canal was dug in the 1840’s. While the neighborhood is awaiting renewal today, the house remains as a relic to the society and tastes of a fledgling United States. The house is open for tours every Saturday and by appointment during the week. The Smithsonian has called it ‘the finest 18th-century house surviving in Georgia.’

Built between 1840 and 1845 by Prince Ferdinand of Saxe-Coburg and Gotha, an extremely influential royal family in Europe, the Palais Coburg is a bright and spacious bit of luxury. Opened in 2003 after extensive restoration, the palais has suites (and only suites) that are clean and classy, sometimes even grandiose with antique furniture and vibrantly lit chandeliers. Many suites are named in honor of important members of the family such as Queen Victoria and Albert of England, and King Leopold I of Belgium, so guests will get a lesson in the history of Europe’s intermarried royal families.

Outside is a quiet garden with a water basin, shade trees, and magnolias. The outdoor café provides sanctuary from the city and is a great place to enjoy breakfast. In addition to two marvelous restaurants, Palais Coburg has an excuisite wine cellar with some 60,000 from four different centuries.

Both charming and affordable (it doesn’t charge a resort fee), this intimate 37-room property also has an unbeatable central location—near the heart of Old Town and just a few blocks from Duval Street and Mallory Square. Part of the Historic Key West Inns collection, the Key Lime Inn features classic Key West style with a 19th-century main house highlighted by a double-height colonnaded entrance and green shutters. Rooms follow suit with high ceilings and classical proportions, and beds are done up in crisp, white linens; most have sitting areas and private walkouts or porches to encourage lingering. Though short on amenities, the grounds are shaded by tall palms and dotted with Caribbean-style clapboard cottages painted in cheery colors with gingerbread trim, and all offer free WiFi. And if the beach doesn’t call you, a large wood deck surrounds the heated outdoor pool, and hammocks and porch swings are placed around the property for maximum relaxation.

Known today as the Hawaii Five-O headquarters façade, Aliiolani Hale means “house of the heavenly king” in the Hawaiian language. The building was designed under King Kamehameha V and served as a palace with government offices for the Kingdom of Hawaii until the monarchy was overthrown in 1893 and the Republic of Hawaii was established. Shortly after Hawaii became a US state, the building was renovated. However, as the government grew, various departments moved out of Aliiolani Hale and now the Hawaii State Supreme Court makes use of this historic building along with a museum about the Hawaii judiciary and a law library. In front of the iconic building, there is a statue of King Kamehameha I, who founded the Kingdom of Hawaii.

New Delhi’s original power hotel, The Imperial opened in 1936 and played host to celebrities and historic figures: It was here, rather than at Connaught Place that Pandit Nehru, Mahatama Gandhi, Muhammad Ali Jinnah, and Lord Mountbatten met to discuss the partition of India and creation of Pakistan. Though renovation has lent a bit of a corporate vibe to the high-ceilinged hallways, the hotel still oozes nostalgia at every turn. A vast museum-worthy collection on display throughout public and private spaces includes life-size oil portraits of princely rulers, statuary, tapestries, old photographs, and British and Indian military and polo regalia. Rooms come in Victorian, Indian heritage, and Art Deco motifs, with marble floors, sumptuous velvet furnishings, and antique rugs. The centerpiece of the palm-studded lawn is a huge, beautifully tiled swimming pool where red-uniformed staff deliver ice-cold drinks to sunbathers in the stultifying heat, but if you prefer a moodier venue for your cocktails, the property has a library-like bar with wood-panelled walls as well as four atmospheric restaurants serving every kind of cuisine. And don’t miss the afternoon tea, enjoyed in the light-filled atrium.

Most people visit the national parks during the summer, but winter provides a completely different wildlife- viewing experience. Guests at the Four Seasons Jackson Hole have multiple options for taking in a snowy Yellowstone. Get a bird’s-eye view of the park on a helicopter photo safari with one of the hotel’s in-house wildlife biologists, who can expertly spot moose, elk, bison, and grizzlies. At night, the hotel’s resident astronomer takes guests to Grand Teton National Park for stargazing sessions. More active travelers can rent fat bikes with oversize tires and pedal out to the Jackson Elk Refuge. From $579. This appeared in the November/December 2014 issue.

“What wisdom can you find that is greater than kindness?” So said local philosopher and writer Jean-Jacques Rousseau, a statue of whom oversees his namesake island, a wee, romantic spot in the middle of the Rhone where it empties into Lake Geneva. The island-park may be served by two bridges, but it feels like a universe of its own and is a favorite of many visitors and locals in Geneva. The tranquil tree-lined island was once a 16th-century fortification that protected the city, then the site of a bustling shipyard before finally being transformed to a peaceful sanctuary in 1832, when the Pont des Bergues bridge was constructed. (The Pont des Bergues ends across from the 1834 Hotel des Bergues, which was the first meeting place of the United Nations and is now a Four Seasons Hotel.)

While construction started on Freiburg’s iconic Gothic church in 1200, it wasn’t finished until almost 300 years later. Today, the cathedral is known mainly for its 380-foot west tower (famously described by art historian Jacob Burckhardt in 1869 as “the most beautiful spire on earth”), but also boasts magnificent pillars, intricate sculptures (including 91 gargoyles), and an equally stunning interior. Incredibly, the church survived several World War II bombings and still contains stained glass windows from medieval times, plus a high altar with an intact triptych by Hans Baldung Grien. The famous tower takes on an octagon shape as you climb to the viewing platform, where, on clear days, you can see across to the Vosges Mountains in France. Be sure to also check out the bell tower, home to the three-ton, 750-year-old Hosanna bell—one of Germany’s oldest.

Le Roeulx has been one of the main residences of the Princes of Croÿ since 1429. It is one of the most imposing classical castle in the country. Its history overshadows that of all but the most prestigious residences in the Low Countries. It opens one day a year for an international hot air balloon tournament. Now if it rains on that day there will be no tournament and no rescheduling. We found that out last year but there will still be lots of food and drinks.

We were offered the chance to visit Pompeii or Herculaneum when we docked at Sorrento. People rave about Pompeii because it’s absolutely huge and gives you a great sense of just how sophisticated Roman civilisation was. Herculaneum, by contrast, was a Roman seaside town, a sort of holiday resort, and doesn’t offer the same kind of scale. Still. I remembered my Latin lessons, and how we’d learned that while Pompeii’s buildings were smashed and burned by the falling volcanic ash, Herculaneum was actually preserved in the thick mud that engulfed it. And it’s true: wandering around the archaeological remains of the town, you feel like you’re in a place that’s only recently been abandoned. The wine shop (above) still has its amphorae stacked to the side, the houses have beautifully preserved frescoes and mosaics. What it lacks in size it more than makes up for in detail.

Featuring a series of boulders that appear to have been gathered, piled, and deliberately set across a few square miles of desert, this site carries a certain air of mystery. Scientists remain baffled about the geological event that could have created the formations, while archaeologists and historians are fascinated by the petroglyphs and paintings drawn by the native Arawak people. Trails weave around the enormous stones, many of which have been named for the animals they resemble. Speaking of which, all sorts of creatures inhabit the area, from iguanas to burrowing owls.

With its historic pueblo-inspired architecture and Spanish Revival style, this landmark Santa Fe hotel looks like it dates back much earlier than 1922, when it was designed by two of the area’s top architects: Mary Elizabeth Jane Coulter and John Gaw Meem. And, in fact, despite the imposing building’s relative youth, the legacy of La Fonda dates back to the 1600s. An inn or hotel has stood on this site since the city’s founding at the end of the Santa Fe Trail.

Now, as one of the city’s most iconic luxury hotels, it presides over the historic Plaza and boasts some of the best views of the city and surrounding mountains and desert. Thanks to a complete (and completely faithful) renovation in 2013, rooms are now bright and airy, outfitted with handcrafted furnishings, local artwork and textiles, energy-efficient casement windows, and all the luxuries expected of a modern grande dame. The fine-dining courtyard restaurant is one of the most romantic dining destinations in town—trumped only by the rooftop Bell Tower Bar, whose sunset views and margarita menu draw locals and in-the-know visitors alike. Throw in a heated outdoor pool (open year-round, a rarity in Santa Fe) and a decadent spa, and it’s no wonder that La Fonda has maintained its reputation for superlative hospitality for so long.

The Inn and Spa at Loretto, one of Santa Fe’s iconic boutique luxury hotels, could easily be mistaken for the ancient Taos Pueblo. The hotel’s angular architecture, soothing desert hues, and romantic lighting draw heavily on the original pueblo. Rooms are outfitted with both traditional touches (handcrafted furniture, Anasazi pottery and artwork, kiva fireplaces, colorful textiles) and modern luxuries (slate-floored bathrooms, iPod docks, flat-screen TVs, private balconies). The restaurant and spa are among the best in the state, and the atmospheric lounge one of the coolest spots in town to sip cocktails and catch live music. And, as if it needed another dose of history, the landmark Loretto Chapel sits on the grounds, guaranteeing both excellent views and easy sightseeing access. Now, if only more pueblos were like this.