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The Basilica San Marco is Venice‘s crown jewel. Situated at the eastern end of Piazza San Marco, the cathedral was built around 1078 on the site of an earlier house of worship. It is famously the home of the remains of the apostle Mark, which were said to have been smuggled from the Holy Land by Crusaders in a barrel of pork. The basilica is not just a wonder from the outside; its glittering gold mosaics make it one of the most breathtaking examples of Byzantine design in the West.

Scrub Island is one place where being shipwrecked might actually be a good thing—pity that dockside boat slips abound. Located on a volcanic speck just 75 miles east of Puerto Rico, Scrub Island Resort is the ultimate tropical idyll, with a spa, marina, and three restaurants. Its 52 suites and villas sit on 230 pristine acres, complete with neutral, colonial–style interiors (think four-poster beds, marble baths with soaking tubs, and floral curtains) that intensify the ocean views. Charter a boat to explore hidden coves or test your nautical skills at the resort’s sailing school. You can always forget what you know once the time comes to lift anchor and head for the mainland.

Carmen lies at the crossroads where quality, creativity, and sustainability (plus every other big-city culinary trend) meet. The namesake proprietress, alongside musician husband Rob Pevitts (both San Francisco Cordon Bleu graduates), is the genius who imported the restaurant’s California-sybarite style to Cartagena. She also brought a passion for everything that comes from the sea, and even imported her father, who’s responsible for serving up crab, lobster, fish, and octopus in line with standards he picked up on his many travels in New York and Japan.

With killer views of the waves crashing onto Ocean Beach, the Beach Chalet Brewery & Restaurant is one of the best places to grab a bite and watch the sunset in San Francisco. Before its current incarnation, the 1925 Spanish revival building served as a beach changing room, an Army outpost during WWII, and a VFW hall. The disused building was shuttered in 1970, but spared for its landmark WPA murals and mosaics. Come to see the murals, and stay for the food and Ocean Beach views. Upstairs, above the visitor center, the Beach Chalet Restaurant serves fresh fish and steaks. Downstairs, opening out to Golden Gate Park, the sunny and more casual Park Chalet offers burgers or fish and chips, and live music on weekends.

The Belmond Villa San Michele knows something about history. Michelangelo designed its facade, Franciscan monks tended its gardens, and Brigitte Bardot stayed here. But, like any elegant host, it’s not brash about its pedigree. Manicured Italian gardens—designed by 15th-century friars—beckon you for sun-soaked strolls. The colonnaded loggia is a pleasant place for a sunset aperitivo or candlelit dinner, especially with a view of Florence and the Arno Valley. The hotel’s expansive rooms are already decked out in the most tasteful, almost understated interpretation of Renaissance luxury—terra-cotta tile floors, heavy wood furnishings, just a dash of red velvet, and plenty of cream-colored walls—and then the panoramic views, original frescoes, and modern Carrara marble bathrooms steal the show. There’s a real-deal cooking school, where the chef actually works with each person in hands-on preparations—no demonstrations-only here. Other perks include the hillside pool, the concierge service that can get you into the Uffizi outside of operating hours, and, from the Loggia Restaurant, a view of the ancient Roman road that once connected Florence to Fiesole.

Inspired by his time in New Orleans, Chef Steve McHugh brought to San Antonio a vision of a modern, welcoming spot with a killer charcuterie program, and that vision became his buzzy restaurant, Cured. Opened in late 2013 and having survived an on-premise fire, the restaurant has drawn discerning carnivores in for plates like monster 2-pound pork shanks, pork cheek poutine and cabrito sliders, all served in a elegantly utilitarian yet warm space. Not to be missed is the fine in-house charcuterie program -- or the see-through curing room front and center as you walk into the dining room. The wonderfully curated beverage menu features craft beers and wonderfully inventive cocktails. Cured is a must-visit culinary experience on any jaunt to the Alamo City.

This popular Mexican-food mainstay in the heart of San Francisco‘s Mission District is one of two places in the city that claim to have invented the Mission-style burrito (the other is El Faro): a hefty, elephant-leg-size wrap distinguished from other burritos by its size and the inclusion of rice and other ingredients. The restaurant was first opened as a meat market in 1967 by Mexican immigrants Raul and Michaela Duran, who are said to have served their first burrito in 1969 after noticing that local workers needed a substantial yet portable meal. The Mission Burrito was born, containing most of the food groups: protein, vegetables, dairy, and grains. The Durans converted their meat market into a full-time restaurant in 1972. Taqueria la Cumbre offers a full menu of Mexican food, all made fresh. The burritos are made assembly-line style. (Fun fact: When the Durans first came to San Francisco, they hired a high school kid to make flour tortillas before school. The kid, Jorge Santana, would go on to be a popular musician, like his brother Carlos.)

This steep hike is about eight miles out and back, but many are willing to make the trek because of the photo opportunity that waits near the summit. Potato Chip Rock is a sliver of granite that protrudes from a boulder. Since it’s sturdy enough to stand on, hikers often head to the edge and strike creative poses to post on Instagram. Located in Poway, the trailhead is 27 miles from downtown San Diego, but well worth the drive—the panoramic vista from the top offers a great perspective of San Diego County’s canyons and hilly topography. In addition to Potato Chip Rock, be sure to check out the other large boulders and rock formations that litter Mount Woodson.

For a little old-school San Telmo atmosphere, you can’t do much better than this classic corner bar. Dating from 1864, the antique building started out as a pulpería (general store), the seedy center of a gambling ring and even a brothel before it was converted into the popular restaurant and bar it is today. On your way in, check out the antique cash register and the gorgeous vitraux (stained glass) over the long bar: it’s no wonder this place has been used as a film set several times over. Then pull up a chair at one of the rustic wooden tables, preferably by the windows for maximum people-watching potential. If it’s morning or time for merienda, ask for a cortado with medialunas; otherwise, order an ice-cold chopp (draft beer) and a monster-sized lomito (steak) sandwich.

Two of my favorite things are beer and bikes, so it was no surprise that I fell in love with the Blue Star Brewing Company in San Antonio. The beer is top-notch and all organic. It also has a stellar food menu and offers great ambiance, both inside and out on the expansive patio. I love the layout of the brew pub, which also includes a bakery and a butcher block. The cool bikes on display are a bonus. My favorite beer on tap is the Pale Ale, but there are many options to please any beer aficionado.

Harry’s Roadhouse, a favorite haunt of locals and visitors, is conveniently open seven days a week. The massive breakfast menu melds regional Mexican and New Mexican fare with items like huevos rancheros and hearty chilaquiles (eggs any style with salsa and cotija cheeses). For your sweet tooth, try the french toast or lemon ricotta pancakes, washed down with a cup of joe.

When someone tells me they’re traveling to Spain and looking for recommendations, San Sebastian (Donostia, in Basque) is my first thought for city destinations in the northern part of the country. It’s charming, beautiful, and steeped in history. Mount Urgull, the hill that stands on the right side of the bay, epitomizes all those characteristics in one easy to explore package. Mount Urgull is an easy walk from anywhere along the Promenade, and you can either walk up from Parte Vieja or walk around by the aquarium and the point to see views of the Bay of Biscay. I’ll recommend that you start with the second way and, coming back down, drop right into Parte Vieja. That way you get the best of both.

Mollusk is a neighborhood surf shop that sells clothing and great boards. They carry my surfboards and handplanes [for body surfing]. They occasionally host art shows and live music. The shop is sort of like the cornerstone of the Sunset. 4500 Irving St., (415) 564-6300, mollusksurfshop.com. This story appeared in the January/February 2012 issue.

While heading out to raucous clubs can be a good time every now and then, sometimes you just want to listen to some good music and chill out for the evening. Luna offers a host of live music shows (check their website for upcoming artists), boasts a great atmosphere, and, to top it all off, you won’t have to push your way to the bar.

Antigua (pronounced An-tee’ga) encompasses 108 square miles of coastline and 365 white sand beaches between the Atlantic Ocean and the Caribbean Sea. For an uncommon, all-inclusive Caribbean holiday, stay at The Galley Bay Resort and Spa. In and around the property are ruins of forts hundreds of years old, wrecks for snorkeling, a spa with tree houses for treatment rooms, plenty of authentic dining options, and even world-class sailing opportunities.