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A visit to the Palazzo Mirto offers the rare opportunity to see the interior of a classic Palermo palace as it was during its extravagant heyday. Located in the historic Kalsa district, Palazzo Mirto was home to the prominent Filangeri family for 400 years; the last remaining member donated the palace to the city in 1982. The vast library, the Chinese smoking room and the cavernous ballroom still have their frescoes, chandeliers, tapestries and opulent furnishings intact.

There are few places where you can better learn about the beauty and complexity of desert ecology than the Desert Botanical Garden, not far from downtown Phoenix. Check out the Desert Discovery Loop Trail for a look at local flora, go for a flashlight tour or cooking class (using plants found in the region, of course), or catch one of the musical performances that are part of the garden’s concert series. Make a point to visit the Desert Terrace Garden for the best views of the surrounding buttes and desert.

When it comes to Kindred, you can forget your preconceived notions of vegan restaurants. The South Park spot features killer cocktails, filling food, and an edgy design, complete with a coffered ceiling, a white-marble bar, and a demon-wolf-head sculpture mounted on the wall. Pair the refreshing Place of Certainty (vodka, elderflower, Aperol, lemon, Thai basil, winter melon bitters, and cucumber) with Kindred’s take on the charcuterie board (smoked golden beets, kale pesto, and red-chili-and-orange-fennel seitan), or order something more substantial, like the beet risotto or the seared cauliflower steak with squash puree and steak sauce. The restaurant also offers an excellent weekend brunch with everything from cinnamon rolls and banana bread French toast to pancakes with bourbon butterscotch.

One of New York’s loveliest historic districts, Brooklyn Heights sits along the East River to the south of the Brooklyn Bridge. Its streets are lined with beautifully preserved and restored 19th-century town houses while a promenade along its western edge offers views of the skyline of downtown Manhattan—especially stunning when the sun is setting over New York’s harbor. Simply wandering its streets, you’ll feel transported back in time, but there are some buildings of special interest you may want to seek out. The celebrated 19th-century preacher Henry Ward Beecher (brother of Harriet Beecher Stowe) presided at Plymouth Church (57 Orange St.). Truman Capote finished Breakfast at Tiffany’s and wrote In Cold Blood during the 10 years he lived at 70 Willow Street, and novelist Thomas Wolfe lived at 5 Montague Terrace from 1933 to 1935. Grace Church (254 Hicks St.) and St. Ann & the Holy Trinity (157 Montague St.) are outstanding examples of 19th-century Gothic Revival architecture. After you are done exploring, Atlantic Avenue, which marks the southern edge of the neighborhood, and Montague Street have a number of restaurants to choose from if you are ready for a meal.

The town of Stromboli, the main settlement on the island, sits at the foot of the volcano overlooking Strombolicchio. Its gleaming white buildings surround the dome of a small church, Chiesa di San Vincenzo. The town is fronted by a stretch of volcanic beach where local fishermen haul out their boats on the coarse black sand.

This Alpine area in Appenzellerland sits at an altitude of more than 5,000 feet and is home to the much-photographed Aescher-Gasthaus, Switzerland’s version of the Tiger’s Nest Monastery. The 19th-century guesthouse was constructed directly into a jagged cliff face and while guests can no longer stay overnight, it’s a popular place for a meal. The cable car to Aescher departs from Wasserauen, and then a 20-minute hike passes ancient Wildkirchli caves that were once home to prehistoric bears and, later, 16th-century hermits. There’s also a grotto chapel built right into the stone, a small museum, and a sheep farm on some seriously steep meadow terrain.

Latin America’s largest jewelry market, this four-level spot in the heart of Guadalajara features more than 700 jewelry stores, labs, and repair shops. Precious and semiprecious stones sparkle alongside gold, silver, costume jewelry, and watches, making it nearly impossible to leave with just one thing.

At the tip of the Baja Peninsula, where the turbulence of the Pacific Ocean meets the calms of the Sea of Cortez, lies Cabo’s crown jewel, Land’s End. Here, the iconic “El Arco” rock formation frames the confluence of waters and shelters a colony of sea lions. This distinctive scene has turned up on countless postcards and Instagram feeds—and rightfully so. Get up close by hiring a panga, kayak, or stand-up paddleboard. Soak in the serenity of the dramatic landscape and consider that if you continued due south, your next landfall would be Antarctica.

Nişantaşı is the posh “Upper East Side” of Istanbul, home to the priciest designer boutiques and old-fashioned couturiers, especially along Teşvikiye and Abdi İpekçi streets. Beymen department store was Turkey’s first luxury retailer and remains a one-stop shopping destination for international and Turkish designers; take a seat outside its sidewalk café to see the fashionable set preen. For a peek at the old-money Istanbul chronicled in Orhan Pamuk’s book The Museum of Innocence, find Hak Pasajı, a shopping arcade just a few steps from the City’s Nişantaşı shopping center. Along with jewelry stores, stationers, and shoemakers, you’ll find Orlando Carlo Calumeno’s shop, a veritable treasure trove of authentic Constantinople relics ranging from French postcards of the old Pera district to museum-quality Ottoman army items.

Taf Coffee started out as a family-owned coffee roastery in the 1990s then quickly moved beyond Greek brews to becoming Athens’ main source for international gourmet roasts. Owner Yannis Taloumis opened the doors to Taf Coffee (a sit-down café) in 2009 and the family’s brand been going strong ever since, recently expanding to Taf Points, a mini-espresso bar concept in Athens and points beyond. The café, at the edge of the funky Exarchia district, is a haven for coffee aficionados interested in a wide variety of brews made by international-award-winning baristas. (Yes, traditional Greek coffee is still on offer.)

Though from Guadalajara (he never let friends forget), Pritzker Prize–winning architect Luis Barragán lived much of his life in Mexico City, where he designed and constructed this, his last residence, completed in 1948. A UNESCO World Heritage site, the home is open to be toured by small groups—by appointment only; English-language guides are available upon request—who want a chance to tap into Barragán’s brand of minimalism, which involved bold monochromism and a masterful use of light; striking horizontality and framing applied to windows, gardens, and views; a highly sui generis Catholic spirituality; and, not least of all, the architect’s bizarre need for control, in everything from what staircases guests might use to what records got played in different rooms.

With its historic pueblo-inspired architecture and Spanish Revival style, this landmark Santa Fe hotel looks like it dates back much earlier than 1922, when it was designed by two of the area’s top architects: Mary Elizabeth Jane Coulter and John Gaw Meem. And, in fact, despite the imposing building’s relative youth, the legacy of La Fonda dates back to the 1600s. An inn or hotel has stood on this site since the city’s founding at the end of the Santa Fe Trail.

Now, as one of the city’s most iconic luxury hotels, it presides over the historic Plaza and boasts some of the best views of the city and surrounding mountains and desert. Thanks to a complete (and completely faithful) renovation in 2013, rooms are now bright and airy, outfitted with handcrafted furnishings, local artwork and textiles, energy-efficient casement windows, and all the luxuries expected of a modern grande dame. The fine-dining courtyard restaurant is one of the most romantic dining destinations in town—trumped only by the rooftop Bell Tower Bar, whose sunset views and margarita menu draw locals and in-the-know visitors alike. Throw in a heated outdoor pool (open year-round, a rarity in Santa Fe) and a decadent spa, and it’s no wonder that La Fonda has maintained its reputation for superlative hospitality for so long.

Nearly 1,000 years after the once-powerful central Mexican city of Cacaxtla was abandoned, would-be looters of the hilltop palace ruins came across fantastically well-preserved and still colorful murals painted in a somewhat puzzling Mayan style. Excavation continues today under an enormous protective shed roof. The Mural del Templo Rojo, pictured, adjoins a stairway leading to the Governor’s Room. The huge nearby Mural de la Batalla, dating from 700 CE or earlier, is a grisly blood-and-guts depiction of a fierce battle between “jaguar” and “bird” warriors. The relatively un-touristed site is a short drive from Tlaxcala, slighting longer from Puebla. You come away from a slow stroll through the labyrinthine ruins with the feeling that centuries of mysterious history have seeped into your heart and bones.

Just inland from Ensenada, Baja California exists a wonderland of fine wine, haciendas and Provencal restaurants. There is an energy here that is worth dawning the bullet proof vest and heading a couple hours south of the Mexican boarder to check out the excitement and culinary innovation. In the Valle de Guadalupe wineries and restaurants are redefining where fine wine comes from and what Mexican cuisine can be. The Valle de Guadalupe sits in a valley that warms through the day and is cooled every evening by the onshore flow off the ocean, allowing perfect conditions for grape growing; which has been going on here for over a hundred years. Additionally, the valley is a source of fine olive oil, locally grown herbs and produce, local farms and seafood from the nearby ocean. The best way to experience this culinary movement is to stay at a winery like Adobe Guadalupe or Vinedos Malagon in the heart of the valley. These wineries offer more than just wine tasting and luxury, they offer activities, ranging from horseback riding to cooking classes, deep sea fishing or dirt biking. The best part of it all is you can still fill up on classic Mexican tacos and mariscos when the fine dining and wine becomes too much.

Sandwiched in between the Railyard District and the plaza, this breezy brick-and-adobe-exposed Mexican-inspired spot features a sprawl of folk art, majolica tiles, distressed windowpanes, and leather banquettes. There’s a range of diverse delights on the menu: duck carnitas, marrow tacos, grilled whole sea bass and, for vegetarians, cauliflower Frito tacos topped with Marcona almonds, raisins, and Spanish olives. For a side dish, order the warm Mexican street corn, known as esquites. To sip, it’s all about house-shaken tequila, smoky mezcal cocktails, and classic Mexican brews like Sol and Bohemia.