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Colombian fashion designer Silvia Tcherassi took the design world by storm when she transformed a 250-year-old mansion in the center of Old Town Cartagena into a contemporary refuge that honors both past and present. Mansion Tcherassi’s seven rooms blend fashion-forward decor (think sparkly gold throw blankets) and original features such as restored stone walls and private balconies, but the vibe is much more understated, with ethereal fabrics, soft colors, and natural wood, in the 42 neutral-hued rooms at sister property Tcherassi Hotel & Spa. You can order fresh-caught seafood and icy raspaos (traditional drinks made with fruit and condensed milk) at the restaurant, while carpaccios, pizzas, and ceviches are on the menu on the rooftop lounge; the Italian restaurant at the mansion extends to a cozy patio facing a plunge pool and vertical garden made with thousands of local plants. After a day spent exploring Old Town’s historic buildings, relax with a Chinese medicine–inspired treatment in the spa, or take a dip in one of the property’s four pools.

Cesare al Casaletto is far off the well-beaten tourist track, but it is easy to get to: just take the 8 tram from Piazza Venezia or Largo Argentina and get off at the very last stop. Fifty yards from the tram tracks sits Rome‘s best trattoria, where spectacular fried appetizers (get them all, or at least the gnocchi fritti and polpette di bollito) give way to classic pasta dishes like carbonara and gricia. The second courses are excellent and fall-off-the-tailbone braised oxtail is a favorite. Pair it all with fairly priced natural wines from all over Italy and be sure to leave room for dessert, preferably the panna cotta.

Design junkies will find plenty to love at The Cape on Monuments Beach. Designed by Mexican architect Javier Sánchez, the hotel eschews resort staples like wicker and rattan for a sleeker look that marries mid-century standards with locally sourced furnishings and art. In the 161 spacious guest rooms, leather headboards and copper-leafed tubs complement private tiled balconies with ocean views. The style extends to the public spaces, which include Manta (acclaimed Mexican chef Enrique Olvera’s globally inspired seafood restaurant), a saltwater pool, and a spa that’s cleverly tucked into a natural rock formation.

About a two-and-a-half hour drive from Santiago (or 30 minutes by helicopter), Puma Lodge is located in the Andean foothills near the Argentine border. The lodge is part of the Chilean-owned Noi hotel group, which also has properties in Patagonia, Atacama, Santiago, and more. Opened in 2011, Puma Lodge has a ski chalet feel, with wooden interiors and a large fireplace in the middle of the bar and lounge area. The 24 rooms are all the same category, and the design is simple and comfortable with touches such as colorful throws and local artwork.

Many guests choose Puma Lodge for the heli-skiing, but there’s plenty on offer year-round and for the less intrepid traveler. Activities include hiking, horseback riding, or heading out for a picnic lunch by the river. There’s also an on-site spa, yoga studio, and wine cave. Outdoor hot tubs are great after skiing, and a swimming pool is a draw in the summer months.

Founded in the 9th century, Santa Maria della Scala was one of Europe’s first hospitals. It was also one of the first hospitals anywhere to disinfect its equipment and only stopped taking in patients in the 1980s. (The writer Italo Calvino died here in 1961.) The early history of the hospital is illustrated in the 15th-century frescoes decorating the walls of the Pilgrim’s Hall, and there is a fascinating archaeological museum housed in the labyrinthine basement rooms.

Beneath the path of planes taking off from LAX is an oceanfront runway for beginner hang gliders to get some air of their own. Sign up for a full (seven flights for $140) or half lesson (four flights for $85) with Windsports, which has been operating with A-class instructors since 1974. The experienced Greg DeWolf, whose longest flight clocked in at 6.5 hours, is a recommended guide. His passion, thoroughness, and humor are just what a novice needs to feel comfortable and confident piloting this new flying contraption. Relaxing is key, and once you do, the flights are a calming enjoyable ride. Just make sure to look up so you remember the experience!

In recent years, one restaurant has set the bar for cool in Cabo San Lucas. Bar Esquina, the Bahia Hotel & Beach House’s on-site bar and grill, features a chic casbah-like design aesthetic, a menu built on Mexican and Mediterranean flavors, and a commitment to organic, locally and responsibly sourced ingredients you taste in every bite. The menu is ever-evolving, but there are standouts you can always expect to find. The tuna tartare is a tiered, artistic creation, featuring tempura and an avocado-yuzu mousse. The Caesar is the signature Bar Esquina salad, here wrapped in a long, flat crouton and served with poached egg and prosciutto. Entrée selections include a generous filet mignon with potatoes au gratin and the short-rib pizza with blue cheese and arugula.

It was love at first sight. Everything about Orvieto is charming, with the exception of the Duomo (Cathedral) which more appropriately would be described as elegant and grand, especially the facade. Originally a thriving center of Etruscan civilization, Orvieto is a little less then half way between Rome and Florence. We had a lovely meal on one of the cute cobble stone lanes before heading up the clock tower and gazing over the perfectly preserved city. You could easily spend a day or two wandering through the town, enjoying its history and culture, both past and present. We were treated with the utmost hospitality at every turn. There weren’t many visitors during our visit, which I found to be unusual, given its popularity on the tourist circuit. This will be a place to revisit, and immerse ourselves into the everyday life of this gorgeous gem.

It makes sense that the California cool of James Perse’s clothing and accessories for men and women has made its way to Cabo, where its sold at one of several shops that opened on the property of Flora Farms in late 2015. Whether you forgot to pack for the coastal climate of Baja or you just want to expand your wardrobe, attentive staff can help you add a few items to your style repertoire.

Miami comes to Los Angeles at this Sydell Group hotel that took over the historic Commercial Exchange building in the center of downtown. Although it has deluxe amenities like a doorman and room service, the Freehand L.A. has a range of room types, from 167 private accommodations to 59 shared rooms with four, six, or eight bunk beds. The hotel deftly manages to combine the social culture of a hostel with innovative design by Roman + Williams, exceptional food and drinks, and stellar communal spaces where locals and travelers mingle naturally. Places to hang out include the lobby area outfitted with handcrafted furnishings, vibrant tapestries, earthy decorative elements, and murals by local artists; the lobby bar, serving tea-infused cocktails and light bites; the grab-and-go Café Integral; the plant-filled restaurant; and the rooftop pool, which is home to the award-winning Broken Shaker lounge. Providing more greenery off the lobby is a floral-filled concept store by Venice’s Flowerboy Project.

Esperanza, an Auberge Resort, sits on the southern tip of the Baja California Peninsula, offering guests exceptional views of the Sea of Cortéz. Each of the hotel’s 57 rooms faces the sea and Esperanza’s private beach but also offers access to four separate swimming pools. Hotel staff keep guests as busy as they want to be with a full schedule of activities, some of which are the usual Baja resort suspects like yoga lessons and cooking classes. A number of options are quite unique, however—book a master tequilero to teach you about the fine art of tequila appreciation, or take classes in Spanish, salsa, painting, and more. Guest rooms are gorgeous, with an earth-tone color scheme and fine, locally made handicrafts as decorative accents. Bathrooms in the casitas look out onto water, while villas have full kitchens and dining rooms.

If you love art in all its many forms, the Museum of Fine Arts (MFA) in Boston is a ‘must-see’ destination. They have a great collection of Impressionism and Asian art works, from Monet and Van Gogh, to Chinese furniture and Japanese paintings, as well as the Egyptian collections. In addition, their newly opened west wing contains many stunning pieces of American art. Besides the arts, there is a cafe, a restaurant, gift shops of course, and a mini cinema for special shows. To get there: The MFA has its own subway stop called, what else, the MFA. If you drive, there are parking garage options as well. You can easily spend half a day here—or more!

Even with all the noted thinkers, artists, politicians, and powerful families who’ve called Florence home, Leonardo da Vinci is arguably the city’s most famous son. This homage focuses less on his artwork and more on Da Vinci’s forward-thinking inventions and theories. The exhibits are separated into five themes, with each including models based on Da Vinci’s instructions. The Earth section includes pieces like printing machines and an oil press; Water has hydraulic saws and water floats; Fire boasts military artillery inspired by the Atlantic Codex; Air has Da Vinci’s parachute, flying machine, and “winged man” paragliding prototype; and Mechanisms includes items based on Da Vinci’s codexes, to demonstrate their principles. Most items are hands-off, but kids will have fun learning how to operate the rotating crane and other models. Most of the pieces are made of wood, so you really get a feel for their bones—and for Da Vinci’s genius.

After arriving on the tiny island of Iona near Mull in 563, Irish pilgrim Saint Columba proceeded to establish a Christian church and monastery, creating a vibrant religious community that lives on to this day. The monastery survived until the 12th century despite repeated Viking raids, and around 1200, the sons of Somerled founded a Benedictine abbey on the site. Though monastic life ended on Iona with the Protestant Reformation of 1560, pilgrimages to St Columba’s Shrine continued for many years. Today, it’s believed that the Book of Kells, along with several other great works of art, was created here.

Visit this most sacred of Scottish sights to see the four iconic high crosses, then tour the abbey church, with its 13th- to 16th-century architecture. You can also stop by St Columba’s Shrine, the longest-standing structure in the abbey, dating to the 9th or 10th century; climb Tòrr an Aba, a hill above the abbey where Saint Columba is said to have had a writing hut; or walk through Reilig Odhráin, the graveyard where ancient Scottish kings were laid to rest. While you’re exploring, keep an eye out for the vallum—a boundary ditch and bank of earth that serves as the only evidence of Columba’s original monastery.

Though his reputation is now arguably overshadowed by that of his former wife, painter and muralist Diego Rivera—commissioned by Mexico’s postrevolutionary governments starting in the late 1920s to adorn several national monuments in complex, pageantry- and allegory-laden wall paintings—was among the first Mexican artists to gain worldwide acclaim. Many of his finest works are on display in the Centro Histórico. Perhaps most spectacular are Rivera’s portrayals of Mexico’s millennia-long history, as seen in the Palacio Nacional on the Zócalo (Mexico City’s main square; take a state-issued ID for admission to the palace); a more contemporary depiction of socialist workers’ struggles (and one which includes a Frida Kahlo cameo) decorates a courtyard at the Secretariat of Public Education. One of the artist’s earliest pieces can be seen inside the amphitheater at the San Ildefonso museum. Additionally, the dazzling Sueño de una Tarde Dominical en la Alameda Central, a surrealist who’s-who of Mexico’s turbulent fin de siècle, is the chief artwork on display at the nearby Museo Mural Diego Rivera.