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Set amid the mangrove swamps, coastal lagoons, and stretches of coral reef in Portobelo National Park, this Design Hotels property features just five colorful villas. The “houses” range from a small, one-bedroom retreat nestled near a waterfall, to an over 8,000-square-foot residence spread over two floors. The whole property is awash in a kaleidoscope of vibrant hues, from the bright interiors with their boldly patterned tiles, decorative fabrics, and local artwork, to the multi-colored lounge chairs surrounding the infinity pool, which seems to merge seamlessly with the turquoise Portobelo Bay. Those seeking adventure can take a deep-sea dive to explore the wreck of a C-45 airplane, while guests looking to relax can book an outdoor massage on the hotel’s century-old barge.

At Isla Colón’s northwest extreme, Bocas del Drago is one of Panama’s most picturesque spots, an idyllic place for relaxing, soaking up sun or just marveling amid powdery white sand and lush jungle greenery. And what other beach affords “swimming with starfish”? Enhance your adventure at great local Caribbean restaurants featuring wiggle-fresh delicacies at delightfully low prices. When the tiny beach at Boca del Drago gets tight, Playa Estrella is a nearby alternative.

A collaboration between two of Siem Reap‘s most stylish women, French-Cambodians Nathalie Saphon-Ridel and Sirivan Chak, Galerie Cambodge specializes in beautiful fair trade clothes and accessories made in Cambodia to the highest quality of workmanship. The women work closely with designers and artisans to source, design and produce natural, eco-friendly garments, accessories and gifts. Collections change regularly, however, you can expect to find anything from the lightest of cotton shirts and scarves that are ideal for Siem Reap’s sultry weather to sturdy handmade leather sandals that will survive years of temple scrambling. Not everything is made in Cambodia—the women have made a few exceptions, such as authentic Panama hats, direct from the source. Also handy for long days in Siem Reap’s blazing heat.

Right in the center of town, Capri Tiberio Palace mixes la dolce vita glamour with a globe-trotting sensibility that’s equal parts quirky and elegant. Wanderlust-inducing knickknacks such as globes, vintage trunks, and an eclectic collection of art stud the public spaces, and bookshelves are stocked with coffee-table tomes from the publisher Taschen. A white baby grand provides the soundtrack for aperitivo hour at the Jacky Bar, where wicker poufs, striped blue-and-white banquettes, and Panama hats repurposed as wall decor signal vacation vibes; things are slightly more reserved at the terrace restaurant, a formal space whose brightly colored dishes (think seared scallops with almond sauce and beef tartare with chestnut cream as well as kosher fare) are rivaled only by the panoramic views of the island’s craggy peaks coast and azure sea. And the indoor-outdoor swimming pool, though small, is a savior in the summer heat.

The Victorian-era glass and wood structure, which looks like a sugar-coated castle atop a grassy slope, is Golden Gate Park’s oldest building. It’s also one of San Francisco’s most splendid historic sites. Wander through five different galleries housing 1,700 species of aquatic and tropical plants along with the world’s largest public collection of high-altitude orchids. The potted plant gallery features rare flowering plants and an assortment of decorative urns and containers from all over the world, including a leftover from San Francisco’s 1915 Panama-Pacific International Exposition. Keep your eyes open for special exhibits, including the annual Butterflies and Blooms, which transforms the conservatory into a magical garden aflutter with hundreds of butterflies.

After the Grand Canyon, Arizona’s second-biggest sightseeing destination is...London Bridge. And unlike many ‘world landmarks’ from up the road in Las Vegas, this is actual Old World stonework, meticulously de-constructed, transported, and re-constructed over the waters of a dammed section of the Colorado River. To be honest, I wouldn’t call this a ‘destination,’ but if you happen to be passing through the area on a road-trip, or if you’re a die-hard anglophile driving through the Desert Southwest, then this curiosity is worth a stop. This early 19th-century bridge began sinking in the early 20th-century as automobile traffic (for which the bridge hadn’t been designed) increased over the Thames, and so in the 1960’s the bridge was literally put up for sale. Arizona entrepreneur Robert P. McCulloch paid about two and a half million dollars for it, had it meticulously disassembled, shipped to California via the Panama Canal, and then trucked across to this spot on the the eastern banks of the Colorado River, a few hours south of Las Vegas. By 1971, the work was finished, and now you can kayak or jet-ski under these curious but venerable arches. (Note--Lake Havasu City has become a wildly popular college-crowd spring-break destination...and summers are brutally hot.)

The first Smithsonian affiliate in the Northwest, this superb museum chronicles the Asian Pacific American Experience. Among its most poignant exhibits is the Letter Cloud installation: old hotel walls frame tales of aging far away from home. It also offers walking tours of the surrounding International District, including Touch Of Chinatown, which visits the elegant Kobo gallery and Uwajimaya, one of America’s largest Asian grocery and gift stores. Stop into the nearby Panama Hotel, home to a teahouse and the nation’s only intact sentō (Japanese public bathhouse). Lockers and marble baths still stand in the basement, which harbored the belongings of Seattle’s 7,050 Japanese-American residents imprisoned in WWII internment camps—the basis for Jamie Ford’s best-selling novel Hotel On The Corner Of Bitter And Sweet.

In Panama you really can buy cheap and cheerful, even when it comes to exclusive boutiques and high-end labels, because of low import duties. In truth it seems as if there were a new mall opening every day, like so many mushrooms after a rain. Albrook Mall is the widest-ranging, and out-of-towners love it. Multiplaza Pacific is swankier, with prices to match, though there are perennially great sales, too. Finally there’s Metromall, the saving grace of shopaholics who have only a few hours between planes (it’s near the airport, and there is a free shuttle service there and back).

To see the Panama Canal in person is to dive deeply into that nation’s history. Coming from the capital, the closest entry point is the Miraflores Visitor Center. Dedicate enough time to check out exhibitions that reveal why the waterway was built here and how the route shaped Panama’s international profile. Head outside to see how the canal works. The structure has several levels, and the third level is always crowded with visitors seeking photo ops. (There’s a restaurant on level four.) If you have time, the Agua Clara observation center on the canal’s Caribbean side offers views of newer, wider locks that opened in 2016.

A 1,200-acre green space filled with museums, theaters, and gardens, Balboa Park is the center of art and culture in San Diego. It’s also one of the city’s most historic sites, built for the Panama–California exhibition in 1915. While the museums are definitely worth seeing, there are also a number of free attractions, including the photogenic Botanical Building, which houses more than 2,100 plants (including Venus flytraps); the Desert Garden, filled with succulents from around the world; and a sculpture court with works by Miró and Rodin. For one of the area’s best views, purchase a timed ticket to climb the California Tower in the Museum of Man. The ornate structure reopened to the public in 2015 after being closed for nearly 80 years and features a spiral staircase to the eighth floor, where you can catch a glimpse of the Cuyamaca Mountains, the Cabrillo Bridge, and even Mexico’s Coronado Islands.

The Cinta Costera is a seaside walk that follows the shores of Panama Bay and features recreational areas and green spaces, sports facilities, and bike paths. A very popular spot, especially on weekends, the promenade brings together all of Panama: a mash-up of athletes, canoodling couples, and families out for a stroll, slurping on ice cream or cucurucho de raspados (sweet, syrupy shaved ice). You’ll also enjoy a view of the city skyline, from the modern districts and their look-at-me skyscrapers to the old colonial quarter. There’s another great vantage point at the Mirador del Pacífico, a 15-acre landfill breakwater that’s become one of the city’s most visited attractions. Other standout “la Cinta” sites include the food stalls at the Mercado del Marisco and Sabores del Chorrillo, as well as the Maracaná soccer stadium.

The town of Gamboa lies at the center of a rain forest on the banks of the Panama Canal, where Lake Gatún and the River Chagres meet about 20 miles from the capital. Gamboa’s Summit Park is home to Panama’s national bird, the harpy eagle, as well as to Soberanía National Park and the Panama Rainforest Discovery Center, where visitors can walk the Camino del Oleoducto (Pipeline Road), a famous bird-watching path where up to 300 avian species can be spotted on a single day. Another tip might be sailing the Chagres in piraguas (local pirogues or handmade dugout canoes) that plumb dense jungles and give visitors the chance to interact with the Emberá Quera indigenous community. This historic community lives off fishing, farming, artisanal craft-making, and tourism. Native-led tours showcase various local customs such as dances as well as vegetable-dye body-painting techniques and their meanings (known as jagua), in addition to the people’s relationship with nature. Navigating the rain forest with a traditional Emberá botanist is a singular experience.

Cajones are the small shallow canyons on the Chame River, favored by nature lovers and thrill-seekers alike. The canyon’s walls are eroded in places in delineated strata that reveal the Isthmus of Panama’s geologic history. You can hike or rappel along the canyon, or swim, float, or tube down the river, through eight pristine pools that invite general splashing about. To get there, drive the Pan-American Highway west from the capital, then merge onto the Bejuco-Sorá road. Los Cajones is twenty minutes away by 4x4 (you can park at the entrance and, for a small fee, take a shuttle service). There are no facilities inside the park at all, so come prepared with food and water.

Panama City’s seafood market stands near the halfway point along the Cinta Costera, so the goodies on offer can be your reward after a long walkabout. Since colonial times, fishermen who sold the city its seafood have anchored here; there’s now an up-to-date market home to nearly a score of open-air stalls where customers chow down on ceviche, fried corvina fish with patacones (fried plantain rounds), filete a lo macho (fish filet in a shellfish ragout), and those same patacones, now stuffed with shrimp or much-celebrated shellfish guacho (think a tropical risotto). Don’t expect anything ritzy: This is plastic-chair-and-table country, but the food is so delicious that you won’t be thinking about the ambience.

The causeway known as Calzada de Amador was constructed a century ago from nearly 3.5 million cubic feet of excavated material from the Panama Canal. It was built as a breakwater for ships awaiting entry as well as to connect Naos, Culebra, Perico, and Flamenco islands—and their U.S.-built fortifications defending the canal—to the mainland. Amador has been recently restored and is one of the best places to enjoy the sunset with an ocean view. One particularly nice approach is going out to Isla Flamenco and hitting one of its restaurant terraces overlooking the surf. There’s also a small shopping center there for duty-free purchases. Of course, if you’re looking for some open-air sun and fun, rent a bike at one of the stalls on shore, near the Figali Convention Center.