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About a two-and-a-half hour drive from Santiago (or 30 minutes by helicopter), Puma Lodge is located in the Andean foothills near the Argentine border. The lodge is part of the Chilean-owned Noi hotel group, which also has properties in Patagonia, Atacama, Santiago, and more. Opened in 2011, Puma Lodge has a ski chalet feel, with wooden interiors and a large fireplace in the middle of the bar and lounge area. The 24 rooms are all the same category, and the design is simple and comfortable with touches such as colorful throws and local artwork.

Many guests choose Puma Lodge for the heli-skiing, but there’s plenty on offer year-round and for the less intrepid traveler. Activities include hiking, horseback riding, or heading out for a picnic lunch by the river. There’s also an on-site spa, yoga studio, and wine cave. Outdoor hot tubs are great after skiing, and a swimming pool is a draw in the summer months.

Founded in the 9th century, Santa Maria della Scala was one of Europe’s first hospitals. It was also one of the first hospitals anywhere to disinfect its equipment and only stopped taking in patients in the 1980s. (The writer Italo Calvino died here in 1961.) The early history of the hospital is illustrated in the 15th-century frescoes decorating the walls of the Pilgrim’s Hall, and there is a fascinating archaeological museum housed in the labyrinthine basement rooms.

Beneath the path of planes taking off from LAX is an oceanfront runway for beginner hang gliders to get some air of their own. Sign up for a full (seven flights for $140) or half lesson (four flights for $85) with Windsports, which has been operating with A-class instructors since 1974. The experienced Greg DeWolf, whose longest flight clocked in at 6.5 hours, is a recommended guide. His passion, thoroughness, and humor are just what a novice needs to feel comfortable and confident piloting this new flying contraption. Relaxing is key, and once you do, the flights are a calming enjoyable ride. Just make sure to look up so you remember the experience!

In recent years, one restaurant has set the bar for cool in Cabo San Lucas. Bar Esquina, the Bahia Hotel & Beach House’s on-site bar and grill, features a chic casbah-like design aesthetic, a menu built on Mexican and Mediterranean flavors, and a commitment to organic, locally and responsibly sourced ingredients you taste in every bite. The menu is ever-evolving, but there are standouts you can always expect to find. The tuna tartare is a tiered, artistic creation, featuring tempura and an avocado-yuzu mousse. The Caesar is the signature Bar Esquina salad, here wrapped in a long, flat crouton and served with poached egg and prosciutto. Entrée selections include a generous filet mignon with potatoes au gratin and the short-rib pizza with blue cheese and arugula.

It was love at first sight. Everything about Orvieto is charming, with the exception of the Duomo (Cathedral) which more appropriately would be described as elegant and grand, especially the facade. Originally a thriving center of Etruscan civilization, Orvieto is a little less then half way between Rome and Florence. We had a lovely meal on one of the cute cobble stone lanes before heading up the clock tower and gazing over the perfectly preserved city. You could easily spend a day or two wandering through the town, enjoying its history and culture, both past and present. We were treated with the utmost hospitality at every turn. There weren’t many visitors during our visit, which I found to be unusual, given its popularity on the tourist circuit. This will be a place to revisit, and immerse ourselves into the everyday life of this gorgeous gem.

Few cuisines marry as well as Japanese and Mexican, a fusion that’s masterfully explored at Nick-San in Cabo San Lucas and San José del Cabo. Founding chefs Ángel Carabajal and Masayuri Niikura blend centuries-old Japanese recipes (including but not limited to sushi) with locally sourced ingredients to create exceptional bursts of flavor and a menu that has inspired additional locations around Mexico. The black and white tuna sashimi and tuna tostada are two of the most popular dishes, especially when paired with Nick-San’s own label of wines and sake. The original location is in downtown Cabo San Lucas, near the marina. A second Nick-San, in the Shoppes at Palmilla at the southern border of San José del Cabo, is a slightly more elegant space (gilding the lily, you might say) and includes a champagne bar.

Before Luis Barragán designed Mexico’s first master-planned community in the suburbs of Mexico City, he dreamed up an urban park neighborhood in his native Guadalajara. He commissioned German artist Matias Goeritz to create an entrance sculpture called El Pájaro Amarillo (The Yellow Bird) and drew plans for an onsite chapel named Templo el Calvario (Temple of Calgary). Unfortunately, the neighborhood today doesn’t look much like Barragán intended—he’d planned for a different kind of tree to be planted on each street so that the area would bloom in a rainbow pattern, and for wider streets lined with shopping malls. However, you can still visit Jardines del Bosque to see the majestic Goeritz sculpture and chapel and, if you squint your eyes, imagine Barragán’s vision come to life.

We live in the age of artisanal everything, from chocolate and coffee, to, you guessed it, water. At Mexico City‘s Casa del Agua, staff produce and bottle “local water” on-site. The bottles—designed artisanally, of course—are charming souvenirs that you can use over and over again (with your own, less expensive water) once you’re home. Be sure to go to the second level of the shop to see the filtration process, and to the terrace level to see where the water is captured.

In reality, the 1,620-hectare (4,000-acre) Barro Colorado Island is a hilltop. Or, at least it was until the creation of Gatún Lake turned it into the largest island in the Canal Zone, one where the Smithsonian Institute operates a research center and gives morning tours. Ships sail tightly past the island, offering the chance to glimpse toucans, iguanas and bats that live among the 1,300 plant species and 381 bird species of this vital tropical woodland.

This archipelago off the coast of La Paz (which takes the name of the main island) is a protected UNESCO Biosphere Reserve. While the islands are uninhabited by humans save for a small fishing camp made of temporary structures, they’re home to a great variety of flora and fauna. In addition to dolphins, frigate birds, and ring-tailed cats, you’ll find the only known black jackrabbit population in the world. Celebrated eco-friendly activities company Cabo Expeditions leads daylong archipelago tours that include exploring the mesmerizing volcanic landscape, a ceviche lunch, and an opportunity to swim on Ensenada Grande Beach—often cited as one of the world’s most beautiful—plus guided snorkeling with the incredibly playful pups at the Los Islotes sea lion colony.

This landmark inn has been around since 1936, when it was known as the Hotel Martin—and the adobe homes that comprise the property date back even earlier. Originally built in the 1800s, the structures are clustered around a central plaza that, today, serves as the hotel lobby. The largest residence is now the restaurant Doc Martin’s, named after its onetime owner, Dr. Thomas Paul Martin, the county physician as well as an avid supporter of the arts. In fact, the Taos Society of Artists was founded in his dining room in 1912, and he later bought the neighboring houses to rent out to writers and artists. When the only hotel in town burned to the ground, Doc bought the Tartleton House (the last on the square and now home to the Adobe Bar) and he and his wife Helen opened for business. The property has been maintained and upgraded over the years (most recently in 2006), but the look (Spanish colonial antiques and brightly patterned bedspreads) hasn’t changed much since then—and that’s part of the charm.

Located in Jardines del Pedregal, an elegant suburb on the outskirts of the city, Tetetlán is worth the trip. Originally the horse stables of a home designed by Mexico’s most influential architect, Luis Barragán, the space was recently restored by an art collector who lives next door. It is many things: a café serving shade-grown local coffee, a showcase for local designers, a restaurant serving creative Mesoamerican dishes, a yoga studio, a hotel for visiting artists who are asked to donate a book to Tetetlán’s extensive collection, and a listening library. But it’s the space’s design that’s truly breathtaking: glass floors look down on the area’s local purple-black volcanic rock, and the sun pouring in from skylights is warmed by rafters painted in Barragán’s signature pink.

Handcrafted paper has a long tradition in this region. The art was learned from 11th-century Arab traders and Amalfi’s fame for paper production grew to comprise 11 mills operating in Valle dei Mulini. Duck into this beautiful store near the Arsenale buildings to cool off and shop for handmade paper and curiosities. Using the old techniques, Andrea De Luca and Giovanna Fusco create gilt-edged cards, leatherbound books, and fine-art prints. In the back of the store, browse the owners’ wonderful collection of antique ceramics, oil and watercolor paintings from the 18th century, as well as original historic maps and reproductions.

From the outside, the Royal Ontario Museum appears to have been struck by a mineral formation from outer space. When the original building was overhauled by starchitect Daniel Libeskind, many locals were dismayed by the new addition, called the Michael Lee-Chin Crystal, but most have come around to its angular charms. Visitors to this museum of world cultures and natural history can work their way through galleries showcasing Chinese sculptures, Canada’s First Nations artifacts and crafts, dinosaur skeletons, and Byzantine artwork. Special exhibits have included everything from the intricate textiles of Mexico to an in-depth look at the culture of tattoos.

Tayrona National Natural Park has become such a popular destination during typical vacation periods that authorities have had to limit admission. But an off-season visit offers singular luxuries like miles of all-but-solitary beaches, jungle trails, and a unique way to observe a variety of monkeys and tropical birds in every brilliant hue. Tayrona can be experienced as a day trip from Santa Marta or as a several-night stay at one of the park’s accommodations. From the main entrance at Cañaveral (El Zaíno), visitors can take a leisurely hike to the ocean while a donkey handles the luggage; horses are also available for those who prefer not to walk. This same park entrance also leads directly to high-roofed, native-wood cabins known as ecohabs, a slightly fancier option for staying in the park.