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Painted by Michelangelo between 1508 and 1512, the frescoes on the Sistine Chapel ceiling are considered some of the finest art ever produced. These religious paintings include nine scenes from the Book of Genesis, of which The Creation of Adam is undoubtedly the most iconic.

Like all outdoor markets in Rome, Campo de’ Fiori is a bustling social center where locals push past throngs of tourists to complete their errands. Every morning you can find nonni shopping for produce with their grandchildren, feisty butchers running the day’s orders, and barmen hand-delivering trays of espresso to the vendors. By late afternoon, the market quiets down as vendors head home for the evening, and slowly buskers and musicians make their way to the square. By sunset, Campo once again surges with energy, this time to fuel the nightlife.

As is the case with many hotels in the Tulum section of Riviera Maya, Casa de las Olas shies away from the “luxe” label, preferring to promote itself as a simple, eco-friendly retreat where intimate spaces and five-star service are more important than linen thread counts and extra amenities. Bright white walls, mosquito nets, private balconies, and canopy beds are what guests can expect in their rooms. This doesn’t mean that Casa de las Olas is skimpy in any way. The staff are known for their thoughtful attention to guests, and the small size of the hotel—just five suites—ensures they are never overwhelmed by guests’ requests or needs. Plus, each room has views of the Caribbean Sea, and the hotel’s private beach is never more than a few steps away.

La Specola, one of the oldest science museums in Europe, contains a collection of specimens of the natural world—some of which date back to the 16th century. It includes strange and wonderful objects ranging from tiny iridescent green beetles and multicolored butterflies to whale and rhinoceros skeletons. There’s even a hippo, preserved by taxidermy, that was once pet to the Medici family and lived in the Boboli Gardens! The extraordinary, if slightly creepy, anatomical waxes filling the last four rooms of the museum were once used to train Florentine medical students. The frescoes and elaborate pietra dura inlays that decorate the walls and ceilings detail Italian scientific achievements.

Bistro Don Giovanni opened more than 20 years ago and is still among the most popular Italian restaurants in Napa, meaning it can be downright impossible to get a table at the eatery unless you roll in late. Dishes include fritto misto, agnolotti with salmon and sweet pea cream sauce, and branzino poached in a tomato-garlic broth. Locals love Mamma Concetta’s meatballs, the beet and haricot vert salad, and, when it’s on the menu, lasagna. Don Giovanni also has a sophisticated bar program that includes a number of specialty cocktails, as well as wine imported from Italy, and the attentive, old-school service is appreciated by patrons. The generous back patio has a fountain and overlooks vineyards and a kitchen garden.

When a South African woman and an Italian man met each other—and Bonaire—through their work on cruise ships, beautiful things ensued. Not least, the handmade glass jewelry at the shop the pair opened here several years ago. Check out, among other baubles, the particularly apt Angelfish Collection.

While filming And God Created Woman here in 1956, French superstar Brigitte Bardot made Ramatuelle’s Pampelonne Beach a summer icon. Today, the beach and neighboring St. Tropez continue to draw celebrity jet-setters like Elton John and Kate Moss, who arrive in luxury cars and yachts to see and be seen on 100-euros-per-day loungers at Le Club 55. More adventurous visitors can tour the coast with a pair of wheels from Vélorama, or a kayak or stand-up paddleboard from Pep’s Spirit (which may be the smarter choice given the endless traffic along the local roads).

With its tiny, intimate location (inside a 1920s-era former home) and all the accolades (including a James Beard semifinalist nod for Best Chef, Southwest), this Bishop Arts District spot remains one of the harder reservations to snag in town—but it’s well-worth it to keep trying. When you do make it in, you’ll be treated to chef/owner David Uygur’s seasonal Italian-inspired menus, which might include crostini topped with a Calabrian chili and bacon pâté, risotto with celery root and foie gras, or duck leg confit served with polenta, topped off with olive oil cake with prune jam and burnt-cinnamon gelato. The meats are house-cured, the pasta homemade, the ingredients local, and—with Uygur’s wife overseeing the dining room—the atmosphere full of charm, all of which has helped make this a favorite for date nights, special occasions, and foodie splurges.

Italian food is the specialty at this restaurant at the Four Seasons, with house-made pastas and braised meats from chef Antonio Minichiello stealing the show. Though the dining room is stylish, the best tables are outside on the veranda—as the name suggests. The brunch features fresh cold-pressed juice and, on weekends, a doughnut-making machine. There’s also an afternoon tea service from 3 p.m. to 4 p.m. that includes scones with cream and lemon curd and a variety of finger sandwiches. For those who prefer cocktails, the evening happy hour is surprisingly affordable.

Buenos Aires is a city of readers—it supports more bookstores per capita than any other place in the world. The crown jewel of the librerías here is the Ateneo Grand Splendid. Housed in a theater where music legends such as Carlos Gardel once attracted vast crowds, the store features shelf after shelf of tempting volumes on its rounded balconies. Italian frescoes on the domed ceiling and plush red-velvet curtains are from the theater’s original 1919 design. The four-story space carries over 120,000 books and a local-music selection, and there’s a café on the erstwhile stage.

One of Canada’s most iconic hotels, the Fairmont Chateau Lake Louise is cradled by the Rocky Mountains, its grand, castle-like structure surrounded by towering peaks and the pristine, protected wilderness of Banff National Park. The hotel was founded in 1890 by Cornelius Van Horne, the general manager of the Canadian Pacific Railway, who envisioned creating a refuge for “the outdoor adventurer and alpinist.” What began as a one-story log cabin ended up helping to kick-start tourism in the Canadian Rockies, launch the Canadian mountaineering scene, and draw a host of notable names to the region, from Marilyn Monroe to Queen Elizabeth II.

Today, guests arrive in a grand lobby outfitted with imposing chandeliers and sweeping staircases. Common areas are decorated with old-timey photos from the hotel’s past, while the 552 spacious rooms and suites are all about showcasing views of the stunning turquoise lake and snowcapped Victoria Glacier. There are plenty of activities to enjoy year-round, from canoeing, hiking, fishing, rafting, and horseback riding in warmer weather, to skiing, snowboarding, ice skating, and snowmobiling in the winter. In between, savor everything from European alpine dishes, authentic Italian fare, and Canadian comfort food to a large selection of bourbons and whiskeys at the seven dining outlets, or head to the spa and health club for a pampering treatment or dip in the indoor heated pool.

Cirque du Soleil’s only resident troupe outside of Las Vegas and Orlando opened in 2014, kicking off yet another stellar attraction for visitors to Cancun and the Riviera Maya. The colorful 70-minute performance - which has been dubbed JOYÀ - offers an immersive theatrical and culinary experience for the whole family. The name JOYÀ, rooted in the Spanish “joya” meaning jewel or pearl, alludes to a person or event of great value. Through this mesmerizing performance, an alchemist’s granddaughter discovers joy and wisdom by sharing an extraordinary experience in an unlikely place.

One of the most iconic landmarks of Montevideo, the Palacio Salvo stands on the Plaza Independencia. The building was intended as a hotel when it was constructed in 1928, according to a design by the Italian architect Mario Palanti, but it never served that purpose and today is home to offices and private apartments. The building is closed to the public, but you can still admire its unusual neo-Gothic design from the plaza.

While many Italian hotels rest on the country’s historic laurels by harking back to bygone eras, from the opulence of the Renaissance to the sleek design heaven of the 1960s, the Meliá Génova—itself an art deco icon—is confident enough to stride straight into contemporary decor. Originally a steel manufacturer’s headquarters, long known as the luxe Bentley Hotel, its geometric lines and burnished metals evoke midcentury styles. But the hotel is undeniably modern and understated, with its bright and airy rooms, designer furnishings, abstract artwork, and luxurious touches like hot tubs on balconies. The serene, Zen-inspired subterranean pool and spa area demonstrates the Meliá’s fearlessness in breaking from Italian Riviera traditions, a fact only reinforced by the sultry restaurant and bar, which serves Spanish, French, and Greek cuisine—near heresy in a country that prides itself on its excellent food. But the bets have paid off: not only does the Meliá attract glamorous out-of-towners, but even the locals know it’s one of the hottest spots in town, as evidenced by the lively scene found in the bar each night.

Fly by Jing is chef Jenny Gao’s pop-up supper club, where 10 lucky diners get to sample 10 to 15 courses of “Sichuan soul food.” Gao was born in China but raised in Toronto, and her dinner menus reflect this East-West tension. Imagine a Chinese-Italian fusion dish with organic black pork dumplings over fresh pasta, the bowl topped with a cured egg-yolk. Dinners happen twice a month and cost about $77, including one cocktail, beer, and wine. Subscribe to Gao’s email newsletter to scoop up tickets to the next culinary event; seats sell out fast.