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In the past, aspiring artists would head for Mexico City as soon as they could scrape together the cash. More recently, however, they’ve been drawn to Guadalajara, where a new crop of funky art galleries and creative spaces has turned neighborhoods like Colonia Lafayette and Colonia Americana into design destinations for Mexico’s cultural set.

Life in San Miguel moves at an easy pace, from poolside breakfast to a hike to an afternoon spa treatment to a leisurely dinner on a terrace. Here’s our list of the best ways to enjoy the lovely, long days in this charming town.

Venture a little off the beaten path for big rewards—tlayudas and parrilladas with a view, samples of organic mezcal, and abundant archaeological treasures.

Located on the southern tip of Mexico’s Baja California Peninsula, Los Cabos (made up of San José del Cabo and Cabo San Lucas) is the ideal beach getaway. Here, a variety of accommodations—from boutique hotels with palapas on the sand to luxury resorts with infinity pools, golf courses, and even butler service—await, all with breathtaking views of surf and sunset.

Surf the world’s most famed waves, from the heavy sets of Tahiti to the fast-breaking rides in Puerto Escondido, Mexico.

Acclaimed Mexican artist/painter Diego Rivera (a.k.a. Mr. Frida Kahlo) created these Aztec mosaic murals, which continue to the left, on the outside walls of this house in the old tourist center of Acapulco. He stayed in this house, which belonged to his final lover Dolores Olmedo, while recovering from cancer, and eventually died here in 1957. The mural is titled Exekatlkalli (House of the Winds).

With ocean at every turn, Fort Myers and Sanibel offer plenty of options for waterfront dining. Your only problem will be deciding whether you want marina views, Gulf of Mexico vistas, or a little bit of both.

From its ancient roots and colonial treasures to modern-day craftspeople, this city lives and breathes art and culture. And Oaxaca’s museums brilliantly showcase it so you can easily take it all in.

Wine aficionados set their sights on the Guanajuato Wine Route, now perhaps second only in Mexico to the trails in Baja California’s long-established Valle de Guadalupe. While wineries have existed in this region for several decades, San Miguel only recently received official designation as a wine route, thanks to wineries like Vega Manchón (owner Ricardo hails from Mexico City); Bodega Dos Búhos, where art by Peter Leventhal mesmerizes visitors almost as much as the wine; or Vinícola Toyán. Newcomer labels like Santísima Trinidad have joined the old-timers in hosting vendimia events every weekend in August, with Santísima adding extra attractions like polo games and olive-oil demonstrations. No going Sideways for oenophiles here; they will head home with a new wine destination secret—and a bottle or two.

It’s no wonder Georgia O’Keeffe came to this New Mexico town to paint. The high-desert setting inspires artists. Think of the city as your oyster: Take in the abundance of local works that occupy a surprising variety of spaces. Hop from ceramic studio to folk art museum, and from photography exhibit to cutting-edge gallery. Even the capitol building is filled with artwork.

If your idea of a perfect beach includes white sands and clear, calm waters, Fort Myers and Sanibel have you covered. Here, you’ll have your choice of beaches with Gulf of Mexico views, great fishing and shelling, a family scene, or the ideal bar for watching the sunset.

Rosewood Mayakoba puts you in a vacation mindset within moments after you land in Mexico. The resort’s 130 suites are strung along the canals of the lagoon or overlook the Caribbean. If you’re looking for a quiet escape along with a serene 17,000-square foot spa on its own island and three restaurants serving the best local dishes and tequilas—then Rosewood Mayakoba is the right resort for you.

Bar Hidalgo 56 is probably one of my top three pintxo bars in the entire city. With a bar stacked full of equally delicious pintxos, a menu of hot pintxos that is incredibly varied and delicious, and an attention to product that you simply don’t find in other bars, Hidalgo 56 is worth a visit. Try the volcano of morcilla.

La Casa de La Abuela is a Oaxaca mainstay, on the corner between the Zocalo and the Alameda, Oaxaca’s two central squares. Find the entrance on Hidalgo street, and climb the steps up to the second floor. As soon as you enter you’ll see a big clay comal and a woman making fresh tortillas, the sign that this is the real deal: authentic Oaxacan food. They serve local specialties including four kinds of mole (almendrado, coloradito, amarillo and mole negro). Choose a spot by the window to enjoy your meal while you watch the action in the square below.